KEGG   Macaca nemestrina (pig-tailed macaque): 105494953
Entry
105494953         CDS       T08765                                 
Symbol
PIK3R3
Name
(RefSeq) LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
mni  Macaca nemestrina (pig-tailed macaque)
Pathway
mni01521  EGFR tyrosine kinase inhibitor resistance
mni01522  Endocrine resistance
mni01524  Platinum drug resistance
mni04012  ErbB signaling pathway
mni04014  Ras signaling pathway
mni04015  Rap1 signaling pathway
mni04024  cAMP signaling pathway
mni04062  Chemokine signaling pathway
mni04066  HIF-1 signaling pathway
mni04068  FoxO signaling pathway
mni04070  Phosphatidylinositol signaling system
mni04071  Sphingolipid signaling pathway
mni04072  Phospholipase D signaling pathway
mni04081  Hormone signaling
mni04140  Autophagy - animal
mni04150  mTOR signaling pathway
mni04151  PI3K-Akt signaling pathway
mni04152  AMPK signaling pathway
mni04210  Apoptosis
mni04211  Longevity regulating pathway
mni04213  Longevity regulating pathway - multiple species
mni04218  Cellular senescence
mni04360  Axon guidance
mni04370  VEGF signaling pathway
mni04380  Osteoclast differentiation
mni04510  Focal adhesion
mni04550  Signaling pathways regulating pluripotency of stem cells
mni04611  Platelet activation
mni04613  Neutrophil extracellular trap formation
mni04620  Toll-like receptor signaling pathway
mni04625  C-type lectin receptor signaling pathway
mni04630  JAK-STAT signaling pathway
mni04650  Natural killer cell mediated cytotoxicity
mni04660  T cell receptor signaling pathway
mni04662  B cell receptor signaling pathway
mni04664  Fc epsilon RI signaling pathway
mni04666  Fc gamma R-mediated phagocytosis
mni04668  TNF signaling pathway
mni04670  Leukocyte transendothelial migration
mni04722  Neurotrophin signaling pathway
mni04725  Cholinergic synapse
mni04750  Inflammatory mediator regulation of TRP channels
mni04810  Regulation of actin cytoskeleton
mni04910  Insulin signaling pathway
mni04914  Progesterone-mediated oocyte maturation
mni04915  Estrogen signaling pathway
mni04917  Prolactin signaling pathway
mni04919  Thyroid hormone signaling pathway
mni04923  Regulation of lipolysis in adipocytes
mni04926  Relaxin signaling pathway
mni04929  GnRH secretion
mni04930  Type II diabetes mellitus
mni04931  Insulin resistance
mni04932  Non-alcoholic fatty liver disease
mni04933  AGE-RAGE signaling pathway in diabetic complications
mni04935  Growth hormone synthesis, secretion and action
mni04960  Aldosterone-regulated sodium reabsorption
mni04973  Carbohydrate digestion and absorption
mni05010  Alzheimer disease
mni05017  Spinocerebellar ataxia
mni05020  Prion disease
mni05100  Bacterial invasion of epithelial cells
mni05135  Yersinia infection
mni05142  Chagas disease
mni05146  Amoebiasis
mni05160  Hepatitis C
mni05161  Hepatitis B
mni05162  Measles
mni05163  Human cytomegalovirus infection
mni05164  Influenza A
mni05165  Human papillomavirus infection
mni05166  Human T-cell leukemia virus 1 infection
mni05167  Kaposi sarcoma-associated herpesvirus infection
mni05168  Herpes simplex virus 1 infection
mni05169  Epstein-Barr virus infection
mni05170  Human immunodeficiency virus 1 infection
mni05171  Coronavirus disease - COVID-19
mni05200  Pathways in cancer
mni05203  Viral carcinogenesis
mni05205  Proteoglycans in cancer
mni05206  MicroRNAs in cancer
mni05207  Chemical carcinogenesis - receptor activation
mni05208  Chemical carcinogenesis - reactive oxygen species
mni05210  Colorectal cancer
mni05211  Renal cell carcinoma
mni05212  Pancreatic cancer
mni05213  Endometrial cancer
mni05214  Glioma
mni05215  Prostate cancer
mni05218  Melanoma
mni05220  Chronic myeloid leukemia
mni05221  Acute myeloid leukemia
mni05222  Small cell lung cancer
mni05223  Non-small cell lung cancer
mni05224  Breast cancer
mni05225  Hepatocellular carcinoma
mni05226  Gastric cancer
mni05230  Central carbon metabolism in cancer
mni05231  Choline metabolism in cancer
mni05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mni05415  Diabetic cardiomyopathy
mni05417  Lipid and atherosclerosis
mni05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mni00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    105494953 (PIK3R3)
   04014 Ras signaling pathway
    105494953 (PIK3R3)
   04015 Rap1 signaling pathway
    105494953 (PIK3R3)
   04370 VEGF signaling pathway
    105494953 (PIK3R3)
