Mycobacterium tuberculosis H37Ra: MRA_1256
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Entry
MRA_1256 CDS
T00540
Symbol
kgd
Name
(GenBank) alpha-ketoglutarate decarboxylase
KO
K01616
multifunctional 2-oxoglutarate metabolism enzyme [EC:
2.2.1.5
4.1.1.71
1.2.4.2
2.3.1.61
]
Organism
mra
Mycobacterium tuberculosis H37Ra
Pathway
mra00020
Citrate cycle (TCA cycle)
mra00630
Glyoxylate and dicarboxylate metabolism
mra00785
Lipoic acid metabolism
mra01100
Metabolic pathways
mra01110
Biosynthesis of secondary metabolites
mra01120
Microbial metabolism in diverse environments
mra01200
Carbon metabolism
mra01210
2-Oxocarboxylic acid metabolism
Module
mra_M00009
Citrate cycle (TCA cycle, Krebs cycle)
mra_M00011
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Brite
KEGG Orthology (KO) [BR:
mra00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00020 Citrate cycle (TCA cycle)
MRA_1256 (kgd)
00630 Glyoxylate and dicarboxylate metabolism
MRA_1256 (kgd)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
MRA_1256 (kgd)
Enzymes [BR:
mra01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)
MRA_1256 (kgd)
2. Transferases
2.2 Transferring aldehyde or ketonic groups
2.2.1 Transketolases and transaldolases
2.2.1.5 2-hydroxy-3-oxoadipate synthase
MRA_1256 (kgd)
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.61 dihydrolipoyllysine-residue succinyltransferase
MRA_1256 (kgd)
4. Lyases
4.1 Carbon-carbon lyases
4.1.1 Carboxy-lyases
4.1.1.71 2-oxoglutarate decarboxylase
MRA_1256 (kgd)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
E1_dh
2-oxoacid_dh
Transket_pyr
OxoGdeHyase_C
2-oxogl_dehyd_N
Motif
Other DBs
NCBI-ProteinID:
ABQ72996
UniProt:
A5U1U6
LinkDB
All DBs
Position
complement(1390667..1394311)
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AA seq
1214 aa
AA seq
DB search
MYRKFRDDPSSVDPSWHEFLVDYSPEPTSQPAAEPTRVTSPLVAERAAAAAPQAPPKPAD
TAAAGNGVVAALAAKTAVPPPAEGDEVAVLRGAAAAVVKNMSASLEVPTATSVRAVPAKL
LIDNRIVINNQLKRTRGGKISFTHLLGYALVQAVKKFPNMNRHYTEVDGKPTAVTPAHTN
LGLAIDLQGKDGKRSLVVAGIKRCETMRFAQFVTAYEDIVRRARDGKLTTEDFAGVTISL
TNPGTIGTVHSVPRLMPGQGAIIGVGAMEYPAEFQGASEERIAELGIGKLITLTSTYDHR
IIQGAESGDFLRTIHELLLSDGFWDEVFRELSIPYLPVRWSTDNPDSIVDKNARVMNLIA
AYRNRGHLMADTDPLRLDKARFRSHPDLEVLTHGLTLWDLDRVFKVDGFAGAQYKKLRDV
LGLLRDAYCRHIGVEYAHILDPEQKEWLEQRVETKHVKPTVAQQKYILSKLNAAEAFETF
