Micropterus salmoides (largemouth bass): 119883493 Help Entry 119883493         CDS       T07309                                  Symbol ryr1b Name (RefSeq) ryanodine receptor 1b isoform X1   KO K04961   ryanodine receptor 1 Organism msam  Micropterus salmoides (largemouth bass) Pathway msam04020   Calcium signaling pathway msam04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:msam00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     119883493 (ryr1b)    04020 Calcium signaling pathway     119883493 (ryr1b)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:msam01009]     119883493 (ryr1b)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:msam04147]     119883493 (ryr1b)    04040 Ion channels [BR:msam04040]     119883493 (ryr1b) Protein phosphatases and associated proteins [BR:msam01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      119883493 (ryr1b) Exosome [BR:msam04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    119883493 (ryr1b) Ion channels [BR:msam04040]  Voltage-gated cation channels   Ryanodine receptor    119883493 (ryr1b) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  119883493 NCBI-ProteinID:  XP_038550089 LinkDB All DBs Position Unknown AA seq 5075 aa AA seqDB search MAEGGEGEEEIQFLRTGDQVVLQCTATVLKEQIKLCLSCEGFGNRLCFLETTSNAQNVPP DLAICTYILEQSLSVRALQEMLNTVELTESSQGGGHRTLLYGHAILLRHSHSGMYLSCLT TSRSLTDKLAFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHL SYASGDLMVDASFMQTLWNMNPISSGCELAEGFLTGGYVIRLFHGHMDECLAIATPEEGE EKRRMAHYEGGAVCSQARSLWRLEPLRISWSGSHMKWGQSFRIRHITTGRYLCLDEEKGL LVVDPERANTKLSAFCFRVSKEKVDVAHKRDVEGMGIPEIKYGESMCFVQHVSTGLWLTY AALDAKAARLGMMKRKVILHQEGHMDDALTVSRSQTEESQAARMIYSTVGLFRQFIKGLD SLSGKNKSPGPVSLPLEGVILSLQDLIFYFRPPEEELEHEEKQTKLRSLRNRQNLFQEEG MITIVLECIDRLNVYNTAAHFSEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFCD NLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLDV LRSLCVCNGVAVRSNQNLITENLLPGRELLLQTNIVNYVTSIRPNIFLGTCEGSTQFKKW YFELMVDHVEAFVTAHASHLRVGWAMTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGTVARQVASPSAHTLAADDVVSCCLDLSVPSISFRINGHPVQGMFENFNVDGLFFPVIS FSAGVKARFLLGGRHGDFKFMPPPGYAPCYEALLPRDRMRIEPIKEYKHDFNGVRNLLGP TMSLTHTSFTPCPVDTVQIVLPPHLESIRVKLAENIHELWAVTRIEQGWTYGTFRDDNKK LHPCLVDFQALPEPERNYNLQMSGETLKTLLALGCHVGMGDEKAEENLKKIKLPKTYVMS NGYKPAPLDLNHVKLTPNQNQLVEKLAENGHNVWARDRVRQGWTYSIVQDIFNKRNPRLV PYNLLDERTKKTNRDSVNNAVRTLIGYGYNIEPPDQESTGHGLENTRGDKVRIFRAEKSY AVTQGKWYFEFEAVTTGEMRVGWARPNVRSDTELGADELAYVFNGNKAQRWHIGNEPFGR QWQSGDVVGCMIDLTEMIIMFTLNGEMLISDSGSEMAFKDIEIGEGFIPVCALGLSQVGR INLGQNVSSLRYFAICGLQEGFEPFAINMKRDITMWFSKSLPQFVPVPTEHNHIEVSRVD GTVDSAPCLKLTHKTFGSQNANTDMLFLRLSMPVQFHETFKIQAGTTPLTHALTIPEEEV VVVEPDSEFEILKKSASRKEQDEEKKELSVPKEITVENDKDTVSEKGKKKGFFSKAKKAA MTPLSPSPAPPAVPRLMEDVVPDDRDDPEIIQNTTTYYYSVRIFAGQEPSGVWVGWVTPD