KEGG   Muntiacus reevesi (Reeves' muntjac): 136146704
Entry
136146704         CDS       T10466                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
mree  Muntiacus reevesi (Reeves' muntjac)
Pathway
mree01521  EGFR tyrosine kinase inhibitor resistance
mree01522  Endocrine resistance
mree01524  Platinum drug resistance
mree04012  ErbB signaling pathway
mree04014  Ras signaling pathway
mree04015  Rap1 signaling pathway
mree04024  cAMP signaling pathway
mree04062  Chemokine signaling pathway
mree04066  HIF-1 signaling pathway
mree04068  FoxO signaling pathway
mree04070  Phosphatidylinositol signaling system
mree04071  Sphingolipid signaling pathway
mree04072  Phospholipase D signaling pathway
mree04081  Hormone signaling
mree04140  Autophagy - animal
mree04150  mTOR signaling pathway
mree04151  PI3K-Akt signaling pathway
mree04152  AMPK signaling pathway
mree04210  Apoptosis
mree04211  Longevity regulating pathway
mree04213  Longevity regulating pathway - multiple species
mree04218  Cellular senescence
mree04360  Axon guidance
mree04370  VEGF signaling pathway
mree04380  Osteoclast differentiation
mree04510  Focal adhesion
mree04550  Signaling pathways regulating pluripotency of stem cells
mree04611  Platelet activation
mree04613  Neutrophil extracellular trap formation
mree04620  Toll-like receptor signaling pathway
mree04625  C-type lectin receptor signaling pathway
mree04630  JAK-STAT signaling pathway
mree04650  Natural killer cell mediated cytotoxicity
mree04660  T cell receptor signaling pathway
mree04662  B cell receptor signaling pathway
mree04664  Fc epsilon RI signaling pathway
mree04666  Fc gamma R-mediated phagocytosis
mree04668  TNF signaling pathway
mree04670  Leukocyte transendothelial migration
mree04722  Neurotrophin signaling pathway
mree04725  Cholinergic synapse
mree04750  Inflammatory mediator regulation of TRP channels
mree04810  Regulation of actin cytoskeleton
mree04910  Insulin signaling pathway
mree04914  Progesterone-mediated oocyte maturation
mree04915  Estrogen signaling pathway
mree04917  Prolactin signaling pathway
mree04919  Thyroid hormone signaling pathway
mree04923  Regulation of lipolysis in adipocytes
mree04926  Relaxin signaling pathway
mree04929  GnRH secretion
mree04930  Type II diabetes mellitus
mree04931  Insulin resistance
mree04932  Non-alcoholic fatty liver disease
mree04933  AGE-RAGE signaling pathway in diabetic complications
mree04935  Growth hormone synthesis, secretion and action
mree04960  Aldosterone-regulated sodium reabsorption
mree04973  Carbohydrate digestion and absorption
mree05010  Alzheimer disease
mree05017  Spinocerebellar ataxia
mree05020  Prion disease
mree05100  Bacterial invasion of epithelial cells
mree05135  Yersinia infection
mree05142  Chagas disease
mree05146  Amoebiasis
mree05160  Hepatitis C
mree05161  Hepatitis B
mree05162  Measles
mree05163  Human cytomegalovirus infection
mree05164  Influenza A
mree05165  Human papillomavirus infection
mree05166  Human T-cell leukemia virus 1 infection
mree05167  Kaposi sarcoma-associated herpesvirus infection
mree05168  Herpes simplex virus 1 infection
mree05169  Epstein-Barr virus infection
mree05170  Human immunodeficiency virus 1 infection
mree05171  Coronavirus disease - COVID-19
mree05200  Pathways in cancer
mree05203  Viral carcinogenesis
mree05205  Proteoglycans in cancer
mree05206  MicroRNAs in cancer
mree05207  Chemical carcinogenesis - receptor activation
mree05208  Chemical carcinogenesis - reactive oxygen species
mree05210  Colorectal cancer
mree05211  Renal cell carcinoma
mree05212  Pancreatic cancer
mree05213  Endometrial cancer
mree05214  Glioma
mree05215  Prostate cancer
mree05218  Melanoma
mree05220  Chronic myeloid leukemia
mree05221  Acute myeloid leukemia
mree05222  Small cell lung cancer
mree05223  Non-small cell lung cancer
mree05224  Breast cancer
mree05225  Hepatocellular carcinoma
mree05226  Gastric cancer
mree05230  Central carbon metabolism in cancer
mree05231  Choline metabolism in cancer
mree05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mree05415  Diabetic cardiomyopathy
mree05417  Lipid and atherosclerosis
mree05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mree00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    136146704 (PIK3R1)
   04014 Ras signaling pathway
    136146704 (PIK3R1)
   04015 Rap1 signaling pathway
    136146704 (PIK3R1)
   04370 VEGF signaling pathway
    136146704 (PIK3R1)
   04630 JAK-STAT signaling pathway
    136146704 (PIK3R1)
   04668 TNF signaling pathway
    136146704 (PIK3R1)
