KEGG   Macaca nemestrina (pig-tailed macaque): 105496357
Entry
105496357         CDS       T08765                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
mni  Macaca nemestrina (pig-tailed macaque)
Pathway
mni00562  Inositol phosphate metabolism
mni01100  Metabolic pathways
mni01521  EGFR tyrosine kinase inhibitor resistance
mni04012  ErbB signaling pathway
mni04014  Ras signaling pathway
mni04015  Rap1 signaling pathway
mni04020  Calcium signaling pathway
mni04062  Chemokine signaling pathway
mni04064  NF-kappa B signaling pathway
mni04066  HIF-1 signaling pathway
mni04070  Phosphatidylinositol signaling system
mni04072  Phospholipase D signaling pathway
mni04360  Axon guidance
mni04370  VEGF signaling pathway
mni04517  IgSF CAM signaling
mni04613  Neutrophil extracellular trap formation
mni04650  Natural killer cell mediated cytotoxicity
mni04658  Th1 and Th2 cell differentiation
mni04659  Th17 cell differentiation
mni04660  T cell receptor signaling pathway
mni04664  Fc epsilon RI signaling pathway
mni04666  Fc gamma R-mediated phagosome formation
mni04670  Leukocyte transendothelial migration
mni04722  Neurotrophin signaling pathway
mni04750  Inflammatory mediator regulation of TRP channels
mni04919  Thyroid hormone signaling pathway
mni04933  AGE-RAGE signaling pathway in diabetic complications
mni04935  Growth hormone synthesis, secretion and action
mni05012  Parkinson disease
mni05022  Pathways of neurodegeneration - multiple diseases
mni05135  Yersinia infection
mni05167  Kaposi sarcoma-associated herpesvirus infection
mni05170  Human immunodeficiency virus 1 infection
mni05171  Coronavirus disease
mni05200  Pathways in cancer
mni05205  Proteoglycans in cancer
mni05206  MicroRNAs in cancer
mni05214  Glioma
mni05223  Non-small cell lung cancer
mni05225  Hepatocellular carcinoma
mni05231  Choline metabolism in cancer
mni05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mni05417  Lipid and atherosclerosis
Module
mni_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mni00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    105496357 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    105496357 (PLCG1)
   04014 Ras signaling pathway
    105496357 (PLCG1)
   04015 Rap1 signaling pathway
    105496357 (PLCG1)
   04370 VEGF signaling pathway
    105496357 (PLCG1)
   04064 NF-kappa B signaling pathway
    105496357 (PLCG1)
   04066 HIF-1 signaling pathway
    105496357 (PLCG1)
   04020 Calcium signaling pathway
    105496357 (PLCG1)
   04070 Phosphatidylinositol signaling system
    105496357 (PLCG1)
   04072 Phospholipase D signaling pathway
    105496357 (PLCG1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    105496357 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    105496357 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    105496357 (PLCG1)
   04660 T cell receptor signaling pathway
    105496357 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    105496357 (PLCG1)
   04659 Th17 cell differentiation
    105496357 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    105496357 (PLCG1)
   04666 Fc gamma R-mediated phagosome formation
    105496357 (PLCG1)
   04670 Leukocyte transendothelial migration
    105496357 (PLCG1)
   04062 Chemokine signaling pathway
    105496357 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    105496357 (PLCG1)
   04919 Thyroid hormone signaling pathway
    105496357 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    105496357 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    105496357 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    105496357 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105496357 (PLCG1)
   05206 MicroRNAs in cancer
    105496357 (PLCG1)
   05205 Proteoglycans in cancer
    105496357 (PLCG1)
   05231 Choline metabolism in cancer
    105496357 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    105496357 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    105496357 (PLCG1)
   05214 Glioma
    105496357 (PLCG1)
   05223 Non-small cell lung cancer
    105496357 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    105496357 (PLCG1)
   05171 Coronavirus disease
    105496357 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    105496357 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    105496357 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    105496357 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    105496357 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    105496357 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    105496357 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    105496357 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mni04131]
    105496357 (PLCG1)
Enzymes [BR:mni01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     105496357 (PLCG1)