YHQYDPSFDLSKVRSVTVTVGDDKGNIHDSMKHSNCYMVWGGDLVSNQQTRFSQEDMVVG CLVDLATGLMTFTANGKELNTFYQVEPNTKLFPAVFVQPSNQNLVQLELGKLKNIMPISA AMFRSERMNPVPQCPPRLDVQMLTPVIWSRMPNHFLNPQVGRVSERLGWMVECTEPLTMM ALHIPEENRCIDILELSERQDLMTFHYHTLMLYCAVCALGNNRVAHALCSHVDESQLFYA IENTYLPGPLRSGFYDLLISIHLESAKRARLGTNREFIIPMSQETLSIKLYPDAKKAHSL PGVGLTTCLRPKLHFSSINFVGTDPDLYTLSPIFPLQELKTQAISMLTEAVLDGSQAMRD PVGGSVEFHFVPILKLISTLLIMGIFNDEDTKHILKMIDPNVFSGKEEEEEEEGEKAEEG GAAEGEIEEEKEEEEAATEAELEDEGVGDEDEELKDVDKAEHKEEEVEPKEEGEEEKEEG EAKGGKVDGEKAEEEKETEAVEAEVKEEEEGLEEGLLQMKLPESVKLQMCTLLQYFCDCE LRHRVEAIVAYSDQFVHDIQSNQRVRYNLLMKAFTMSAAETARRTREFRSPPQDQVLLLT NFKHGPEDDDCPVPDEVKDTLAEFHNDLLLHCGIHIEEEAVEEEVDTSLGGRLFSLIDKI KNLRKKKEEEKPEVEEEPKPSTLQELISHTMIHWAQESFIQNPELVRLMFSLLHRQYDGL GELIRALPKAYAINAVSVQDTMDLLECLGQIRSLLIVQMGPEEERLMIQSIGNIMNNKVF YQHPNLMRALGMHETVMEVMVNVLGGGGDSKEIRFPHMVTNCCRFLCYFCRISRQNQRSM FDHLGYLLQNSGIGLGMSGSTPLDVAAASCIDNNELALALQEQDLEMVVTYLAGCGLQMC PMLLSKGYPDIGWNPCGGEKYLDFLRFAVFVNGESVEENANVVVRLLIRRPECFGPALRG EGGNGLLAAMEEAIKISEDPARDGPTVKKDRRFMFGGEEQQEENRVHLGNAIMAFYSALI DLLGRCAPEMHLIQAGKGEALRIRAILRSLVPIEDLVGVISLPVQIPAYGKDGQIIEPKM SASFVPDHKASMVLFLDRVYGIDNQDFMLHVLEVGFLPDMRAAASLDTVAFSTTEMALAL NRYLCSAVLPLLTKCAPLFAGTDHRAIMIDSMLHTIYRLSRGRALTKAQRDVIEECLMSL CKYLRPSMLQHLLRRLVFDVPILNEYAKMPLKLLTNHYERCWKYYCLPNGWANFGVTSEE ELHLSRKLFWGIFESLAHKKFDAELFKIAMPCLCAIAGAIPPDYVDATYSSHTEKKASVD AEGNFDPKPVETTNTIIPERLDTFINKYAEHTHDRWAFEKIQNNWTYGEVLDENAKTHPM LRPYKTFSEKDKEIYRWPIKESIKAMLAWEWTLEKAREGEGEVEKKVATRKISQTAQATY DPSHGYNPQPVDIVGMALSRELQSMAEQLAENYHNTWGRKKKLELQSKGGGTHPLLVPYD TLTAKEKARDREKAQDLLKFLQLNGYAVTRGMKDMEQDISSIEKRFAYGFLQKLLKWMDI AQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLVNQYFKNHCLYFLSTPAKVLGSGG HSSNKEKEMIASIFCKLAALVRHRVSLFGTDAGAVVNCLHILSRSLDARTVMKSGPEIVK AGLRQFFESAADDIEKMVENLKLGKVSSRNQVKGVSQNINYTTNALLPVLTTLFDHIAQH QFGDDVILDDLQISCYRLMCSIYSLGTVKTPHAEKQRPALGECLAHLAAAMPVAFLEPAL NEFNTFSVYTTKTPRERTILGLPNQVEELCPDIPELEVLMKEIHDMAESGARYTEMPHMI EITLPMLCNYLPRWWERGIENFPDLEGQLCTSVTSEHLNQLLGSIMKIVVNNLGIDEASW MKRLAVFAQPIVSRAKPEMLKSHFIPTMEKLKKRSGKVVAEEDQLRMEGKTELDSENGTI KDEFAVLCRDLYALYPLLIRFVDNNRARWLTCPDPDAEEFFRMVGEIFIFWSKSHNFKRE EQNFVVMNEINNMSFLTADSKSKMSKAGDGESGGSEQERTKKKRRGDRYSVQTSLIVAAL KKLLPIGLNMCSPADQELINLAKIRYSLRDTDEEVREFLHNNLHLQGKVEDPAMRWQMSL YKEMAGKAEDAEDPEKVVKRVQEVSAVLYHIEVTEHPYKSKKMVWHKLLSKQRRRAVVAC FRMTPLYNIPKHRATNMFLDAYKRNWLGTEGYSFEDKMIDDLSKAMEEEEEEEEETETKP DPLHQLILHFSRTALTEKAKLDVDHLYMSYADIMAKSCHIGEEDEGGEQEGEEPSFEVRQ TEMEKEMEKQRLLYQQSRLHNRGAAEMVLQMISACKGEPGVMVSSTLKLGISILNGGNSD VQQRMLDYLKDKKDVGFFLSIQALMQTCSVLDLNAFERQNKAEGLGMVSEEGTNKKLERD EKVMSDDEFTCDIFRFLQLLCEGHNNDFQNYLRTQTGSTTTINVIICTVDYLLRLQESIS DFYWYYSGKDIIDEPGKRNFSKAMTVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVG FLHVFAHMMMKLAQDSSQIGLLKELLDLQKDMVVMLLSLLEGNVVNGTIAKQMVDMLVES SSNVEMILKFFDMFLKLKDIVASDAFRDYVTDPRGLISKKDFSKAMDSQKQYSPSEIQFL