LQTKYVGQKRFSLEGAESVIPMMDAAIDQCAEHGLDEVVIGMPHRGRLNVLANIVGKPYS
QIFTEFEGNLNPSQAHGSGDVKYHLGATGLYLQMFGDNDIQVSLTANPSHLEAVDPVLEG
LVRAKQDLLDHGSIDSDGQRAFSVVPLMLHGDAAFAGQGVVAETLNLANLPGYRVGGTIH
IIVNNQIGFTTAPEYSRSSEYCTDVAKMIGAPIFHVNGDDPEACVWVARLAVDFRQRFKK
DVVIDMLCYRRRGHNEGDDPSMTNPYVYDVVDTKRGARKSYTEALIGRGDISMKEAEDAL
RDYQGQLERVFNEVRELEKHGVQPSESVESDQMIPAGLATAVDKSLLARIGDAFLALPNG
FTAHPRVQPVLEKRREMAYEGKIDWAFGELLALGSLVAEGKLVRLSGQDSRRGTFSQRHS
VLIDRHTGEEFTPLQLLATNSDGSPTGGKFLVYDSPLSEYAAVGFEYGYTVGNPDAVVLW
EAQFGDFVNGAQSIIDEFISSGEAKWGQLSNVVLLLPHGHEGQGPDHTSARIERFLQLWA
EGSMTIAMPSTPSNYFHLLRRHALDGIQRPLIVFTPKSMLRHKAAVSEIKDFTEIKFRSV
LEEPTYEDGIGDRNKVSRILLTSGKLYYELAARKAKDNRNDLAIVRLEQLAPLPRRRLRE
TLDRYENVKEFFWVQEEPANQGAWPRFGLELPELLPDKLAGIKRISRRAMSAPSSGSSKV
HAVEQQEILDEAFG
NT seq
3645 nt
NT seq
+upstream
nt +downstream
nt
atgtaccgcaagttccgcgacgacccctcctcggtcgatcccagctggcacgagttcctg
gttgactacagccccgaacccacctcccaaccagctgccgaaccaacccgggttacctcg
ccactcgttgccgagcgggccgctgcggccgccccgcaggcaccccccaagccggccgac
accgcggccgcgggcaacggcgtggtcgccgcactggccgccaaaactgccgttcccccg
ccagccgaaggtgacgaggtagcggtgctgcgcggcgccgccgcggccgtcgtcaagaac
atgtccgcgtcgttggaggtgccgacggcgaccagcgtccgggcggtcccggccaagcta
ctgatcgacaaccggatcgtcatcaacaaccagttgaagcggacccgcggcggcaagatc
tcgttcacgcatttgctgggctacgccctggtgcaggcggtgaagaaattcccgaacatg
aaccggcactacaccgaagtcgacggcaagcccaccgcggtcacgccggcgcacaccaat
ctcggcctggcgatcgacctgcaaggcaaggacgggaagcgttccctggtggtggccggc
atcaagcggtgcgagaccatgcgattcgcgcagttcgtcacggcctacgaagacatcgta
cgccgggcccgcgacggcaagctgaccactgaagactttgccggcgtgacgatttcgctg
accaatcccggaaccatcggcaccgtgcattcggtgccgcggctgatgcccggccagggc
gccatcatcggcgtgggcgccatggaataccccgccgagtttcaaggcgccagcgaggaa
cgcatcgccgagctgggcatcggcaaattgatcactttgacctccacctacgaccaccgc
atcatccagggcgcggaatcgggcgacttcctgcgcaccatccacgagttgctgctctcg
gatggcttctgggacgaggtcttccgcgaactgagcatcccatatctgccggtgcgctgg
agcaccgacaaccccgactcgatcgtcgacaagaacgctcgcgtcatgaacttgatcgcg
gcctaccgcaaccgcggccatctgatggccgataccgacccgctgcggttggacaaagct
cggttccgcagtcaccccgacctcgaagtgctgacccacggcctgacgctgtgggatctc
gatcgggtgttcaaggtcgacggctttgccggtgcgcagtacaagaaactgcgcgacgtg
ctgggcttgctgcgcgatgcctactgccgccacatcggcgtggagtacgcccatatcctc
gaccccgaacaaaaggagtggctcgaacaacgggtcgagaccaagcacgtcaaacccact
gtggcccaacagaaatacatcctcagcaagctcaacgccgccgaggcctttgaaacgttc
