KEGG   Mustela nigripes (black-footed ferret): 132000809
Entry
132000809         CDS       T09425                                 
Symbol
PIK3R3
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
mnp  Mustela nigripes (black-footed ferret)
Pathway
mnp01521  EGFR tyrosine kinase inhibitor resistance
mnp01522  Endocrine resistance
mnp01524  Platinum drug resistance
mnp04012  ErbB signaling pathway
mnp04014  Ras signaling pathway
mnp04015  Rap1 signaling pathway
mnp04024  cAMP signaling pathway
mnp04062  Chemokine signaling pathway
mnp04066  HIF-1 signaling pathway
mnp04068  FoxO signaling pathway
mnp04070  Phosphatidylinositol signaling system
mnp04071  Sphingolipid signaling pathway
mnp04072  Phospholipase D signaling pathway
mnp04081  Hormone signaling
mnp04140  Autophagy - animal
mnp04150  mTOR signaling pathway
mnp04151  PI3K-Akt signaling pathway
mnp04152  AMPK signaling pathway
mnp04210  Apoptosis
mnp04211  Longevity regulating pathway
mnp04213  Longevity regulating pathway - multiple species
mnp04218  Cellular senescence
mnp04360  Axon guidance
mnp04370  VEGF signaling pathway
mnp04380  Osteoclast differentiation
mnp04510  Focal adhesion
mnp04550  Signaling pathways regulating pluripotency of stem cells
mnp04611  Platelet activation
mnp04613  Neutrophil extracellular trap formation
mnp04620  Toll-like receptor signaling pathway
mnp04625  C-type lectin receptor signaling pathway
mnp04630  JAK-STAT signaling pathway
mnp04650  Natural killer cell mediated cytotoxicity
mnp04660  T cell receptor signaling pathway
mnp04662  B cell receptor signaling pathway
mnp04664  Fc epsilon RI signaling pathway
mnp04666  Fc gamma R-mediated phagocytosis
mnp04668  TNF signaling pathway
mnp04670  Leukocyte transendothelial migration
mnp04722  Neurotrophin signaling pathway
mnp04725  Cholinergic synapse
mnp04750  Inflammatory mediator regulation of TRP channels
mnp04810  Regulation of actin cytoskeleton
mnp04910  Insulin signaling pathway
mnp04914  Progesterone-mediated oocyte maturation
mnp04915  Estrogen signaling pathway
mnp04917  Prolactin signaling pathway
mnp04919  Thyroid hormone signaling pathway
mnp04923  Regulation of lipolysis in adipocytes
mnp04926  Relaxin signaling pathway
mnp04929  GnRH secretion
mnp04930  Type II diabetes mellitus
mnp04931  Insulin resistance
mnp04932  Non-alcoholic fatty liver disease
mnp04933  AGE-RAGE signaling pathway in diabetic complications
mnp04935  Growth hormone synthesis, secretion and action
mnp04960  Aldosterone-regulated sodium reabsorption
mnp04973  Carbohydrate digestion and absorption
mnp05010  Alzheimer disease
mnp05017  Spinocerebellar ataxia
mnp05020  Prion disease
mnp05100  Bacterial invasion of epithelial cells
mnp05135  Yersinia infection
mnp05142  Chagas disease
mnp05146  Amoebiasis
mnp05160  Hepatitis C
mnp05161  Hepatitis B
mnp05162  Measles
mnp05163  Human cytomegalovirus infection
mnp05164  Influenza A
mnp05165  Human papillomavirus infection
mnp05166  Human T-cell leukemia virus 1 infection
mnp05167  Kaposi sarcoma-associated herpesvirus infection
mnp05168  Herpes simplex virus 1 infection
mnp05169  Epstein-Barr virus infection
mnp05170  Human immunodeficiency virus 1 infection
mnp05171  Coronavirus disease - COVID-19
mnp05200  Pathways in cancer
mnp05203  Viral carcinogenesis
mnp05205  Proteoglycans in cancer
mnp05206  MicroRNAs in cancer
mnp05207  Chemical carcinogenesis - receptor activation
mnp05208  Chemical carcinogenesis - reactive oxygen species
mnp05210  Colorectal cancer
mnp05211  Renal cell carcinoma
mnp05212  Pancreatic cancer
mnp05213  Endometrial cancer
mnp05214  Glioma
mnp05215  Prostate cancer
mnp05218  Melanoma
mnp05220  Chronic myeloid leukemia
mnp05221  Acute myeloid leukemia
mnp05222  Small cell lung cancer
mnp05223  Non-small cell lung cancer
mnp05224  Breast cancer
mnp05225  Hepatocellular carcinoma
mnp05226  Gastric cancer
mnp05230  Central carbon metabolism in cancer
mnp05231  Choline metabolism in cancer
mnp05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mnp05415  Diabetic cardiomyopathy
mnp05417  Lipid and atherosclerosis
mnp05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mnp00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    132000809 (PIK3R3)
   04014 Ras signaling pathway
    132000809 (PIK3R3)
   04015 Rap1 signaling pathway
    132000809 (PIK3R3)
   04370 VEGF signaling pathway
