KEGG   Nannospalax galili (Upper Galilee mountains blind mole rat): 103726892
Entry
103726892         CDS       T03372                                 
Symbol
Jak3
Name
(RefSeq) Janus kinase 3
  KO
K11218  Janus kinase 3 [EC:2.7.10.2]
Organism
ngi  Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi04062  Chemokine signaling pathway
ngi04151  PI3K-Akt signaling pathway
ngi04217  Necroptosis
ngi04550  Signaling pathways regulating pluripotency of stem cells
ngi04630  JAK-STAT signaling pathway
ngi04658  Th1 and Th2 cell differentiation
ngi04659  Th17 cell differentiation
ngi05161  Hepatitis B
ngi05162  Measles
ngi05166  Human T-cell leukemia virus 1 infection
ngi05169  Epstein-Barr virus infection
ngi05200  Pathways in cancer
ngi05203  Viral carcinogenesis
ngi05223  Non-small cell lung cancer
ngi05340  Primary immunodeficiency
Brite
KEGG Orthology (KO) [BR:ngi00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    103726892 (Jak3)
   04151 PI3K-Akt signaling pathway
    103726892 (Jak3)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    103726892 (Jak3)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    103726892 (Jak3)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    103726892 (Jak3)
   04659 Th17 cell differentiation
    103726892 (Jak3)
   04062 Chemokine signaling pathway
    103726892 (Jak3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103726892 (Jak3)
   05203 Viral carcinogenesis
    103726892 (Jak3)
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    103726892 (Jak3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    103726892 (Jak3)
   05161 Hepatitis B
    103726892 (Jak3)
   05162 Measles
    103726892 (Jak3)
   05169 Epstein-Barr virus infection
    103726892 (Jak3)
  09163 Immune disease
   05340 Primary immunodeficiency
    103726892 (Jak3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ngi01001]
    103726892 (Jak3)
Enzymes [BR:ngi01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     103726892 (Jak3)
Protein kinases [BR:ngi01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   103726892 (Jak3)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 SH2_1 FERM_F1 Jak1_Phl SH2 pKID ABC1 Haspin_kinase
Other DBs
NCBI-GeneID: 103726892
NCBI-ProteinID: XP_008822806
UniProt: A0A8C6RK14
LinkDB
Position
Un
AA seq 1104 aa
MVPPSEETPLIPQRSCSLSSSEAGALHVLLPPRGPEPPQRLFFSFGDHLAEDLCVQAAKA
CGILPVYHSLFALATEDLSCWFPPSHIFSVEDSDTQVLVYRLRFYFPDWFGLETCHRFAL
RKDLAGAILDLHALEHLFAQHRSDLVSGRLPMGLSLNEQGECLSLAVLDLARMACEQAQR
PRELLRTVSYKFCLPPSLRDLIQGLSFVTRRRIRRTVSRALRRVAACQADRHSLMAKYII
DLERLYPAAAAETFHVGLPGAVGGQDSPGLLRVAGGSGISWSPGDPELFQPFCDFPEIVD
VSITQAPRVGPVAELRLVTVTRTDGHILEAEFPGLPHALSFVALVDGYFRLTCDPSHFFH
REVAPPRLLEEVAELCHGPITLDFAVHKLKAAGSVPGSYVLRRSPQDYDSFLLTVCVQTP
LGPDYKGCLIRRDPTGTFSLVGLSQPHSSLRELLAACWHAGLHIDGIALNLTSCCPPRPR
EKSNLVVIRRGCSPTPTSPGRAPVHCKLTQLTFHKIPLDTLEWQENLGHGSFTKIYRGRR
HEAVDGEAHDSEVLLKVMDARHRNYMESFLEAASLMSQVSYPHLVLLHGVCMAGDSTMVQ
EFVHLGAIDTYLRKRGHQVSASWKLQVTKQLAYALNYLEDKGFPHGNVSARKLLLAREGS
DGSPPFIKLSDPGVSPTVLSLEMLTDRIPWVAPECLQEPQTLGLEADKWGFGATVWEVFS
GIPMPLAALEPAKKLKFYEDHQQLPAPKWSELALLIQQCMAYDPGRRPSFRAILRDLNSL
ITSDYELLSDLTPGTLAPRDGLWSGTQLYACQDPTIFEERHLKYISQLGKGNFGSVELCR
YDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHNDFIVKYRGVSYGPGRQSLRL
VMEYLPSGCLRDFLQRHRARLHAGRLLLFAWQICKGMEYLGACRCVHRDLAARNILVESE
AHVKIADFGLAKLLPLGKDYYVVREPGQSPIFWYAPESLADNVFSRQSDVWSFGVLLYEL
FTYSDKNCSPSVEFLRMMGPEREGAALCRLLELLAEGRRLPAPPACPAEVHELMKLCWAP
SPEDRPAFSALGPQLDTLWRGSRG
