Macaca thibetana thibetana (Pere David's macaque): 126931154
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Entry
126931154 CDS
T08579
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
KO
K00070
3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:
1.1.1.145
5.3.3.1
]
Organism
mthb
Macaca thibetana thibetana (Pere David's macaque)
Pathway
mthb00140
Steroid hormone biosynthesis
mthb01100
Metabolic pathways
mthb04913
Ovarian steroidogenesis
mthb04925
Aldosterone synthesis and secretion
mthb04927
Cortisol synthesis and secretion
mthb04934
Cushing syndrome
Module
mthb_M00107
Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
mthb_M00110
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
mthb_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
mthb_M00977
C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:
mthb00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
126931154
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
126931154
04925 Aldosterone synthesis and secretion
126931154
04927 Cortisol synthesis and secretion
126931154
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
126931154
Enzymes [BR:
mthb01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.145 3beta-hydroxy-Delta5-steroid dehydrogenase
126931154
5. Isomerases
5.3 Intramolecular oxidoreductases
5.3.3 Transposing C=C bonds
5.3.3.1 steroid Delta-isomerase
126931154
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Gene cluster
GFIT
Motif
Pfam:
3Beta_HSD
Epimerase
NAD_binding_4
GDP_Man_Dehyd
Polysacc_synt_2
NAD_binding_10
RmlD_sub_bind
KR
NmrA
Ldh_1_N
Sacchrp_dh_NADP
adh_short
Semialdhyde_dh
Ilm1
Motif
Other DBs
NCBI-GeneID:
126931154
NCBI-ProteinID:
XP_050604940
LinkDB
All DBs
Position
1:118743787..118751553
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AA seq
373 aa
AA seq
DB search
MTGWSCLVTGAGGFLGQRIVRLLVEEKELKEIRVLDKAFRPELREEFSKLQNKTKLTVLE
GDILDEPFLKRACQDISVVIHTACIIDVFGVTHRESVMNVNVKGTQLLLEACVQASVPVF
IYTSSIEVAGPNSYKEIIQNGHEEEALENTWSAPYPYSKKLAEKAVLAADGWTLKDGGTL
YTCALRPTYIYGEGSQFLSAGINEALNNNGILSSVGKFSTVNPVYVGNVAWAHILALRAL
RNPKKAPSVRGQFYYISDDTPHQSYDNLSYTLSKEFGLRLDSRWSLPLALMYWIGFLLEI
VSFLLRPIYTYRPPFNRHMVTLSNSVFTFSYKKAQRDLAYEPLYSWEEAKQKTVEWVGSL
VDRHKETLKSKTQ
NT seq
1122 nt
NT seq
+upstream
nt +downstream
nt
atgacgggctggagctgccttgtgacaggagcaggagggtttctgggtcagaggatcgtc
cgcctcttggtggaggagaaggagctgaaggagatcagggtcttggacaaggccttcaga
ccagagctgagggaggaattttccaagctccagaacaagaccaagctgacagtgctggaa
ggagacattctggatgagccattcctgaagagagcctgccaggacatctcggttgtcatc
cacaccgcctgtatcattgatgtctttggtgtcactcacagagagtccgtcatgaacgtc
aatgtgaaaggtacccagctcctgttagaggcctgtgtccaagctagtgtgccagtcttc
atctacaccagtagcatagaggtagccggacccaactcgtacaaggaaatcatccagaac
ggccacgaagaagaggctctggaaaacacatggtctgctccatacccatacagcaaaaag
cttgctgagaaggctgtgctggcagctgatgggtggactctgaaagacggtggcaccttg
tacacttgtgccttaagacccacgtatatctatggggaaggaagccaattcctttctgct
ggtataaatgaggcactgaacaacaatgggatcctgtcaagtgttggcaagttctccact
gttaacccagtctatgttggcaacgtggcctgggcccacattctggccttgagggccctg
cggaaccccaagaaggccccaagtgtccgaggacagttttactacatctcagatgacacg
cctcaccaaagttatgataaccttagttataccctgagcaaagagttcggcctccgcctt
gattccagatggagccttcctttagccctgatgtactggattggtttcctgctggaaata
gtgagcttccttctcaggccaatttacacctatcgaccaccctttaaccgccacatggtg
acattgtcaaatagcgtgttcaccttctcttacaagaaggctcagcgagatctggcatat
gagccactctacagctgggaggaagccaagcagaaaaccgtggagtgggttggttccctt
gtggaccggcacaaggagaccctgaagtccaagactcagtga
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