Mustela nigripes (black-footed ferret): 132010799
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Entry
132010799 CDS
T09425
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2 isoform X1
KO
K04369
mitogen-activated protein kinase kinase 2 [EC:
2.7.12.2
]
Organism
mnp
Mustela nigripes (black-footed ferret)
Pathway
mnp01521
EGFR tyrosine kinase inhibitor resistance
mnp01522
Endocrine resistance
mnp04010
MAPK signaling pathway
mnp04012
ErbB signaling pathway
mnp04014
Ras signaling pathway
mnp04015
Rap1 signaling pathway
mnp04022
cGMP-PKG signaling pathway
mnp04024
cAMP signaling pathway
mnp04066
HIF-1 signaling pathway
mnp04068
FoxO signaling pathway
mnp04071
Sphingolipid signaling pathway
mnp04072
Phospholipase D signaling pathway
mnp04140
Autophagy - animal
mnp04148
Efferocytosis
mnp04150
mTOR signaling pathway
mnp04151
PI3K-Akt signaling pathway
mnp04210
Apoptosis
mnp04218
Cellular senescence
mnp04270
Vascular smooth muscle contraction
mnp04370
VEGF signaling pathway
mnp04371
Apelin signaling pathway
mnp04540
Gap junction
mnp04550
Signaling pathways regulating pluripotency of stem cells
mnp04613
Neutrophil extracellular trap formation
mnp04620
Toll-like receptor signaling pathway
mnp04650
Natural killer cell mediated cytotoxicity
mnp04660
T cell receptor signaling pathway
mnp04662
B cell receptor signaling pathway
mnp04664
Fc epsilon RI signaling pathway
mnp04720
Long-term potentiation
mnp04722
Neurotrophin signaling pathway
mnp04730
Long-term depression
mnp04810
Regulation of actin cytoskeleton
mnp04910
Insulin signaling pathway
mnp04912
GnRH signaling pathway
mnp04915
Estrogen signaling pathway
mnp04916
Melanogenesis
mnp04917
Prolactin signaling pathway
mnp04919
Thyroid hormone signaling pathway
mnp04921
Oxytocin signaling pathway
mnp04926
Relaxin signaling pathway
mnp04929
GnRH secretion
mnp04934
Cushing syndrome
mnp04935
Growth hormone synthesis, secretion and action
mnp05010
Alzheimer disease
mnp05022
Pathways of neurodegeneration - multiple diseases
mnp05132
Salmonella infection
mnp05135
Yersinia infection
mnp05160
Hepatitis C
mnp05161
Hepatitis B
mnp05163
Human cytomegalovirus infection
mnp05164
Influenza A
mnp05165
Human papillomavirus infection
mnp05166
Human T-cell leukemia virus 1 infection
mnp05167
Kaposi sarcoma-associated herpesvirus infection
mnp05170
Human immunodeficiency virus 1 infection
mnp05200
Pathways in cancer
mnp05205
Proteoglycans in cancer
mnp05206
MicroRNAs in cancer
mnp05207
Chemical carcinogenesis - receptor activation
mnp05208
Chemical carcinogenesis - reactive oxygen species
mnp05210
Colorectal cancer
mnp05211
Renal cell carcinoma
mnp05213
Endometrial cancer
mnp05214
Glioma
mnp05215
Prostate cancer
mnp05216
Thyroid cancer
mnp05218
Melanoma
mnp05219
Bladder cancer
mnp05220
Chronic myeloid leukemia
mnp05221
Acute myeloid leukemia
mnp05223
Non-small cell lung cancer
mnp05224
Breast cancer
mnp05225
Hepatocellular carcinoma
mnp05226
Gastric cancer
mnp05230
Central carbon metabolism in cancer
mnp05231
Choline metabolism in cancer
mnp05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
mnp00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
132010799 (MAP2K2)
04012 ErbB signaling pathway
132010799 (MAP2K2)