LSCSEADENEMINFEEFADRFQEPAKDIGFNIAVLLTNLSEHVPHDTRLQNFLEQAESVL NYFRPFLGRIEIMGASRKIERIYFEISEANRNQWEMPQVRESKRQFIFDVVNEGGESEKM EMFVNFCEDTIFEMNIAASISEPEGDGAEEEDDEEEEEGGGNEGESGEGEEGSREGEDSE STSAFADFLKSVVNFFNMFTFRNLRRRYRKLRKMTVKEMVVCLVTFIYTVLMGILIFVYN ICKGFFTLIWKVLFGGGLVEGAKKMTVTEILASMPDPTQDEVHGDLPPEPGAREVQDADG AADLLDAVGGEEEEEDSEAREGGRLPGFNTPGGLGDFGETTPEEPPTPEGTPLLKRKLLA AAVGGQDEGETVHSEEEAPQETEKADIENGEKTEKAEPEPEVQEVKEEEIELKEEGPVKT KAKKDKKHAEEGFELWNELEVQRIKFMNYLSRNFYNLRFLALFIAFALNFILLFYKVSES PPGEEDFEGSALFEGSGLFEGSGAEEDGSGLDDGAGEDDEEEGPLYYFLEESTGYMEPAM AFFGIIHTIISFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYVTEQPEDDDIKGQWDR LVLNTPTFPNNYWDKFVKRKVLDKYGDIYGRERIAELLGMDLASLDVSAMTHGKKSEPDT SMFSWITSIDIKYQIWKFGVVFTDNTFLYLVWYMLMSLLGHYNNFFFAAHLLDIAMGVKT LRTILSSVTHNGKQLMMTVGLLAVVVYLYTVVAFNFFRKFYNMSEDEDEPDMKCDDMMTC YLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGE LRDQQEQVREDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDETE HTGQESYVWKMYQERCWDFYPAGDCFRKQYEDQLG NT seq 15228 nt NT seq  +upstreamnt  +downstreamnt atggcagaagggggagagggagaggaggagattcagttcctgcgaacgggtgaccaggtt gttctgcagtgcactgccactgtcctgaaggaacagattaagctatgtctgtcctgcgag ggctttgggaaccgtctctgcttcctggaaaccacatccaacgctcagaatgtgcctccg gacctggccatatgtacctacattctggaacagtccctgtcggtccgcgctctgcaggag atgttgaacacggttgagttgaccgagtcgtcccaaggtggaggtcatcgtaccttactg tacggtcatgccatccttctgagacacagccactcaggcatgtacctgagctgtttgaca acatctcggtcactcacggacaagctggcctttgacgtgggcttacaagaagattccact ggagaggcatgttggtggaccattcatccagcctctaagcaaaggtcagaaggtgaaaag gtcagggtgggtgacgacctcatccttgtcagtgtttcctctgagagatacttgcacctc tcctatgccagtggagatctgatggtggatgcctccttcatgcagaccctgtggaacatg aacccaattagttcaggatgtgaactagctgaggggtttctgacaggaggttacgttatc aggctgttccacggccacatggacgagtgtctggccattgctacaccagaggaaggagag gaaaagcgcaggatggctcattatgaaggtggtgctgtgtgcagtcaggctcgatccctg tggaggttggagcctctcagaatcagctggagtggtagccacatgaagtgggggcagtct ttccgtattcgccacatcaccacaggccggtacctgtgtctggatgaggagaagggtctg ttggtggttgacccagagagggccaacaccaaactatctgctttctgctttcgtgtttca aaggagaaggtggatgtggctcataaacgtgatgttgaggggatgggcattccagagatc aagtatggagagtccatgtgcttcgtccagcatgtgtctacaggcctgtggctcacatat gctgccctggatgccaaagctgctcgtttaggaatgatgaagagaaaggtcattctgcac caggagggtcatatggatgatgccctaactgtgtctcgctcccaaactgaagagtctcag gctgctcgaatgatttacagcactgtaggcctcttcaggcagttcataaagggtttggac tctctgagtgggaagaacaagtcaccagggcctgtgtcacttcctctggagggggtcatc ctctcgcttcaggatctcatcttctactttcgtcctcctgaggaggaactggagcacgag gagaagcagaccaaactccgctccctgcgcaaccggcagaacctcttccaagaggaggga atgatcaccattgtgcttgagtgcattgaccgcctgaatgtgtacaacactgctgcccac ttttctgaatttgctggggaggaggctgcagagtcctggaaggagatcgtcaacctcctt tacgagctgctggcttctctaattagaggaaaccgctctaattgcgcgttgttctgtgac aacctggactggctggtcagcaagctcgaccgtctggaggcctcttcaggtattcttgag