KEGG   Mustela nigripes (black-footed ferret): 132010799
Entry
132010799         CDS       T09425                                 
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2 isoform X1
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
mnp  Mustela nigripes (black-footed ferret)
Pathway
mnp01521  EGFR tyrosine kinase inhibitor resistance
mnp01522  Endocrine resistance
mnp04010  MAPK signaling pathway
mnp04012  ErbB signaling pathway
mnp04014  Ras signaling pathway
mnp04015  Rap1 signaling pathway
mnp04022  cGMP-PKG signaling pathway
mnp04024  cAMP signaling pathway
mnp04066  HIF-1 signaling pathway
mnp04068  FoxO signaling pathway
mnp04071  Sphingolipid signaling pathway
mnp04072  Phospholipase D signaling pathway
mnp04140  Autophagy - animal
mnp04148  Efferocytosis
mnp04150  mTOR signaling pathway
mnp04151  PI3K-Akt signaling pathway
mnp04210  Apoptosis
mnp04218  Cellular senescence
mnp04270  Vascular smooth muscle contraction
mnp04370  VEGF signaling pathway
mnp04371  Apelin signaling pathway
mnp04540  Gap junction
mnp04550  Signaling pathways regulating pluripotency of stem cells
mnp04613  Neutrophil extracellular trap formation
mnp04620  Toll-like receptor signaling pathway
mnp04650  Natural killer cell mediated cytotoxicity
mnp04660  T cell receptor signaling pathway
mnp04662  B cell receptor signaling pathway
mnp04664  Fc epsilon RI signaling pathway
mnp04720  Long-term potentiation
mnp04722  Neurotrophin signaling pathway
mnp04730  Long-term depression
mnp04810  Regulation of actin cytoskeleton
mnp04910  Insulin signaling pathway
mnp04912  GnRH signaling pathway
mnp04915  Estrogen signaling pathway
mnp04916  Melanogenesis
mnp04917  Prolactin signaling pathway
mnp04919  Thyroid hormone signaling pathway
mnp04921  Oxytocin signaling pathway
mnp04926  Relaxin signaling pathway
mnp04929  GnRH secretion
mnp04934  Cushing syndrome
mnp04935  Growth hormone synthesis, secretion and action
mnp05010  Alzheimer disease
mnp05022  Pathways of neurodegeneration - multiple diseases
mnp05132  Salmonella infection
mnp05135  Yersinia infection
mnp05160  Hepatitis C
mnp05161  Hepatitis B
mnp05163  Human cytomegalovirus infection
mnp05164  Influenza A
mnp05165  Human papillomavirus infection
mnp05166  Human T-cell leukemia virus 1 infection
mnp05167  Kaposi sarcoma-associated herpesvirus infection
mnp05170  Human immunodeficiency virus 1 infection
mnp05200  Pathways in cancer
mnp05205  Proteoglycans in cancer
mnp05206  MicroRNAs in cancer
mnp05207  Chemical carcinogenesis - receptor activation
mnp05208  Chemical carcinogenesis - reactive oxygen species
mnp05210  Colorectal cancer
mnp05211  Renal cell carcinoma
mnp05213  Endometrial cancer
mnp05214  Glioma
mnp05215  Prostate cancer
mnp05216  Thyroid cancer
mnp05218  Melanoma
mnp05219  Bladder cancer
mnp05220  Chronic myeloid leukemia
mnp05221  Acute myeloid leukemia
mnp05223  Non-small cell lung cancer
mnp05224  Breast cancer
mnp05225  Hepatocellular carcinoma
mnp05226  Gastric cancer
mnp05230  Central carbon metabolism in cancer
mnp05231  Choline metabolism in cancer
mnp05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mnp00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    132010799 (MAP2K2)
   04012 ErbB signaling pathway
    132010799 (MAP2K2)
   04014 Ras signaling pathway
    132010799 (MAP2K2)
   04015 Rap1 signaling pathway
    132010799 (MAP2K2)
   04370 VEGF signaling pathway
    132010799 (MAP2K2)
   04371 Apelin signaling pathway
    132010799 (MAP2K2)
   04066 HIF-1 signaling pathway
    132010799 (MAP2K2)
   04068 FoxO signaling pathway
    132010799 (MAP2K2)
   04072 Phospholipase D signaling pathway
    132010799 (MAP2K2)
   04071 Sphingolipid signaling pathway
    132010799 (MAP2K2)
   04024 cAMP signaling pathway
    132010799 (MAP2K2)
   04022 cGMP-PKG signaling pathway
    132010799 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    132010799 (MAP2K2)
   04150 mTOR signaling pathway
    132010799 (MAP2K2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    132010799 (MAP2K2)
   04148 Efferocytosis
    132010799 (MAP2K2)
  09143 Cell growth and death
   04210 Apoptosis
    132010799 (MAP2K2)
   04218 Cellular senescence
    132010799 (MAP2K2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    132010799 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    132010799 (MAP2K2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    132010799 (MAP2K2)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    132010799 (MAP2K2)
   04620 Toll-like receptor signaling pathway
    132010799 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    132010799 (MAP2K2)
   04660 T cell receptor signaling pathway
    132010799 (MAP2K2)
   04662 B cell receptor signaling pathway
    132010799 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    132010799 (MAP2K2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    132010799 (MAP2K2)
   04929 GnRH secretion
    132010799 (MAP2K2)
   04912 GnRH signaling pathway