04014 Ras signaling pathway
132010799 (MAP2K2)
04015 Rap1 signaling pathway
132010799 (MAP2K2)
04370 VEGF signaling pathway
132010799 (MAP2K2)
04371 Apelin signaling pathway
132010799 (MAP2K2)
04066 HIF-1 signaling pathway
132010799 (MAP2K2)
04068 FoxO signaling pathway
132010799 (MAP2K2)
04072 Phospholipase D signaling pathway
132010799 (MAP2K2)
04071 Sphingolipid signaling pathway
132010799 (MAP2K2)
04024 cAMP signaling pathway
132010799 (MAP2K2)
04022 cGMP-PKG signaling pathway
132010799 (MAP2K2)
04151 PI3K-Akt signaling pathway
132010799 (MAP2K2)
04150 mTOR signaling pathway
132010799 (MAP2K2)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
132010799 (MAP2K2)
04148 Efferocytosis
132010799 (MAP2K2)
09143 Cell growth and death
04210 Apoptosis
132010799 (MAP2K2)
04218 Cellular senescence
132010799 (MAP2K2)
09144 Cellular community - eukaryotes
04540 Gap junction
132010799 (MAP2K2)
04550 Signaling pathways regulating pluripotency of stem cells
132010799 (MAP2K2)
09142 Cell motility
04810 Regulation of actin cytoskeleton
132010799 (MAP2K2)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
132010799 (MAP2K2)
04620 Toll-like receptor signaling pathway
132010799 (MAP2K2)
04650 Natural killer cell mediated cytotoxicity
132010799 (MAP2K2)
04660 T cell receptor signaling pathway
132010799 (MAP2K2)
04662 B cell receptor signaling pathway
132010799 (MAP2K2)
04664 Fc epsilon RI signaling pathway
132010799 (MAP2K2)
09152 Endocrine system
04910 Insulin signaling pathway
132010799 (MAP2K2)
04929 GnRH secretion
132010799 (MAP2K2)
04912 GnRH signaling pathway
132010799 (MAP2K2)
04915 Estrogen signaling pathway
132010799 (MAP2K2)
04917 Prolactin signaling pathway
132010799 (MAP2K2)
04921 Oxytocin signaling pathway
132010799 (MAP2K2)
04926 Relaxin signaling pathway
132010799 (MAP2K2)
04935 Growth hormone synthesis, secretion and action
132010799 (MAP2K2)
04919 Thyroid hormone signaling pathway
132010799 (MAP2K2)
04916 Melanogenesis
132010799 (MAP2K2)
09153 Circulatory system
04270 Vascular smooth muscle contraction
132010799 (MAP2K2)
09156 Nervous system
04720 Long-term potentiation
132010799 (MAP2K2)
04730 Long-term depression
132010799 (MAP2K2)
04722 Neurotrophin signaling pathway
132010799 (MAP2K2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
132010799 (MAP2K2)
05206 MicroRNAs in cancer
132010799 (MAP2K2)
05205 Proteoglycans in cancer
132010799 (MAP2K2)
05207 Chemical carcinogenesis - receptor activation
132010799 (MAP2K2)
05208 Chemical carcinogenesis - reactive oxygen species
132010799 (MAP2K2)
05230 Central carbon metabolism in cancer
132010799 (MAP2K2)
05231 Choline metabolism in cancer
132010799 (MAP2K2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
132010799 (MAP2K2)
09162 Cancer: specific types
05210 Colorectal cancer
132010799 (MAP2K2)
05225 Hepatocellular carcinoma
132010799 (MAP2K2)
05226 Gastric cancer
132010799 (MAP2K2)
05214 Glioma
132010799 (MAP2K2)
05216 Thyroid cancer
132010799 (MAP2K2)
05221 Acute myeloid leukemia
132010799 (MAP2K2)
05220 Chronic myeloid leukemia
132010799 (MAP2K2)
05218 Melanoma
132010799 (MAP2K2)
05211 Renal cell carcinoma
132010799 (MAP2K2)
05219 Bladder cancer
132010799 (MAP2K2)