gtgctgtactgtgtgttaattgaaagccctgaggttctgaacatcatccaggagaaccac attaaatccatcatctccctcctggacaagcatggaaggaatcataaggtcctggatgtc ttgcgatctctttgtgtgtgtaatggtgtagctgtgaggtccaaccagaacctcatcact gaaaacctgcttccgggtcgcgaactcttgctgcagaccaacattgtaaactatgttacc agtataagaccaaacatcttcctgggtacatgtgaggggtccacgcagtttaagaagtgg tactttgagttaatggtagaccatgtggaagcctttgtgacagcgcatgcttcccacctg cgtgtgggctgggctatgacagagggctacagcccctaccctggaggaggagaaggctgg ggaggcaacggtgtgggagatgacctctactcctatggctttgatggactgcatctgtgg tcaggcactgtagcccgtcaggtggcttcgcccagtgcacacaccctggctgcagatgat gtcgttagctgctgtctggatctgagcgtgcccagtatctccttccgtattaatggccac ccagttcagggcatgtttgaaaacttcaatgtggatggcctctttttccctgttattagc ttctctgctggagtcaaggctcggttcctccttggtggtcgtcacggagacttcaagttc atgccgccgcctggctatgccccatgctacgaggctctgctgcctagagacagaatgcgt attgaacccatcaaggagtacaagcacgacttcaacggtgtgcgcaacctgctgggtccc accatgtccctcacccacacctctttcaccccctgccctgtggacactgttcagattgta ttgccaccccacttggagagtatcagagtgaagctggcagagaatattcacgaactctgg gctgtcactcgtattgagcagggctggacctatgggactttcagagatgacaataagaag ctccatccttgtctggtggacttccaggctctccctgaaccagagaggaactacaacctg cagatgtctggcgagactcttaagactctcctggcactgggttgccacgttggaatgggt gacgagaaagcagaggagaatctcaagaagatcaagctgcccaagacctatgtgatgagc aatggatacaaacctgccccccttgacctcaaccatgtcaaactgacaccaaaccagaac cagcttgtagaaaaactggcagaaaatggacataatgtttgggcaagagaccgggtacgg caaggatggacctacagtattgtgcaggacatcttcaataagcgaaaccctcgtctggta ccttacaacctgctggacgagagaaccaagaaaaccaaccgagacagtgttaacaacgct gtccgcaccctcattggctatggctacaacattgagcctccagatcaggagagcactggc catggcctcgaaaacacccgtggggacaaggtacgaatctttagggcagaaaagtcatat gctgtcacccaagggaagtggtactttgagtttgaggcagtcaccacgggggagatgaga gtgggttgggcacgtcctaatgttcgctctgacactgaactgggagcagatgaactggcc tacgtctttaatggcaataaggctcaaagatggcatattggcaatgagcctttcggtcgc cagtggcaatctggcgatgtagttggttgtatgattgacctgactgagatgatcatcatg ttcacactcaacggagaaatgttgatcagtgactcgggctcggagatggctttcaaagac attgaaattggggaaggttttatcccagtgtgtgccctgggcctgtctcaggttggaagg atcaatcttggtcagaatgtcagcagcctacgctactttgccatctgtggcctgcaggaa ggatttgaaccttttgctatcaatatgaaacgagatattaccatgtggttcagtaaaagt ttgccccaatttgtgcctgtacccaccgagcacaatcatatagaggtctcccgtgtggat gggactgtggacagtgccccctgtctgaaactgacacataagacatttggatcacagaac gccaacaccgacatgctgttcctcagactcagcatgcctgtccagttccacgagaccttc aagatccaggcaggcaccacccctctaacccatgccctcactatacccgaggaggaagtg gttgtggtggagcccgactcagaatttgaaattctgaaaaagtctgccagccgcaaggag caggatgaggaaaagaaggagctgtctgtacctaaggagatcactgtggaaaatgacaag gacacagtgtcagaaaagggaaagaaaaaaggattcttctccaaggccaagaaggctgcc atgacacctctctccccttctcctgcacctccagcagtgccacgtttgatggaagacgta gtcccagatgacagagatgatccggagatcatccagaatactaccacttattactattct gtaaggattttcgctggacaggagccttctggtgtgtgggttggctgggtcactcctgac taccaccagtatgatccatcctttgacctctccaaagtgcgctctgtcactgttactgtg ggagatgacaaaggcaacatacatgatagtatgaagcacagtaactgttacatggtgtgg