KEGG   Nannospalax galili (Upper Galilee mountains blind mole rat): 103751690
Entry
103751690         CDS       T03372                                 
Symbol
Irs2
Name
(RefSeq) insulin receptor substrate 2
  KO
K07187  insulin receptor substrate 2
Organism
ngi  Nannospalax galili (Upper Galilee mountains blind mole rat)
Pathway
ngi04022  cGMP-PKG signaling pathway
ngi04068  FoxO signaling pathway
ngi04081  Hormone signaling
ngi04140  Autophagy - animal
ngi04152  AMPK signaling pathway
ngi04211  Longevity regulating pathway
ngi04213  Longevity regulating pathway - multiple species
ngi04910  Insulin signaling pathway
ngi04920  Adipocytokine signaling pathway
ngi04923  Regulation of lipolysis in adipocytes
ngi04930  Type II diabetes mellitus
ngi04931  Insulin resistance
ngi04932  Non-alcoholic fatty liver disease
ngi04935  Growth hormone synthesis, secretion and action
ngi05010  Alzheimer disease
ngi05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:ngi00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    103751690 (Irs2)
   04022 cGMP-PKG signaling pathway
    103751690 (Irs2)
   04152 AMPK signaling pathway
    103751690 (Irs2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    103751690 (Irs2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    103751690 (Irs2)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    103751690 (Irs2)
   04923 Regulation of lipolysis in adipocytes
    103751690 (Irs2)
   04920 Adipocytokine signaling pathway
    103751690 (Irs2)
   04935 Growth hormone synthesis, secretion and action
    103751690 (Irs2)
  09149 Aging
   04211 Longevity regulating pathway
    103751690 (Irs2)
   04213 Longevity regulating pathway - multiple species
    103751690 (Irs2)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    103751690 (Irs2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103751690 (Irs2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    103751690 (Irs2)
   04932 Non-alcoholic fatty liver disease
    103751690 (Irs2)
   04931 Insulin resistance
    103751690 (Irs2)
SSDB
Motif
Pfam: IRS PH PH_11 MEKK4_N
Other DBs
NCBI-GeneID: 103751690
NCBI-ProteinID: XP_008853420
LinkDB
Position
Un
AA seq 1313 aa
NNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEATAGAGGGSAPQPPRLEYYESEKKWRS
KAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDEYFAVAAENEQEQEGWYRALTDLVS
EGRAASDTASGATGGSCSASLPGALGGSAGAAGSDDSYGLVAPATAAYREVWQVNLKPKG
LGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLMNIRRCGHSDSFFFIEVGRSAVTG
PGELWMQADDSVVAQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRHH
