Mycobacterium tuberculosis Erdman = ATCC 35801: ERDMAN_2466
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Entry
ERDMAN_2466 CDS
T02526
Symbol
aceE
Name
(GenBank) pyruvate dehydrogenase subunit E1
KO
K00163
pyruvate dehydrogenase E1 component [EC:
1.2.4.1
]
Organism
mtn
Mycobacterium tuberculosis Erdman = ATCC 35801
Pathway
mtn00010
Glycolysis / Gluconeogenesis
mtn00020
Citrate cycle (TCA cycle)
mtn00620
Pyruvate metabolism
mtn00785
Lipoic acid metabolism
mtn01100
Metabolic pathways
mtn01110
Biosynthesis of secondary metabolites
mtn01120
Microbial metabolism in diverse environments
mtn01200
Carbon metabolism
mtn01210
2-Oxocarboxylic acid metabolism
Module
mtn_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
mtn00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
ERDMAN_2466 (aceE)
00020 Citrate cycle (TCA cycle)
ERDMAN_2466 (aceE)
00620 Pyruvate metabolism
ERDMAN_2466 (aceE)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
ERDMAN_2466 (aceE)
Enzymes [BR:
mtn01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
ERDMAN_2466 (aceE)
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GFIT
Motif
Pfam:
PDH_E1_M
Transketolase_C_1
Transketolase_N
Transketolase_C
Motif
Other DBs
NCBI-ProteinID:
BAL66257
UniProt:
A0A0H3LB38
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Position
2503817..2506609
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AA seq
930 aa
AA seq
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MTTDFARHDLAQNSNSASEPDRVRVIREGVASYLPDIDPEETSEWLESFDTLLQRCGPSR
ARYLMLRLLERAGEQRVAIPALTSTDYVNTIPTELEPWFPGDEDVERRYRAWIRWNAAIM
VHRAQRPGVGVGGHISTYASSAALYEVGFNHFFRGKSHPGGGDQVFIQGHASPGIYARAF
LEGRLTAEQLDGFRQEHSHVGGGLPSYPHPRLMPDFWEFPTVSMGLGPLNAIYQARFNHY
LHDRGIKDTSDQHVWCFLGDGEMDEPESRGLAHVGALEGLDNLTFVINCNLQRLDGPVRG
NGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDGALVNLMNTTPDGDYQTYKANDG
GYVRDHFFGRDPRTKALVENMSDQDIWNLKRGGHDYRKVYAAYRAAVDHKGQPTVILAKT
IKGYALGKHFEGRNATHQMKKLTLEDLKEFRDTQRIPVSDAQLEENPYLPPYYHPGLNAP
EIRYMLDRRRALGGFVPERRTKSKALTLPGRDIYAPLKKGSGHQEVATTMATVRTFKEVL
RDKQIGPRIVPIIPDEARTFGMDSWFPSLKIYNRNGQLYTAVDADLMLAYKESEVGQILH
EGINEAGSVGSFIAAGTSYATHNEPMIPIYIFYSMFGFQRTGDSFWAAADQMARGFVLGA
TAGRTTLTGEGLQHADGHSLLLAATNPAVVAYDPAFAYEIAYIVESGLARMCGENPENIF
FYITVYNEPYVQPPEPENFDPEGVLRGIYRYHAATEQRTNKAQILASGVAMPAALRAAQM
LAAEWDVAADVWSVTSWGELNRDGVAIETEKLRHPDRPAGVPYVTRALENARGPVIAVSD
WMRAVPEQIRPWVPGTYLTLGTDGFGFSDTRPAARRYFNTDAESQVVAVLEALAGDGEID
PSVPVAAARQYRIDDVAAAPEQTTDPGPGA
NT seq
2793 nt
NT seq
+upstream
nt +downstream
nt
ttgaccaccgatttcgcccgccacgatctggcccaaaactcaaacagcgcaagcgaaccc
gaccgagttcgggtgatccgcgagggtgtggcgtcgtatttgcccgacattgatcccgag
gagacctcggagtggctggagtcctttgacacgctgctgcaacgctgcggcccgtcgcgg
