Mustela putorius furo (domestic ferret): 101672983 Help Entry 101672983         CDS       T07239                                  Symbol RYR1 Name (RefSeq) ryanodine receptor 1   KO K04961   ryanodine receptor 1 Organism mpuf  Mustela putorius furo (domestic ferret) Pathway mpuf04020   Calcium signaling pathway mpuf04371   Apelin signaling pathway mpuf04713   Circadian entrainment mpuf04730   Long-term depression mpuf04921   Oxytocin signaling pathway mpuf05017   Spinocerebellar ataxia mpuf05020   Prion disease mpuf05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:mpuf00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     101672983 (RYR1)    04020 Calcium signaling pathway     101672983 (RYR1)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     101672983 (RYR1)   09156 Nervous system    04730 Long-term depression     101672983 (RYR1)   09159 Environmental adaptation    04713 Circadian entrainment     101672983 (RYR1)  09160 Human Diseases   09164 Neurodegenerative disease    05017 Spinocerebellar ataxia     101672983 (RYR1)    05020 Prion disease     101672983 (RYR1)    05022 Pathways of neurodegeneration - multiple diseases     101672983 (RYR1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:mpuf01009]     101672983 (RYR1)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:mpuf04147]     101672983 (RYR1)    04040 Ion channels [BR:mpuf04040]     101672983 (RYR1) Protein phosphatases and associated proteins [BR:mpuf01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      101672983 (RYR1) Exosome [BR:mpuf04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    101672983 (RYR1) Ion channels [BR:mpuf04040]  Voltage-gated cation channels   Ryanodine receptor    101672983 (RYR1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 AIF_C Motif Other DBs NCBI-GeneID:  101672983 NCBI-ProteinID:  XP_004776330 Ensembl:  ENSMPUG00000017796 LinkDB All DBs Position Unknown AA seq 4854 aa AA seqDB search MGDGGEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPP DLAICCFILEQSLSVRALQEMLANTVEAGVESSQGGGHRTLLYGHAILLRHTHSGMYLSC LTTSRSMTDKLAFDVGLQEDATGEACWWTMHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSTASGELQVDASFMQTLWNMNPICSGCEEGYVTGGHVLRLYHGHMDECLTISPADSED QRRLVHYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRIRHVTTGRYLALTEDQGLV VVDASKAHTKATSFCFRISKEKLDMAPKRDVDGMGPPEIKYGESLCFVQHVASGLWLTYA APDPKALRLGVLKKKAMLHQEGHMDDALSLTRCQQEESQAARMIYSTAGLYNQFIKGLDS FSGKPRGSGPPAGTALPIEGVILSLQDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQE EGMLSLVLNCIDRLNVYTTAAHFAEFAGEEAAESWKEIVNLLYELLASLIRGNRTNCALF STNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVL DVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVTSIRPNIFVGRAEGTTQYG KWYFEVMVDEVAPFLTAQATHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLH