Mycobacterium tuberculosis H37Rv: Rv2241
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Entry
Rv2241 CDS
T00015
Symbol
aceE
Name
(RefSeq) pyruvate dehydrogenase E1 component
KO
K00163
pyruvate dehydrogenase E1 component [EC:
1.2.4.1
]
Organism
mtu
Mycobacterium tuberculosis H37Rv
Pathway
mtu00010
Glycolysis / Gluconeogenesis
mtu00020
Citrate cycle (TCA cycle)
mtu00620
Pyruvate metabolism
mtu00785
Lipoic acid metabolism
mtu01100
Metabolic pathways
mtu01110
Biosynthesis of secondary metabolites
mtu01120
Microbial metabolism in diverse environments
mtu01200
Carbon metabolism
mtu01210
2-Oxocarboxylic acid metabolism
Module
mtu_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
mtu00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
Rv2241 (aceE)
00020 Citrate cycle (TCA cycle)
Rv2241 (aceE)
00620 Pyruvate metabolism
Rv2241 (aceE)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
Rv2241 (aceE)
Enzymes [BR:
mtu01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
Rv2241 (aceE)
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Gene cluster
GFIT
Motif
Pfam:
PDH_E1_M
Transketolase_C_1
Transketolase_N
Transketolase_C
Motif
Other DBs
NCBI-GeneID:
887246
NCBI-ProteinID:
NP_216757
TubercuList:
Rv2241
UniProt:
P9WIS9
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All DBs
Position
2512539..2515244
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AA seq
901 aa
AA seq
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MASYLPDIDPEETSEWLESFDTLLQRCGPSRARYLMLRLLERAGEQRVAIPALTSTDYVN
TIPTELEPWFPGDEDVERRYRAWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGF
NHFFRGKSHPGGGDQVFIQGHASPGIYARAFLEGRLTAEQLDGFRQEHSHVGGGLPSYPH
PRLMPDFWEFPTVSMGLGPLNAIYQARFNHYLHDRGIKDTSDQHVWCFLGDGEMDEPESR
GLAHVGALEGLDNLTFVINCNLQRLDGPVRGNGKIIQELESFFRGAGWNVIKVVWGREWD
ALLHADRDGALVNLMNTTPDGDYQTYKANDGGYVRDHFFGRDPRTKALVENMSDQDIWNL
KRGGHDYRKVYAAYRAAVDHKGQPTVILAKTIKGYALGKHFEGRNATHQMKKLTLEDLKE
FRDTQRIPVSDAQLEENPYLPPYYHPGLNAPEIRYMLDRRRALGGFVPERRTKSKALTLP
GRDIYAPLKKGSGHQEVATTMATVRTFKEVLRDKQIGPRIVPIIPDEARTFGMDSWFPSL
KIYNRNGQLYTAVDADLMLAYKESEVGQILHEGINEAGSVGSFIAAGTSYATHNEPMIPI
YIFYSMFGFQRTGDSFWAAADQMARGFVLGATAGRTTLTGEGLQHADGHSLLLAATNPAV
VAYDPAFAYEIAYIVESGLARMCGENPENIFFYITVYNEPYVQPPEPENFDPEGVLRGIY
RYHAATEQRTNKAQILASGVAMPAALRAAQMLAAEWDVAADVWSVTSWGELNRDGVAIET
EKLRHPDRPAGVPYVTRALENARGPVIAVSDWMRAVPEQIRPWVPGTYLTLGTDGFGFSD
TRPAARRYFNTDAESQVVAVLEALAGDGEIDPSVPVAAARQYRIDDVAAAPEQTTDPGPG
A
NT seq
2706 nt
NT seq
+upstream
nt +downstream
nt
gtggcgtcgtatttgcccgacattgatcccgaggagacctcggagtggctggagtccttt
gacacgctgctgcaacgctgcggcccgtcgcgggcccgctacctgatgttgcggctgcta
gagcgggccggcgagcagcgggtggccatcccggcattgacgtctaccgactatgtcaac