   04630 JAK-STAT signaling pathway
    105494953 (PIK3R3)
   04668 TNF signaling pathway
    105494953 (PIK3R3)
   04066 HIF-1 signaling pathway
    105494953 (PIK3R3)
   04068 FoxO signaling pathway
    105494953 (PIK3R3)
   04070 Phosphatidylinositol signaling system
    105494953 (PIK3R3)
   04072 Phospholipase D signaling pathway
    105494953 (PIK3R3)
   04071 Sphingolipid signaling pathway
    105494953 (PIK3R3)
   04024 cAMP signaling pathway
    105494953 (PIK3R3)
   04151 PI3K-Akt signaling pathway
    105494953 (PIK3R3)
   04152 AMPK signaling pathway
    105494953 (PIK3R3)
   04150 mTOR signaling pathway
    105494953 (PIK3R3)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    105494953 (PIK3R3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    105494953 (PIK3R3)
  09143 Cell growth and death
   04210 Apoptosis
    105494953 (PIK3R3)
   04218 Cellular senescence
    105494953 (PIK3R3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    105494953 (PIK3R3)
   04550 Signaling pathways regulating pluripotency of stem cells
    105494953 (PIK3R3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    105494953 (PIK3R3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    105494953 (PIK3R3)
   04613 Neutrophil extracellular trap formation
    105494953 (PIK3R3)
   04620 Toll-like receptor signaling pathway
    105494953 (PIK3R3)
   04625 C-type lectin receptor signaling pathway
    105494953 (PIK3R3)
   04650 Natural killer cell mediated cytotoxicity
    105494953 (PIK3R3)
   04660 T cell receptor signaling pathway
    105494953 (PIK3R3)
   04662 B cell receptor signaling pathway
    105494953 (PIK3R3)
   04664 Fc epsilon RI signaling pathway
    105494953 (PIK3R3)
   04666 Fc gamma R-mediated phagocytosis
    105494953 (PIK3R3)
   04670 Leukocyte transendothelial migration
    105494953 (PIK3R3)
   04062 Chemokine signaling pathway
    105494953 (PIK3R3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    105494953 (PIK3R3)
   04923 Regulation of lipolysis in adipocytes
    105494953 (PIK3R3)
   04929 GnRH secretion
    105494953 (PIK3R3)
   04915 Estrogen signaling pathway
    105494953 (PIK3R3)
   04914 Progesterone-mediated oocyte maturation
    105494953 (PIK3R3)
   04917 Prolactin signaling pathway
    105494953 (PIK3R3)
   04926 Relaxin signaling pathway
    105494953 (PIK3R3)
   04935 Growth hormone synthesis, secretion and action
    105494953 (PIK3R3)
   04919 Thyroid hormone signaling pathway
    105494953 (PIK3R3)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    105494953 (PIK3R3)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    105494953 (PIK3R3)
  09156 Nervous system
   04725 Cholinergic synapse
    105494953 (PIK3R3)
   04722 Neurotrophin signaling pathway
    105494953 (PIK3R3)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    105494953 (PIK3R3)
  09158 Development and regeneration
   04360 Axon guidance
    105494953 (PIK3R3)
   04380 Osteoclast differentiation
    105494953 (PIK3R3)
  09149 Aging
   04211 Longevity regulating pathway
    105494953 (PIK3R3)
   04213 Longevity regulating pathway - multiple species
    105494953 (PIK3R3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105494953 (PIK3R3)
   05206 MicroRNAs in cancer
    105494953 (PIK3R3)
   05205 Proteoglycans in cancer
    105494953 (PIK3R3)
   05207 Chemical carcinogenesis - receptor activation
    105494953 (PIK3R3)
   05208 Chemical carcinogenesis - reactive oxygen species
    105494953 (PIK3R3)
   05203 Viral carcinogenesis
    105494953 (PIK3R3)
   05230 Central carbon metabolism in cancer
    105494953 (PIK3R3)
   05231 Choline metabolism in cancer
    105494953 (PIK3R3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    105494953 (PIK3R3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    105494953 (PIK3R3)
   05212 Pancreatic cancer
    105494953 (PIK3R3)
   05225 Hepatocellular carcinoma
    105494953 (PIK3R3)
   05226 Gastric cancer
    105494953 (PIK3R3)
   05214 Glioma
    105494953 (PIK3R3)
   05221 Acute myeloid leukemia
    105494953 (PIK3R3)
   05220 Chronic myeloid leukemia
    105494953 (PIK3R3)
   05218 Melanoma
    105494953 (PIK3R3)
   05211 Renal cell carcinoma
    105494953 (PIK3R3)
   05215 Prostate cancer
    105494953 (PIK3R3)
   05213 Endometrial cancer
    105494953 (PIK3R3)
   05224 Breast cancer
    105494953 (PIK3R3)
   05222 Small cell lung cancer