    132000809 (PIK3R3)
   04630 JAK-STAT signaling pathway
    132000809 (PIK3R3)
   04668 TNF signaling pathway
    132000809 (PIK3R3)
   04066 HIF-1 signaling pathway
    132000809 (PIK3R3)
   04068 FoxO signaling pathway
    132000809 (PIK3R3)
   04070 Phosphatidylinositol signaling system
    132000809 (PIK3R3)
   04072 Phospholipase D signaling pathway
    132000809 (PIK3R3)
   04071 Sphingolipid signaling pathway
    132000809 (PIK3R3)
   04024 cAMP signaling pathway
    132000809 (PIK3R3)
   04151 PI3K-Akt signaling pathway
    132000809 (PIK3R3)
   04152 AMPK signaling pathway
    132000809 (PIK3R3)
   04150 mTOR signaling pathway
    132000809 (PIK3R3)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    132000809 (PIK3R3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    132000809 (PIK3R3)
  09143 Cell growth and death
   04210 Apoptosis
    132000809 (PIK3R3)
   04218 Cellular senescence
    132000809 (PIK3R3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    132000809 (PIK3R3)
   04550 Signaling pathways regulating pluripotency of stem cells
    132000809 (PIK3R3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    132000809 (PIK3R3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    132000809 (PIK3R3)
   04613 Neutrophil extracellular trap formation
    132000809 (PIK3R3)
   04620 Toll-like receptor signaling pathway
    132000809 (PIK3R3)
   04625 C-type lectin receptor signaling pathway
    132000809 (PIK3R3)
   04650 Natural killer cell mediated cytotoxicity
    132000809 (PIK3R3)
   04660 T cell receptor signaling pathway
    132000809 (PIK3R3)
   04662 B cell receptor signaling pathway
    132000809 (PIK3R3)
   04664 Fc epsilon RI signaling pathway
    132000809 (PIK3R3)
   04666 Fc gamma R-mediated phagocytosis
    132000809 (PIK3R3)
   04670 Leukocyte transendothelial migration
    132000809 (PIK3R3)
   04062 Chemokine signaling pathway
    132000809 (PIK3R3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    132000809 (PIK3R3)
   04923 Regulation of lipolysis in adipocytes
    132000809 (PIK3R3)
   04929 GnRH secretion
    132000809 (PIK3R3)
   04915 Estrogen signaling pathway
    132000809 (PIK3R3)
   04914 Progesterone-mediated oocyte maturation
    132000809 (PIK3R3)
   04917 Prolactin signaling pathway
    132000809 (PIK3R3)
   04926 Relaxin signaling pathway
    132000809 (PIK3R3)
   04935 Growth hormone synthesis, secretion and action
    132000809 (PIK3R3)
   04919 Thyroid hormone signaling pathway
    132000809 (PIK3R3)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    132000809 (PIK3R3)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    132000809 (PIK3R3)
  09156 Nervous system
   04725 Cholinergic synapse
    132000809 (PIK3R3)
   04722 Neurotrophin signaling pathway
    132000809 (PIK3R3)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    132000809 (PIK3R3)
  09158 Development and regeneration
   04360 Axon guidance
    132000809 (PIK3R3)
   04380 Osteoclast differentiation
    132000809 (PIK3R3)
  09149 Aging
   04211 Longevity regulating pathway
    132000809 (PIK3R3)
   04213 Longevity regulating pathway - multiple species
    132000809 (PIK3R3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    132000809 (PIK3R3)
   05206 MicroRNAs in cancer
    132000809 (PIK3R3)
   05205 Proteoglycans in cancer
    132000809 (PIK3R3)
   05207 Chemical carcinogenesis - receptor activation
    132000809 (PIK3R3)
   05208 Chemical carcinogenesis - reactive oxygen species
    132000809 (PIK3R3)
   05203 Viral carcinogenesis
    132000809 (PIK3R3)
   05230 Central carbon metabolism in cancer
    132000809 (PIK3R3)
   05231 Choline metabolism in cancer
    132000809 (PIK3R3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    132000809 (PIK3R3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    132000809 (PIK3R3)
   05212 Pancreatic cancer
    132000809 (PIK3R3)
   05225 Hepatocellular carcinoma
    132000809 (PIK3R3)
   05226 Gastric cancer
    132000809 (PIK3R3)
   05214 Glioma
    132000809 (PIK3R3)
   05221 Acute myeloid leukemia
    132000809 (PIK3R3)
   05220 Chronic myeloid leukemia
    132000809 (PIK3R3)
   05218 Melanoma
    132000809 (PIK3R3)
   05211 Renal cell carcinoma
    132000809 (PIK3R3)
   05215 Prostate cancer
    132000809 (PIK3R3)
   05213 Endometrial cancer
    132000809 (PIK3R3)
