KEGG   Myotis brandtii (Brandt's bat): 102250563
Entry
102250563         CDS       T02920                                 
Symbol
BRCA1
Name
(RefSeq) BRCA1, DNA repair associated
  KO
K10605  breast cancer type 1 susceptibility protein [EC:2.3.2.27]
Organism
myb  Myotis brandtii (Brandt's bat)
Pathway
myb01524  Platinum drug resistance
myb03440  Homologous recombination
myb03460  Fanconi anemia pathway
myb04120  Ubiquitin mediated proteolysis
myb04151  PI3K-Akt signaling pathway
myb05206  MicroRNAs in cancer
myb05224  Breast cancer
Brite
KEGG Orthology (KO) [BR:myb00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    102250563 (BRCA1)
  09124 Replication and repair
   03440 Homologous recombination
    102250563 (BRCA1)
   03460 Fanconi anemia pathway
    102250563 (BRCA1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    102250563 (BRCA1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    102250563 (BRCA1)
  09162 Cancer: specific types
   05224 Breast cancer
    102250563 (BRCA1)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    102250563 (BRCA1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:myb01009]
    102250563 (BRCA1)
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:myb04121]
    102250563 (BRCA1)
   03036 Chromosome and associated proteins [BR:myb03036]
    102250563 (BRCA1)
   03400 DNA repair and recombination proteins [BR:myb03400]
    102250563 (BRCA1)
Enzymes [BR:myb01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     102250563 (BRCA1)
Protein phosphatases and associated proteins [BR:myb01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     102250563 (BRCA1)
Ubiquitin system [BR:myb04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    102250563 (BRCA1)
  Multi subunit type E3
   BRCC complex
    102250563 (BRCA1)
Chromosome and associated proteins [BR:myb03036]
 Eukaryotic type
  Centrosome formation proteins
   Centrosome duplication proteins
    Regulators of centriole replication
     102250563 (BRCA1)
DNA repair and recombination proteins [BR:myb03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    BRCA1-core complex
     102250563 (BRCA1)
    BRCA1-A complex
     102250563 (BRCA1)
    BRCA1-B complex
     102250563 (BRCA1)
    BRCA1-C complex
     102250563 (BRCA1)
    BRCA complex
     102250563 (BRCA1)
   FA (Fanconi anemia) pathway
    Downstream FA components
     102250563 (BRCA1)
SSDB
Motif
Pfam: BRCT_assoc BRCT RTT107_BRCT_5
Other DBs
NCBI-GeneID: 102250563
NCBI-ProteinID: XP_014402687
