Nannospalax galili (Upper Galilee mountains blind mole rat): 103727788
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Entry
103727788 CDS
T03372
Symbol
Irs1
Name
(RefSeq) insulin receptor substrate 1
KO
K16172
insulin receptor substrate 1
Organism
ngi
Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi04022
cGMP-PKG signaling pathway
ngi04068
FoxO signaling pathway
ngi04081
Hormone signaling
ngi04140
Autophagy - animal
ngi04150
mTOR signaling pathway
ngi04151
PI3K-Akt signaling pathway
ngi04152
AMPK signaling pathway
ngi04211
Longevity regulating pathway
ngi04213
Longevity regulating pathway - multiple species
ngi04722
Neurotrophin signaling pathway
ngi04910
Insulin signaling pathway
ngi04920
Adipocytokine signaling pathway
ngi04923
Regulation of lipolysis in adipocytes
ngi04930
Type II diabetes mellitus
ngi04931
Insulin resistance
ngi04932
Non-alcoholic fatty liver disease
ngi04935
Growth hormone synthesis, secretion and action
ngi04960
Aldosterone-regulated sodium reabsorption
ngi05010
Alzheimer disease
ngi05206
MicroRNAs in cancer
ngi05415
Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:
ngi00001
]
09130 Environmental Information Processing
09132 Signal transduction
04068 FoxO signaling pathway
103727788 (Irs1)
04022 cGMP-PKG signaling pathway
103727788 (Irs1)
04151 PI3K-Akt signaling pathway
103727788 (Irs1)
04152 AMPK signaling pathway
103727788 (Irs1)
04150 mTOR signaling pathway
103727788 (Irs1)
09133 Signaling molecules and interaction
04081 Hormone signaling
103727788 (Irs1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
103727788 (Irs1)
09150 Organismal Systems
09152 Endocrine system
04910 Insulin signaling pathway
103727788 (Irs1)
04923 Regulation of lipolysis in adipocytes
103727788 (Irs1)
04920 Adipocytokine signaling pathway
103727788 (Irs1)
04935 Growth hormone synthesis, secretion and action
103727788 (Irs1)
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
103727788 (Irs1)
09156 Nervous system
04722 Neurotrophin signaling pathway
103727788 (Irs1)
09149 Aging
04211 Longevity regulating pathway
103727788 (Irs1)
04213 Longevity regulating pathway - multiple species
103727788 (Irs1)
09160 Human Diseases
09161 Cancer: overview
05206 MicroRNAs in cancer
103727788 (Irs1)
09164 Neurodegenerative disease
05010 Alzheimer disease
103727788 (Irs1)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
103727788 (Irs1)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
103727788 (Irs1)
04932 Non-alcoholic fatty liver disease
103727788 (Irs1)
04931 Insulin resistance
103727788 (Irs1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
IRS
PH
PH_11
Motif
Other DBs
NCBI-GeneID:
103727788
NCBI-ProteinID:
XP_008824062
UniProt:
A0A8C6QZA5
LinkDB
All DBs
Position
Un
AA seq
1225 aa
AA seq
DB search
MASPPDTDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKAH
HDAAPGGGGGSCSGSSGLGEAGEDLSYGDTGPGPAFKEVWQVILKPKGLGQTKNLIGIYR
LCLTSKTISFVKLNTDAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQVDDSV
VAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLTRRSR
TESITATSPASMAGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHRGSSR
LHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSPSDGG
FISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGTSTLAAPNGHYI
LSRGGNGHRYIPGANLGTSPALTGEEAANAADLDNRFRKRTHSAGTSPTISHQKTPSQSS
VASIEEYTEMMPTYPPGGGSGGRLPSYRHSAFVPTHSYPEEGLEMPALERRGGHHRPDST
LHTDDGYMPMSPGVAPVPSNRKGNGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMMM
SPSGSCSPDIGGRSSNNSSAAPSGSSYGKLWTNGVAGHHSHALTHAKPVESSGGKLLPCT
GDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPRESEEGARHQHL
RLSSSSGRLLYTATAEDSSSSTSSDSVGGSYCGARPHHHVLQPHLPRKVDTAAQTNGRLP
RPTKLSLGDLKASTLPRAREQQQQPQQTPLHPPEPKSPGEYVNIEFGSDQPGYLAGPMTS
RSSPSVRCPPQLQPAPREEETGTEEYMNMDLGPGRRAAWQESGGEMGRVGPAPPGAATAS
RPTRLVPSSRGDYMTMQMGHPRQSYVDTSPVAPVSYADMRTGIATEEVSLPRATAAAPSS
SSTASASPAAPQGAAEVAARSSLLGGPQGPGGISAFTRVNLSPNRNQSAKVIRADPQGCR
RRHSSETFSSTPTATRAGNTVPFGAGAAVGGGGGGSSSEDVKRHSSASFENVWLKPGEPG