gcccgctacctgatgttgcggctgctagagcgggccggcgagcagcgggtggccatcccg
gcattgacgtctaccgactatgtcaacaccatcccgaccgagctggagccgtggttcccc
ggcgacgaagacgtcgaacgtcgttatcgagcgtggatcagatggaatgcggccatcatg
gtgcaccgtgcgcaacgaccgggtgtgggcgtgggtggccatatctcgacctacgcgtcg
tccgcggcgctctatgaggtcggtttcaaccacttcttccgcggcaagtcgcacccgggc
ggcggcgatcaggtgttcatccagggccacgcttccccgggaatctacgcgcgcgccttc
ctcgaagggcggttgaccgccgagcaactcgacggattccgccaggaacacagccatgtc
ggcggcgggttgccgtcctatccgcacccgcggctcatgcccgacttctgggaattcccc
accgtgtcgatgggtttgggcccgctcaacgccatctaccaggcacggttcaaccactat
ctgcatgaccgcggtatcaaagacacctccgatcaacacgtgtggtgttttttgggcgac
ggcgagatggacgaacccgagagccgtgggctggcccacgtcggcgcgctggaaggcttg
gacaacttgaccttcgtgatcaactgcaatctgcagcgactcgacggcccggtgcgcggc
aacggcaagatcatccaggagctggagtcgttcttccgcggtgccggctggaacgtcatc
aaggtggtgtggggccgcgaatgggatgccctgctgcacgccgaccgcgacggtgcgctg
gtgaatttaatgaatacaacacccgatggcgattaccagacctataaggccaacgacggc
ggctacgtgcgtgaccacttcttcggccgcgacccacgcaccaaggcgctggtggagaac
atgagcgaccaggatatctggaacctcaaacggggcggccacgattaccgcaaggtttac
gccgcctaccgcgccgccgtcgaccacaagggacagccgacggtgatcctggccaagacc
atcaaaggctacgcgctgggcaagcatttcgaaggacgcaatgccacccaccagatgaaa
aaactgaccctggaagaccttaaggagtttcgtgacacgcagcggattccggtcagcgac
gcccagcttgaagagaatccgtacctgccgccctactaccaccccggcctcaacgccccg
gagattcgttacatgctcgaccggcgccgggccctcgggggctttgttcccgagcgcagg
accaagtccaaagcgctgaccctgccgggtcgcgacatctacgcgccgctgaaaaagggc
tctgggcaccaggaggtggccaccaccatggcgacggtgcgcacgttcaaagaagtgttg
cgcgacaagcagatcgggccgcggatagtcccgatcattcccgacgaggcccgcaccttc
gggatggactcctggttcccgtcgctaaagatctataaccgcaatggccagctgtatacc
gcggttgacgccgacctgatgctggcctacaaggagagcgaagtcgggcagatcctgcac
gagggcatcaacgaagccgggtcggtgggctcgttcatcgcggccggcacctcgtatgcg
acgcacaacgaaccgatgatccccatttacatcttctactcgatgttcggcttccagcgc
accggcgatagcttctgggccgcggccgaccagatggctcgagggttcgtgctcggggcc
accgccgggcgcaccaccctgaccggtgagggcctgcaacacgccgacggtcactcgttg
ctgctggccgccaccaacccggcggtggttgcctacgacccggccttcgcctacgaaatc
gcctacatcgtggaaagcggactggccaggatgtgcggggagaacccggagaacatcttc
ttctacatcaccgtctacaacgagccgtacgtgcagccgccggagccggagaacttcgat
cccgagggcgtgctgcggggtatctaccgctatcacgcggccaccgagcaacgcaccaac
aaggcgcagatcctggcctccggggtagcgatgcccgcggcgctgcgggcagcacagatg
ctggccgccgagtgggatgtcgccgccgacgtgtggtcggtgaccagttggggcgagcta
aaccgcgacggggtggccatcgagaccgagaagctccgccaccccgatcggccggcgggc
gtgccctacgtgacgagagcgctggagaatgctcggggcccggtgatcgcggtgtcggac
tggatgcgcgcggtccccgagcagatccgaccgtgggtgccgggcacatacctcacgttg
ggcaccgacgggttcggcttttccgacactcggcccgccgctcgccgctacttcaacacc
gacgccgaatcccaggtggtcgcggttttggaggcgttggcgggcgacggcgagatcgac
ccatcggtgccggtcgcggccgcccgccagtaccggatcgacgacgtggcggctgcgccc
gagcagaccacggatcccggtcccggggcctaa
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