   04066 HIF-1 signaling pathway
    136146704 (PIK3R1)
   04068 FoxO signaling pathway
    136146704 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    136146704 (PIK3R1)
   04072 Phospholipase D signaling pathway
    136146704 (PIK3R1)
   04071 Sphingolipid signaling pathway
    136146704 (PIK3R1)
   04024 cAMP signaling pathway
    136146704 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    136146704 (PIK3R1)
   04152 AMPK signaling pathway
    136146704 (PIK3R1)
   04150 mTOR signaling pathway
    136146704 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    136146704 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    136146704 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    136146704 (PIK3R1)
   04218 Cellular senescence
    136146704 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    136146704 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    136146704 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    136146704 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    136146704 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    136146704 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    136146704 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    136146704 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    136146704 (PIK3R1)
   04660 T cell receptor signaling pathway
    136146704 (PIK3R1)
   04662 B cell receptor signaling pathway
    136146704 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    136146704 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    136146704 (PIK3R1)
   04670 Leukocyte transendothelial migration
    136146704 (PIK3R1)
   04062 Chemokine signaling pathway
    136146704 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    136146704 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    136146704 (PIK3R1)
   04929 GnRH secretion
    136146704 (PIK3R1)
   04915 Estrogen signaling pathway
    136146704 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    136146704 (PIK3R1)
   04917 Prolactin signaling pathway
    136146704 (PIK3R1)
   04926 Relaxin signaling pathway
    136146704 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    136146704 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    136146704 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    136146704 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    136146704 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    136146704 (PIK3R1)
   04722 Neurotrophin signaling pathway
    136146704 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    136146704 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    136146704 (PIK3R1)
   04380 Osteoclast differentiation
    136146704 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    136146704 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    136146704 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    136146704 (PIK3R1)
   05206 MicroRNAs in cancer
    136146704 (PIK3R1)
   05205 Proteoglycans in cancer
    136146704 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    136146704 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    136146704 (PIK3R1)
   05203 Viral carcinogenesis
    136146704 (PIK3R1)
   05230 Central carbon metabolism in cancer
    136146704 (PIK3R1)
   05231 Choline metabolism in cancer
    136146704 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    136146704 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    136146704 (PIK3R1)
   05212 Pancreatic cancer
    136146704 (PIK3R1)
   05225 Hepatocellular carcinoma
    136146704 (PIK3R1)
   05226 Gastric cancer
    136146704 (PIK3R1)
   05214 Glioma
    136146704 (PIK3R1)
   05221 Acute myeloid leukemia
    136146704 (PIK3R1)
   05220 Chronic myeloid leukemia
    136146704 (PIK3R1)
   05218 Melanoma
    136146704 (PIK3R1)
   05211 Renal cell carcinoma
    136146704 (PIK3R1)
   05215 Prostate cancer
    136146704 (PIK3R1)
   05213 Endometrial cancer
    136146704 (PIK3R1)
   05224 Breast cancer
    136146704 (PIK3R1)
   05222 Small cell lung cancer
    136146704 (PIK3R1)
   05223 Non-small cell lung cancer
    136146704 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    136146704 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    136146704 (PIK3R1)
   05161 Hepatitis B
    136146704 (PIK3R1)
   05160 Hepatitis C
    136146704 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    136146704 (PIK3R1)
   05164 Influenza A
    136146704 (PIK3R1)
   05162 Measles
