Entry
Name
Protein export - Mus pahari (shrew mouse)
Description
The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role.
Class
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Mus pahari (shrew mouse) [GN:
mpah ]
Gene
110315724 Sec61a1; protein transport protein Sec61 subunit alpha [KO:K10956 ]
110333596 Sec61a2; protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956 ]
110330908 Sec61g; protein transport protein Sec61 subunit gamma isoform X1 [KO:K07342 ]
110331002 Srp72; signal recognition particle subunit SRP72 isoform X1 [KO:K03108 ]
110331090 Srp68; signal recognition particle subunit SRP68 isoform X1 [KO:K03107 ]
110333263 Srp19; signal recognition particle 19 kDa protein isoform X1 [KO:K03105 ]
110329134 signal recognition particle 19 kDa protein-like isoform X1 [KO:K03105 ]
110328706 Srpra; signal recognition particle receptor subunit alpha isoform X1 [KO:K13431 ]
110339187 Get4; Golgi to ER traffic protein 4 homolog isoform X1 [KO:K23387 ]
110326637 Sgta; small glutamine-rich tetratricopeptide repeat-containing protein alpha [KO:K16365 ]
110325264 Spcs1; signal peptidase complex subunit 1 [KO:K12946 ] [EC:3.4.-.-]
110325504 Spcs2; signal peptidase complex subunit 2 [KO:K12947 ] [EC:3.4.-.-]
110336781 Spcs3; signal peptidase complex subunit 3 [KO:K12948 ] [EC:3.4.-.-]
110319111 Immp1l; mitochondrial inner membrane protease subunit 1 [KO:K09647 ] [EC:3.4.21.-]
110324517 Immp2l; mitochondrial inner membrane protease subunit 2 [KO:K09648 ] [EC:3.4.21.-]
Reference
Authors
Dalbey RE, Robinson C.
Title
Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane.
Journal
Reference
Authors
Berks BC, Sargent F, Palmer T.
Title
The Tat protein export pathway.
Journal
Reference
Authors
Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C, Berks BC, Palmer T.
Title
TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.
Journal
Reference
Authors
Jongbloed JD, Martin U, Antelmann H, Hecker M, Tjalsma H, Venema G, Bron S, van Dijl JM, Muller J.
Title
TatC is a specificity determinant for protein secretion via the twin-arginine translocation pathway.
Journal
Reference
Authors
Rapoport TA
Title
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
Journal
Reference
Authors
Flower AM
Title
The SecY translocation complex: convergence of genetics and structure.
Journal
Reference
Authors
Osborne AR, Rapoport TA, van den Berg B
Title
Protein translocation by the Sec61/SecY channel.
Journal
Reference
Authors
Paetzel M, Karla A, Strynadka NC, Dalbey RE
Title
Signal peptidases.
Journal
Reference
Authors
Paetzel M, Dalbey RE, Strynadka NC
Title
The structure and mechanism of bacterial type I signal peptidases. A novel antibiotic target.
Journal
Reference
Authors
Ng SY, Chaban B, VanDyke DJ, Jarrell KF
Title
Archaeal signal peptidases.
Journal
Reference
Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
Journal
Reference
Authors
Nakatogawa H, Murakami A, Ito K
Title
Control of SecA and SecM translation by protein secretion.
Journal
KO pathway
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