HLVNLPPSQTGLVRRSRTDSLAATPPAAKCNSCRVRTASEGDGGTAAGTGTAAGRPVSVA
GSPLSPGPVRAPLSRSHTLSGGCGGRQSKVALAPAGGALQHSRSMSMPVAHSPPAATSPG
SLSSSSGHGSGSYPLPPGPHPHLPHPLHHPPGQRPSSGSASASGSPSDPGFMSLDEYGSS
PGDLRAFCSHRSNTPESIAETPPARDGSGAELYGYMTMDRPLSHCGRPYRRVSGDGAQDL
DRGLRKRTYSLTTPARQRPVPQPSSASLDEYTLMRATFSGSSGRLCPSFPASSPKVAYHP
YPEDYGDIEIGSQKSSSSNLGTDDGYMPMTPGAALMSGGPGSCKSDDYMPMSPTSVSAPK
QILQPRPAAAALPPSGAAVPAPPSVVGRTFPVNGGSYKASSPAESSPEDSGYMRMWCGSK
LSMESADPKLLPNGDYLNMSPSEAGTAGTPPDFFSAALQGGGEGLKGVPGYCYGSLPRSY
KAPYPCSGDSDQYVLMSSPVGRILEEERQESEATPGTSQLPGTFGAGGGGHTQPHHSAVP
SPMRPSGCSGRPEGFLSQRCRAVRPTRLSLEGLQTLPSMHEYPVPAEPKSPGEYINIDFS
EAGAHLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSSDSRQRSPLSDYMNLDFSS
PKSPKPGTHSGEQAGSLDGLLSPEASSPYPPLPPRPSASPSSLKQPLPPAPGELYRLPPA
SAAATSQGPSAASTSSEPGDNGDYTEMAFGVAATPPQPIAAPPKPEGTRVTSPTSGLKRL
SLMDQVSGVEAFLQATQPPDPHRGAKVIRADPQGGRRRHSSETFSSTTMVTPVSPSFAHN
SKRHNSASVENVSLRKSSEGNSSSLLGGGLAGGDEQPTSPAQGPHSLAVPPTPQARPWSP
GQPGGLVGCPGGSSSPMRRETSAGFQNGLNYIAIDVRDEQGLLSQPQTQHPQPGDKSSWG
RTRSLGGLLSTVGGNGTSAVCGGPGPGTLPSASTYASIDFLSHHLKEATVVKE
NT seq 3942 nt   +upstreamnt  +downstreamnt
aacaaccacagcgtgcgcaagtgcggctacctgcgcaaacagaagcacggccacaaacgc
ttcttcgtgttgcgcggccccggcgccggcggcgacgaggcgactgcgggcgcgggcggg
gggtcggcaccgcagccgccgcggctcgagtactacgagagcgagaagaagtggaggagc
aaggcgggcgcgccgaagcgggtgatcgccctcgactgctgcctgaacatcaacaagcgc
gcggacgccaagcacaagtatctgatcgccctctacaccaaggacgaatacttcgccgtc
gcggcggagaacgagcaggagcaggagggctggtaccgcgcgctcaccgacctggtcagc
gagggccgcgcggccagcgacacggccagcggggccaccggcgggtcctgcagcgcctcc
ctgccgggcgccctaggcggctctgcgggcgccgccggctccgatgacagctacgggctc
gtggcgcccgccacggctgcctaccgtgaggtgtggcaggtgaacctgaagcccaagggc
ctgggccagagcaagaacctgacgggcgtgtaccggctgtgcctgtcggcgcgcaccatc
ggcttcgtgaagctcaactgcgagcagccgtcggtgacgctgcaactcatgaacatccgc
cgctgcggccactctgacagcttctttttcatcgaggtgggccgctcggccgtcacgggc
cccggcgagctatggatgcaagccgacgattccgtggtggcgcagaacatccacgagacc
atcctggaggccatgaaggcgctgaaggagctcttcgaattccggccgcgcagcaaaagc
cagtcgtcggggtcgtcggccacgcaccccatcagcgtcccgggcgcgcgccgccatcac
cacctggtcaacttgccccctagccagacgggcctggtgcgccgctcgcgcacggacagc
ctggccgccaccccgccggctgccaagtgcaactcgtgccgggtccgtacggccagcgag
ggcgacggcggcacagccgctgggaccggcacggcggcaggcaggccggtgtcggtggct
gggagccccctgagtcccgggccggtgcgcgcgcccctgagccgctcgcacaccctgagc
ggcggctgcggcggccgccagagcaaagtggcgctggcgccggcagggggagccctgcaa
cacagccgttccatgtccatgccggtggcgcactcacccccggcagccaccagccccggg
agcctgtcctccagcagtgggcacggctcgggctcctatccgttacctcccggtccccac
ccgcacctgccacacccgttgcaccacccccctggccagcgcccctccagcggcagcgcc
tctgcctcgggctcccccagtgacccaggcttcatgtccctggacgagtacggctcaagc