LinkDB
Position
Un
AA seq 1809 aa
MLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIIHAFELDTGLPFTNSYSF
SKKENNSPEHLNEEVSMIQSLGFRNRTLRFRQREPENPTLETSLSAQLSNLGIVRSRRTK
QQVQSQKKSVYIELGSDSSEDSANKGRYYSVRDHELLQITPQGARAEARLNPAKKAACEF
SGDITNIEHHQSSNKDLTTTEKHAAEKHTEKYQGISVSNLHVEPCGTDTHASSLQHENSS
LLLTKDRMNVEKAEFCNESKQPGLARSQQSRWAESKETCNDRQTPSTEKRVILDADPLNG
EKELPRSDHPRDSQDVPWITRSSSIQKVNEWFSRRDEILTSDGSHNGKSESNAEVAGAVE
VANEVDGYSGSPGKITLMAHDPHGVLTCESERVHSKPVESNIEDKIFGRTYRRKASLPNL
SHITENLIVGASAIEPQITQACPLTNKLKRKRRSTSGLHPEDFIKKVDLAVVQKTPEEII
KGTDRIEQNGHEMNITNNDHENETKGDCVQKEKNANLTESLGKESAFTSKAEPISSSISN
LELELNVHGSKAPKKNRLKRKSSTRPIHALELVVNRNPSPSNHTELQIDSCSSSEEVKEK
NSDQIPVRHSKKLQLMEGKEPATGAKKSNKSDEQINKKLAGDAFLERNLTNIPGVFTNGS
SSNKLQEFVDPNLQREETEENLGTVQMSNSTKDLEDLTLSGGRSVQIDRSKESTNIVLVP
ETDYGTQDSVSLLEPDTPGKAKTAPNQCGDLCAAVKSPKELIHGCSKDIRNDREGFKDLL
RCEVNHTQETSMEVEESELDTQDLQNTFKVSKRQSFALFSNPEKECATVYAHSQSLRKQS
PKVTLECGQKEENQGKKESKIKHVQAVHTAVGFPVVCEKDKKPGEYAKYSIKGTSRHCPS
SQFRGNETELTITDKYGISQNPYHIPSISPIRSFVKTVSKKNLSEEKFEEHLVSPERAMG
NENIQSTVSPISLSNIRESAFKESSSSSTNEGGSSINEVGSSGENIHAELDINKGSKLTA
MLRLGLMQPEVYKPSLPVSNCKHPEVKRQGDNEGVVQAVNADFPPCQISDNLEQPMGSSP
VSQVCSETPDDLLTDDEIKENSGFDESGIKERSAVFSKDVQKEEFRRSPSPLAHTHLTRS
RQRRARKLESSEEDMSSEDEELPCFQHLLFGKVIKIPSPSTSVATKSLSNKTEENLLLKS
SLNNCSNQVMLTKASQEHHLSEEARCSRSLFSSQCSASEDLTANTNTQGPVLIFEPPSQQ
MRYQPENQEFLRDKELISDDDDDERETGLEEENQEEQSADSDLDEAAFEYESETNLSEDY
SGLSSQSDILTTQQRDTMQDNLIKIKQEIDQVEAVLEQQGSQPSDRSPSCASEDLLNPRQ
NTPQNVLTSEKSDEYPVSQNPESLSADKFQESLDSSTRYKNKEPGMESSSTSQLLDDRWY
VHCHSQSLQNRNRPSQKEFIESVDVEEQQLTKSETQDLMEPSYLPRQDPEGSPCLQSGIS
LFSDDPESDPSEDRAPESAHVCSMPASTSALKLPQFQVESAKSPAATHTTNAAGYDVREE
SASREKPEVTSSAKTGNKRISMVASGLTPKELTRVHKFARKHHITLTDLITEETTHVIMK
TDAEFVCERTLKYFLGIAGGKWIVSYFWVTQSIKERKILDERDFEVRGDVINGRNHQGPK
RARESQDRKIFKGLEICCYGPFTNMPTGQLEWMVQLCGASVVKEPSLFTLGKGTHPVVVM
QPDAWTDDSGLRVIGQMCEVPMVTREWVLDSVALYQCQELDTYLIPQGPGAAADSCQPCG
EPVSTGPQE
NT seq 5430 nt   +upstreamnt  +downstreamnt
atgctgaaacttctcaaccagaagaaagggccgtcacagtgtcctttgtgtaagaatgat
ataaccaaaagaagcctacaagaaagtacaagatttagtcaacttgttgaagagctattg
aaaatcattcatgcttttgaacttgatacaggattgccatttacaaacagttatagcttt
tcaaaaaaggaaaataattctcctgagcatctaaatgaggaagtttctatgatccaaagt
ttgggcttccgaaaccgtaccctaagatttcgacagcgtgaacctgaaaatcctaccttg
gaaaccagccttagtgcccaactctctaaccttggaattgtgagatcacggaggacaaag
cagcaggtacaatctcagaaaaagtctgtctacattgaattgggatctgattcttctgaa
gattcggctaataaaggaagatattacagtgtgagagatcatgaactgttacaaatcact
cctcaaggagccagggctgaagccagattaaatcctgcaaaaaaggctgcttgtgagttt