NT seq 3315 nt   +upstreamnt  +downstreamnt
atggtacctccaagtgaagagacacccctgatccctcaacgctcctgcagcctgtcatcc
tcagaggcaggagccctgcatgtacttctccctcctcggggccctgagcctccccaacga
ctgttcttttcctttggggaccacttggccgaggatctgtgtgtgcaggctgccaaggcc
tgtggcatcctgcccgtgtatcactcactgtttgctctggccactgaagacttgtcctgc
tggttccccccgagccacatcttctccgtggaggactcagacacccaagtcttggtctac
aggctgcgcttttacttccctgactggtttggcctggagacctgtcaccgctttgctctg
cgaaaagatttggcaggcgccatccttgacctgcatgctttagaacacctcttcgctcag
caccgcagtgacctggtgagtggccgccttcctatgggcctcagcctcaacgagcaaggg
gagtgcctgagcctggccgtgctggacctggcccggatggcttgtgagcaggcccagcgg
cccagggagctgctgaggactgtcagctacaagttctgcctgccgcccagcctgagggac
ctcatccagggcttgagcttcgtgacgcggaggcgcatccgcaggaccgtgagtcgcgcg
ttgcgccgcgtggccgcctgccaggcggaccggcactcgctcatggccaagtacatcata
gacctggagcggttatacccagcggccgccgccgagaccttccacgtggggctcccgggg
gcggtgggcggccaggattcacctgggctgctgcgcgtagcgggaggcagcggcatctcc
tggagtcccggagacccagagctttttcagcccttctgtgactttcccgaaatcgtggac
gtcagcatcacgcaagccccgagggtgggtccggtggcggagctccgactggtcacggtc
accaggacagacggccacatcctggaagccgagtttccggggctaccacacgcgctgtcc
ttcgtggctcttgtggatggctacttccgcctgacctgtgaccccagccacttcttccat
cgggaggtggctccaccccggctgctggaggaggtggcagaactgtgccatggccccatc
acgctggactttgctgtccacaagctcaaggcggcaggctccgtgccaggctcttacgtt
cttcgccgcagcccacaggactacgatagctttctcctcacagtctgtgtccagactccc
cttggcccagattacaagggctgcctcatccgacgggaccccacagggaccttctccctg
gttggcctcagccagccccacagcagtcttcgagaactcctggcagcctgctggcatgct
gggctacacatagatggcattgccttgaatctcacatcctgctgcccccccagacccaga
gaaaagtccaatttggttgtgatccggaggggctgcagcccaactcccacgtcccctggc
cgggccccagttcactgcaaactgacacagctgaccttccacaagatccccctggacacc
ctggagtggcaagagaacttgggccatgggtccttcaccaagatctaccgtggccggcgg
catgaggcagtggacggcgaggcccacgactcagaagtcctcctgaaagtgatggacgcc
aggcaccgaaactatatggagtcctttctggaagctgcaagtttgatgagtcaagtgtcc
taccctcacctcgtgttgctgcatggtgtctgcatggctggagacagcaccatggtgcag
gaatttgtgcacctgggagcgattgacacatacctacgtaagcgaggccaccaggtttcg
gccagttggaagcttcaggtgaccaagcagctggcctatgccctcaactacttggaggac
aaaggcttcccacatggcaacgtctcagcccggaagttgctcctggcacgagagggatct
gatgggagtccacccttcatcaagctgagtgaccctggtgtcagtcccactgtgctgagc
ctggaaatgctcacagacaggatcccctgggtggcccctgagtgtcttcaggagcctcag
acacttggcttggaggctgacaagtgggggtttggtgctacggtgtgggaggtgttcagt
ggcatacccatgcctcttgctgccctggagcctgccaagaaactcaagttttatgaggac
caccagcagctgccagcccccaagtggtctgagctggcactgctcatccagcagtgcatg
gcatatgaccctggccgacggccctccttccgtgccatcctgagagatctcaacagcctt
attacctcagattatgagcttctctcagacctgacccctggcaccctggcaccccgagac
gggctgtggagtggcacccagctctatgcctgccaggaccccaccatcttcgaagaaaga
caccttaagtacatctcgcagctgggcaagggcaactttggcagcgtggagctgtgtcgc
tacgaccctcttggggacaacacaggtgccctggtggccgtgaaacagttgcagcacagc
gggccagaccagcagagggacttccagcgggagatccagattctcaaggcgctgcacaac
gacttcatcgtcaagtaccgaggcgtcagctacgggccgggtcggcagagcctgcggctg
gtgatggagtacctgccgagcggctgtctgcgggacttcctgcagcgccatcgtgcgcgc
ctgcacgccggccgcctgctgttgttcgcctggcagatctgcaagggcatggagtacctt
ggcgcctgccgctgcgtacaccgcgacctggccgctcgcaacatcctggtggagagcgag
gcgcacgtcaagatcgccgactttggactcgccaagctgctgccgctagggaaggactac
tacgtggtccgcgagccgggacagagccccatcttctggtacgcccctgagtccctggcc
gacaacgtcttctcccgccagtcagacgtgtggagcttcggcgtactgctatatgaactc
ttcacctacagtgacaagaactgcagcccctcagttgagttcctgcgcatgatgggacca
gagcgggaaggggctgctctgtgtcgcctcctagagctgctggccgagggccgccgcttg
ccggcacctcccgcctgccccgccgaggttcacgagctcatgaagctgtgctgggcaccc
agccccgaggacaggccggccttcagtgcgctgggcccacagctggacactctgtggcgt
gggagccgcgggtag

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