ggaggggacctggtcagcaatcagcagacccgcttcagccaggaggacatggttgttggc tgcttggttgacctggcaacaggtctcatgacctttacagccaacggaaaggagcttaac accttctaccaggttgagcccaataccaagctgttccctgctgtctttgttcagccctcc aatcagaacttggtgcagctagagctgggaaaactcaagaacatcatgcccatctcggca gccatgttccgcagcgaacgtatgaacccggtcccccagtgccctcccaggttggatgtc cagatgttgaccccagttatctggagtcgcatgcccaaccacttcctcaacccgcaggtg ggcagagtgagtgagaggttgggctggatggtggagtgtactgaacccctcaccatgatg gctctgcacatcccagaggagaacaggtgtattgacatcctggagctgtcggagcgtcag gatctgatgacgtttcactaccatacccttatgctctactgcgctgtgtgcgcacttggc aataaccgcgtggctcatgccttgtgcagccatgtggatgaatcccagcttttctatgcc attgagaacacctacctgcccggacctctccgcagcggcttctacgacctgctcatcagc attcacctggaatctgctaaacgggcacgcctgggcaccaatagggaatttatcatccct atgtctcaagagactctgagcatcaagctgtaccctgatgcaaagaaagcccattctcta cccggtgttggcctcaccacctgcttacggcccaagttgcatttttcatccatcaacttt gtcggcacggaccccgatctgtacacccttagtcctattttccccctgcaggagctgaag acccaggcgattagcatgttaacagaggctgtgctggatggtagccaagctatgcgggat ccagtaggaggcagtgtggagttccactttgtcccaatcctgaagctaatcagtacactg ctcattatgggtatcttcaacgacgaggacaccaagcacatcctgaagatgatcgatcca aatgttttcagtggaaaggaagaggaggaggaagaggagggagagaaagctgaggagggt ggagctgctgaaggagaaatcgaggaagagaaggaggaggaagaggcggcaactgaggcc gagcttgaggacgaaggagttggtgacgaggatgaggagctgaaagatgtggataaagca gagcataaggaggaagaagttgagcctaaggaggaaggagaagaggagaaggaggaggga gaggccaaaggaggaaaagtagatggagagaaggcagaggaggagaaggagacagaggca gtggaagcagaagtgaaagaggaggaggagggtctggaagagggattactccagatgaag ctaccagagtctgtcaaactgcagatgtgcacactcttgcagtacttctgcgactgcgag ctgcgacacagagttgaagccattgtggcctattcagaccagtttgtccatgatattcag agcaaccaacgtgttcgttacaatctattaatgaaagccttcaccatgtctgctgctgag actgcacgcaggacccgcgagttccgttcaccaccacaggaccaggttcttttgctgacc aactttaagcatggtccagaggacgatgattgtccagtgcctgatgaggtgaaggacact cttgcagagttccacaatgacctcctgcttcactgtggtatacatattgaggaggaggca gtggaggaagaggtggacacctcactggggggcagactcttcagtctgatcgacaagatc aagaacttgcgcaagaagaaggaggaagagaagccagaggttgaagaggaaccaaaaccc agcacccttcaggaactgatctcccacactatgatccactgggctcaggagtcatttatt cagaaccccgaacttgtgcgtctgatgttcagcctgctccacaggcagtatgatggcctc ggcgagctgattcgagctctgcccaaagcctatgccatcaatgctgtgtctgttcaggac accatggacctacttgagtgtttgggacagatacgttcgctgcttattgtccagatgggc ccagaagaggagcggctcatgatccagagcatcgggaacatcatgaacaacaaggtgttc taccaacaccccaatctgatgagagctcttggtatgcatgagactgtcatggaggtgatg gtcaatgtcctgggcggaggaggagattcgaaggagattcgattcccccatatggtgacc aactgctgtcggttcctgtgttacttttgtcgtatcagccgacagaaccagcgctccatg tttgaccatttaggctaccttttacagaacagcggcattggcttgggaatgagtgggtcc acacctctggatgtggctgcagcttcctgtattgacaacaatgagctggccttggctcta caagagcaggacctggaaatggtggtgacatacttggcgggctgcgggctgcagatgtgt ccaatgcttctttcaaagggctaccctgacatcggctggaacccctgtggaggagagaaa tacctggatttcctccgctttgctgtctttgttaatggagagagcgtggaggagaatgct