Mycobacterium tuberculosis BT2: HKBT2_2366
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Entry
HKBT2_2366 CDS
T03153
Symbol
aceE
Name
(GenBank) pyruvate dehydrogenase subunit E1
KO
K00163
pyruvate dehydrogenase E1 component [EC:
1.2.4.1
]
Organism
mtuu
Mycobacterium tuberculosis BT2
Pathway
mtuu00010
Glycolysis / Gluconeogenesis
mtuu00020
Citrate cycle (TCA cycle)
mtuu00620
Pyruvate metabolism
mtuu00785
Lipoic acid metabolism
mtuu01100
Metabolic pathways
mtuu01110
Biosynthesis of secondary metabolites
mtuu01120
Microbial metabolism in diverse environments
mtuu01200
Carbon metabolism
mtuu01210
2-Oxocarboxylic acid metabolism
Module
mtuu_M00307
Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:
mtuu00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
HKBT2_2366 (aceE)
00020 Citrate cycle (TCA cycle)
HKBT2_2366 (aceE)
00620 Pyruvate metabolism
HKBT2_2366 (aceE)
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
HKBT2_2366 (aceE)
Enzymes [BR:
mtuu01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
HKBT2_2366 (aceE)
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Gene cluster
GFIT
Motif
Pfam:
PDH_E1_M
Transketolase_C_1
Transketolase_N
Transketolase_C
Motif
Other DBs
NCBI-ProteinID:
AHJ47163
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Position
2497525..2500317
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AA seq
930 aa
AA seq
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MTTDFARHDLAQNSNSASEPDRVRVIREGVASYLPDIDPEETSEWLESFDTLLQRCGPSR
ARYLMLRLLERAGEQRVAIPALTSTDYVNTIPTELEPWFPGDEDVERRYRAWIRWNAAIM
VHRAQRPGVGVGGHISTYASSAALYEVGFNHFFRGKSHPGGGDQVFIQGHASPGIYARAF
LEGRLTAEQLDGFRQEHSHVGGGLPSYPHPRLMPDFWEFPTVSMGLGPLNAIYQARFNHY
LHDRGIKDTSDQHVWCFLGDGEMDEPESRGLAHVGALEGLDNLTFVINCNLQRLDGPVRG
NGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDGALVNLMNTTPDGDYQTYKANDG
GYVRDHFFGRDPRTKALVENMSDQDIWNLKRGGHDYRKVYAAYRAAVDHKGQPTVILAKT
IKGYALGKHFEGRNATHQMKKLTLEDLKEFRDTQRIPVSDAQLEENPYLPPYYHPGLNAP
EIRYMLDRRRALGGFVPERRTKSKALTLPGRDIYAPLKKGSGHQEVATTMATVRTFKEVL
RDKQIGPRIVPIIPDEARTFGMDSWFPSLKIYNRNGQLYTAVDADLMLAYKESEVGQILH
EGINEAGSVGSFIAAGTSYATHNEPMIPIYIFYSMFGFQRTGDSFWAAADQMARGFVLGA
TAGRTTLTGEGLQHADGHSLLLAATNPAVVAYDPAFAYEIAYIVESGLARMCGENPENIF
FYITVYNEPYVQPPEPENFDPEGVLRGIYRYHAATEQRTNKAQILASGVAMPAALRAAQM
LAAEWDVAADVWSVTSWGELNRDGVAIETEKLRHPDRPAGVPYVTRALENARGPVIAVSD
WMRAVPEQIRPWVPGTYLTLGTDGFGFSDTRPAARRYFNTDAESQVVAVLEALAGDGEID
PSVPVAAARQYRIDDVAAAPEQTTDPGPGA
NT seq
2793 nt
NT seq
+upstream
nt +downstream
nt
ttgaccaccgatttcgcccgccacgatctggcccaaaactcaaacagcgcaagcgaaccc
gaccgagttcgggtgatccgcgagggtgtggcgtcgtatttgcccgacattgatcccgag
gagacctcggagtggctggagtcctttgacacgctgctgcaacgctgcggcccgtcgcgg
gcccgctacctgatgttgcggctgctagagcgggccggcgagcagcgggtggccatcccg
