Nannospalax galili (Upper Galilee mountains blind mole rat): 103747244
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Entry
103747244 CDS
T03372
Symbol
Plcg1
Name
(RefSeq) phospholipase C gamma 1
KO
K01116
phosphatidylinositol phospholipase C, gamma-1 [EC:
3.1.4.11
]
Organism
ngi
Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi00562
Inositol phosphate metabolism
ngi01100
Metabolic pathways
ngi01521
EGFR tyrosine kinase inhibitor resistance
ngi04012
ErbB signaling pathway
ngi04014
Ras signaling pathway
ngi04015
Rap1 signaling pathway
ngi04020
Calcium signaling pathway
ngi04062
Chemokine signaling pathway
ngi04064
NF-kappa B signaling pathway
ngi04066
HIF-1 signaling pathway
ngi04070
Phosphatidylinositol signaling system
ngi04072
Phospholipase D signaling pathway
ngi04360
Axon guidance
ngi04370
VEGF signaling pathway
ngi04613
Neutrophil extracellular trap formation
ngi04650
Natural killer cell mediated cytotoxicity
ngi04658
Th1 and Th2 cell differentiation
ngi04659
Th17 cell differentiation
ngi04660
T cell receptor signaling pathway
ngi04664
Fc epsilon RI signaling pathway
ngi04666
Fc gamma R-mediated phagocytosis
ngi04670
Leukocyte transendothelial migration
ngi04722
Neurotrophin signaling pathway
ngi04750
Inflammatory mediator regulation of TRP channels
ngi04919
Thyroid hormone signaling pathway
ngi04933
AGE-RAGE signaling pathway in diabetic complications
ngi04935
Growth hormone synthesis, secretion and action
ngi05012
Parkinson disease
ngi05022
Pathways of neurodegeneration - multiple diseases
ngi05135
Yersinia infection
ngi05167
Kaposi sarcoma-associated herpesvirus infection
ngi05170
Human immunodeficiency virus 1 infection
ngi05171
Coronavirus disease - COVID-19
ngi05200
Pathways in cancer
ngi05205
Proteoglycans in cancer
ngi05206
MicroRNAs in cancer
ngi05214
Glioma
ngi05223
Non-small cell lung cancer
ngi05225
Hepatocellular carcinoma
ngi05231
Choline metabolism in cancer
ngi05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
ngi05417
Lipid and atherosclerosis
Module
ngi_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
ngi00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
103747244 (Plcg1)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
103747244 (Plcg1)
04014 Ras signaling pathway
103747244 (Plcg1)
04015 Rap1 signaling pathway
103747244 (Plcg1)
04370 VEGF signaling pathway
103747244 (Plcg1)
04064 NF-kappa B signaling pathway
103747244 (Plcg1)
04066 HIF-1 signaling pathway
103747244 (Plcg1)
04020 Calcium signaling pathway
103747244 (Plcg1)
04070 Phosphatidylinositol signaling system
103747244 (Plcg1)
04072 Phospholipase D signaling pathway
103747244 (Plcg1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
103747244 (Plcg1)
04650 Natural killer cell mediated cytotoxicity
103747244 (Plcg1)
04660 T cell receptor signaling pathway
103747244 (Plcg1)
04658 Th1 and Th2 cell differentiation
103747244 (Plcg1)
04659 Th17 cell differentiation
103747244 (Plcg1)
04664 Fc epsilon RI signaling pathway
103747244 (Plcg1)
04666 Fc gamma R-mediated phagocytosis
103747244 (Plcg1)
04670 Leukocyte transendothelial migration
103747244 (Plcg1)
04062 Chemokine signaling pathway
103747244 (Plcg1)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
103747244 (Plcg1)
04919 Thyroid hormone signaling pathway