LWTGHVARPVTSPGQHLLAPEDVVSCCLDLSVPSISFRINGCPVQGVFEAFNLDGLFFPV VSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCHEAVLPRERLHLEPIKEYRREGPRGPHLV GPSRCLSHTDFVPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGLVRDDN KRLHPCLVDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYM MSNGYKPAPLDLSHVRLTPAQMTLVDRLAENGHNVWARDRVAQGWSYSAVQDIPARRNPR LVPYRLLDEATKRSNRDSLCQAVRTLLGYGYNIEPPDQEPSQVESQSRWDRVRIFRAEKS YTVQSGRWYFEFEAVTTGEMRVGWARPDLRPDVELGADELAYVFNGHRGQRWHLGSEPFG RPWQPGDVVGCMIDLTENTIIFTLNGEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVG HLNLGQDVSSLRFFAICGLQEGFEPFAINMQRPVTTWFSKSLPQFEAVPLEHPHYEVARV DGTVDTPPCLRLSHRTWGSQNSLVEMLFLRLSLPVQFHQHFRCTAGATPLAHPGLQPPAE DEARAAEPDPDYENLRRSAGRWGEAEGGKEGNAKEGAPGGNAQAGLEAQPVRVENEKDAT TEKNKKRGFLFKAKKVAMMTQPPATPTLPRLPREVVPADNRDDPEIILNTTTYYYSVRVF AGQEPSCVWVGWVTPDYHQHDMNFELSKVRAVTVTMGDEQGNVHSSLKCSNCYMVWGGDF VSSGQQGRISHTDLVIGCLVDLATGLMTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQN VIQFELGKQKNIMPLSAAMFLSERKNPAPQCPPRLEVQMLMPVSWSRMPNHFLQVETRRA GERLGWAVQCQEPLIMMALHIPEENRSMDILELSERLDLQRFHSHTLRLYRAVCALGNNR VAHALCSHVDQAQLLHALEDAHLPGPLRAGYYDLLISIHLESACRSRRSMLSEYIVPLTE ETRAITLFPPGRSAEDGPRRHGLPGVGVTTSLRPPHHFSPPCFVAALPAAGVAEAPARLS PSIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFVPVLKLVSTLLVMGIFADEDV KQILKMIEPEVFTEEEEEEEEEEEEEDEEEKEEDEEEEAQEKEDEEKEEEETAEGEKEEG LEEGLLQMKLPESVKLQMCHLLEYFCDQELQHRVESLAAFAERYVDKLQANQRDRYGLLM KAFTMSAAETARRTREFRSPPQEQINMLLHFKDGGDEEECPLPEEVRQDLLEFHQDLLAH CGIQLEGEEEEPEEEATLGSRLMSLLEKVRLVKKKEEKPEEEPPAEESKPQSLQELVSHT VVRWAQEDFVQSPELVRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLGQ IRSLLIVQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGGES KEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSGIGLGMQGSTPLDVAAASV IDNNELALALQEQDLEKVVSYLAGCGLQSCPMLLAKGYPDIGWNPCGGERYLDFLRFAVF VNGESVEENANVVVRLLIRKPECFGPALRGEGGSGLLAAIEEAIRISEDPARDGPGVRRD RRREHFGEEPPEENRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSL VPLDDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFLDRVYGIENQDFLLH VLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCAPLFAGTEHRAIMVD SMLHTVYRLSRGRSLTKAQRDVIEDCLMALCRYIRPSMLQHLLRRLVFDVPILNEFAKMP LKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSLAHKKYDAELYRMAM PCLCAIAGALPPDYVDASYSSKAEKKATVDAEGNFDPRPVETLNVIIPEKLDSFINKFAE YTHEKWAFDKIQNNWSYGENIDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMIAWE WTIEKAREGEEEKTEKKKTRKISQSAQTYDPREGYSPQPPDLSGVTLSRELQAMAEQLAE NYHNTWGRKKKQELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRG LKDMELDTSSIEKRFAFGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAK ILLPLINQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVSLFGTD APAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLRLGKVSQART QVKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTKN TYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNACSVYTTKSPRERALLGLPNSVEEMC