KEGG   Nannospalax galili (Upper Galilee mountains blind mole rat): 103728305
Entry
103728305         CDS       T03372                                 
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 4-like
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
ngi  Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi00140  Steroid hormone biosynthesis
ngi01100  Metabolic pathways
ngi04913  Ovarian steroidogenesis
ngi04925  Aldosterone synthesis and secretion
ngi04927  Cortisol synthesis and secretion
ngi04934  Cushing syndrome
Module
ngi_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
ngi_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
ngi_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
ngi_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:ngi00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    103728305
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    103728305
   04925 Aldosterone synthesis and secretion
    103728305
   04927 Cortisol synthesis and secretion
    103728305
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    103728305
Enzymes [BR:ngi01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     103728305
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     103728305
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4
Other DBs
NCBI-GeneID: 103728305
NCBI-ProteinID: XP_008824594
LinkDB
Position
Un
AA seq 265 aa
TQNLLEACVQASVPIFIYTSSIDVAGPNSYKEIVQNGHEGEHHESTWSDPYPYSKKLAEK
AVLAANGDILNNGGTLHTCALRPMYIYGERNPFMSDVVIRALKNKDILPVTGKFSVVNPV
YVGNVAWAHILASRGLRDPQKAPSIQGKFYYISDVTPHQSYDELNYTMGREWGLCLDSRL
SLPLPLLYWLAFLLETVSFLLRPVYNYKPPFNRHSITLANSVFTFSYKKAQQDLGYEPRF
SWEEAKRETARWIGSLVKQHKGKLN
NT seq 797 nt   +upstreamnt  +downstreamnt
gtacccagaacttgttggaggcctgtgtccaagctagcgtcccaatcttcatctatacca
gctcaattgatgttgcagggcccaactcatacaaggagatcgttcaaaatggccatgaag
gagagcatcatgaaagcacatggtctgatccatacccatacagcaaaaagctggctgaga
aggcggtgctggcagccaatggggacatccttaataatggtggcactttgcatacatgtg
ccttaagacccatgtacatctatggggagagaaacccattcatgtctgatgtggtgatta
gagcccttaagaataaggatatcctgcctgttactggtaaattctctgtagtcaacccag
tgtatgtgggcaatgtggcctgggcacacattctggcctccaggggccttcgggaccccc
aaaaggcaccaagcatccaaggaaagttctactacatctcagatgtcacacctcaccaaa
gctatgatgaattaaattacaccatgggcagggaatggggcctctgccttgattccaggc
tgagccttcctctgcccctactgtactggctggccttcctgctggaaacagtgagtttct
tgcttcgtccagtttacaactataagcctccctttaaccgccattcaatcacactggcaa
atagcgtgttcactttctcctacaagaaagctcagcaagatctgggctatgagccccgct
tcagctgggaggaagccaagcgggagactgcaaggtggatcgggtcactagtgaaacagc
acaaggggaagctcaac

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