    105494953 (PIK3R3)
   05223 Non-small cell lung cancer
    105494953 (PIK3R3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    105494953 (PIK3R3)
   05170 Human immunodeficiency virus 1 infection
    105494953 (PIK3R3)
   05161 Hepatitis B
    105494953 (PIK3R3)
   05160 Hepatitis C
    105494953 (PIK3R3)
   05171 Coronavirus disease - COVID-19
    105494953 (PIK3R3)
   05164 Influenza A
    105494953 (PIK3R3)
   05162 Measles
    105494953 (PIK3R3)
   05168 Herpes simplex virus 1 infection
    105494953 (PIK3R3)
   05163 Human cytomegalovirus infection
    105494953 (PIK3R3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    105494953 (PIK3R3)
   05169 Epstein-Barr virus infection
    105494953 (PIK3R3)
   05165 Human papillomavirus infection
    105494953 (PIK3R3)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    105494953 (PIK3R3)
   05100 Bacterial invasion of epithelial cells
    105494953 (PIK3R3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    105494953 (PIK3R3)
   05142 Chagas disease
    105494953 (PIK3R3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105494953 (PIK3R3)
   05017 Spinocerebellar ataxia
    105494953 (PIK3R3)
   05020 Prion disease
    105494953 (PIK3R3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105494953 (PIK3R3)
   05418 Fluid shear stress and atherosclerosis
    105494953 (PIK3R3)
   05415 Diabetic cardiomyopathy
    105494953 (PIK3R3)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    105494953 (PIK3R3)
   04932 Non-alcoholic fatty liver disease
    105494953 (PIK3R3)
   04931 Insulin resistance
    105494953 (PIK3R3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    105494953 (PIK3R3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    105494953 (PIK3R3)
   01524 Platinum drug resistance
    105494953 (PIK3R3)
   01522 Endocrine resistance
    105494953 (PIK3R3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mni04131]
    105494953 (PIK3R3)
Membrane trafficking [BR:mni04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    105494953 (PIK3R3)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 SH2_1 Transcrip_act
Other DBs
NCBI-GeneID: 105494953
NCBI-ProteinID: XP_024652764
Ensembl: ENSMNEG00000042202
LinkDB
Position
Unknown
AA seq 478 aa
MPAFTPPGAVGWRLSGAMYNTVWSMDHDDADWREVMMPYSTELIFYIEMDPPALPPKPPK
PMTSAVTNGMKDSSVSLQDAEWYWGDISREEVNDKLRDMPDGTFXVRDASTKMQGDYTLT
LRKGGNNKLIKIYHRDGKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRY
QQDQLVKEDNIDAVGKKLQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETI
KIFEEQCHTQEQHSKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKK
QALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNAWLGIKNEDADENYFI
NEEDENLPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKH
CVIYSTARGYGFAEPYNLYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR
NT seq 1437 nt   +upstreamnt  +downstreamnt
atgcctgcttttacccctccaggcgcggttgggtggcgcctcagcggcgcgatgtacaat
acggtgtggagtatggaccacgatgacgcagactggagggaggtgatgatgccctattcg
acagaactgatattttatattgaaatggatcctccagctcttccaccaaagccacctaag
ccaatgacttcagcagttacaaatggaatgaaggacagttctgtttctcttcaggatgca
gaatggtactggggggatatttcaagggaggaggtaaatgacaaattgcgggatatgcca
gatgggaccttcnntgtccgagatgcctcaacaaaaatgcagggagattatactttgact
ttgcggaagggaggcaataataagttaataaagatctatcaccgggatggcaaatatggc
ttttctgatcctctgacatttaattccgtggtggagctcattaaccactatcaccatgaa
tctcttgctcagtacaatcccaagcttgatgtgaagctgatgtacccagtgtccagatac
caacaggatcagttggtaaaagaagataatattgatgcagtaggtaaaaaactgcaagaa
taccactctcagtatcaagagaagagtaaagagtatgataggctctatgaagaatatacg
agaacatcccaggaaatacagatgaagaggactgcaatagaagcttttaatgaaacaatt
aaaatatttgaagagcagtgtcacacacaagaacaacatagcaaagagtatattgagcga
tttcgcagagaggggaatgaaaaggaaattgaacgaattatgatgaattatgataaattg
aaatcacgtctgggagagattcatgatagcaaaatgcgtctagagcaggatttgaagaaa
caagctttggacaaccgagaaatagataaaaaaatgaatagtatcaaacctgacctgatc
cagctgcgaaagatccgagatcagcaccttgtatggctcaatcacaaaggggtgagacag
aaacgcctgaatgcctggctgggaattaagaatgaggatgctgatgagaactattttatc
aatgaggaagatgaaaacctgccccactatgatgagaaaacctggtttgttgaggatatc
aatcgagtacaagcagaggacttgctttatgggaaacctgatggtgcattcttaattcgt
gagagtagcaagaaaggatgctatgcttgctctgtggtggctgatggggaagtgaagcac
tgtgtgatctacagcactgctcggggctatggctttgcagagccctacaacctgtacagc
tctctgaaggagctagtgctccattaccagcagacatccttggttcagcacaacgactcc
ctcaatgtcaggcttgcctaccctgttcatgcacagatgccctcgctgtgcagataa

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