PDIPVLERLMADIGVLAESGARYTEMPHVIEITLPMLCSYLPRWWERGPEAPPPALPAGA PPPCTAVTSDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLHSHFIP TIGRLRKRAGKVVAEEEQLRLEAKAEAEEGELLVRDEFSVLCRDLYALYPLLIRYVDNNR AHWLTEPNPSAEELFRMVGEIFIYWSKSHNFKREEQNFVVQNEINNMSFLTADNKSKMAK AGDVQSGGSDQERTKKKRRGDRYSVQTSLIVATLKKMLPIGLNMCAPTDQELITQAKNRY ALKDTDEEVREYLQNNLHLQGKVEGSPSLRWQMALYRGVPGREEDADDPEKIVRRVQEVS AVLYHLEQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPTHRACNMFLESYKAG WILTEDHSFEDRMIDDLSKAGEQEEEEEEVEEKKPDPLHQLVLHFSRTALTEKSKLDEDY LYMAYADIMAKSCHMEEGGENGEADEEEVEVSFEEKEMEKQRLLYQQARLHNRGAAEMVL QMISACKGETGAMVSSTLKLGISILNGGNADVQQKMLDYLKDKKEVGFFQSIQALMQTCS VLDLNAFERQNKAEGLGMVNEDGTVINRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQ NYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSKAMSVAKQ VFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELLKELLDLQ KDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVGSEAFQDY VTDPRGLISKKDFQKAMDSQKQFTGPEIQFLLSCSEADENEMINCEEFANRFQEPARDIG FNVAVLLTNLSEHVPHDPRLRTFLELAESILEYFRPYLGRIEIMGASRRIERIYFEISET NRMQWEMPQVKESKRQFIFDVVNEGGESEKMELFVSFCEDTIFEMQIAAQISEPEGEPEE DEDDGAGGLGDMGDTTPAEPPTPEGSPIIKRKLGVDGEEEELPPEPEPEPEPEPEKADAE NGEKEEVPEPPPEPPKKTAPPPPPPKKEEAGGGGLEFWGELEVQRVKFLNYLSRNFYTLR FLALFLAFAINFILLFYKVSDSPPGEDDVEGSAAGDLSGAGSGGGSGWGSGAGEEAEGDE DENMVYYFLEESTGYMEPALRCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEF DGLYITEQPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAELLGM DLATLEITAHNERKPEPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGH YNNFFFAAHLLDIAMGVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFY NKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFF VIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEH NLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS NT seq 14565 nt NT seq  +upstreamnt  +downstreamnt atgggtgacggaggagagggcgaggatgaggtccagtttctgcgcacggacgacgaagtg gtccttcagtgcagcgccactgttctcaaggagcaactgaaactctgcctggccgccgag ggctttggcaaccgcctctgcttcctggagcccaccagcaatgcccagaatgtgcccccc gatctggccatctgttgcttcatcctggagcagtccttgtcggtccgagccctgcaggag atgctggccaacaccgtggaggctggtgtggagtcatcccagggcggaggccacaggaca ctcctgtacggccatgccatcctgctccggcacacacacagcggcatgtacttgagctgc cttaccacctcccgctccatgactgacaagctggccttcgacgtgggactgcaggaagac gccacaggagaggcctgttggtggacgatgcatccggcctccaagcagaggtcggaagga gagaaggtccgcgtgggggatgacctcatccttgttagtgtctcctcagagcgctacctg cacctgtccacggccagcggggagctccaggtcgatgcctccttcatgcagacactgtgg aatatgaaccccatctgctctggctgcgaagaaggctatgtaactgggggccatgtcctc cgcctttatcacggacacatggatgaatgtctgaccatttcccctgctgacagtgaggac cagcgcagacttgtccactatgaggggggagctgtgtgcacccacgcccgctccctctgg agactggagccgctgagaatcagctggagtgggagccacctgcgctggggccagccgctc cgtatccggcacgtcaccactgggcggtacctggcgctcaccgaggaccagggcctggtg gtggttgatgccagcaaggcccacaccaaggccacctccttctgcttccgcatctccaag