aatgtagtggtgcgtctgctcatccgtcggcctgagtgcttcggcccagccctgagagga gagggtggtaatggtctgctggctgccatggaggaggccatcaagatctcagaggatcca gcaagggatggacccactgtcaaaaaagacagacgtttcatgtttggtggtgaagaacag caggaggagaatcgtgtacatctgggaaatgccatcatggctttctactctgcccttatt gatctgctgggtcgctgcgcccctgagatgcatctgatccaagcaggcaagggtgaagcc ctaagaatcagggccatcctgaggtctctggtgccaatagaggatctggtgggagttatc agcttgcctgtgcagattcctgcctacggcaaagatggtcaaattattgagcctaagatg tcagccagttttgtgccagaccacaaggcctccatggtgctgttccttgatagagtgtat ggcattgacaaccaggacttcatgcttcatgtgctggaggttggcttcctgcccgacatg agagctgcagcctctctggacacggtggcattcagtacgactgaaatggccttggcactg aaccgctacctctgttcggctgttctgcctcttctcaccaagtgtgccccattgtttgct gggacagaccaccgagccatcatgatcgactccatgctccacaccatctatcgtttgtca cgtggccgagctcttaccaaggctcagagggacgtcattgaggagtgcctcatgtcgctc tgcaagtaccttcgaccctccatgctgcagcatctgcttagacggctggtatttgatgtg cccatcctcaacgaatatgcaaagatgcctctaaagctgttgaccaatcactatgagcgc tgttggaagtactactgtttgcctaatggatgggctaatttcggtgtgacttcagaggag gagcttcatctttctcgtaaactcttttggggaatatttgaatctttggcacacaagaaa tttgatgcagagctcttcaagatcgccatgccctgcctctgtgctatcgcaggagccatc ccacctgactatgtggatgccacttactcctctcacactgagaagaaagcctctgtggat gctgaaggcaacttcgatcctaaaccagtggagaccaccaacaccatcatcccagagagg ctggatacttttatcaataagtatgcagagcacactcatgacagatgggcctttgagaag attcagaacaactggacctacggagaggtgttagatgagaatgctaagacgcacccaatg ctccggccatacaaaacattctctgaaaaggacaaggagatataccgttggcccatcaaa gaatccatcaaagccatgctggcctgggagtggacattggagaaagccagggagggggag ggagaagtcgagaagaaggtcgccacacgcaaaatctcacaaactgctcaggccacttat gatcccagtcacggctacaaccctcagccagtagatattgtaggaatggctctgtccaga gagctgcagtctatggctgagcagctggctgagaattatcacaacacctggggcaggaag aagaagttggagctacagtccaaaggcggtggcacccatcctttgcttgtgccttatgac accttgacggctaaagagaaggccagagacagagagaaggcacaggacctgctcaagttc ctacagctcaatggatatgctgttacaaggggaatgaaggacatggagcaggatatttcc tctatcgagaagcgttttgcctatggtttcctccagaagcttcttaaatggatggacatt gcccaggagttcatcgctcatcttgaggccgtggttagcagtggtagagtggagaagtca ccacatgaacaagagatcaaattctttgccaagatcctcctgccactggtaaatcagtac ttcaagaaccactgcctctacttcctctccactcctgctaaagtcttgggtagtggaggg cattcctccaataaggagaaggagatgattgccagtatcttctgtaagttggctgctttg gtgaggcacagagtatctctttttggaacagatgcaggtgcagtggtaaactgtctgcac atcctctcacgatcactcgatgccaggactgttatgaaatcaggccctgagattgttaag gctggcctgcgccagttctttgagagtgctgcagatgacattgagaagatggttgagaat ctgaaacttggcaaagtttccagtcgaaaccaggtaaagggtgtgtcccagaatatcaac tacaccaccaatgccctgttgccagtcctcactacactgtttgaccatattgcccagcac cagtttggagatgacgtcatattggatgacttgcaaatatcctgctatcgtttaatgtgc agtatctactctctgggcacagtaaagactccacatgcagagaaacagcgaccagctctt ggcgagtgtttggcccacttagcagcagctatgccagtagccttccttgagccagcactg aatgagtttaacacattttctgtttacaccaccaagactccaagagaaagaactattctg ggtcttcctaaccaagtggaggagctgtgccctgacattccagagctggaggtcctgatg