Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise): 112413050
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Entry
112413050 CDS
T08872
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
KO
K00070
3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:
1.1.1.145
5.3.3.1
]
Organism
nasi
Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
Pathway
nasi00140
Steroid hormone biosynthesis
nasi01100
Metabolic pathways
nasi04913
Ovarian steroidogenesis
nasi04925
Aldosterone synthesis and secretion
nasi04927
Cortisol synthesis and secretion
nasi04934
Cushing syndrome
Module
nasi_M00107
Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
nasi_M00110
C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
nasi_M00976
C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
nasi_M00977
C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:
nasi00001
]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
112413050
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
112413050
04925 Aldosterone synthesis and secretion
112413050
04927 Cortisol synthesis and secretion
112413050
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
112413050
Enzymes [BR:
nasi01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.145 3beta-hydroxy-Delta5-steroid dehydrogenase
112413050
5. Isomerases
5.3 Intramolecular oxidoreductases
5.3.3 Transposing C=C bonds
5.3.3.1 steroid Delta-isomerase
112413050
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SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
3Beta_HSD
Epimerase
NAD_binding_4
GDP_Man_Dehyd
Polysacc_synt_2
NAD_binding_10
RmlD_sub_bind
KR
NmrA
Sacchrp_dh_NADP
Ldh_1_N
NAD_binding_7
Motif
Other DBs
NCBI-GeneID:
112413050
NCBI-ProteinID:
XP_024620663
UniProt:
A0A341D0X6
LinkDB
All DBs
Position
Unknown
AA seq
373 aa
AA seq
DB search
MAGWSCLVTGGGGFLGQRIVHLLAEEKELQEIRVLDKVFRPEVREEFSKLQSKIRLTLLE
GDILDEQCLKEACQGASVVIHTASVIDVMNAVQRETIMNVNVRGTQLLLETCVQASVPVF
IHTSTIEVAGPNSYREIIQDGHEEEHLETAWSSPYPYSKKLAEKAVLGANGWALKNGGTL
YTCALRPMYIYGEGSPLLFAHVDSALKNNGILSNHCKFSRVNPVYVGNVAWAHILALRAL
RDPQKAPTIQGQFYYISDGTPHQSYDDLNYTLGKEWGLCLDSGMSLPVSLKYWLAFLLEI
VSFLLSPIYKYRPPFNCHLVTLSNSVFTFSYKKAQRELGYEPLFTWEEAKQKTKEWVGSL
VKQHKETLKTKTH
NT seq
1122 nt
NT seq
+upstream
nt +downstream
nt
atggcagggtggagctgccttgtgacaggaggaggagggtttctgggtcagaggatcgtc
cacttgttggcagaggagaaggagctgcaggagatccgggtgctggacaaagtcttcaga
ccagaagttcgggaggaattttctaagctccagagcaagatcaggctgaccttgctggaa
ggagacatcctggatgagcagtgcctgaaggaagcctgccagggtgcctcggtggtcatc
cacaccgcctctgtcatcgatgttatgaacgccgttcagcgagagaccatcatgaatgtc
aatgtgagaggtacccagctcctgttggagacctgtgtccaggctagtgtgccagtcttc
atccataccagcaccatagaggtggctgggcccaactcctacagggagatcatccaggac
ggccacgaagaagagcatcttgaaacggcatggtcctctccgtacccatacagcaaaaag
cttgccgagaaggctgtgctgggagctaatgggtgggctcttaaaaatggcggcaccttg
tacacttgtgccttaaggcccatgtacatctatggggaggggagcccgttactttttgcc
cacgtggacagtgccctgaagaacaatggaatcctgtcaaatcactgcaagttctccaga
gtcaacccagtctatgttggcaacgtggcctgggcccacattctggccttgagggccctg
cgggacccccaaaaggccccaaccatccaaggacagttctactacatctcagacggcaca
cctcaccagagctatgatgacctcaattacactttgggcaaagaatggggcctctgcttg
gattccgggatgagcctccctgtttctctgaagtattggcttgccttcctgctggagata
gtgagcttcttgctcagtccaatttacaaatatcgaccccccttcaactgccacctggta
accctgtcaaatagtgtgttcaccttctcctataagaaagctcagcgagagctggggtat
gagcccctcttcacctgggaggaagccaagcagaaaaccaaggagtgggtcggctccctg
gtgaaacagcacaaggagaccctgaaaacaaagactcactga
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