gagaagctggatatggcccccaagcgggatgtggatggcatgggtccccccgagatcaag tatggggagtcactgtgcttcgtgcagcacgtggcctcaggcctgtggctcacctatgcc gccccagaccccaaggccctgcggcttggtgtgctcaagaagaaggccatgctgcaccag gaaggccacatggatgacgcattatcactgacccgctgccagcaggaggagtcccaggct gcccgcatgatttacagcactgctggcctgtacaaccagttcatcaagggcctggacagc ttcagcgggaagccgcggggctcggggccaccagcgggcacagcgctgcccatcgagggt gtcatcctgagcctgcaggacctcatcggctacttcgagccgccctccgaggagctgcag cacgaggagaagcagagcaagctgcgcagcctgcggaaccgccagagcctcttccaggag gaggggatgctctccttggtcctgaactgcattgaccgcctaaatgtctacaccactgcc gcccactttgccgaatttgcaggggaggaggcagccgagtcctggaaagagattgtgaac ctgctctatgaactcctggcctccctgatccgtggcaatcgtaccaactgtgccctcttt tccaccaacctggactggctggttagcaagctggatcggctggaggcctcctctgggatc ctcgaggtgctgtactgtgtcctgattgagagtcctgaggtgctaaacatcatccaggag aaccacatcaagtccatcatctccctcctggacaagcacgggaggaaccacaaggtgcta gatgtgctgtgttccctgtgtgtgtgcaatggcgtggccgtgcgctccaaccaagatctc attactgagaacttgctccctggccgtgaacttctgctgcagacaaacctcatcaactat gtcaccagcatccgccctaacatctttgtgggccgagcggagggcaccacacagtatggc aaatggtactttgaggtgatggtggacgaggtggctccattcctgacggctcaggccacc cacctgcgggtgggctgggccctcactgagggctacagcccctacccagggggcggcgag ggctggggcggtaatggtgtcggcgatgacctctattcctacggctttgatggcctgcat ctctggacaggacacgtggcacgcccggtgacttccccagggcagcacctcctggccccg gaggatgtggtcagctgctgcctggacctcagtgtgccgtccatctccttccgcatcaat ggctgtcctgtgcagggcgtctttgaggccttcaatctggatgggctcttcttccctgtt gttagcttttcggctggtgtcaaggtgcggtttctccttggtggccgccatggcgaattc aagttcctccctccacctggctatgccccatgccacgaggctgtgctccctcgagagcga cttcatctggagcccatcaaggagtatcgacgggaggggcctcgggggccccacttggtg ggccccagccgctgcctctcacacactgactttgtgccctgccccgtggacactgtccag attgtcctgcctccccatctggagcgtattcgggagaagctggcggagaacatccatgaa ctctgggcgctaactcgcattgagcagggctggacctacggcctggttcgggatgacaat aagaggctgcacccgtgtcttgtggacttccacagccttccagagcccgagaggaattac aacctgcagatgtctggggagacgctcaagactctactggcgctgggctgccatgtgggc atggcagatgagaaggcggaggacaacctgaagaagaccaaactccccaagacgtacatg atgagcaacgggtacaagccggcgcccctagacctgagccacgtgcggctgacaccggca cagatgacgctggtggaccggctggcagagaatgggcacaacgtatgggcacgggaccgc gtagcccagggctggagctacagtgcggtgcaggacatcccagcacgccgcaaccctcgc cttgtgccctaccgcctgctggatgaggccaccaaacgcagcaaccgggatagcctctgc caggccgtgcgcacgctgctgggctatggctacaacatcgagccgcctgaccaggagccc agtcaggtggagagccagtctcgctgggaccgggtgcgtatcttccgggcagagaaatcc tatacggtgcagagtggacgctggtactttgagtttgaagcggtcaccacgggtgagatg cgagtgggctgggcgaggcccgacctgcggcctgacgtggagctgggagctgatgagctg gcctatgtcttcaacgggcaccgcggccagcgatggcacctgggcagtgaaccatttggg cgcccatggcagccaggtgatgtcgtgggctgcatgatcgacctcacagagaacaccatt atcttcaccctcaatggtgaggtcctcatgtccgattcaggctctgagacggccttccgg gaaatcgagattggagatggcttcctgcctgtctgtagcttgggacctggccaggtgggt cacctgaacctgggccaggatgtgagctctctgcggttcttcgccatctgtggcctccag