05215 Prostate cancer
132010799 (MAP2K2)
05213 Endometrial cancer
132010799 (MAP2K2)
05224 Breast cancer
132010799 (MAP2K2)
05223 Non-small cell lung cancer
132010799 (MAP2K2)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
132010799 (MAP2K2)
05170 Human immunodeficiency virus 1 infection
132010799 (MAP2K2)
05161 Hepatitis B
132010799 (MAP2K2)
05160 Hepatitis C
132010799 (MAP2K2)
05164 Influenza A
132010799 (MAP2K2)
05163 Human cytomegalovirus infection
132010799 (MAP2K2)
05167 Kaposi sarcoma-associated herpesvirus infection
132010799 (MAP2K2)
05165 Human papillomavirus infection
132010799 (MAP2K2)
09171 Infectious disease: bacterial
05132 Salmonella infection
132010799 (MAP2K2)
05135 Yersinia infection
132010799 (MAP2K2)
09164 Neurodegenerative disease
05010 Alzheimer disease
132010799 (MAP2K2)
05022 Pathways of neurodegeneration - multiple diseases
132010799 (MAP2K2)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
132010799 (MAP2K2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
132010799 (MAP2K2)
01522 Endocrine resistance
132010799 (MAP2K2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mnp01001
]
132010799 (MAP2K2)
Enzymes [BR:
mnp01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
132010799 (MAP2K2)
Protein kinases [BR:
mnp01001
]
Serine/threonine kinases: STE group
STE7 family
132010799 (MAP2K2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Haspin_kinase
Seadorna_VP7
Kdo
APH
Motif
Other DBs
NCBI-GeneID:
132010799
NCBI-ProteinID:
XP_059244648
LinkDB
All DBs
Position
2:complement(2832363..2856657)
Genome browser
AA seq
404 aa
AA seq
DB search
MLARRKPVLPALTINPAIAEGPSPTSEGASEANLVDLQKKLAELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPVVDGVEGEPHSISPRPRP
PGRPISGHGTDSRPAMAIFELLDYIVNEPPPPGQTPVILPSPEPRFLLTLSLSFLSPGAL
WRGPQPGRRLNTAHGALEAKGKATGTVKGGPEGRAERTPAAELA
NT seq
1215 nt
NT seq
+upstream
nt +downstream
nt
atgctggcccggaggaagccggtgctgccggcgctcactatcaaccccgccatcgccgag
ggcccgtcccccaccagcgagggcgcctccgaagcaaacttggtggacctccagaagaag
ctggcagagctagaactggatgagcagcagaagaagcgactggaagccttcctcacccag
aaggccaaggtcggggagctcaaggacgatgactttgaacggatctcggagctgggagct
gggaacggcggggtggtcaccaaggtccagcacagaccgtccggactcatcatggcgaga
aagctgatccacctggagatcaagccggccatccggaaccagatcatccgcgagctgcag
gtgctacacgagtgtaactctccgtacatcgtgggcttctacggggccttctacagcgac
ggcgagatcagcatctgcatggagcacatggatggtggctccctggaccaggtgttgaaa
gaagccaagagaattcccgaggagatcctggggaaggtcagcattgcggttctccggggt
ttggcgtatctccgggaaaagcaccagatcatgcaccgagatgtgaaaccttccaacatc
ctcgtcaactcccgaggggagatcaagctgtgcgattttggggtgagcggacagctcatc
gactccatggccaactccttcgtgggaacgcggtcctacatgtctccggagcggctgcag
ggcacgcactactccgtgcagtcggacatctggagcatggggctgtcgctggtggagctg
tccatcggaaggtaccccatccccccgccagacgccaaggagctggaggccatatttggc
cggcccgtggtggacggggtagaaggagagcctcacagcatctcgccgcggccgagaccc
cccggacgccccatcagcggtcacgggacagacagccggccggccatggccatcttcgag
ctgctggactatattgtgaacgagccgcctcccccaggacaaacaccggtcatcctgccc
tcgcccgagccacgctttctcttgactctgtcactgtcttttctgtcccctggtgcccta
tggcggggcccgcagcctggccggaggctgaacacagctcacggagcccttgaggctaaa
ggcaaagcgacaggaaccgtgaaggggggtcccgagggccgggcagagcgcaccccagca
gcggaactcgcatag
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integrated database retrieval system