KEGG   Sciurus carolinensis (gray squirrel): 124977089
Entry
124977089         CDS       T08117                                 
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
ncar  Sciurus carolinensis (gray squirrel)
Pathway
ncar00562  Inositol phosphate metabolism
ncar01100  Metabolic pathways
ncar01521  EGFR tyrosine kinase inhibitor resistance
ncar04012  ErbB signaling pathway
ncar04014  Ras signaling pathway
ncar04015  Rap1 signaling pathway
ncar04020  Calcium signaling pathway
ncar04062  Chemokine signaling pathway
ncar04064  NF-kappa B signaling pathway
ncar04066  HIF-1 signaling pathway
ncar04070  Phosphatidylinositol signaling system
ncar04072  Phospholipase D signaling pathway
ncar04360  Axon guidance
ncar04370  VEGF signaling pathway
ncar04613  Neutrophil extracellular trap formation
ncar04650  Natural killer cell mediated cytotoxicity
ncar04658  Th1 and Th2 cell differentiation
ncar04659  Th17 cell differentiation
ncar04660  T cell receptor signaling pathway
ncar04664  Fc epsilon RI signaling pathway
ncar04666  Fc gamma R-mediated phagocytosis
ncar04670  Leukocyte transendothelial migration
ncar04722  Neurotrophin signaling pathway
ncar04750  Inflammatory mediator regulation of TRP channels
ncar04919  Thyroid hormone signaling pathway
ncar04933  AGE-RAGE signaling pathway in diabetic complications
ncar04935  Growth hormone synthesis, secretion and action
ncar05012  Parkinson disease
ncar05022  Pathways of neurodegeneration - multiple diseases
ncar05135  Yersinia infection
ncar05167  Kaposi sarcoma-associated herpesvirus infection
ncar05170  Human immunodeficiency virus 1 infection
ncar05171  Coronavirus disease - COVID-19
ncar05200  Pathways in cancer
ncar05205  Proteoglycans in cancer
ncar05206  MicroRNAs in cancer
ncar05214  Glioma
ncar05223  Non-small cell lung cancer
ncar05225  Hepatocellular carcinoma
ncar05231  Choline metabolism in cancer
ncar05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ncar05417  Lipid and atherosclerosis
Module
ncar_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ncar00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    124977089
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    124977089
   04014 Ras signaling pathway
    124977089
   04015 Rap1 signaling pathway
    124977089
   04370 VEGF signaling pathway
    124977089
   04064 NF-kappa B signaling pathway
    124977089
   04066 HIF-1 signaling pathway
    124977089
   04020 Calcium signaling pathway
    124977089
   04070 Phosphatidylinositol signaling system
    124977089
   04072 Phospholipase D signaling pathway
    124977089
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    124977089
   04650 Natural killer cell mediated cytotoxicity
    124977089
   04660 T cell receptor signaling pathway
    124977089
   04658 Th1 and Th2 cell differentiation
    124977089
   04659 Th17 cell differentiation
    124977089
   04664 Fc epsilon RI signaling pathway
    124977089
   04666 Fc gamma R-mediated phagocytosis
    124977089
   04670 Leukocyte transendothelial migration
    124977089
   04062 Chemokine signaling pathway
    124977089
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    124977089
   04919 Thyroid hormone signaling pathway
    124977089
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    124977089
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    124977089
  09158 Development and regeneration
   04360 Axon guidance
    124977089
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    124977089
   05206 MicroRNAs in cancer
    124977089
   05205 Proteoglycans in cancer
    124977089
   05231 Choline metabolism in cancer
    124977089
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    124977089
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    124977089
   05214 Glioma
    124977089
   05223 Non-small cell lung cancer
    124977089
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    124977089
   05171 Coronavirus disease - COVID-19
    124977089
   05167 Kaposi sarcoma-associated herpesvirus infection
    124977089
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    124977089
  09164 Neurodegenerative disease
   05012 Parkinson disease
    124977089
   05022 Pathways of neurodegeneration - multiple diseases
    124977089
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    124977089
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    124977089
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    124977089
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ncar04131]
    124977089
Enzymes [BR:ncar01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     124977089
Membrane trafficking [BR:ncar04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    124977089
 Endocytosis
  Macropinocytosis
   Phospholipase C
    124977089
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH C2 SH3_1 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 EF-hand_7