gaaggctttgagccattcgccatcaacatgcagcgcccagtcaccacctggttcagcaaa agcctcccccaatttgaggccgtgcccctcgagcacccccactatgaggtggcccgtgtg gatggcaccgtggacacaccgccctgcctgcgcctgagccaccgcacctggggctcccag aacagtctggtggagatgctcttcctccggcttagccttccggtccagttccaccagcac ttccggtgtactgcaggggccaccccactagcacaccctggcttgcagccccccgctgag gatgaagcccgggcggcggaacctgaccccgactatgaaaacctgcggcgctcagcaggg cgctggggcgaggctgaggggggcaaagaaggaaatgccaaggagggggcgcccgggggc aatgcccaggctgggttggaggcccagcccgtcagggtggagaatgagaaggatgctacc acagagaagaacaaaaagagagggttcttattcaaggccaagaaggtcgccatgatgacc cagccaccagccactcccactctgccccgactccctcgagaggtcgtgccagctgacaac cgtgatgaccctgagatcatcctcaataccaccacgtactattactctgtgagggtcttc gctggccaggagcccagctgcgtgtgggtaggctgggtcacccctgactaccatcagcat gacatgaacttcgagctcagcaaggtccgggcagtgacagtgaccatgggggacgaacaa ggcaacgtccacagcagcctcaagtgcagcaactgctacatggtgtggggcggggacttc gtgagctccgggcagcagggccggatcagccacacagaccttgtcattggctgcctggtg gacttggccactggtctgatgacctttactgccaatggcaaagagagcaacacctttttc caggtggagcccaacacgaagctgtttcctgccgtctttgtcctgcccactcaccagaac gtaatccagtttgagttggggaagcagaagaacatcatgccgctgtcggctgccatgttt ctgagtgagcgcaagaacccggccccgcagtgcccgcctcggctagaggtgcagatgctg atgcccgtctcgtggagccgtatgcccaatcacttcctgcaggtggagacacgacgtgcg ggcgagcggctgggctgggccgtgcagtgccaggagccgctgatcatgatggctttgcac atccctgaggagaaccgatccatggacatcctggagctgtcggagcgcctggacctgcag cggttccactcccacaccctccgcctctaccgtgcagtgtgcgcgctgggcaacaaccgc gtggcgcatgctctgtgcagccacgtggaccaggcgcagctgctgcacgcgctggaggat gcgcacctgccggggccgctgcgggctggttactatgacctcctcatcagcatccacctg gaaagcgcctgccgcagccgccgctccatgctctctgagtacatcgtgcccctcacggag gagacccgtgccatcactctcttcccacccggaagaagcgcagaagacggtccccgccgc cacgggctgcctggcgttggcgtcaccacctcgctgcggcctccacaccatttctcaccc ccctgtttcgtggccgccctgccggctgccggggtggcggaagctccggcccgcctcagc cccagcatccctctggaggccctgcgggataaagcactgagaatgctgggggaggccgtg cgagatggtgggcagcacgcacgtgaccctgtcgggggctctgtggagttccagttcgta cccgtgctcaagctcgtgtccaccctgctggtgatgggcatctttgccgatgaggatgtg aaacagatcttgaagatgattgaacctgaagtattcactgaggaagaagaggaagaggaa gaggaggaagaagaagaagatgaagaggagaaggaggaggatgaagaggaagaggcacag gagaaagaagatgaggaaaaagaggaagaggagacagcagaaggggagaaagaagaaggc ttggaggaagggctgctccagatgaagttgccagaatctgtgaagttacagatgtgccac ctgctggagtatttctgtgaccaagagctacagcaccgggtggaatccctagcagccttt gcggagcgctatgtggacaagctccaggccaaccagcgggaccgctatggcctcctcatg aaagccttcaccatgtctgctgctgagactgcaagacgtactcgcgagttccgctcccca ccccaggagcagataaacatgctgttgcacttcaaagatggtggggatgaggaagagtgt cctctccctgaagaagtccgacaggatttgctggaatttcatcaagacttgctggcacac tgtggaattcagctggagggggaggaggaggaaccagaggaagaggccaccctgggcagc cgtctgatgagcctgttggagaaagtacggttggtgaagaagaaggaggagaaacccgag gaggaaccaccagctgaggagagcaaaccccagtcactgcaggagctggtgtcccacaca gtggtgcgttgggctcaagaggacttcgtgcagagccccgagctcgtccgggccatgttc agcctcctgcaccgacagtacgacggactcggggagctgctgcgtgccctgccccgggca