KEGG   Mycobacterium tuberculosis H37Rv: Rv1248c
Entry
Rv1248c           CDS       T00015                                 
Name
(RefSeq) multifunctional 2-oxoglutarate dehydrogenase E1 component/2-oxoglutarate dehydrogenase dihydrolipoyllysine-residue succinyltransferase
  KO
K01616  multifunctional 2-oxoglutarate metabolism enzyme [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
Organism
mtu  Mycobacterium tuberculosis H37Rv
Pathway
mtu00020  Citrate cycle (TCA cycle)
mtu00630  Glyoxylate and dicarboxylate metabolism
mtu00785  Lipoic acid metabolism
mtu01100  Metabolic pathways
mtu01110  Biosynthesis of secondary metabolites
mtu01120  Microbial metabolism in diverse environments
mtu01200  Carbon metabolism
mtu01210  2-Oxocarboxylic acid metabolism
Module
mtu_M00009  Citrate cycle (TCA cycle, Krebs cycle)
mtu_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Brite
KEGG Orthology (KO) [BR:mtu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    Rv1248c
   00630 Glyoxylate and dicarboxylate metabolism
    Rv1248c
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    Rv1248c
Enzymes [BR:mtu01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.2  oxoglutarate dehydrogenase (succinyl-transferring)
     Rv1248c
 2. Transferases
  2.2  Transferring aldehyde or ketonic groups
   2.2.1  Transketolases and transaldolases
    2.2.1.5  2-hydroxy-3-oxoadipate synthase
     Rv1248c
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.61  dihydrolipoyllysine-residue succinyltransferase
     Rv1248c
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.71  2-oxoglutarate decarboxylase
     Rv1248c
SSDB
Motif
Pfam: E1_dh 2-oxoacid_dh Transket_pyr OxoGdeHyase_C 2-oxogl_dehyd_N
Other DBs
NCBI-GeneID: 887084
NCBI-ProteinID: NP_215764
TubercuList: Rv1248c
UniProt: P9WIS5
LinkDB
Position
complement(1389357..1393052)
AA seq 1231 aa
MANISSPFGQNEWLVEEMYRKFRDDPSSVDPSWHEFLVDYSPEPTSQPAAEPTRVTSPLV
AERAAAAAPQAPPKPADTAAAGNGVVAALAAKTAVPPPAEGDEVAVLRGAAAAVVKNMSA
SLEVPTATSVRAVPAKLLIDNRIVINNQLKRTRGGKISFTHLLGYALVQAVKKFPNMNRH
YTEVDGKPTAVTPAHTNLGLAIDLQGKDGKRSLVVAGIKRCETMRFAQFVTAYEDIVRRA
RDGKLTTEDFAGVTISLTNPGTIGTVHSVPRLMPGQGAIIGVGAMEYPAEFQGASEERIA
ELGIGKLITLTSTYDHRIIQGAESGDFLRTIHELLLSDGFWDEVFRELSIPYLPVRWSTD
NPDSIVDKNARVMNLIAAYRNRGHLMADTDPLRLDKARFRSHPDLEVLTHGLTLWDLDRV
FKVDGFAGAQYKKLRDVLGLLRDAYCRHIGVEYAHILDPEQKEWLEQRVETKHVKPTVAQ
QKYILSKLNAAEAFETFLQTKYVGQKRFSLEGAESVIPMMDAAIDQCAEHGLDEVVIGMP
HRGRLNVLANIVGKPYSQIFTEFEGNLNPSQAHGSGDVKYHLGATGLYLQMFGDNDIQVS
LTANPSHLEAVDPVLEGLVRAKQDLLDHGSIDSDGQRAFSVVPLMLHGDAAFAGQGVVAE
TLNLANLPGYRVGGTIHIIVNNQIGFTTAPEYSRSSEYCTDVAKMIGAPIFHVNGDDPEA
CVWVARLAVDFRQRFKKDVVIDMLCYRRRGHNEGDDPSMTNPYVYDVVDTKRGARKSYTE
ALIGRGDISMKEAEDALRDYQGQLERVFNEVRELEKHGVQPSESVESDQMIPAGLATAVD
KSLLARIGDAFLALPNGFTAHPRVQPVLEKRREMAYEGKIDWAFGELLALGSLVAEGKLV
RLSGQDSRRGTFSQRHSVLIDRHTGEEFTPLQLLATNSDGSPTGGKFLVYDSPLSEYAAV
GFEYGYTVGNPDAVVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQLSNVVLLLPHGHEGQ
GPDHTSARIERFLQLWAEGSMTIAMPSTPSNYFHLLRRHALDGIQRPLIVFTPKSMLRHK
AAVSEIKDFTEIKFRSVLEEPTYEDGIGDRNKVSRILLTSGKLYYELAARKAKDNRNDLA
IVRLEQLAPLPRRRLRETLDRYENVKEFFWVQEEPANQGAWPRFGLELPELLPDKLAGIK
RISRRAMSAPSSGSSKVHAVEQQEILDEAFG
NT seq 3696 nt   +upstreamnt  +downstreamnt
gtggccaacataagttcaccattcgggcaaaacgaatggctggtcgaagagatgtaccgc
aagttccgcgacgacccctcctcggtcgatcccagctggcacgagttcctggttgactac
agccccgaacccacctcccaaccagctgccgaaccaacccgggttacctcgccactcgtt
gccgagcgggccgctgcggccgccccgcaggcaccccccaagccggccgacaccgcggcc
gcgggcaacggcgtggtcgccgcactggccgccaaaactgccgttcccccgccagccgaa
