KEGG   Nomascus leucogenys (northern white-cheeked gibbon): 100583968
Entry
100583968         CDS       T03265                                 
Symbol
TNF
Name
(RefSeq) tumor necrosis factor
  KO
K03156  tumor necrosis factor superfamily, member 2
Organism
nle  Nomascus leucogenys (northern white-cheeked gibbon)
Pathway
nle01523  Antifolate resistance
nle04010  MAPK signaling pathway
nle04060  Cytokine-cytokine receptor interaction
nle04061  Viral protein interaction with cytokine and cytokine receptor
nle04064  NF-kappa B signaling pathway
nle04071  Sphingolipid signaling pathway
nle04150  mTOR signaling pathway
nle04210  Apoptosis
nle04217  Necroptosis
nle04350  TGF-beta signaling pathway
nle04380  Osteoclast differentiation
nle04612  Antigen processing and presentation
nle04620  Toll-like receptor signaling pathway
nle04621  NOD-like receptor signaling pathway
nle04622  RIG-I-like receptor signaling pathway
nle04625  C-type lectin receptor signaling pathway
nle04640  Hematopoietic cell lineage
nle04650  Natural killer cell mediated cytotoxicity
nle04657  IL-17 signaling pathway
nle04660  T cell receptor signaling pathway
nle04664  Fc epsilon RI signaling pathway
nle04668  TNF signaling pathway
nle04920  Adipocytokine signaling pathway
nle04930  Type II diabetes mellitus
nle04931  Insulin resistance
nle04932  Non-alcoholic fatty liver disease
nle04933  AGE-RAGE signaling pathway in diabetic complications
nle04936  Alcoholic liver disease
nle04940  Type I diabetes mellitus
nle05010  Alzheimer disease
nle05014  Amyotrophic lateral sclerosis
nle05020  Prion disease
nle05022  Pathways of neurodegeneration - multiple diseases
nle05132  Salmonella infection
nle05133  Pertussis
nle05134  Legionellosis
nle05135  Yersinia infection
nle05140  Leishmaniasis
nle05142  Chagas disease
nle05143  African trypanosomiasis
nle05144  Malaria
nle05145  Toxoplasmosis
nle05146  Amoebiasis
nle05152  Tuberculosis
nle05160  Hepatitis C
nle05161  Hepatitis B
nle05163  Human cytomegalovirus infection
nle05164  Influenza A
nle05165  Human papillomavirus infection
nle05166  Human T-cell leukemia virus 1 infection
nle05168  Herpes simplex virus 1 infection
nle05169  Epstein-Barr virus infection
nle05170  Human immunodeficiency virus 1 infection
nle05171  Coronavirus disease - COVID-19
nle05205  Proteoglycans in cancer
nle05310  Asthma
nle05321  Inflammatory bowel disease
nle05322  Systemic lupus erythematosus
nle05323  Rheumatoid arthritis
nle05330  Allograft rejection
nle05332  Graft-versus-host disease
nle05410  Hypertrophic cardiomyopathy
nle05414  Dilated cardiomyopathy
nle05417  Lipid and atherosclerosis
nle05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:nle00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100583968 (TNF)
   04350 TGF-beta signaling pathway
    100583968 (TNF)
   04064 NF-kappa B signaling pathway
    100583968 (TNF)
   04668 TNF signaling pathway
    100583968 (TNF)
   04071 Sphingolipid signaling pathway
    100583968 (TNF)
   04150 mTOR signaling pathway
    100583968 (TNF)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    100583968 (TNF)
   04061 Viral protein interaction with cytokine and cytokine receptor
    100583968 (TNF)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    100583968 (TNF)
   04217 Necroptosis
    100583968 (TNF)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    100583968 (TNF)
   04620 Toll-like receptor signaling pathway
    100583968 (TNF)
   04621 NOD-like receptor signaling pathway
    100583968 (TNF)
   04622 RIG-I-like receptor signaling pathway
    100583968 (TNF)
   04625 C-type lectin receptor signaling pathway
    100583968 (TNF)
   04650 Natural killer cell mediated cytotoxicity
    100583968 (TNF)
   04612 Antigen processing and presentation
    100583968 (TNF)
   04660 T cell receptor signaling pathway
    100583968 (TNF)
   04657 IL-17 signaling pathway
    100583968 (TNF)
   04664 Fc epsilon RI signaling pathway