tacaccatctccccatcatctgtggaagacaccatgagcttgcttgagtgcctcggccag atccggtccctgcttattgtgcagatgggtccccaggaggaaaacctcatgatccagagc attgggaacatcatgaacaacaaagtcttttaccaacacccgaacctgatgcgggccctg ggcatgcacgagacggtcatggaggtcatggtgaatgtcctcgggggtggtggcgaatcc aaggagatccgcttccccaagatggtgacaagttgctgccgcttcctctgttatttctgt cgcatcagccggcagaaccaacgctccatgtttgaccacctgagctacctgctggagaac agtggcatcggcctaggcatgcagggctccacgcctctggatgtggcagctgcctccgtc atcgacaacaacgagctggccttggcattgcaagagcaggacctggagaaggtggtatcc tacctggcgggttgtggccttcagagctgccccatgctcctggccaaagggtacccggac atcggctggaacccatgtggcggggagcgctacctggactttctgcgcttcgctgtcttc gtcaacggtgagagcgtggaggagaacgccaacgtggtggtgcggctgctcatccgcaag cctgagtgtttcgggcctgccctgcggggtgagggcggctcagggctgctggccgccatc gaagaggccattcgaatctctgaggacccggcgcgcgatggcccaggcgtccgtagggac cggcggcgtgagcacttcggtgaggagcccccggaggagaaccgggtgcacctgggacac gccatcatgtccttctacgctgccttgattgacctactgggacgctgtgcgccggagatg cacctaatccaagccggcaagggagaggccctgcggatccgtgccatcctgcgctccctc gtgccgctggacgaccttgtgggcatcatcagcctcccactgcagatccccaccctgggc aaagatggggctctggtgcagccgaagatgtcggcatcctttgtgccagaccacaaggcg tccatggtgctcttcctggaccgcgtgtatggtatcgagaaccaggacttcttgctgcat gtgctggatgtggggttcctgcctgacatgcgggcagccgcttcgctagacacggccact ttcagcacaacagagatggcgctggcgctgaaccgctacttgtgcctggcggtgctgccg ctcatcaccaagtgcgcgccgctgttcgcggggacagagcaccgcgccatcatggtggac tccatgctgcacactgtgtaccgcctgtcccgtggccgctcgctcaccaaggcgcagcgc gacgtcatcgaggactgtctcatggcgctctgcaggtacatccggccgtccatgctgcag cacttgctgcggcgcctggtgttcgacgtgcccatcctgaacgagttcgccaagatgccg ctcaagctcctcaccaaccactatgaacgctgctggaagtactactgcctccccaccggc tgggctaacttcggggtcacctccgaggaagagctgcacctcactcgcaaactcttctgg ggcatctttgactcgctggcgcataagaagtatgacgcagagctgtaccgcatggctatg ccttgtctgtgtgccatcgcaggggccctgccccctgactacgtggatgcctcatactca tccaaggccgagaaaaaggccacagtggacgctgaaggcaacttcgatcctcggcctgtg gagaccctcaatgtgatcatcccagagaagctggactccttcattaacaagtttgcggag tacacgcatgagaagtgggccttcgacaagatccagaacaattggtcctatggggagaac atagatgaggaactgaagacccatcccatgctgaggccctataagaccttttcagagaag gacaaagagatttaccgctggcccatcaaggagtccttgaaggccatgattgcctgggaa tggacgatagagaaggccagggagggggaagaggagaagacagagaagaagaaaacgcgg aagatatcccaaagtgcccagacttatgatccgcgagaaggctacagcccccagcccccc gacctcagcggagttaccctgtcccgggagctgcaggccatggcagaacagctggcggag aattaccacaacacgtgggggcggaagaagaagcaggagctggaggccaaaggtggtggg acccaccctctgctggtcccctacgacacactcacagccaaggagaaggcacgagatcga gagaaggcccaggagcttctaaagttcctgcagatgaacggctatgctgtcaccagaggc cttaaggacatggagttggacacgtcttccattgagaaacgatttgcttttggcttcctg cagcagttgctgcgctggatggacatctcccaggaatttatcgcccatttggaggctgtg gtcagcagtggacgagtagaaaagtctccacatgaacaagagattaagttctttgccaag atcctgctccctttgatcaaccagtacttcaccaaccactgcctctatttcctgtccaca ccggccaaagtgctgggcagtggcggccatgcctccaacaaggagaaggaaatgatcacc