Other DBs
NCBI-GeneID: 124977089
NCBI-ProteinID: XP_047396301
LinkDB
Position
2:complement(17569462..17602639)
AA seq 1290 aa
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYNAQKTMDLPFLEASTLRT
GERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCPDAMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKDHAFVASEYPVILSIEDHCSIA
QQRNMAQHFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRSEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLW
FPSNYVEEMVNPAALEPEREHLDENSPLGDLLRGVLDVPTCQIAIRPEGKNNRLFVFSIS
LTSVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPCAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDGAKQKTEFVVDNGLNPVW
PAKPFQFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKIGYRAVPLKNNYSEDL
ELASLLIKIDIFPAKENGDLSPFGGTSLRERSSDASSQLFHGRTREGSFEARYQQPFEDF
RISQEHLTDHFDSRERRAPRRTRVNGDNRL
NT seq 3873 nt   +upstreamnt  +downstreamnt
atggctggtgccgcgtccccatgcgccaatggctgcgggcccggcgcgccctcggacgcc
gaggtgctgcacctctgccgcagccttgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggcccgagcggaagaccttccaggtcaagctggagacgcgccagatc
acgtggagccgcggcgccgacaagatcgagggggccattgatattcgtgaaatcaaggag
attcgcccagggaagacctcacgggactttgatcgctatcaagaggaccctgctttccgc
ccagaccagtcacattgctttgttatcctctatggaatggaattccgcctaaaaaccctg
agcctgcaagccacatccgaggatgaggtgaacatgtggatcaagggcttaacttggctg
atggaggacacattacaggcagccacacccctgcagatcgagaggtggctccgaaagcag
ttctactcagtggatcggaatcgcgaggatcgtatatcagccaaggacctgaagaacatg
ctgtctcaggtcaattaccgggtccccaacatgcgcttcctccgagagcggctgacggac
ctggagcagcgcagcggggacatcacctatggacagtttgctcagctgtaccgcagcctc
atgtacaacgcccagaagacgatggacctccccttcttggaagccagcaccttgaggact
ggggagcgaccggagctctgccgagtgtctcttcctgaattccagcagttcctccttgag
taccagggggagctctgggctgtggaccggctccaggtgcaggagttcatgctcagcttt
ctccgagaccccttgcgagagattgaggagccatacttcttcctggatgagtttgtcacc
ttcctgttctccaaagaaaacagcgtgtggaactcccagctggacgccgtgtgcccagac
gccatgaacaacccgctctcccactactggatctcctcctcgcacaacacgtacctgact
ggggaccagttctccagcgagtcctccctggaagcctatgctcgctgcttgcggatgggc
tgtcgctgcatcgagttggactgctgggacggccccgacgggatgccagtcatttaccac
ggacacaccctaaccaccaagatcaagttctccgatgtcctgcacaccatcaaggatcat
gccttcgtggcctcagagtaccctgtcattctgtccattgaggaccactgcagcattgcc
cagcagaggaacatggctcagcacttcaagaaggtgcttggggacacactcctcaccaag
cctgtggacattgctgctgatgggctcccgtcacccaaccagctcaagaggaagatcctt
atcaagcacaagaagctggctgagggcagtgcctatgaggaggtgcccacctcggtgatg
tactccgagaacgacatcagcaactccatcaagaatggcatcctctacctggaggatccc
gtaaaccatgagtggtatccccactacttcgttctgaccagcagcaagatctactactct
gaggagaccagcagtgaccaaggcaacgaggatgaggaggagcccaaggaggccagtgga
agcacagagctgcactccaatgagaagtggttccacgggaagctcggcgcggggcgggat
gggcggcacattgcagagcgcctgctcactgagtactgcatcgagactggggctcccgat
ggctccttcttagtgcgcgagagtgagaccttcgtgggtgactacacgctgtctttctgg
cggaacgggaaagtccagcactgccgaatccactcccggcaggatgctggaacccccaag
ttcttcttgacggacaacctcgtctttgactctctctacgacctcatcacacactatcag
caggtgcccctgcgctgcaatgagtttgagatgcgcctttcagagcctgtcccacagacc
aatgcccacgagagcaaagagtggtaccacgcaagcctgaccagagcacaggccgagcac
atgctgatgcgtgtgccccgggacggggccttcctggtgcggaaacggagcgagcccaac
tcatatgccatctccttccgggccgaaggcaagatcaagcactgccgtgtccaacaggag
ggccagactgtgatgctgggaaactcagagttcgacagcctcgtcgatctcatcagctac
tatgagaagcacccgctgtaccgcaagatgaagctgcgctaccccatcaatgaggaggcg
ctggagaagataggcacagccgagcctgactatggggccctgtacgaaggccgcaaccct
ggcttctatgtggaggcaaaccctatgccgactttcaagtgtgcggtcaaagccctcttt
gactacaaggcccagagagaggacgagctgaccttcaccaagagtgccatcatccagaat
gtagagaaacaagatggaggctggtggcgaggggactatggtgggaagaagcagctgtgg
ttcccatcaaactatgtggaagaaatggtcaacccagcagccctggagcctgagagggag
cacttggacgagaacagccctttgggggacttgctgcggggggtcttggatgtgcctacc
tgtcagattgccatccgccctgagggcaagaacaaccggctcttcgtcttctccatcagc
ctgacgtcagtggcccactggtccctggatgttgcagctgactcccaggaggaactgcag
gactgggtgaagaagatccgagaagtggcccagaccgcagatgccaggctcactgagggg
aagatgatggaacggaggaagaagatcgccctcgagctctctgagcttgtcgtctactgc
cggcctgttcccttcgatgaagagaagattggcacagaacgtgcctgctaccgggacatg
tcgtctttcccggaaaccaaggctgagaaatatgtgaacaaggccaaaggcaagaagttt
ctccagtataatcggctgcagctctcccgcatctaccccaagggccagcggctggactct
tccaattatgatcctttgcccatgtggatctgtggcagtcaacttgtggccctcaacttc
caaaccccagacaagcccatgcagatgaaccaggccctcttcatggctggtggacactgt
ggttacgtgctacagccaagcaccatgcgagacgaggcctttgacccctttgacaagagt
agcctccgtggacttgagccctgtgccatctgcatcgaggtgctgggggcccggcacttg
ccaaagaatggccgaggcatcgtgtgtccttttgtggagattgaggtggctggagcagag
tatgacggcgccaaacagaagacagagtttgtggtggataatggactcaaccctgtgtgg
ccggccaagcccttccagttccagatcagtaatcctgaatttgccttccttcgctttgtg
gtgtatgaggaagacatgtttagtgaccagaacttcttggctcaggctactttcccggtg
aaaggcctgaagataggatacagagcggtgcctttgaagaacaactacagcgaagacctg
gagttggcctccctgctcattaagatcgacattttccctgccaaggagaatggtgacctc
agtcccttcggtggtacatccctgcgagagcggagctcagatgcctccagccagctgttt
catggccggacccgggaaggctcctttgaggcacgctaccagcagccatttgaggacttc
cgcatctcccaggagcatctcacagaccacttcgacagtcgggagcgaagggccccaagg
aggactcgggtcaatggagacaaccgcctctag

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