ggtgacgaggtagcggtgctgcgcggcgccgccgcggccgtcgtcaagaacatgtccgcg
tcgttggaggtgccgacggcgaccagcgtccgggcggtcccggccaagctactgatcgac
aaccggatcgtcatcaacaaccagttgaagcggacccgcggcggcaagatctcgttcacg
catttgctgggctacgccctggtgcaggcggtgaagaaattcccgaacatgaaccggcac
tacaccgaagtcgacggcaagcccaccgcggtcacgccggcgcacaccaatctcggcctg
gcgatcgacctgcaaggcaaggacgggaagcgttccctggtggtggccggcatcaagcgg
tgcgagaccatgcgattcgcgcagttcgtcacggcctacgaagacatcgtacgccgggcc
cgcgacggcaagctgaccactgaagactttgccggcgtgacgatttcgctgaccaatccc
ggaaccatcggcaccgtgcattcggtgccgcggctgatgcccggccagggcgccatcatc
ggcgtgggcgccatggaataccccgccgagtttcaaggcgccagcgaggaacgcatcgcc
gagctgggcatcggcaaattgatcactttgacctccacctacgaccaccgcatcatccag
ggcgcggaatcgggcgacttcctgcgcaccatccacgagttgctgctctcggatggcttc
tgggacgaggtcttccgcgaactgagcatcccatatctgccggtgcgctggagcaccgac
aaccccgactcgatcgtcgacaagaacgctcgcgtcatgaacttgatcgcggcctaccgc
aaccgcggccatctgatggccgataccgacccgctgcggttggacaaagctcggttccgc
agtcaccccgacctcgaagtgctgacccacggcctgacgctgtgggatctcgatcgggtg
ttcaaggtcgacggctttgccggtgcgcagtacaagaaactgcgcgacgtgctgggcttg
ctgcgcgatgcctactgccgccacatcggcgtggagtacgcccatatcctcgaccccgaa
caaaaggagtggctcgaacaacgggtcgagaccaagcacgtcaaacccactgtggcccaa
cagaaatacatcctcagcaagctcaacgccgccgaggcctttgaaacgttcctacagacc
aagtacgtcggccagaagcggttctcgctggaaggcgccgaaagcgtgatcccgatgatg
gacgcggcgatcgaccagtgcgctgagcacggcctcgacgaggtggtcatcgggatgccg
caccggggccggctcaacgtgctggccaacatcgtcggcaagccgtactcgcagatcttc
accgagttcgagggcaacctgaatccgtcgcaggcgcacggctccggtgacgtcaagtac
cacctgggcgccaccgggctgtacctgcagatgttcggcgacaacgacattcaggtgtcg
ctgaccgccaacccgtcgcatctggaggccgtcgacccggtgctggagggattggtgcgg
gccaagcaggatctgctcgaccacggaagcatcgacagcgacggccaacgggcgttctcg
gtggtgccgctgatgttgcatggcgatgccgcgttcgccggtcagggtgtggtcgccgag
acgctgaacctggcgaatctgccgggctaccgcgtcggcggcaccatccacatcatcgtc
aacaaccagatcggcttcaccaccgcgcccgagtattccaggtccagcgagtactgcacc
gacgtcgcaaagatgatcggggcaccgatctttcacgtcaacggcgacgacccggaggcg
tgtgtctgggtggcgcggttggcggtggacttccgacaacggttcaagaaggacgtcgtc
atcgacatgctgtgctaccgccgccgcgggcacaacgagggtgacgacccgtcgatgacc
aacccctacgtgtacgacgtcgtcgacaccaagcgcggggcccgcaaaagctacaccgaa
gccctgatcggacgtggcgacatctcgatgaaggaggccgaggacgcgctgcgcgactac
cagggccagctggaacgggtgttcaacgaagtgcgcgagctggagaagcacggtgtgcag
ccgagcgagtcggtcgagtccgaccagatgattcccgcggggctggccactgcggtggac
aagtcgctgctggcccggatcggcgatgcgttcctcgccttgccgaacggcttcaccgcg
cacccgcgagtccaaccggtgctggagaagcgccgggagatggcctatgaaggcaagatc
gactgggcctttggcgagctgctggcgctgggctcgctggtggccgaaggcaagctggtg
cgcttgtcggggcaggacagccgccgcggcaccttctcccagcggcattcggttctcatc
gaccgccacactggcgaggagttcacaccactgcagctgctggcgaccaactccgacggc
agcccgaccggcggaaagttcctggtctacgactcgccactgtcggagtacgccgccgtc
ggcttcgagtacggctacactgtgggcaatccggacgccgtggtgctctgggaggcgcag
ttcggcgacttcgtcaacggcgcgcagtcgatcatcgacgagttcatcagctccggtgag
gccaagtggggccaattgtccaacgtcgtgctgctgttaccgcacgggcacgaggggcag
ggacccgaccacacttctgcccggatcgaacgcttcttgcagttgtgggcggaaggttcg
atgaccatcgcgatgccgtcgactccgtcgaactacttccacctgctacgccggcatgcc
ctggacggcatccaacgcccgctgatcgtgttcacgcccaagtcgatgttgcgtcacaag
gccgccgtcagcgaaatcaaggacttcaccgagatcaagttccgctcagtgctggaggaa
cccacctatgaggacggcatcggagaccgcaacaaggtcagccggatcctgctgaccagt
ggcaagctgtattacgagctggccgcccgcaaggccaaggacaaccgcaatgacctcgcg
atcgtgcggcttgaacagctcgccccgctgcccaggcgtcgactgcgtgaaacgctggac
cgctacgagaacgtcaaggagttcttctgggtccaagaggaaccggccaaccagggtgcg
tggccgcgattcgggctcgaactacccgagctgctgcctgacaagttggccgggatcaag
cgaatctcgcgccgggcgatgtcagccccgtcgtcaggctcgtcgaaggtgcacgccgtc
gaacagcaggagatcctcgacgaggcgttcggctga

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