agcctcttctgcaagcttgctgctcttgtccgtcaccgagtttctctcttcgggacagat gctccggctgtggtcaactgccttcacatcctggcccgctccctggatgcaaggacagtg atgaagtcaggccccgagatcgtgaaggctggcctccgttccttctttgagagcgcatca gaggacatcgagaagatggtggagaacctgcgcctggggaaggtgtcccaggcgcgcacg caggtgaagggcgtgggccagaacctcacctacaccaccgtggccctgctgcccgtcctc accacgctcttccagcacatcgcccagcaccagttcggagacgacgtcatcctggatgac gtccaggtctcttgctaccgaacgctgtgcagtatctactctctgggaaccaccaagaac acttacgtagaaaagctgcggccagccctgggggagtgcctggcccgtcttgcagcagct atgccggtggcgttcctggagcctcagctgaatgagtataatgcctgctcagtgtacact accaagtctccccgggagcgggccctcctggggctccccaatagtgtggaggagatgtgt cctgacatcccagtgctggagcggcttatggcggacatcggtgtgctggccgagtcggga gcccgctacacggagatgccacacgtcatcgagatcacattgcccatgctgtgcagctac ctgccccgctggtgggagcgcgggcccgaggcgccaccccctgccctgcccgcaggggcc cccccgccctgcacagcggtcacctctgaccacctcaactccctgctggggaacatcctg cggatcatcgtcaacaacctgggcattgacgaggcatcgtggatgaagcgtctggccgtg tttgcccagcccattgtgagccgggcccggcctgagcttctgcattcccacttcatccct accattgggcgcttgcgcaagcgggcggggaaggtggtagctgaggaggagcagctgcgc ctggaggccaaggccgaagcggaggagggcgagctcctggtgcgggatgagttctctgtg ctctgccgggacctgtacgccctctacccactgctcatccgctatgtggacaacaacagg gcgcactggctgacggagcccaatcccagcgctgaggagctgttccggatggtgggcgag atcttcatctactggtccaagtcccataacttcaagcgtgaggagcagaacttcgtggtc cagaatgagatcaacaacatgtcatttctgactgctgacaataagagcaaaatggccaag gcgggagatgtacagtcaggtggctcagaccaggaacgcaccaagaagaagcgccgaggg gaccggtactctgtgcagacatccctgattgtcgccacgctcaagaagatgctgcccatc ggcctgaatatgtgtgcgcccacggaccaggaactcatcacacaggccaagaaccgctat gccctgaaagacacagacgaggaggtccgggaatatctgcaaaacaaccttcaccttcaa ggaaaggtcgaaggctccccttctttgcgctggcagatggccctgtaccgtggtgtcccg ggccgtgaggaggacgccgatgaccccgagaaaatcgtgcgcagggttcaggaagtgtct gcggtgctctaccacctggagcagaccgagcacccttacaaatccaagaaggccgtgtgg cacaagctcttgtccaagcagcgccggagggcagtggttgcctgtttccgcatgaccccc ctgtacaacctgcccacgcaccgggcctgtaacatgttcctggagagttacaaggccggg tggatcctgactgaagaccacagctttgaagaccgcatgatcgatgacctttcaaaagct ggggagcaggaggaggaggaggaggaggtggaggagaagaagccggaccccctacatcag ctggtccttcacttcagccgcactgccctgactgagaagagcaaactggatgaggattac ctgtatatggcgtatgctgacatcatggcaaagagctgccacatggaggagggaggggag aatggcgaagcagatgaggaagaagtggaggtgtcctttgaggagaaagagatggagaaa cagaggctgctgtaccagcaggcgcggctgcacaaccggggagccgccgagatggtgctc cagatgatcagtgcctgcaaaggagagacgggcgccatggtgtcctccaccctgaagctg ggcatctccatcctaaacggaggcaatgcagatgtgcaacagaaaatgctggattatctg aaggacaagaaggaagtgggcttcttccagagtatccaggcgctgatgcaaacatgcagc gtcctggatctcaatgctttcgagagacagaacaaggcagaggggctgggcatggtgaac gaggatggaactgtcatcaatcgccagaacggagagaaggtcatggcagatgacgaattc acccaagacctgttccgattcctacaactgctctgtgaggggcacaacaatgatttccag aactacctacggacacaaacggggaacacgaccactattaacattatcatctgcacagtg gactacctcctgaggctgcaggagtccatcagcgacttctactggtactactctggcaaa gatgtcattgaggagcagggcaagaggaacttttccaaggccatgtcggtcgctaaacag