    132010799 (MAP2K2)
   04915 Estrogen signaling pathway
    132010799 (MAP2K2)
   04917 Prolactin signaling pathway
    132010799 (MAP2K2)
   04921 Oxytocin signaling pathway
    132010799 (MAP2K2)
   04926 Relaxin signaling pathway
    132010799 (MAP2K2)
   04935 Growth hormone synthesis, secretion and action
    132010799 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    132010799 (MAP2K2)
   04916 Melanogenesis
    132010799 (MAP2K2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    132010799 (MAP2K2)
  09156 Nervous system
   04720 Long-term potentiation
    132010799 (MAP2K2)
   04730 Long-term depression
    132010799 (MAP2K2)
   04722 Neurotrophin signaling pathway
    132010799 (MAP2K2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    132010799 (MAP2K2)
   05206 MicroRNAs in cancer
    132010799 (MAP2K2)
   05205 Proteoglycans in cancer
    132010799 (MAP2K2)
   05207 Chemical carcinogenesis - receptor activation
    132010799 (MAP2K2)
   05208 Chemical carcinogenesis - reactive oxygen species
    132010799 (MAP2K2)
   05230 Central carbon metabolism in cancer
    132010799 (MAP2K2)
   05231 Choline metabolism in cancer
    132010799 (MAP2K2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    132010799 (MAP2K2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    132010799 (MAP2K2)
   05225 Hepatocellular carcinoma
    132010799 (MAP2K2)
   05226 Gastric cancer
    132010799 (MAP2K2)
   05214 Glioma
    132010799 (MAP2K2)
   05216 Thyroid cancer
    132010799 (MAP2K2)
   05221 Acute myeloid leukemia
    132010799 (MAP2K2)
   05220 Chronic myeloid leukemia
    132010799 (MAP2K2)
   05218 Melanoma
    132010799 (MAP2K2)
   05211 Renal cell carcinoma
    132010799 (MAP2K2)
   05219 Bladder cancer
    132010799 (MAP2K2)
   05215 Prostate cancer
    132010799 (MAP2K2)
   05213 Endometrial cancer
    132010799 (MAP2K2)
   05224 Breast cancer
    132010799 (MAP2K2)
   05223 Non-small cell lung cancer
    132010799 (MAP2K2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    132010799 (MAP2K2)
   05170 Human immunodeficiency virus 1 infection
    132010799 (MAP2K2)
   05161 Hepatitis B
    132010799 (MAP2K2)
   05160 Hepatitis C
    132010799 (MAP2K2)
   05164 Influenza A
    132010799 (MAP2K2)
   05163 Human cytomegalovirus infection
    132010799 (MAP2K2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    132010799 (MAP2K2)
   05165 Human papillomavirus infection
    132010799 (MAP2K2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    132010799 (MAP2K2)
   05135 Yersinia infection
    132010799 (MAP2K2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    132010799 (MAP2K2)
   05022 Pathways of neurodegeneration - multiple diseases
    132010799 (MAP2K2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    132010799 (MAP2K2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    132010799 (MAP2K2)
   01522 Endocrine resistance
    132010799 (MAP2K2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mnp01001]
    132010799 (MAP2K2)
Enzymes [BR:mnp01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     132010799 (MAP2K2)
Protein kinases [BR:mnp01001]
 Serine/threonine kinases: STE group
  STE7 family
   132010799 (MAP2K2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7 Kdo APH
Other DBs
NCBI-GeneID: 132010799
NCBI-ProteinID: XP_059244648
LinkDB
Position
2:complement(2832363..2856657)
AA seq 404 aa
MLARRKPVLPALTINPAIAEGPSPTSEGASEANLVDLQKKLAELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPVVDGVEGEPHSISPRPRP
PGRPISGHGTDSRPAMAIFELLDYIVNEPPPPGQTPVILPSPEPRFLLTLSLSFLSPGAL
WRGPQPGRRLNTAHGALEAKGKATGTVKGGPEGRAERTPAAELA
NT seq 1215 nt   +upstreamnt  +downstreamnt
atgctggcccggaggaagccggtgctgccggcgctcactatcaaccccgccatcgccgag
ggcccgtcccccaccagcgagggcgcctccgaagcaaacttggtggacctccagaagaag
ctggcagagctagaactggatgagcagcagaagaagcgactggaagccttcctcacccag
aaggccaaggtcggggagctcaaggacgatgactttgaacggatctcggagctgggagct
gggaacggcggggtggtcaccaaggtccagcacagaccgtccggactcatcatggcgaga
aagctgatccacctggagatcaagccggccatccggaaccagatcatccgcgagctgcag
gtgctacacgagtgtaactctccgtacatcgtgggcttctacggggccttctacagcgac
ggcgagatcagcatctgcatggagcacatggatggtggctccctggaccaggtgttgaaa
gaagccaagagaattcccgaggagatcctggggaaggtcagcattgcggttctccggggt
ttggcgtatctccgggaaaagcaccagatcatgcaccgagatgtgaaaccttccaacatc
ctcgtcaactcccgaggggagatcaagctgtgcgattttggggtgagcggacagctcatc
gactccatggccaactccttcgtgggaacgcggtcctacatgtctccggagcggctgcag
ggcacgcactactccgtgcagtcggacatctggagcatggggctgtcgctggtggagctg
tccatcggaaggtaccccatccccccgccagacgccaaggagctggaggccatatttggc
cggcccgtggtggacggggtagaaggagagcctcacagcatctcgccgcggccgagaccc
cccggacgccccatcagcggtcacgggacagacagccggccggccatggccatcttcgag
ctgctggactatattgtgaacgagccgcctcccccaggacaaacaccggtcatcctgccc
tcgcccgagccacgctttctcttgactctgtcactgtcttttctgtcccctggtgcccta
tggcggggcccgcagcctggccggaggctgaacacagctcacggagcccttgaggctaaa
ggcaaagcgacaggaaccgtgaaggggggtcccgagggccgggcagagcgcaccccagca
gcggaactcgcatag

DBGET integrated database retrieval system