ctacagaccaagtacgtcggccagaagcggttctcgctggaaggcgccgaaagcgtgatc
ccgatgatggacgcggcgatcgaccagtgcgctgagcacggcctcgacgaggtggtcatc
gggatgccgcaccggggccggctcaacgtgctggccaacatcgtcggcaagccgtactcg
cagatcttcaccgagttcgagggcaacctgaatccgtcgcaggcgcacggctccggtgac
gtcaagtaccacctgggcgccaccgggctgtacctgcagatgttcggcgacaacgacatt
caggtgtcgctgaccgccaacccgtcgcatctggaggccgtcgacccggtgctggaggga
ttggtgcgggccaagcaggatctgctcgaccacggaagcatcgacagcgacggccaacgg
gcgttctcggtggtgccgctgatgttgcatggcgatgccgcgttcgccggtcagggtgtg
gtcgccgagacgctgaacctggcgaatctgccgggctaccgcgtcggcggcaccatccac
atcatcgtcaacaaccagatcggcttcaccaccgcgcccgagtattccaggtccagcgag
tactgcaccgacgtcgcaaagatgatcggggcaccgatctttcacgtcaacggcgacgac
ccggaggcgtgtgtctgggtggcgcggttggcggtggacttccgacaacggttcaagaag
gacgtcgtcatcgacatgctgtgctaccgccgccgcgggcacaacgagggtgacgacccg
tcgatgaccaacccctacgtgtacgacgtcgtcgacaccaagcgcggggcccgcaaaagc
tacaccgaagccctgatcggacgtggcgacatctcgatgaaggaggccgaggacgcgctg
cgcgactaccagggccagctggaacgggtgttcaacgaagtgcgcgagctggagaagcac
ggtgtgcagccgagcgagtcggtcgagtccgaccagatgattcccgcggggctggccact
gcggtggacaagtcgctgctggcccggatcggcgatgcgttcctcgccttgccgaacggc
ttcaccgcgcacccgcgagtccaaccggtgctggagaagcgccgggagatggcctatgaa
ggcaagatcgactgggcctttggcgagctgctggcgctgggctcgctggtggccgaaggc
aagctggtgcgcttgtcggggcaggacagccgccgcggcaccttctcccagcggcattcg
gttctcatcgaccgccacactggcgaggagttcacaccactgcagctgctggcgaccaac
tccgacggcagcccgaccggcggaaagttcctggtctacgactcgccactgtcggagtac
gccgccgtcggcttcgagtacggctacactgtgggcaatccggacgccgtggtgctctgg
gaggcgcagttcggcgacttcgtcaacggcgcgcagtcgatcatcgacgagttcatcagc
tccggtgaggccaagtggggccaattgtccaacgtcgtgctgctgttaccgcacgggcac
gaggggcagggacccgaccacacttctgcccggatcgaacgcttcttgcagttgtgggcg
gaaggttcgatgaccatcgcgatgccgtcgactccgtcgaactacttccacctgctacgc
cggcatgccctggacggcatccaacgcccgctgatcgtgttcacgcccaagtcgatgttg
cgtcacaaggccgccgtcagcgaaatcaaggacttcaccgagatcaagttccgctcagtg
ctggaggaacccacctatgaggacggcatcggagaccgcaacaaggtcagccggatcctg
ctgaccagtggcaagctgtattacgagctggccgcccgcaaggccaaggacaaccgcaat
gacctcgcgatcgtgcggcttgaacagctcgccccgctgcccaggcgtcgactgcgtgaa
acgctggaccgctacgagaacgtcaaggagttcttctgggtccaagaggaaccggccaac
cagggtgcgtggccgcgattcgggctcgaactacccgagctgctgcctgacaagttggcc
gggatcaagcgaatctcgcgccgggcgatgtcagccccgtcgtcaggctcgtcgaaggtg
cacgccgtcgaacagcaggagatcctcgacgaggcgttcggctga
DBGET
integrated database retrieval system