tctggggacataacaaatattgaacatcatcaatccagtaataaagatttgaccaccact
gagaagcatgcagctgagaagcatacagaaaagtatcagggtatttctgtttcaaacttg
catgtggagccatgtggcacagatactcatgccagctcattacagcatgagaacagcagt
ttactactcaccaaagacagaatgaatgtagaaaaggctgaattctgtaatgaaagcaag
cagcctggcttagcaaggagccagcagagcagatgggctgaaagtaaagaaacatgtaat
gataggcagactcccagcacagagaaaagggtaattctggatgctgatcctctgaatggg
gaaaaagaacttccacgctctgaccatcctagagattcccaagatgtgccttggataaca
cggagcagtagcatacagaaagttaatgagtggttttccagacgtgatgaaatactaact
tctgatggctcacataatggcaagtctgagtcaaatgctgaagtagctggtgcagtggaa
gttgcaaatgaagtagatgggtattctggttctccagggaaaataaccttaatggcccat
gatcctcatggtgttttaacatgtgaaagtgaaagagttcactccaaaccagtagaaagt
aatattgaagataaaatatttgggagaacctatcggaggaaggcaagcctccctaacttg
agccacataactgaaaatctaattgtgggagcatctgctatagaacctcagataacacaa
gcgtgtcccctcacaaataaactaaagcgtaaaaggagaagtacatcgggccttcatcct
gaggattttattaagaaagtagatttggcagttgttcaaaagactcccgaagagataatt
aagggaactgaccgaatagaacagaatggtcatgagatgaatattactaataatgatcat
gagaatgaaacaaaaggtgattgtgttcagaaagagaaaaatgctaacctaacagaatca
ctgggaaaagaatctgcgttcacaagtaaagctgaacctataagcagcagcataagcaat
ttggaactagaattaaatgtccacggttcaaaagcacctaagaagaataggctgaagagg
aagtcctctaccaggcctattcatgcccttgaactagtagtcaatagaaatccaagccca
tctaaccacactgaactacaaattgatagttgttctagcagtgaagaggtgaaggaaaaa
aattctgaccaaataccagtcagacacagcaagaagcttcaactcatggaaggtaaagaa
cctgcaactggagccaaaaagagtaataagtcagatgaacaaataaataaaaaacttgca
ggtgatgcttttctagaacgaaacttaacaaacatacctggtgtttttactaatggttca
agttctaataaacttcaagagtttgtcgatcctaacctacaaagagaagaaacagaagag
aacctaggaacagttcaaatgtctaatagtaccaaagacctcgaagatctgacattaagt
ggaggaagaagtgtgcaaattgatagatctaaagagagtaccaatattgtattggtacct
gaaactgattatggcacacaggatagtgtctcattactggaacctgacaccccagggaag
gcaaaaacagctccaaatcaatgtggggatctgtgtgcagcagttaaaagtcctaaagaa
cttattcacggttgttctaaagatattagaaatgacagagagggctttaaggatctcttg
agatgtgaagttaaccacacacaggagacaagcatggaagtggaagagagtgaacttgat
acacaggatttacagaatacattcaaggtgtcaaagcgccagtcatttgctctgttttca
aatccagaaaaggaatgtgcaacagtctatgctcactcccagtctttaaggaaacaaagt
ccaaaagtcactcttgaatgtggacaaaaagaagaaaatcagggaaagaaagaatctaaa
atcaagcatgtacaggcagttcacacagctgtaggctttcctgtggtttgtgagaaagac
aaaaagccaggagagtatgccaaatacagcataaaaggaacctctaggcattgtccgtcc
tctcagttcagaggcaacgaaactgaactcactattaccgataaatatggaatttcacaa
aacccatatcatataccgtccatttctcccatcaggtcatttgttaaaactgtaagtaag
aaaaacctgtcagaggaaaagtttgaggaacatttagtgtcacctgaaagagcaatggga
aatgagaacattcaaagtacagtgagcccaattagcctaagtaacattagagaaagcgct
tttaaagaaagcagctcaagcagtactaatgaaggaggctctagtatcaatgaagtaggt
