KEGG   PATHWAY: mye00633
Entry
mye00633                    Pathway                                
Name
Nitrotoluene degradation - Mycobacterium sp. EPa45
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
mye00633  Nitrotoluene degradation
mye00633

Other DBs
UMBBD: tnt tnt2 dnt
GO: 0046260
Organism
Mycobacterium sp. EPa45 [GN:mye]
Gene
AB431_24860  1,2-oxophytodienoate reductase [KO:K10680] [EC:1.-.-.-]
AB431_09790  hydrogenase [KO:K06281] [EC:1.12.99.6]
AB431_09795  hydrogenase expression protein HypE [KO:K06282] [EC:1.12.99.6]
Compound
C01468  4-Cresol
C06002  (S)-Methylmalonate semialdehyde
C11006  2,4-Dinitrotoluene
C14401  2,4-Diaminotoluene
C16391  Trinitrotoluene
C16392  4-Hydroxylamino-2,6-dinitrotoluene
C16393  2-Hydroxylamino-4,6-dinitrotoluene
C16394  4-Amino-2,6-dinitrotoluene
C16395  2-Amino-4,6-dinitrotoluene
C16396  2,4-Diamino-6-nitrotoluene
C16397  2,6-Diamino-4-nitrotoluene
C16398  2-Amino-4-nitrotoluene
C16399  2,4-Diamino-6-hydroxylaminotoluene
C16400  2,4,6-Triaminotoluene
C16401  2,4,6-Trihydroxytoluene
C16402  2,4-Dihydroxylamino-6-nitrotoluene
C16403  4-Amino-2-hydroxylamino-6-nitrotoluene
C16411  4,4',6,6'-Tetranitro-2,2'-azoxytoluene
C16412  2,4',6,6'-Tetranitro-2',4-azoxytoluene
C16413  2,2',6,6'-Tetranitro-4,4'-azoxytoluene
C16414  2-Amino-5-hydroxyl-4-hydroxylamino-6-nitrotoluene
C16420  4-Acetamido-2-amino-6-nitrotoluene
C18315  4-Methyl-5-nitrocatechol
C18316  2-Hydroxy-5-methylquinone
C18317  2,4,5-Trihydroxytoluene
C18318  cis,cis-2,4-Dihydroxy-5-methyl-6-oxo-2,4-hexadienoate
C18320  4-Amino-2-nitrotoluene
Reference
  Authors
Esteve-Nunez A, Ramos JL.
  Title
Metabolism of 2,4,6-trinitrotoluene by Pseudomonas sp. JLR11.
  Journal
Environ Sci Tech 32:3802-3808 (1998)
DOI:10.1021/es9803308
Reference
PMID:8534088
  Authors
Gilcrease PC, Murphy VG.
  Title
Bioconversion of 2,4-diamino-6-nitrotoluene to a novel metabolite under anoxic and aerobic conditions.
  Journal
Appl Environ Microbiol 61:4209-14 (1995)
DOI:10.1128/AEM.61.12.4209-4214.1995
Reference
  Authors
Esteve-Nunez A, Caballero A, Ramos JL.
  Title
Biological degradation of 2,4,6-trinitrotoluene.
  Journal
Microbiol Mol Biol Rev 65:335-52, table of contents (2001)
DOI:10.1128/MMBR.65.3.335-352.2001
Reference
  Authors
Fleischmann TJ, Walker KC, Spain JC, Hughes JB, Morrie Craig A.
  Title
Anaerobic transformation of 2,4,6-TNT by bovine ruminal microbes.
  Journal
Biochem Biophys Res Commun 314:957-63 (2004)
DOI:10.1016/j.bbrc.2003.12.193
Reference
  Authors
Borch T, Gerlach R.
  Title
Use of reversed-phase high-performance liquid chromatography-diode array detection for complete separation of 2,4,6-trinitrotoluene metabolites and EPA Method 8330 explosives: influence of temperature and an ion-pair reagent.
  Journal
J Chromatogr A 1022:83-94 (2004)
DOI:10.1016/j.chroma.2003.09.067
Reference
  Authors
Yin H, Wood TK, Smets BF.
  Title
Reductive transformation of TNT by Escherichia coli: pathway description.
  Journal
Appl Microbiol Biotechnol 67:397-404 (2005)
DOI:10.1007/s00253-004-1736-x
Reference
  Authors
Kutty R, Bennett GN.
  Title
Biochemical characterization of trinitrotoluene transforming oxygen-insensitive nitroreductases from Clostridium acetobutylicum ATCC 824.
  Journal
Arch Microbiol 184:158-67 (2005)
DOI:10.1007/s00203-005-0036-x
Reference
  Authors
Fiorella PD, Spain JC.
  Title
Transformation of 2,4,6-Trinitrotoluene by Pseudomonas pseudoalcaligenes JS52.
  Journal
Appl Environ Microbiol 63:2007-2015 (1997)
DOI:10.1128/AEM.63.5.2007-2015.1997
Reference
  Authors
Gonzalez-Perez MM, van Dillewijn P, Wittich RM, Ramos JL.
  Title
Escherichia coli has multiple enzymes that attack TNT and release nitrogen for growth.
  Journal
Environ Microbiol 9:1535-40 (2007)
DOI:10.1111/j.1462-2920.2007.01272.x
Reference
  Authors
Noguera DR, Freedman DL
  Title
Reduction and Acetylation of 2,4-Dinitrotoluene by a Pseudomonas aeruginosa Strain.
  Journal
Appl Environ Microbiol 62:2257-63 (1996)
DOI:10.1128/AEM.62.7.2257-2263.1996
Reference
PMID:9922262
  Authors
Haigler BE, Johnson GR, Suen WC, Spain JC
  Title
Biochemical and genetic evidence for meta-ring cleavage of 2,4, 5-trihydroxytoluene in Burkholderia sp. strain DNT.
  Journal
J Bacteriol 181:965-72 (1999)
DOI:10.1128/JB.181.3.965-972.1999
Reference
  Authors
Johnson GR, Jain RK, Spain JC
  Title
Origins of the 2,4-dinitrotoluene pathway.
  Journal
J Bacteriol 184:4219-32 (2002)
DOI:10.1128/JB.184.15.4219-4232.2002
Related
pathway
mye00280  Valine, leucine and isoleucine degradation
mye00623  Toluene degradation
KO pathway
ko00633   
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