    100583968 (TNF)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    100583968 (TNF)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100583968 (TNF)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    100583968 (TNF)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100583968 (TNF)
   05170 Human immunodeficiency virus 1 infection
    100583968 (TNF)
   05161 Hepatitis B
    100583968 (TNF)
   05160 Hepatitis C
    100583968 (TNF)
   05171 Coronavirus disease - COVID-19
    100583968 (TNF)
   05164 Influenza A
    100583968 (TNF)
   05168 Herpes simplex virus 1 infection
    100583968 (TNF)
   05163 Human cytomegalovirus infection
    100583968 (TNF)
   05169 Epstein-Barr virus infection
    100583968 (TNF)
   05165 Human papillomavirus infection
    100583968 (TNF)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100583968 (TNF)
   05135 Yersinia infection
    100583968 (TNF)
   05133 Pertussis
    100583968 (TNF)
   05134 Legionellosis
    100583968 (TNF)
   05152 Tuberculosis
    100583968 (TNF)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100583968 (TNF)
   05144 Malaria
    100583968 (TNF)
   05145 Toxoplasmosis
    100583968 (TNF)
   05140 Leishmaniasis
    100583968 (TNF)
   05142 Chagas disease
    100583968 (TNF)
   05143 African trypanosomiasis
    100583968 (TNF)
  09163 Immune disease
   05310 Asthma
    100583968 (TNF)
   05322 Systemic lupus erythematosus
    100583968 (TNF)
   05323 Rheumatoid arthritis
    100583968 (TNF)
   05321 Inflammatory bowel disease
    100583968 (TNF)
   05330 Allograft rejection
    100583968 (TNF)
   05332 Graft-versus-host disease
    100583968 (TNF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100583968 (TNF)
   05014 Amyotrophic lateral sclerosis
    100583968 (TNF)
   05020 Prion disease
    100583968 (TNF)
   05022 Pathways of neurodegeneration - multiple diseases
    100583968 (TNF)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100583968 (TNF)
   05418 Fluid shear stress and atherosclerosis
    100583968 (TNF)
   05410 Hypertrophic cardiomyopathy
    100583968 (TNF)
   05414 Dilated cardiomyopathy
    100583968 (TNF)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100583968 (TNF)
   04940 Type I diabetes mellitus
    100583968 (TNF)
   04936 Alcoholic liver disease
    100583968 (TNF)
   04932 Non-alcoholic fatty liver disease
    100583968 (TNF)
   04931 Insulin resistance
    100583968 (TNF)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100583968 (TNF)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    100583968 (TNF)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:nle04052]
    100583968 (TNF)
   00536 Glycosaminoglycan binding proteins [BR:nle00536]
    100583968 (TNF)
Cytokines and neuropeptides [BR:nle04052]
 Cytokines
  Tumor necrosis fators
   100583968 (TNF)
Glycosaminoglycan binding proteins [BR:nle00536]
 Heparan sulfate / Heparin
  Cytokines
   100583968 (TNF)
SSDB
Motif
Pfam: TNF
Other DBs
NCBI-GeneID: 100583968
NCBI-ProteinID: XP_003272142
Ensembl: ENSNLEG00000028057
UniProt: A0A2I3HVV8
LinkDB
Position
22a:52604482..52607247
AA seq 233 aa
MSTESMIRDVELAEEALPKKTGGPQGSRRCFLLSLFSFLLVAGATTLFCLLHFGVIGPQR
EEFPKDLPLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVQLT
DNQLVVPSEGLYLIYSQVLFKGQGCPPTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
NT seq 702 nt   +upstreamnt  +downstreamnt
atgagcactgaaagcatgatccgggacgtggagctggctgaggaggcgctccccaagaag
acaggggggccccagggctccaggcggtgctttctcctcagcctcttctccttcctgctc
gtggcaggcgccaccacgctcttctgcctgctgcactttggagtgatcggcccacagagg
gaagagttccccaaggacctccctctaatcagccctctggcccaggcagtcagatcatct
tctcgaaccccgagtgacaagcctgtagcccatgttgtagcaaaccctcaagctgagggg
cagctccagtggctgaaccgccgggccaatgccctcctggccaatggcgtgcagctgaca
gataaccagctggtggtgccatcagagggcctgtacctcatctactcccaggtcctcttc
aagggccaaggctgcccccccacccatgtgctcctcacccacaccatcagccgcatcgcc
gtctcctaccagaccaaggtcaacctcctctctgccatcaagagcccctgccagagggag
accccagagggggctgaggccaagccctggtatgagcccatctatctgggaggggtattc
cagctggagaagggtgatcgactcagcgctgagatcaatcggcctgactatctcgacttt
gccgagtctgggcaggtctacttcgggatcattgccctgtga

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