gtgttcaacagcctcacggagtacatccagggcccctgcaccgggaaccagcagagcctg gcacatagccgcctctgggatgctgtggtgggattcctgcacgtgtttgcccacatgatg atgaagctcgctcaggactccagccagatcgagctgctgaaggagctgctagatctccag aaggacatggtggtgatgttgctgtcgctactagaagggaatgtggtgaacggcatgatt gcccggcagatggtggacatgcttgtggaatcctcatccaacgtggagatgatcctcaag ttcttcgacatgttcctgaaactcaaggacatcgtgggctcggaggccttccaggactat gttacggatccccgtggcctcatctccaagaaggacttccagaaggctatggacagccag aagcagttcaccggcccagaaatccagttcctgctttcctgctccgaagccgatgagaac gaaatgatcaactgtgaggagttcgccaaccgcttccaggagcctgcccgcgacatcggc ttcaacgtggcggtgctgctgaccaacctgtcggagcacgtgccccacgacccacgcctg cgcaccttcctcgagctggcggagagcatcctcgagtacttccggccctacctgggccgc atcgagattatgggcgcctcgcgccgcatcgagcgcatctactttgagatctcagagacc aaccgcatgcagtgggagatgccccaggtcaaggagtccaagcgccagttcatcttcgac gtggtgaacgagggcggcgagtccgagaagatggagctcttcgtgagcttctgcgaggac accatcttcgagatgcagatcgccgcgcagatctccgagcccgagggcgagccggaggag gacgaagacgacggcgcgggcggcctcggggacatgggtgacacgacgccggcggagccg cccacgcccgagggctcccccatcatcaagaggaagctgggggtggatggagaggaagag gagctgcctccagaacctgagccggagcctgaacctgagcctgagaaagccgatgctgag aatggggagaaggaagaagtccctgaacccccaccagagccccccaagaagacagcacct cctccaccccctccaaagaaggaggaggctggaggtgggggcttggaattctggggagaa ctggaagtacagagggtgaagttcttgaactacctttcccggaacttctataccctgcga ttccttgcactcttcttggcctttgccatcaacttcatcttgctgttttataaggtttca gactcgccaccaggggaggatgacgtggagggctcagcagctggggacctgtcaggtgca gggtctggtggcggctctggctggggctcaggggccggtgaggaagcggagggtgatgag gacgagaacatggtgtactacttcctggaggagagcaccggctacatggagcccgccttg cgctgtctgagcctgctccatacgctggtggccttcctctgcatcattggctacaactgc ctcaaggtgcccctagtgatctttaaacgggagaaggagctggcccgaaagctggagttt gacggcctctacatcacagagcagcctgaggatgacgacgtgaagggccagtgggaccgg ctggtgctcaacacgccgtctttccccagcaattactgggataagtttgtcaagcggaag gtcctggacaagcatggggacatctatgggcgggagcggatcgccgagctgctgggcatg gatctggccacactggagatcacagcccacaatgagcgaaagcccgaaccaccaccggga ctgctcacctggctcatgtccattgatgtcaagtatcagatctggaagtttggggtcatc ttcacagacaattctttcctatatctgggctggtacatggtgatgtccctcctgggacac tacaacaacttcttcttcgctgcccacctcctggacattgccatgggggtcaagacgctg cgaaccatcctctcctccgtcacccataatgggaagcagctggtgatgaccgtgggcctc ctggcggtggttgtctacctctacaccgtggtggccttcaacttcttccgcaagttctac aacaagagtgaggatgaggatgagcctgacatgaagtgtgacgatatgatgacgtgttac ctgtttcacatgtacgtgggtgtccgagccggtgggggcatcggagatgagattgaggat ccagcaggcgatgaatatgagctgtaccgagtggtcttcgacatcaccttcttcttcttt gtcatcgtcatcctgctggccatcatccagggtctgatcattgacgcttttggcgagctc cgagaccaacaagagcaagtgaaggaagatatggagaccaagtgcttcatctgcgggatc ggcagcgattactttgatacgacaccgcacgggttcgagacccacacgctagaggagcac aacctggctaattacatgtttttcttgatgtatctgataaataaggacgagacggaacac actggccaggagtcttacgtctggaagatgtaccaagagagatgttgggatttcttccca gctggcgattgtttccgcaagcagtatgaggaccagcttagctga

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