103747244 (Plcg1)
09156 Nervous system
04722 Neurotrophin signaling pathway
103747244 (Plcg1)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
103747244 (Plcg1)
09158 Development and regeneration
04360 Axon guidance
103747244 (Plcg1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
103747244 (Plcg1)
05206 MicroRNAs in cancer
103747244 (Plcg1)
05205 Proteoglycans in cancer
103747244 (Plcg1)
05231 Choline metabolism in cancer
103747244 (Plcg1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
103747244 (Plcg1)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
103747244 (Plcg1)
05214 Glioma
103747244 (Plcg1)
05223 Non-small cell lung cancer
103747244 (Plcg1)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
103747244 (Plcg1)
05171 Coronavirus disease - COVID-19
103747244 (Plcg1)
05167 Kaposi sarcoma-associated herpesvirus infection
103747244 (Plcg1)
09171 Infectious disease: bacterial
05135 Yersinia infection
103747244 (Plcg1)
09164 Neurodegenerative disease
05012 Parkinson disease
103747244 (Plcg1)
05022 Pathways of neurodegeneration - multiple diseases
103747244 (Plcg1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
103747244 (Plcg1)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
103747244 (Plcg1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
103747244 (Plcg1)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
ngi04131
]
103747244 (Plcg1)
Enzymes [BR:
ngi01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
103747244 (Plcg1)
Membrane trafficking [BR:
ngi04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
103747244 (Plcg1)
Endocytosis
Macropinocytosis
Phospholipase C
103747244 (Plcg1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PI-PLC-X
SH2
PI-PLC-Y
EF-hand_PLCG2
PH
C2
SH3_1
EF-hand_PLCG1
SH3_2
SH3_9
PH_12
GDPD
EF-hand_6
PH_9
EF-hand_7
DUF7145
Motif
Other DBs
NCBI-GeneID:
103747244
NCBI-ProteinID:
XP_008847808
LinkDB
All DBs
Position
Un
AA seq
1291 aa
AA seq
DB search
MAGATTPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRT
GERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLNTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLSRAQAEHMLMRVPRDGAFLVRKRNEANSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLW
FPSNYVEEMISPAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKS
SLRGLEPCVICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW
PAKPFHFHINNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLIKIDVFPAKQENGDLSPFGGTSLRERVSDASSQLFHGRAREGSFEARYQQPFED
FRISQEHLADHFDSRERRAPRRTRVNGDNRL
NT seq
3876 nt
NT seq
+upstream
nt +downstream
nt
atggcgggcgccacgaccccctgcgccaatggctgcgggcccggcgcgccctccgatgcc
gaggtgttgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcggccggaacggaagaccttccaggtcaaactggagacgcgccagatc
acgtggagccgcggcgccgacaagatcgagggggccattgatattcgtgaaatcaaagag
atccgcccagggaagacttctcgagactttgaccgctaccaagaagaccctgctttccgg
ccagaccagtcacactgctttgtcatcctctatggaatggaattccgcctgaagacccta
agcctgcaagccacatctgaggatgaagtgaacatgtggatcaagggcttaacttggctg
atggaggacacattgcaggcagccacacccctgcagattgagaggtggctccggaaacag
ttctactcagtggaccggaaccgtgaggatcgtatatcagccaaggacctgaagaacatg
ttgtcacaagtcaattatcgggtccccaacatgcgcttcctccgagaacggctgacggac
ctggaacagcgcagcggggacatcacctatggacagtttgctcagctgtaccgcagcctc
atgtacagcgcacagaagacgatggacctccccttcttggaagccagcactttgagaact