aaggagatccatgacatggctgagtctggggctcgctacacagaaatgccccatatgatt gagataaccctgcccatgttgtgtaactacctcccacggtggtgggagaggggcatagaa aatttccctgacctggagggtcagctctgcacctctgtcacctccgagcatcttaaccaa ctgctgggtagcattatgaagattgtggttaacaatctgggtatagatgaggcctcctgg atgaagagattggcagtgtttgcccagcctattgtcagcagggctaaaccagagatgctt aaatcccacttcatccctaccatggaaaagctgaagaagcgctcagggaaagttgtggca gaggaggatcagctgcgcatggagggcaagacggagttggacagtgaaaatggaaccatc aaagatgagtttgctgtgctgtgtcgggacctgtatgctctctaccccttgcttatccga ttcgtggacaataacagggcacggtggttgacctgtccagacccagatgcagaggaattt ttcaggatggtgggagagatcttcattttctggtccaaatcccacaactttaagagggag gagcagaactttgtggtgatgaatgagatcaataacatgtctttcctgactgctgacagt aagagcaagatgagcaaggccggagatggagagtctggaggctcagagcaggaacgtacc aagaagaagcggcggggtgatcgctactctgtgcagacttccctaattgtagcagcattg aagaagcttcttcccattggtctcaatatgtgctctcctgcagaccaggagctcatcaat cttgccaagatcagatactcactgagagacacagatgaagaggtgagggagttcttgcac aacaatctacatttgcaaggcaaggtggaggacccagctatgcgctggcagatgtctctg tataaggagatggctggaaaggcagaagatgctgaggaccctgagaaggtggtgaaaagg gtacaagaggtgtctgctgtgctttaccacattgaggtgactgagcatccgtacaagtcc aagaaaatggtgtggcacaagctgctgtccaaacagcgtcgcagggctgtggtggcctgt ttcaggatgacacccctgtacaacatccccaagcacagggcaaccaacatgttcctggat gcctacaagcgcaactggttagggactgagggttactcatttgaggacaagatgattgat gacttatcaaaagccatggaggaagaggaggaagaggaagaggagactgagacgaagcct gacccccttcatcagctgattcttcatttcagccgcacagctctcacagaaaaggctaaa cttgatgttgaccatctctatatgtcttatgctgatattatggcaaagagctgccacatt ggtgaggaggacgaagggggagagcaggagggggaggagccatcctttgaggtgcgacag acagagatggaaaaggagatggagaaacagaggcttctgtaccagcagtcccgtctacac aatcgtggggcagcagagatggtgctgcagatgatcagtgcctgtaaaggtgaacctgga gtcatggtttcttccacactcaaactgggaatttccatcctcaacggaggcaacagtgat gtacagcagagaatgctggactacctgaaggataaaaaggatgtgggattcttccttagc attcaggctctgatgcagacgtgcagcgttttggacctgaacgcttttgagagacagaac aaggccgagggccttgggatggtttcagaggagggcactaataagaagctagaacgtgat gagaaagtgatgtcggatgatgaatttacatgtgacatcttccgcttcctgcagcttctt tgtgagggccacaataatgattttcagaactacctgagaactcagacaggcagcaccact accatcaatgtcatcatttgcactgtggactacctgcttcgactacaggagtcaatcagt gacttttactggtactactctggaaaagacattattgatgaacctggtaagaggaatttc tccaaagcaatgactgtggccaagcaggtcttcaacagtttgactgagtacatccagggt ccctgtactggtaaccagcagtctctggcccacagcagattgtgggacgctgttgtgggc ttcctgcacgtctttgctcacatgatgatgaaacttgctcaggactccagtcaaattgga ctgttgaaggagctgttggatctgcagaaggacatggtagtgatgcttctatctcttctt gaaggcaatgtggtgaatggtactattgccaagcagatggttgacatgctggtggagtcc tccagcaacgtggagatgattcttaagttcttcgacatgttccttaagctcaaggacata gtggcgtctgacgctttccgagattatgtgactgacccccgtgggctaatctccaagaag gacttctccaaggccatggacagccagaagcaatattctccctcagaaatccagttcctc ctctcttgctcagaggctgatgagaatgagatgatcaactttgaggaatttgctgatcgt ttccaggagccagcaaaagacattggtttcaatattgccgttctgctcacaaacctttca