Membrane trafficking [BR:mni04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    105496357 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    105496357 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF_HAND_2_PLCG PH C2 SH3_1 EF_HAND_1_PLCG SH3_9 SH3_2 PH_12 GDPD EF-hand_6 EF-hand_7 PH_9
Other DBs
NCBI-GeneID: 105496357
NCBI-ProteinID: XP_011764995
Ensembl: ENSMNEG00000042674
LinkDB
Position
Unknown
AA seq 1291 aa
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA
GERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLQTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQHFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSS
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPCAISVEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLIKIDIFPAKQENGDLSPFSGTSLRERGSDASGQLFHGRAREGSFESRYQQPFED
FRVSQEHLADHFDSRERRAPRRTRVNGDNRL
NT seq 3876 nt   +upstreamnt  +downstreamnt
atggcgggcgccgcatccccctgcgccaacggctgcgggcccggcgcgccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcgacccgagcggaagaccttccaggtcaagctggagacgcgccagatc
acgtggagccggggcgccgacaagatagagggggccattgatattcgagaaatcaaggag
attcgcccagggaagacctcacgagactttgatcgctatcaagaggaccccgctttccgg
ccggaccagtcacactgctttgtcattctctatggaatggaattccgtctgaagacgctg
agcctgcaagccacatctgaggatgaagtgaacatgtggatcaagggcttaacttggctg
atggaggatacattgcaggcacccacacccctgcagattgagaggtggctccggaagcag
ttttactcagtggatcggaatcgtgaggatcgtatatcagccaaggacctaaagaacatg
ctgtcccaggtcaactaccgggtccccaacatgcgcttcctccgagaacggctgacggac
ctggagcagcgcagcggggacatcacctacgggcagtttgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcttggaagccagtactctgagggct
ggggagcggccggagctttgccgagtgtcccttcctgagttccagcagttccttcttgac
taccagggggagctgtgggctgttgatcgcctccaggtgcaggagttcatgctcagcttc
ctccgagaccccttgcgagagatcgaggagccatacttcttcctggatgagtttgtcacc
ttcctgttctccaaagagaatagtgtgtggaactcacagctggatgcagtatgcccggac
accatgaacaaccccctttcccactattggatctcctcctcacacaacacgtacctgacc
ggggaccagttctccagtgagtcctccttggaagcctatgctcgctgcctgcggatgggc
tgtcgctgcattgagttggactgctgggacggcccagatgggatgccagttatttaccat
gggcacacccttaccaccaagatcaagttctcagatgtcctgcaaaccatcaaggagcat
gcctttgtggcctcagagtacccagtcatcctgtccattgaggaccactgcagcattgcc
cagcagaggaacatggcccagcacttcaagaaggtgctaggggacacactcctcaccaag
cccgtggagatctccgccgatgggctcccctcacccaaccagcttaagaggaagatcctc
atcaagcacaagaagctggctgagggcagtgcctacgaggaggtgcctacatccatgatg
tactctgagaacgacatcagcaactccatcaagaatggcatcctctacctggaggaccct
gtgaaccatgaatggtatccccactacttcgttctgaccagcagcaagatctactactct
gaggagaccagcagtgaccagggcaacgaggatgaggaggagcccaaggaggtcagcagc
agcacagagctgcactccaatgagaagtggttccatgggaagctaggggcagggcgtgac
gggcggcacatcgctgagcgcctgctcactgagtactgcatcgagaccggggcccctgac
ggctccttcctcgtgcgagagagtgagaccttcgtgggcgactacacgctctctttctgg
cggaacgggaaagtccagcactgccgtatccactcacggcaagatgctgggacccccaag
ttcttcttgacagacaacctcgtctttgactccctctatgacctcatcacacactaccag
caggtgcccctgcgctgcaatgagtttgagatgcgactttcagagcctgtcccacagacc
aatgcccatgagagcaaagagtggtaccacgcgagcctgaccagagcacaggctgagcac
atgctgatgcgtgtccctcgtgatggggccttcctggtgcggaagcggaatgagcccaac
tcatatgccatctctttccgggctgaaggcaagatcaagcattgccgtgtccagcaagag
ggccagactgtgatgctagggaactcggagttcgacagccttgttgacctcatcagctac
tatgagaagcacccgctataccgcaagatgaagctgcgctatccaatcaatgaggaggcg
ctggagaagattggcacagctgagcctgactacggggccctgtatgagggacgcaaccct
ggcttctatgtagaggcaaaccctatgccaactttcaagtgtgcagtcaaagccctcttt
gactacaaggcccagagggaggatgagctgaccttcaccaagagcgccatcatccagaat
gtggagaagcaagagggaggctggtggcgaggggactacggagggaagaagcagctgtgg
ttcccatcaaactacgtggaagagatggtcaaccccgtggccctggagccagagagggag
cacttggacgagaacagccccctaggggacttgctgcggggggtcttggatgtgccggct
tgtcagattgccatccgtcctgagggcaagaacaaccggctcttcgtcttctccatcagc
atggcgtcggtggcccactggtccctggatgttgctgccgactcacaggaggagctgcag
gactgggtgaaaaagatccgtgaagtggcccagaccgcagatgccaggctcactgaaggg
aagataatggaacggaggaagaagatcgccctggagctctctgaacttgttgtctactgc
cggcctgttcccttcgatgaagagaagattggcacagaacgtgcttgctaccgggacatg
tcatccttcccggaaaccaaggctgagaaatacgtgaacaaggccaaaggcaagaagttc
cttcagtacaatcgactgcagctctcccgcatctaccctaagggccagcgactggattcc
tccaactacgatcctttgcccatgtggatctgtggcagtcagctggtggccctcaacttc
cagacccctgacaagcctatgcagatgaaccaggctctcttcatgacgggcaggcactgt
ggctacgtgctgcagccaagcaccatgcgggatgaggccttcgacccctttgacaagagc
agcctccgcgggctggagccatgtgccatctctgttgaggtgctgggtgcccgacatttg
ccaaagaatggccgaggcattgtgtgcccttttgtggagattgaggtggctggagctgag
tatgacagcaccaagcagaagacagagtttgtggtggacaatggactcaaccctgtatgg
ccggccaagcccttccacttccagatcagtaaccctgaatttgcctttctgcgctttgtg
gtgtatgaggaagacatgtttagtgaccagaatttcctggctcaggctactttcccggta
aaaggcctgaagacaggatacagagcagtgcctttgaagaacaactacagtgaggacctg
gagttggcctccctgctgatcaagattgacattttccctgccaagcaggagaatggtgac
ctcagtcccttcagtggtacgtccctgcgggagcggggctcagatgcctcaggccagctg
ttccacggccgagcccgggaaggctcctttgaatcccgctaccagcagccatttgaggac
ttccgcgtctcccaggagcatcttgcagaccattttgacagtcgagaacgaagggcccca
agaaggactcgggtcaatggagacaaccgcctctag

DBGET integrated database retrieval system