GAPKEPTQVCGAAAGVENGLNYIDLDLVKDFKQRPQERPPQQQPPSSPAPHQPPGCSEAS
PTSRSSEELSAYASISFQKQPEDRQ
NT seq
3678 nt
NT seq
+upstream
nt +downstream
nt
atggcgagccctccggatactgatggcttctcggacgtgcgcaaggtgggctacctgcgc
aaacccaagagtatgcacaagcgctttttcgtgctgcgggctgccagcgaggccgggggc
ccggcgcgactggagtactatgagaacgagaagaagtggcgccacaagtcgagcgccccc
aaacgctcgatccccctcgagagctgtttcaacattaacaagcgagctgactccaagaac
aagcacctggtggctctctacacccgggacgagcactttgccattgccgcggatagcgag
gccgagcaggacagctggtaccaggctctcctgcagctgcacaaccgagcaaaggcccac
catgacgcagcccccggaggaggcggcggtagctgcagcggcagctccggcctcggggag
gcaggggaggacttgagctatggagacacgggcccaggacctgcgttcaaggaggtctgg
caggtgatcctcaaacccaaaggcctgggtcagacaaagaacttgattggcatctaccgc
ctctgcctgaccagcaagaccatcagcttcgtgaagctgaacaccgacgcagccgctgtg
gtgctgcagctgatgaacatcagacgctgcggccactccgagaacttcttcttcatcgag
gtgggccgttcagcagtgacagggcctggcgagttctggatgcaggtagatgactccgtg
gtggcccagaacatgcacgagaccatcctagaggcgatgcgggccatgagtgatgagttt
cgccctcgaagcaagagtcagtcttcgtccaattgctccaaccccatcagcgtccccctc
cgcagacaccatctcaacaatcctccacccagccaggtggggctgacccgccgatcgcgc
accgagagcatcactgccacctctcctgccagcatggcgggagggaagccaggctccttc
cgcgtgcgcgcctccagcgatggcgaaggcaccatgtcccgcccggcctcggtggacggc
agccccgtgagtcctagcaccaacaggacccacgcccatcggcatcgtggtagctccagg
ctgcaccccccactcaaccacagccgttccatcccgatgccttcttctcgctgctcacct
tcagccaccagcccagttagtctgtcgtccagtagcaccagtggccacggctccacctca
gactgtctctttccccggcggtccagtgcctctgtgtccggctctcccagcgatggcggt
ttcatttcttctgatgaatatggctctagtccctgtgatttccgaagttccttccgtagt
gtcactccagattccctgggccacaccccaccggcacggggcgaggaggagctgagcaac
tatatctgcatgggtggcaaggggacctccactttggctgcccccaatggtcactacatt
ttgtctcggggtggcaatggtcaccgttacatcccaggagctaacttggggacaagccca
gccttgactggggaggaagccgccaacgctgcagatctggataaccgctttcggaagaga
acccactcagcagggacatcgccaaccatttctcaccagaagaccccctcacagtcctct
gtggcttctattgaggaatatacagagatgatgccaacctacccaccaggagggggcagt
ggaggccgactgcccagttaccggcattctgcctttgtgcccacccactcctatcccgag
gaggggctagagatgcccgccttagagcgtcgtggtggccaccatcgtccagactccacc
ctccacactgatgatggctacatgcccatgtccccaggggtggctccagtacccagcaac
cgaaaaggaaatggagactatatgcccatgagccccaagagtgtatctgccccacagcag
atcatcaaccccatcagacgccaccctcagagagttgaccccaatggctacatgatgatg
tcccccagtggcagctgctctcctgacattggaggccggtccagcaacaacagcagtgca
gccccttctgggagcagctatgggaagctatggacaaatggcgtagcaggccatcattct
catgccctgactcatgccaaacctgtagagagcagcggtggcaaactcttgccttgcaca
ggtgactacatgaacatgtccccagtgggggactccaacactagcagcccctcagactgc
tactacggcccagaggacccccagcacaagcctgtactctcttactactccttaccaagg
tcctttaagcacacccagcgccccagggagtcagaggagggtgctcggcaccagcatctt
cgcctctcctccagctccggtcgccttctctacactgcaactgcggaagactcttcctct
tctaccagcagtgacagtgttggtgggagttactgtggggctaggccccaccaccatgtc
ctgcagccccatcttcctcgaaaggtggacacagctgctcagaccaacggccgcctgcct
cggcccacaaagctatccctgggggatctcaaggccagcaccttacctcgggctcgagag
caacagcaacagccacaacaaactccgctgcaccctcctgagcccaagagtccaggggaa
tatgtgaatattgaatttgggagtgaccagcctggctatttagctggccccatgacttcc
cgtagctccccttctgttcggtgtccaccccagctccagccagctcccagagaggaagag
actggcactgaggagtacatgaacatggacttggggccaggccggagggcagcctggcag
gagagtggtggggagatgggcagagtgggcccggcacctccaggggctgccactgctagc
aggcctacccggttggtgcccagtagccggggtgactacatgaccatgcagatgggtcat
cctcgtcagagctacgtggatacctctccagtggcccctgtcagctatgctgacatgcgg
acaggcattgctacagaggaggtgagcctgcctagagccacagcagctgctccctcgtcg
tcttccacagcctctgcttctcccgctgcgcctcaaggagcagctgaggtagctgctcgc
tcttccctgctggggggtcctcagggacctgggggcataagcgccttcaccagggtgaac
ctcagtcctaaccgcaaccagagtgccaaagtgatccgagcagacccacaagggtgccgg
aggaggcatagctccgagacattctcctcaacccctactgccacccgggctggcaacact
gtgccctttggagcaggggctgcagtagggggcggtggcgggggcagcagcagtgaggat
gtaaaacgccacagctctgcatcatttgaaaacgtgtggctgaaacctggggagccaggg
ggagctcccaaggagccgactcaagtgtgtggggctgctgcaggggtggagaatggactt
aactacatagacctggatttggtcaaggacttcaaacagcgccctcaggagcgcccccct
caacagcagcccccatcttccccagcccctcaccagcccccgggctgcagtgaggcgagc
cccaccagccgctccagcgaggaattaagcgcctatgccagcatcagctttcagaagcag
ccagaggaccgtcagtag
DBGET
integrated database retrieval system