    136146704 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    136146704 (PIK3R1)
   05163 Human cytomegalovirus infection
    136146704 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    136146704 (PIK3R1)
   05169 Epstein-Barr virus infection
    136146704 (PIK3R1)
   05165 Human papillomavirus infection
    136146704 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    136146704 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    136146704 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    136146704 (PIK3R1)
   05142 Chagas disease
    136146704 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    136146704 (PIK3R1)
   05017 Spinocerebellar ataxia
    136146704 (PIK3R1)
   05020 Prion disease
    136146704 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    136146704 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    136146704 (PIK3R1)
   05415 Diabetic cardiomyopathy
    136146704 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    136146704 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    136146704 (PIK3R1)
   04931 Insulin resistance
    136146704 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    136146704 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    136146704 (PIK3R1)
   01524 Platinum drug resistance
    136146704 (PIK3R1)
   01522 Endocrine resistance
    136146704 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mree04131]
    136146704 (PIK3R1)
Membrane trafficking [BR:mree04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    136146704 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 AAA_13 SH3_9 SH3_2 Laminin_I CCDC113_CCDC96_CC FANCI_S2
Other DBs
NCBI-GeneID: 136146704
NCBI-ProteinID: XP_065761804
LinkDB
Position
14:56887860..56965191
AA seq 724 aa
MSAEGYQYRALYDYKKERDEDIDLHLGDILTVNKGSLVALGFSDGQEAKPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGPSKTEADSEQQASTLPDLAE
QFAPPDVAPPLLIKLVEAIEKKGLECSTLYRTQSSSSPAELRQLLDCDAASLDLEMFDVH
VLADAFKRYLLDLPNPVIPVAVFSELISLASEVQSSEEYIQLLKKLIRSPSIPHQYWLTL
QYLLKHFFKLSQTSSKNLLNARVLSELFSPLLFRFPAASSENTEHLIKIIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEDYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNETEIQRIMHNYEKLKSRISEIVD
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYGSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atgagcgcggagggataccagtaccgggcgctctacgactataaaaaggagcgggacgag
gacattgacttgcacttgggggacatactgactgtgaacaaggggtccttagtcgccctt
ggattcagtgatggccaggaggccaagcctgaagaaattggctggttaaatggctataac
gagaccacaggggagaggggagactttccggggacttacgtagaatacattggaaggaag
aagatctcgcctcccacaccaaagccccggccaccgcgaccccttcctgttgccccaggc
ccttcaaaaaccgaagcagacagtgagcaacaagcttccacgctcccggaccttgcagag
cagttcgcaccccctgacgtcgctccaccgcttcttatcaagctcgtggaagccattgaa
aagaaaggtctggaatgttcaactctatacagaacacagagctccagcagcccggccgag
ttacgacagcttcttgattgtgatgccgcctccttggacttggagatgttcgatgtgcat
gttttagctgatgccttcaaacggtatctcctggacttaccgaatcctgtcattccggta
gccgttttcagtgaactgatttctttggcctcagaagtgcagagttctgaagaatacatc
cagctgttgaagaagctcattaggtcacccagcatacctcatcagtactggctcacactg
cagtatttgctaaaacatttcttcaagctctctcaaacgtccagcaaaaatcttttgaat
gcaagagtactttctgaactcttcagccctctgctcttcagattcccagcagcaagttct
gagaatactgaacacctcataaaaattatagaaatcttaatctccaccgaatggaatgaa
cgccagcctgcaccagcactgcctcccaaaccaccaaaacccactactgtagccaacaac
ggtatgaataacaatatgtctttacaagatgctgaatggtactggggagatatctcgagg
gaagaagtgaatgaaaaacttcgagatacagctgacgggacctttttggtacgagacgca
tctactaaaatgcatggggattacactcttacactaaggaaaggaggaaataacaaatta
atcaaaatatttcaccgagatgggaaatatggcttctctgacccattaaccttcaactct
gtggttgaactaataaaccactaccggaatgaatctctagctcagtataatcccaaactg
gatgtgaaattactttatccagtatccaaataccaacaggatcaagttgtcaaagaagat
aatattgaagctgtagggaaaaaattacatgaatataacactcaatttcaagaaaaaagt
cgggaatatgatagattatatgaagactatacccgaacttcccaggaaatccaaatgaaa
agaacagctattgaagcatttaatgaaaccataaaaatatttgaagaacagtgccaaacc
caggagcggtacagcaaagaatacatagaaaagtttaaacgtgaaggcaatgagacagaa
atccagaggattatgcataattatgaaaagttaaagtctcgaatcagtgaaattgtcgac
agcaggaggagattggaagaggacttgaagaagcaggcggctgagtatcgtgagattgac
aagcgcatgaacagcattaagccagacctcattcagctaagaaagacaagagaccaatac
ttgatgtggttgactcagaaaggtgttcggcagaagaagttgaacgagtggctgggcaat
gaaaacacggaagaccaatattcgctggtagaagatgatgaggatttgccccaccatgac
gagaagacttggaatgttggaagcagcaaccgaaacaaagcagaaaacctgctgcggggg
aagcgagacggcactttcctcgtccgggaaagcagcaagcagggctgctacgcctgctcg
gtggtggtggacggcgaggtcaagcactgcgtcatcaacaagacggccacgggctacggc
ttcgccgagccctacaacctgtacggctccctcaaggagctggtgcttcactaccagcac
acgtccctcgtgcagcacaacgactccctcaacgtcacactagcctacccggtgtacgcg
cagcagaggcgatga

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