KEGG   Sciurus carolinensis (gray squirrel): 124986648
Entry
124986648         CDS       T08117                                 
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
ncar  Sciurus carolinensis (gray squirrel)
Pathway
ncar01521  EGFR tyrosine kinase inhibitor resistance
ncar01522  Endocrine resistance
ncar01524  Platinum drug resistance
ncar04012  ErbB signaling pathway
ncar04014  Ras signaling pathway
ncar04015  Rap1 signaling pathway
ncar04024  cAMP signaling pathway
ncar04062  Chemokine signaling pathway
ncar04066  HIF-1 signaling pathway
ncar04068  FoxO signaling pathway
ncar04070  Phosphatidylinositol signaling system
ncar04071  Sphingolipid signaling pathway
ncar04072  Phospholipase D signaling pathway
ncar04081  Hormone signaling
ncar04140  Autophagy - animal
ncar04150  mTOR signaling pathway
ncar04151  PI3K-Akt signaling pathway
ncar04152  AMPK signaling pathway
ncar04210  Apoptosis
ncar04211  Longevity regulating pathway
ncar04213  Longevity regulating pathway - multiple species
ncar04218  Cellular senescence
ncar04360  Axon guidance
ncar04370  VEGF signaling pathway
ncar04380  Osteoclast differentiation
ncar04510  Focal adhesion
ncar04550  Signaling pathways regulating pluripotency of stem cells
ncar04611  Platelet activation
ncar04613  Neutrophil extracellular trap formation
ncar04620  Toll-like receptor signaling pathway
ncar04625  C-type lectin receptor signaling pathway
ncar04630  JAK-STAT signaling pathway
ncar04650  Natural killer cell mediated cytotoxicity
ncar04660  T cell receptor signaling pathway
ncar04662  B cell receptor signaling pathway
ncar04664  Fc epsilon RI signaling pathway
ncar04666  Fc gamma R-mediated phagocytosis
ncar04668  TNF signaling pathway
ncar04670  Leukocyte transendothelial migration
ncar04722  Neurotrophin signaling pathway
ncar04725  Cholinergic synapse
ncar04750  Inflammatory mediator regulation of TRP channels
ncar04810  Regulation of actin cytoskeleton
ncar04910  Insulin signaling pathway
ncar04914  Progesterone-mediated oocyte maturation
ncar04915  Estrogen signaling pathway
ncar04917  Prolactin signaling pathway
ncar04919  Thyroid hormone signaling pathway
ncar04923  Regulation of lipolysis in adipocytes
ncar04926  Relaxin signaling pathway
ncar04929  GnRH secretion
ncar04930  Type II diabetes mellitus
ncar04931  Insulin resistance
ncar04932  Non-alcoholic fatty liver disease
ncar04933  AGE-RAGE signaling pathway in diabetic complications
ncar04935  Growth hormone synthesis, secretion and action
ncar04960  Aldosterone-regulated sodium reabsorption
ncar04973  Carbohydrate digestion and absorption
ncar05010  Alzheimer disease
ncar05017  Spinocerebellar ataxia
ncar05020  Prion disease
ncar05100  Bacterial invasion of epithelial cells
ncar05135  Yersinia infection
ncar05142  Chagas disease
ncar05146  Amoebiasis
ncar05160  Hepatitis C
ncar05161  Hepatitis B
ncar05162  Measles
ncar05163  Human cytomegalovirus infection
ncar05164  Influenza A
ncar05165  Human papillomavirus infection
ncar05166  Human T-cell leukemia virus 1 infection
ncar05167  Kaposi sarcoma-associated herpesvirus infection
ncar05168  Herpes simplex virus 1 infection
ncar05169  Epstein-Barr virus infection
ncar05170  Human immunodeficiency virus 1 infection
ncar05171  Coronavirus disease - COVID-19
ncar05200  Pathways in cancer
ncar05203  Viral carcinogenesis
ncar05205  Proteoglycans in cancer
ncar05206  MicroRNAs in cancer
ncar05207  Chemical carcinogenesis - receptor activation
ncar05208  Chemical carcinogenesis - reactive oxygen species
ncar05210  Colorectal cancer
ncar05211  Renal cell carcinoma
ncar05212  Pancreatic cancer
ncar05213  Endometrial cancer
ncar05214  Glioma
ncar05215  Prostate cancer
ncar05218  Melanoma
ncar05220  Chronic myeloid leukemia
ncar05221  Acute myeloid leukemia
ncar05222  Small cell lung cancer
ncar05223  Non-small cell lung cancer
ncar05224  Breast cancer
ncar05225  Hepatocellular carcinoma
ncar05226  Gastric cancer
ncar05230  Central carbon metabolism in cancer
ncar05231  Choline metabolism in cancer
ncar05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ncar05415  Diabetic cardiomyopathy