cctggcgacctgagagccttctgcagccaccggagcaacacacccgagtccatcgcggag
accccgccagccagggacggcagcggggccgagctctacgggtacatgaccatggatagg
cccctgagccactgtggtcgcccctaccgtagggtctctggggatggagctcaggacttg
gaccgagggctaaggaagaggacttactccctgaccacgcctgcccggcagcggccagta
ccccaaccctcctctgcctccctggatgagtacaccctcatgcgggcgacgttttcaggc
agctcaggccgcctctgcccatctttccctgcgtcctcccccaaagtggcctaccaccct
tatcccgaggactatggggacattgagataggctctcaaaagagctccagcagtaacctg
gggactgatgatggttacatgcccatgacccctggggcggccctcatgagtggtggcccc
ggtagctgcaagagcgatgactacatgcccatgagccccaccagcgtgtctgcccccaag
cagatactgcagcccaggcctgcagcagcggccttgcccccctctggagcagcggttcca
gctcccccttctgtggtgggcagaaccttcccagtgaatggaggcagctacaaggccagc
tccccagcagagagctcccccgaggacagcgggtacatgcgcatgtggtgtggttccaag
ctgtccatggagagcgctgacccaaagctgctgcccaacggggactacctcaacatgtcc
cccagtgaggcgggcaccgccggcacccctcctgacttcttctcagcagctttgcaggga
ggcggggagggcctcaaaggcgtccctggttactgctatggctctttgccccgctcttat
aaggccccgtacccctgcagcggggacagcgaccagtatgtgctcatgagctcccctgtg
gggcggattttggaggaggaaaggcaggagtccgaggccaccccagggacctcccaattg
cctggcacctttggggcaggtggaggtggccatacccagcctcatcactcagcagtgcct
tctcccatgaggccgagtggctgcagtggccgccctgagggcttcctgagccagcgctgc
cgagcagtacggcccactcgtctgtcactagaggggcttcagacccttcccagcatgcat
gagtaccctgtgcctgcagagcccaagagccctggcgagtacatcaacattgactttagc
gaggcaggtgctcatctgtccccgcctgcccccccactgctggcctcggctgcctcatcc
tcttccttgctatctgccagcagtcctgcctcctctttgggctcaggcaccccgggcacc
agcagcgacagtcggcagcgctccccactctctgactatatgaacctcgatttcagctct
cctaagtcccccaaacctggtacccacagtggggaacaagccggctctctggatggcctc
ctctccccagaggcctcttccccatacccacctctgcccccacgtccttcggcctcccca
tcctccctgaagcagcctctgccacctgccccaggagagctgtatcgcctgcctccagca
tcagctgctgccacctcccagggccccagcgctgcctcaacctcctctgagcctggggat
aatggtgactatacagagatggcatttggtgtggctgcaaccccaccacaaccgattgca
gcacccccaaagccagagggtaccagagtaaccagccccacatcgggcctgaagagactg
agtctcatggaccaggtgtctggggtggaggccttcctgcaggccacccagccccctgac
ccccaccggggggccaaggtcatccgtgcagacccacaaggtggacgtcgacgccatagc
tctgagaccttttcttcgaccaccatggtcaccccggtgtccccgtcctttgctcacaac
tccaagcgtcacaactcggcctctgtggaaaacgtctctctcaggaaaagcagtgagggc
aacagcagcagtctcctgggagggggccttgcaggaggtgatgagcaacccacatccccg
gcacagggaccacattcactggccgtgccccctacaccacaggctaggccctggagccca
ggtcagcctggaggtttggttggctgtcctgggggcagtagttctcccatgcgcagagag
acctccgcaggcttccagaacggcctcaactatatcgccattgatgtgagagatgagcaa
gggctgttgtcccagcctcagacgcagcatccacagccaggagacaagagctcctggggc
cggacccgtagccttggggggctcctcagcaccgttggaggcaatggtactagcgcggtg
tgtgggggcccaggccctggcaccttaccctccgccagcacctacgctagcatcgacttc
ttgtctcatcacttgaaggaggccacagtcgtgaaagagtga

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