gcattgacgtctaccgactatgtcaacaccatcccgaccgagctggagccgtggttcccc
ggcgacgaagacgtcgaacgtcgttatcgagcgtggatcagatggaatgcggccatcatg
gtgcaccgtgcgcaacgaccgggtgtgggcgtgggtggccatatctcgacctacgcgtcg
tccgcggcgctctatgaggtcggtttcaaccacttcttccgcggcaagtcgcacccgggc
ggcggcgatcaggtgttcatccagggccacgcttccccgggaatctacgcgcgcgccttc
ctcgaagggcggttgaccgccgagcaactcgacggattccgccaggaacacagccatgtc
ggcggcgggttgccgtcctatccgcacccgcggctcatgcccgacttctgggaattcccc
accgtgtcgatgggtttgggcccgctcaacgccatctaccaggcacggttcaaccactat
ctgcatgaccgcggtatcaaagacacctccgatcaacacgtgtggtgttttttgggcgac
ggcgagatggacgaacccgagagccgtgggctggcccacgtcggcgcgctggaaggcttg
gacaacttgaccttcgtgatcaactgcaatctgcagcgactcgacggcccggtgcgcggc
aacggcaagatcatccaggagctggagtcgttcttccgcggtgccggctggaacgtcatc
aaggtggtgtggggccgcgaatgggatgccctgctgcacgccgaccgcgacggtgcgctg
gtgaatttaatgaatacaacacccgatggcgattaccagacctataaggccaacgacggc
ggctacgtgcgtgaccacttcttcggccgcgacccacgcaccaaggcgctggtggagaac
atgagcgaccaggatatctggaacctcaaacggggcggccacgattaccgcaaggtttac
gccgcctaccgcgccgccgtcgaccacaagggacagccgacggtgatcctggccaagacc
atcaaaggctacgcgctgggcaagcatttcgaaggacgcaatgccacccaccagatgaaa
aaactgaccctggaagaccttaaggagtttcgtgacacgcagcggattccggtcagcgac
gcccagcttgaagagaatccgtacctgccgccctactaccaccccggcctcaacgccccg
gagattcgttacatgctcgaccggcgccgggccctcgggggctttgttcccgagcgcagg
accaagtccaaagcgctgaccctgccgggtcgcgacatctacgcgccgctgaaaaagggc
tctgggcaccaggaggtggccaccaccatggcgacggtgcgcacgttcaaagaagtgttg
cgcgacaagcagatcgggccgcggatagtcccgatcattcccgacgaggcccgcaccttc
gggatggactcctggttcccgtcgctaaagatctataaccgcaatggccagctgtatacc
gcggttgacgccgacctgatgctggcctacaaggagagcgaagtcgggcagatcctgcac
gagggcatcaacgaagccgggtcggtgggctcgttcatcgcggccggcacctcgtatgcg
acgcacaacgaaccgatgatccccatttacatcttctactcgatgttcggcttccagcgc
accggcgatagcttctgggccgcggccgaccagatggctcgagggttcgtgctcggggcc
accgccgggcgcaccaccctgaccggtgagggcctgcaacacgccgacggtcactcgttg
ctgctggccgccaccaacccggcggtggttgcctacgacccggccttcgcctacgaaatc
gcctacatcgtggaaagcggactggccaggatgtgcggggagaacccggagaacatcttc
ttctacatcaccgtctacaacgagccgtacgtgcagccgccggagccggagaacttcgat
cccgagggcgtgctgcggggtatctaccgctatcacgcggccaccgagcaacgcaccaac
aaggcgcagatcctggcctccggggtagcgatgcccgcggcgctgcgggcagcacagatg
ctggccgccgagtgggatgtcgccgccgacgtgtggtcggtgaccagttggggcgagcta
aaccgcgacggggtggccatcgagaccgagaagctccgccaccccgatcggccggcgggc
gtgccctacgtgacgagagcgctggagaatgctcggggcccggtgatcgcggtgtcggac
tggatgcgcgcggtccccgagcagatccgaccgtgggtgccgggcacatacctcacgttg
ggcaccgacgggttcggcttttccgacactcggcccgccgctcgccgctacttcaacacc
gacgccgaatcccaggtggtcgcggttttggaggcgttggcgggcgacggcgagatcgac
ccatcggtgccggtcgcggccgcccgccagtaccggatcgacgacgtggcggctgcgccc
gagcagaccacggatcccggtcccggggcctaa
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