ncar05417  Lipid and atherosclerosis
ncar05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ncar00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    124986648
   04014 Ras signaling pathway
    124986648
   04015 Rap1 signaling pathway
    124986648
   04370 VEGF signaling pathway
    124986648
   04630 JAK-STAT signaling pathway
    124986648
   04668 TNF signaling pathway
    124986648
   04066 HIF-1 signaling pathway
    124986648
   04068 FoxO signaling pathway
    124986648
   04070 Phosphatidylinositol signaling system
    124986648
   04072 Phospholipase D signaling pathway
    124986648
   04071 Sphingolipid signaling pathway
    124986648
   04024 cAMP signaling pathway
    124986648
   04151 PI3K-Akt signaling pathway
    124986648
   04152 AMPK signaling pathway
    124986648
   04150 mTOR signaling pathway
    124986648
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    124986648
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    124986648
  09143 Cell growth and death
   04210 Apoptosis
    124986648
   04218 Cellular senescence
    124986648
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    124986648
   04550 Signaling pathways regulating pluripotency of stem cells
    124986648
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    124986648
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    124986648
   04613 Neutrophil extracellular trap formation
    124986648
   04620 Toll-like receptor signaling pathway
    124986648
   04625 C-type lectin receptor signaling pathway
    124986648
   04650 Natural killer cell mediated cytotoxicity
    124986648
   04660 T cell receptor signaling pathway
    124986648
   04662 B cell receptor signaling pathway
    124986648
   04664 Fc epsilon RI signaling pathway
    124986648
   04666 Fc gamma R-mediated phagocytosis
    124986648
   04670 Leukocyte transendothelial migration
    124986648
   04062 Chemokine signaling pathway
    124986648
  09152 Endocrine system
   04910 Insulin signaling pathway
    124986648
   04923 Regulation of lipolysis in adipocytes
    124986648
   04929 GnRH secretion
    124986648
   04915 Estrogen signaling pathway
    124986648
   04914 Progesterone-mediated oocyte maturation
    124986648
   04917 Prolactin signaling pathway
    124986648
   04926 Relaxin signaling pathway
    124986648
   04935 Growth hormone synthesis, secretion and action
    124986648
   04919 Thyroid hormone signaling pathway
    124986648
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    124986648
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    124986648
  09156 Nervous system
   04725 Cholinergic synapse
    124986648
   04722 Neurotrophin signaling pathway
    124986648
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    124986648
  09158 Development and regeneration
   04360 Axon guidance
    124986648
   04380 Osteoclast differentiation
    124986648
  09149 Aging
   04211 Longevity regulating pathway
    124986648
   04213 Longevity regulating pathway - multiple species
    124986648
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    124986648
   05206 MicroRNAs in cancer
    124986648
   05205 Proteoglycans in cancer
    124986648
   05207 Chemical carcinogenesis - receptor activation
    124986648
   05208 Chemical carcinogenesis - reactive oxygen species
    124986648
   05203 Viral carcinogenesis
    124986648
   05230 Central carbon metabolism in cancer
    124986648
   05231 Choline metabolism in cancer
    124986648
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    124986648
  09162 Cancer: specific types
   05210 Colorectal cancer
    124986648
   05212 Pancreatic cancer
    124986648
   05225 Hepatocellular carcinoma
    124986648
   05226 Gastric cancer
    124986648
   05214 Glioma
    124986648
   05221 Acute myeloid leukemia
    124986648
   05220 Chronic myeloid leukemia
    124986648
   05218 Melanoma
    124986648
   05211 Renal cell carcinoma
    124986648
   05215 Prostate cancer
    124986648
   05213 Endometrial cancer
    124986648