accatcccgaccgagctggagccgtggttccccggcgacgaagacgtcgaacgtcgttat
cgagcgtggatcagatggaatgcggccatcatggtgcaccgtgcgcaacgaccgggtgtg
ggcgtgggtggccatatctcgacctacgcgtcgtccgcggcgctctatgaggtcggtttc
aaccacttcttccgcggcaagtcgcacccgggcggcggcgatcaggtgttcatccagggc
cacgcttccccgggaatctacgcgcgcgccttcctcgaagggcggttgaccgccgagcaa
ctcgacggattccgccaggaacacagccatgtcggcggcgggttgccgtcctatccgcac
ccgcggctcatgcccgacttctgggaattccccaccgtgtcgatgggtttgggcccgctc
aacgccatctaccaggcacggttcaaccactatctgcatgaccgcggtatcaaagacacc
tccgatcaacacgtgtggtgttttttgggcgacggcgagatggacgaacccgagagccgt
gggctggcccacgtcggcgcgctggaaggcttggacaacttgaccttcgtgatcaactgc
aatctgcagcgactcgacggcccggtgcgcggcaacggcaagatcatccaggagctggag
tcgttcttccgcggtgccggctggaacgtcatcaaggtggtgtggggccgcgaatgggat
gccctgctgcacgccgaccgcgacggtgcgctggtgaatttaatgaatacaacacccgat
ggcgattaccagacctataaggccaacgacggcggctacgtgcgtgaccacttcttcggc
cgcgacccacgcaccaaggcgctggtggagaacatgagcgaccaggatatctggaacctc
aaacggggcggccacgattaccgcaaggtttacgccgcctaccgcgccgccgtcgaccac
aagggacagccgacggtgatcctggccaagaccatcaaaggctacgcgctgggcaagcat
ttcgaaggacgcaatgccacccaccagatgaaaaaactgaccctggaagaccttaaggag
tttcgtgacacgcagcggattccggtcagcgacgcccagcttgaagagaatccgtacctg
ccgccctactaccaccccggcctcaacgccccggagattcgttacatgctcgaccggcgc
cgggccctcgggggctttgttcccgagcgcaggaccaagtccaaagcgctgaccctgccg
ggtcgcgacatctacgcgccgctgaaaaagggctctgggcaccaggaggtggccaccacc
atggcgacggtgcgcacgttcaaagaagtgttgcgcgacaagcagatcgggccgcggata
gtcccgatcattcccgacgaggcccgcaccttcgggatggactcctggttcccgtcgcta
aagatctataaccgcaatggccagctgtataccgcggttgacgccgacctgatgctggcc
tacaaggagagcgaagtcgggcagatcctgcacgagggcatcaacgaagccgggtcggtg
ggctcgttcatcgcggccggcacctcgtatgcgacgcacaacgaaccgatgatccccatt
tacatcttctactcgatgttcggcttccagcgcaccggcgatagcttctgggccgcggcc
gaccagatggctcgagggttcgtgctcggggccaccgccgggcgcaccaccctgaccggt
gagggcctgcaacacgccgacggtcactcgttgctgctggccgccaccaacccggcggtg
gttgcctacgacccggccttcgcctacgaaatcgcctacatcgtggaaagcggactggcc
aggatgtgcggggagaacccggagaacatcttcttctacatcaccgtctacaacgagccg
tacgtgcagccgccggagccggagaacttcgatcccgagggcgtgctgcggggtatctac
cgctatcacgcggccaccgagcaacgcaccaacaaggcgcagatcctggcctccggggta
gcgatgcccgcggcgctgcgggcagcacagatgctggccgccgagtgggatgtcgccgcc
gacgtgtggtcggtgaccagttggggcgagctaaaccgcgacggggtggccatcgagacc
gagaagctccgccaccccgatcggccggcgggcgtgccctacgtgacgagagcgctggag
aatgctcggggcccggtgatcgcggtgtcggactggatgcgcgcggtccccgagcagatc
cgaccgtgggtgccgggcacatacctcacgttgggcaccgacgggttcggcttttccgac
actcggcccgccgctcgccgctacttcaacaccgacgccgaatcccaggtggtcgcggtt
ttggaggcgttggcgggcgacggcgagatcgacccatcggtgccggtcgcggccgcccgc
cagtaccggatcgacgacgtggcggctgcgcccgagcagaccacggatcccggtcccggg
gcctaa
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