tccagtggtgaaaacattcatgcagaactagatataaacaaaggatcaaaattaactgct
atgctcagattaggtctcatgcaacccgaagtctataagccaagccttcctgtaagtaat
tgtaaacatcctgaagtaaaaaggcaaggagacaacgaaggagtagttcaggctgttaat
gcagacttccctccatgtcaaatttcagataacctagaacaacctatgggaagtagtcct
gtttctcaggtttgttctgagacaccagatgacttgttaactgatgatgaaataaaggag
aatagcggctttgatgaaagtggcattaaggaaagatctgctgtttttagcaaagatgtt
cagaaagaagaattcagaaggagccctagccccttagcccatacacatttgactcggagt
cgccaaagaagggccaggaaattagagtcctcagaagaggacatgtctagtgaggatgaa
gagcttccttgcttccaacatttattatttggtaaagtaatcaaaataccttctccatct
accagtgttgccacaaagagtctgtctaataaaacagaggagaacctgttattaaagagc
agcttaaataactgtagtaaccaggtaatgttgacaaaggcatcccaggaacatcacctt
agtgaggaagcaagatgttctagaagcttattttcctcacagtgcagtgcgtcagaggac
ttgaccgccaatacaaacacccagggtcctgtcttgatctttgagcctccttcccagcaa
atgaggtatcagcctgaaaaccaggaatttctgcgtgacaaggaattgatttcagacgat
gacgatgacgaaagggaaactggcctggaggaggaaaatcaagaagaacagagtgcggat
tcagacttagatgaagcagcatttgaatatgagagtgaaacaaacctctctgaagactat
tcggggctgtcctcccagagcgatattttaacaactcagcagagggatacgatgcaagat
aacctgatcaagatcaagcaggaaatagaccaagtggaagctgtgttagagcagcagggg
agccagccttctgacagatccccgtcttgtgcttctgaggacctactaaatccacgacaa
aacacaccacaaaacgtattaacttcagagaaaagtgatgaatatcctgtaagccagaat
ccagaaagcctttctgcagacaaatttcaagagtctctggatagttccaccagatataaa
aataaagaaccaggaatggaaagctcttctacatcccagttgttagatgacaggtggtat
gtgcactgccactcacagagtctccagaacagaaaccgcccatctcaaaaggagttcatt
gagagtgttgatgtagaggagcaacaactgaccaagtctgagacccaagatttaatggag
ccgtcttatttgccaagacaagatccagagggaagtccttgcctacaatctggcatcagc
ctcttctctgatgacccagagtctgatccctctgaagacagagccccggagtcagctcat
gtttgcagcatgccagcttcaacctctgcattgaaattaccccaatttcaagttgaatct
gctaagagtccagctgctactcatactactaatgctgctgggtatgatgtgagggaagaa
agtgccagcagggagaagccagaggtgacatcttcagcaaaaacaggcaacaaaagaata
tctatggtggcatcaggcttgaccccaaaagaacttacgcgtgtgcacaagtttgccaga
aaacaccacatcactttaactgatctaattactgaagagactactcatgtcattatgaaa
acagatgctgaatttgtatgtgaacggacactgaaatattttctgggaattgcaggagga
aaatggatagttagctatttctgggtgacccagtctattaaagaaagaaagattctagat
gagcgtgattttgaagtcagaggagatgttatcaatggaaggaaccaccaaggtccaaag
cgagcaagagagtcccaggacagaaagatcttcaagggcctagaaatctgttgctatggg
ccttttaccaacatgcccacaggtcaactagagtggatggtgcagctttgtggggcttct
gtggtgaaggagccttcattattcaccctcggcaagggcactcacccagttgtggtcatg
cagccggatgcctggacagacgacagtggcttgcgcgtgattgggcagatgtgtgaggta
cctatggtaacccgagagtgggtgttggacagtgtagccctctaccagtgccaggagctg
gacacctacctgataccccagggccccggagctgctgctgattcctgccaaccatgtgga
gagcctgtctccacaggaccccaagaataa

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