   05224 Breast cancer
    124986648
   05222 Small cell lung cancer
    124986648
   05223 Non-small cell lung cancer
    124986648
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    124986648
   05170 Human immunodeficiency virus 1 infection
    124986648
   05161 Hepatitis B
    124986648
   05160 Hepatitis C
    124986648
   05171 Coronavirus disease - COVID-19
    124986648
   05164 Influenza A
    124986648
   05162 Measles
    124986648
   05168 Herpes simplex virus 1 infection
    124986648
   05163 Human cytomegalovirus infection
    124986648
   05167 Kaposi sarcoma-associated herpesvirus infection
    124986648
   05169 Epstein-Barr virus infection
    124986648
   05165 Human papillomavirus infection
    124986648
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    124986648
   05100 Bacterial invasion of epithelial cells
    124986648
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    124986648
   05142 Chagas disease
    124986648
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    124986648
   05017 Spinocerebellar ataxia
    124986648
   05020 Prion disease
    124986648
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    124986648
   05418 Fluid shear stress and atherosclerosis
    124986648
   05415 Diabetic cardiomyopathy
    124986648
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    124986648
   04932 Non-alcoholic fatty liver disease
    124986648
   04931 Insulin resistance
    124986648
   04933 AGE-RAGE signaling pathway in diabetic complications
    124986648
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    124986648
   01524 Platinum drug resistance
    124986648
   01522 Endocrine resistance
    124986648
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ncar04131]
    124986648
Membrane trafficking [BR:ncar04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    124986648
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 SH2_1 Laminin_I PI_PP_I Bap31_Bap29_C Exonuc_VII_L Transcrip_act
Other DBs
NCBI-GeneID: 124986648
NCBI-ProteinID: XP_047411118
LinkDB
Position
6:56247753..56328890
AA seq 454 aa
MYNTVWNMEDLDLEYAKTDINCGTDLMFYIEMDPPALPPKPPKPTTAANNGMNNNISLQD
AEWYWGEISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKY
GFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLH
EYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIE
KFKREGNEKEIQRIMHNYDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDL
IQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSN
RNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYGS
LKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR
NT seq 1365 nt   +upstreamnt  +downstreamnt
atgtacaacactgtttggaacatggaagacctggatttagaatatgccaagacagatata
aactgtggcacagacttgatgttttatatagaaatggatccaccagcactgcctcctaaa
ccgcccaaacccaccactgcagccaacaacggtatgaacaacaatatttccttacaggat
gctgaatggtactggggagagatctcgagggaagaagtgaatgaaaaacttcgagataca
gcagatggaacctttctggtacgagatgcctctactaaaatgcacggtgattatactctt
acactaaggaaaggaggaaataataaattaatcaaaatatttcaccgagatggaaaatat
ggcttctctgacccattaaccttcaattctgtggttgaattaataaaccactaccggaat
gaatctctagctcagtacaatcccaaactggatgtgaaattactttatccagtgtccaaa
taccaacaggatcaagttgtcaaagaagataatattgaagctgtagggaaaaaattacat
gaatataacactcaatttcaagaaaaaagtcgggaatatgatagattatatgaagaatat
actcgtacttcccaggaaatccaaatgaaaagaacagctattgaagcatttaatgaaacc
ataaaaatatttgaagaacagtgccaaacccaggagcggtacagcaaagaatacatagaa
aagtttaaacgtgaaggcaatgaaaaagaaatacagaggatcatgcataattatgataag
ctaaagtctcgaatcagtgaaattattgacagtagaaggaggttggaggaagacttgaag
aagcaggcagctgagtatcgtgagattgacaagcgtatgaacagcatcaaaccagacctc
attcaactgagaaagaccagggatcagtacttgatgtggttgactcaaaaaggtgtccgg
caaaagaagctgaacgagtggctgggcaacgagaacaccgaagaccaatattctctggtg
gaagacgatgaggatttgccccaccatgatgagaagacatggaatgtcggaagcagcaac
cgaaacaaagccgaaaacttattgcgagggaagagagatggtacttttcttgtccgggag
agcagtaagcagggctgctacgcctgctctgtagtagtggatggtgaagtcaagcattgt
gtcatcaacaagacggcgactggctacggctttgcggagccctataacctgtacggctcc
ctgaaggagctggtgctacattaccaacacacctccctggtgcagcacaatgactccctc
aacgtcacgctagcgtacccggtgtatgcacagcagaggcgatga

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