gagcacgtaccccatgacactcgccttcagaacttcctggagcaggcagagagcgtgctc aactacttccgccctttccttggtcgtattgagatcatgggagccagcaggaagatcgag cgcatttactttgaaatcagcgaggcaaaccgcaaccagtgggaaatgcctcaagtcagg gagtccaaacggcaattcatctttgatgtggtcaatgagggtggtgagagtgagaaaatg gagatgtttgtgaacttctgtgaggacaccatctttgagatgaacattgctgcatcgatc tctgagcctgagggagatggtgcagaagaagaagatgatgaggaagaagaggagggtggt ggaaatgaaggagagtctggagaaggagaggaaggcagtagagaaggggaagattcagag tcaacctcagcctttgcagactttctcaagagcgtggttaacttcttcaacatgttcacc ttccgtaacctgcggcgtaggtaccgcaaactaagaaaaatgacagttaaggagatggtg gtctgtctggttacatttatctacactgttctgatgggtatcctgatatttgtttataat atatgtaagggtttcttcacactcatatggaaggtgttgtttggtggaggcttagttgag ggcgccaagaagatgacagtgacagagatccttgctagtatgccagatcccacacaggac gaagttcacggggacttgccacctgaaccaggggcaagagaggtccaagacgcagacgga gcagcagacctgttagatgctgtgggaggagaggaggaagaggaggatagtgaggcgagg gaaggaggacgtcttcctggtttcaatactcctgggggacttggagactttggtgagacg acacctgaagagcctccgactccagagggcacgccactactgaagagaaaattgttggcc gctgcagtgggaggacaagatgagggggaaacagttcattccgaagaggaggctcctcag gagactgagaaagcagacattgaaaatggtgagaagactgagaaggctgaacctgaacct gaggtacaggaggtaaaggaggaagagattgagcttaaagaggaagggccagtgaagacc aaggcaaagaaagacaagaaacatgctgaggagggctttgagctgtggaatgagctggaa gttcagaggattaaattcatgaactacctttctcgcaacttctacaaccttcggttcctg gccctgttcattgcctttgctctcaatttcatcctgctcttctacaaggtgtctgagagt cctccaggcgaggaggactttgagggttctgcactgtttgagggctctggcttatttgaa ggctctggtgcagaggaggatgggtctggattagatgacggagctggagaagatgatgaa gaagaaggtccattatactacttcttagaagagagcacagggtacatggagcccgctatg gctttcttcggtatcatccacaccatcatctcctttctctgcatcatcggctacaactgc ctcaaggtccctctggttatcttcaagagagagaaggagttagccagaaagctggagttt gatggtctctatgtcactgagcagcctgaggatgatgacatcaagggccagtgggacaga ctggtgctcaacaccccaactttccctaacaattactgggacaagtttgtgaaaagaaag gtgctggataaatatggggacatctatggcagagagagaattgcggagttgctcggtatg gacttggcttctctagatgtcagtgccatgacccatggaaagaagtctgaaccagacaca tcaatgttcagctggataacatctattgacatcaagtaccagatctggaagtttggtgtt gttttcactgacaataccttcctctacctggtttggtacatgttaatgtctctgcttgga cactacaacaacttcttctttgccgctcatcttttggacatcgccatgggtgtcaaaacc ctgcggaccattctgtcctctgttactcacaatggcaaacagctgatgatgacagtgggt ttgctggctgtagttgtgtacctttacaccgtggtggccttcaacttcttccgcaagttc tacaacatgagtgaggatgaggatgaaccagacatgaagtgtgatgacatgatgacttgt tacctgttccacatgtatgtcggtgtccgtgctggtggtggcataggagatgaaattgag gacccagccggagatgaatatgagctctaccgtgtagtgtttgacattaccttcttcttc tttgtcatcgtcatcctgctggctatcatccagggtttgatcattgatgcctttggagag ctgagagaccagcaggagcaggtcagagaggacatggagacaaagtgtttcatctgtgga ataggaagtgactactttgacacaacgccacatggcttcgagacacacaccttagaagaa cataacttagccaactacatgttcttcctgatgtatctcataaacaaagatgaaacagaa cacacaggacaggagtcatacgtgtggaagatgtaccaggagcgatgctgggacttctat cctgctggagactgctttaggaagcagtatgaggatcagcttggataa

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