   05224 Breast cancer
    132000809 (PIK3R3)
   05222 Small cell lung cancer
    132000809 (PIK3R3)
   05223 Non-small cell lung cancer
    132000809 (PIK3R3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    132000809 (PIK3R3)
   05170 Human immunodeficiency virus 1 infection
    132000809 (PIK3R3)
   05161 Hepatitis B
    132000809 (PIK3R3)
   05160 Hepatitis C
    132000809 (PIK3R3)
   05171 Coronavirus disease - COVID-19
    132000809 (PIK3R3)
   05164 Influenza A
    132000809 (PIK3R3)
   05162 Measles
    132000809 (PIK3R3)
   05168 Herpes simplex virus 1 infection
    132000809 (PIK3R3)
   05163 Human cytomegalovirus infection
    132000809 (PIK3R3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    132000809 (PIK3R3)
   05169 Epstein-Barr virus infection
    132000809 (PIK3R3)
   05165 Human papillomavirus infection
    132000809 (PIK3R3)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    132000809 (PIK3R3)
   05100 Bacterial invasion of epithelial cells
    132000809 (PIK3R3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    132000809 (PIK3R3)
   05142 Chagas disease
    132000809 (PIK3R3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    132000809 (PIK3R3)
   05017 Spinocerebellar ataxia
    132000809 (PIK3R3)
   05020 Prion disease
    132000809 (PIK3R3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    132000809 (PIK3R3)
   05418 Fluid shear stress and atherosclerosis
    132000809 (PIK3R3)
   05415 Diabetic cardiomyopathy
    132000809 (PIK3R3)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    132000809 (PIK3R3)
   04932 Non-alcoholic fatty liver disease
    132000809 (PIK3R3)
   04931 Insulin resistance
    132000809 (PIK3R3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    132000809 (PIK3R3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    132000809 (PIK3R3)
   01524 Platinum drug resistance
    132000809 (PIK3R3)
   01522 Endocrine resistance
    132000809 (PIK3R3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mnp04131]
    132000809 (PIK3R3)
Membrane trafficking [BR:mnp04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    132000809 (PIK3R3)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 SH2_1 Transcrip_act Exonuc_VII_L
Other DBs
NCBI-GeneID: 132000809
NCBI-ProteinID: XP_059230587
LinkDB
Position
14:complement(35903238..36025557)
AA seq 461 aa
MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVTNGMKDSSVSL
QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG
KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK
LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY
IERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKP
DLIQLRKIRDQHLVWLNHKGVRQKRLNAWLGIKNEDADETYFISEEDENLPHYDEKTWFV
EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN
LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR
NT seq 1386 nt   +upstreamnt  +downstreamnt
atgtacaatacggtgtggagtatggaccgcgatgacgcagactggagggaggtgatgatg
ccctattcgacagaactgatattttatattgaaatggatcctccagctcttccaccaaag
ccacctaagccaatgacttcagctgttacaaatggaatgaaggacagttctgtttctctt
caggatgcagaatggtactggggggatatttcaagggaggaggttaatgataaattacgg
gatatgccagatggtacattcttggtcagagatgcctcaacaaaaatgcagggggattat
actttgactttgcggaagggaggcaataataaattaataaagatctatcatcgagatggt
aaatacggcttttctgatcctctgacatttaattctgtggtggagctcattaaccactat
catcatgaatctcttgctcagtacaatcccaaacttgatgtgaagctaatgtacccagtg
tccagataccaacaggatcagctggtaaaagaagacaacattgatgcagttggtaaaaaa
ctgcaagagtaccactctcagtatcaggaaaagagtaaagagtatgataggctatatgag
gaatataccagaacatcccaggagatacagatgaagaggactgcaattgaagcttttaat
gaaacaattaaaatatttgaagagcagtgtcacacacaagaacaacatagcaaagaatat
attgagcgatttcgcagagaggggaatgaaaaggaaattgaacgaattatgatgaattat
gacaaattgaaatcacgtctcggtgagattcatgatagcaaaatgcgtctagagcaggat
ttgaagaaacaagctttggacaaccgggaaatagataaaaaaatgaacagtatcaaacct
gacctaatccagctgcgcaagatccgagatcagcaccttgtgtggctcaatcacaaagga
gtgagacagaagcgcctcaatgcctggctgggaatcaagaacgaggatgctgatgagacg
tattttatcagtgaggaagatgaaaacctgccacattatgatgagaaaacctggtttgtt
gaggatatcaatcgagtacaagcggaggacttgctttatgggaaacccgatggtgcattt
ttaattcgtgagagtagcaagaaaggatgttatgcttgctctgtggttgccgatggggaa
gtgaagcactgtgtgatctacagcaccgctcggggctacggctttgcagagccctacaac
ctgtacagctccctgaaggagctggtgctccattaccagcagacatccctcgttcagcac
aacgactccctcaatgtcaggcttgcctaccctgtccacgcacagatgccttccctctgc
agataa

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