ggggagcggccagagctctgtcgggtatctcttcccgagttccagcagtttctccttgag
taccagggggaactatgggcagttgaccgccttcaggtgcaggaattcatgctcagtttc
ctcagagaccccttgcgagagattgaggaaccatacttctttttggatgagtttgttacc
tttctgttctccaaagagaacagtgtgtggaactcccagctggatgccgtgtgcccagac
accatgaacaaccctctctcccactactggatctcgtcctcgcataacacgtacctgact
ggggaccagttctccagcgaatcctcactggaagcttatgctcgctgcctgaggatgggc
tgtcgctgcattgagttggattgctgggacggcccagatgggatgccagtcatttaccac
gggcatacccttaccaccaagatcaagttctcagatgtcctgaacacaatcaaggagcat
gctttcgtggcctcagagtacccagtcatcctgtccattgaggaccactgcagcattgcc
cagcagaggaacatggcccagtacttcaagaaggtgcttggggacacactcctcaccaag
cctgtggacattgccgctgatgggctcccctcacccaaccagctcaaaaggaagattctt
attaagcacaagaagctggccgagggcagtgcctatgaggaagtgcctacttctgtgatg
tactctgagaatgacatcagcaactccatcaagaatggcatcctctacctggaagaccct
gtgaaccatgaatggtatccccactacttcgttctgaccagcagcaagatctactactct
gaggagacaagcagtgaccagggcaatgaggatgaagaggagccaaaggaggccagtggg
agcacagaactgcactccaatgagaagtggttccatgggaagctcggggctggacgagat
gggcggcacattgctgagcgcctcctcaccgagtactgcattgagaccggggctcctgat
ggctccttcctagtgcgagaaagcgagacctttgtgggcgactacacactgtctttctgg
cggaatgggaaagtccagcactgccgtatccactctcgacaggatgccggtacccccaag
ttcttcttgacagataaccttgtctttgactccctctatgacctcatcacacactatcag
caggtgccacttcgctgcaatgagtttgagatgcgcctttcagagcctgttccacagaca
aatgcccacgagagcaaagagtggtaccatgcaagcctgtcgagagctcaggctgaacac
atgctgatgcgtgtaccacgtgatggggctttcctggtgcggaaacggaatgaggccaac
tcatacgctatctccttccgggctgagggaaagataaagcactgccgagtccagcaggag
ggccaaactgtgatgctggggaactccgagttcgacagccttgtcgacctcatcagctac
tacgagaagcaccccctgtaccgcaaaatgaagttgcgctaccccatcaacgaggaggca
ctggagaagattggcacagcagagcctgattacggggcactgtatgaaggccgcaaccct
ggcttctatgtggaggcaaaccccatgccaactttcaagtgtgcagtcaaagccctcttt
gactacaaggcccagagagaggatgagctgaccttcaccaagagtgccatcatccagaat
gtagagaagcaagatggtggctggtggcgaggggactatggtgggaagaagcagctgtgg
ttcccttcaaactacgtggaagagatgatcagcccagcagccctggagccagagagggag
cacctggacgagaacagccccctgggggacttgctgcggggggtcttggatgtgccagcc
tgtcagattgccattcgtcctgagggcaagaacaaccggctgttcgtgttctccatcagc
atggcatcagtggctcactggtccctagatgttgcagctgactcgcaggaggagttgcag
gactgggtgaaaaagatccgggaagtggcccagactgcagatgccaggcttactgagggg
aagatgatggaacggaggaagaagatcgccttggagctttctgagctcgtggtctactgc
cggcctgttccgtttgatgaagagaagattggcacagaacgagcctgttaccgggacatg
tcatcctttccggaaaccaaagctgagaagtacgtgaacaaggccaaaggcaagaagttc
ctccagtacaatcgcctgcagctctcccgcatctaccccaagggccagcgactggactcc
tccaattacgatcctctgcccatgtggatctgtggcagtcagcttgtggctctcaatttc
cagaccccagacaagcctatgcagatgaaccaggccctcttcatggccggtggacactgt
ggctacgtgctgcagccaagcaccatgagagatgaagcctttgacccctttgacaagagc
agcctccgaggactggagccctgtgtcatctgcattgaggtgctgggggcccggcatctg
ccaaagaatggccgaggcattgtgtgtccttttgtggagattgaggtggctggagcagag
tatgacagcaccaagcaaaaaacagagtttgtagtggacaatgggctgaaccctgtgtgg
ccagccaagcccttccacttccatatcaataaccctgaatttgccttcctgcgctttgtg
gtgtatgaagaagacatgtttagtgaccagaacttcttagctcaggctactttcccagtg
aaaggcctgaagacaggctatagagcagtgcctctgaaaaacaactacagtgaagacctg
gagttggcctccctgctcatcaagattgacgttttccctgccaagcaggagaacggtgac
ctcagtccctttggtggtacatccctgcgggaacgggtctctgatgcctcaagccagctg
tttcatgggcgggctcgggaaggctcctttgaagcccgctatcaacagccatttgaagac
ttccgcatctcccaggagcatctcgcagatcattttgacagtcgagaacgaagggcccca
agaaggactcgggtcaacggagacaaccgcctctag
DBGET
integrated database retrieval system
