KEGG   Nomascus leucogenys (northern white-cheeked gibbon): 100591458
Entry
100591458         CDS       T03265                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
nle  Nomascus leucogenys (northern white-cheeked gibbon)
Pathway
nle00562  Inositol phosphate metabolism
nle01100  Metabolic pathways
nle01521  EGFR tyrosine kinase inhibitor resistance
nle04012  ErbB signaling pathway
nle04014  Ras signaling pathway
nle04015  Rap1 signaling pathway
nle04020  Calcium signaling pathway
nle04062  Chemokine signaling pathway
nle04064  NF-kappa B signaling pathway
nle04066  HIF-1 signaling pathway
nle04070  Phosphatidylinositol signaling system
nle04072  Phospholipase D signaling pathway
nle04360  Axon guidance
nle04370  VEGF signaling pathway
nle04613  Neutrophil extracellular trap formation
nle04650  Natural killer cell mediated cytotoxicity
nle04658  Th1 and Th2 cell differentiation
nle04659  Th17 cell differentiation
nle04660  T cell receptor signaling pathway
nle04664  Fc epsilon RI signaling pathway
nle04666  Fc gamma R-mediated phagocytosis
nle04670  Leukocyte transendothelial migration
nle04722  Neurotrophin signaling pathway
nle04750  Inflammatory mediator regulation of TRP channels
nle04919  Thyroid hormone signaling pathway
nle04933  AGE-RAGE signaling pathway in diabetic complications
nle04935  Growth hormone synthesis, secretion and action
nle05012  Parkinson disease
nle05022  Pathways of neurodegeneration - multiple diseases
nle05135  Yersinia infection
nle05167  Kaposi sarcoma-associated herpesvirus infection
nle05170  Human immunodeficiency virus 1 infection
nle05171  Coronavirus disease - COVID-19
nle05200  Pathways in cancer
nle05205  Proteoglycans in cancer
nle05206  MicroRNAs in cancer
nle05214  Glioma
nle05223  Non-small cell lung cancer
nle05225  Hepatocellular carcinoma
nle05231  Choline metabolism in cancer
nle05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
nle05417  Lipid and atherosclerosis
Module
nle_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:nle00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100591458 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100591458 (PLCG1)
   04014 Ras signaling pathway
    100591458 (PLCG1)
   04015 Rap1 signaling pathway
    100591458 (PLCG1)
   04370 VEGF signaling pathway
    100591458 (PLCG1)
   04064 NF-kappa B signaling pathway
    100591458 (PLCG1)
   04066 HIF-1 signaling pathway
    100591458 (PLCG1)
   04020 Calcium signaling pathway
    100591458 (PLCG1)
   04070 Phosphatidylinositol signaling system
    100591458 (PLCG1)
   04072 Phospholipase D signaling pathway
    100591458 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    100591458 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    100591458 (PLCG1)
   04660 T cell receptor signaling pathway
    100591458 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    100591458 (PLCG1)
   04659 Th17 cell differentiation
    100591458 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    100591458 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    100591458 (PLCG1)
   04670 Leukocyte transendothelial migration
    100591458 (PLCG1)
   04062 Chemokine signaling pathway
    100591458 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    100591458 (PLCG1)
   04919 Thyroid hormone signaling pathway
    100591458 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    100591458 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100591458 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    100591458 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100591458 (PLCG1)
   05206 MicroRNAs in cancer
    100591458 (PLCG1)
   05205 Proteoglycans in cancer
    100591458 (PLCG1)
   05231 Choline metabolism in cancer
    100591458 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100591458 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    100591458 (PLCG1)
   05214 Glioma
    100591458 (PLCG1)
   05223 Non-small cell lung cancer
    100591458 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100591458 (PLCG1)
   05171 Coronavirus disease - COVID-19
    100591458 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100591458 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100591458 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    100591458 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    100591458 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100591458 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100591458 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100591458 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:nle04131]
    100591458 (PLCG1)
Enzymes [BR:nle01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100591458 (PLCG1)
Membrane trafficking [BR:nle04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100591458 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100591458 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH C2 SH3_1 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7
Other DBs
NCBI-GeneID: 100591458
NCBI-ProteinID: XP_030681918
Ensembl: ENSNLEG00000006479
LinkDB
Position
13:complement(22864686..22903572)
AA seq 1291 aa
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRA
GERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCLDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLLTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQHFKKVLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSMM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEVSS
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVNPVALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSNMRDEAFDPFDKS
SLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLIKIDIFPAKQENGDLSPFSGTSLRERGSDASGQLFHGRTREGSFESRYQQPFED
FRISQEHLADHFDSRERRAPRRTRVNGDNRL
NT seq 3876 nt   +upstreamnt  +downstreamnt
atggcgggcgctgcgtccccttgcgccaacggctgcgggcccggcgcgccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtctcagcgacccgagcggaagaccttccaggtcaagctggagacgcgccagatc
acgtggagccggggcgccgacaagatcgagggggccattgatattcgcgaaattaaggag
atccgcccggggaagacctcacgggactttgatcgctatcaagaggacccagctttccgg
ccggaccagtcacattgctttgtcattctctatggaatggaatttcgcctgaaaacgctg
agcctgcaagccacatctgaggatgaagtgaacatgtggatcaagggcttaacttggctg
atggaggatacattgcaggcacccacacccctgcagatagagaggtggctccggaagcag
ttttactcagtggatcggaatcgtgaggatcgtatatcagccaaggacctgaagaacatg
ctgtcccaggtcaactaccgggtccccaacatgcgcttcctccgagagcggctgacggac
ctggagcagcgcagcggggacatcacctacgggcagtttgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcttggaagccagtactctgagggct
ggggagcggccggagctttgccgagtgtcccttcctgagttccagcagttccttcttgac
taccagggggagctgtgggctgttgatcgcctccaggtgcaagagttcatgctcagcttc
ctccgagaccccttacgagagatcgaggagccatacttcttcctggatgagtttgtcacc
ttcctgttctccaaagagaacagtgtgtggaactcacagctggatgcagtatgcctggac
accatgaacaaccctctttcccactactggatctcctcctcacacaacacgtacctgacc
ggggaccagttctccagtgagtcctccttggaagcctatgctcgctgcctgcggatgggc
tgtcgctgcattgagttggactgctgggacggcccggatgggatgccagttatttaccat
gggcacacccttaccaccaagatcaagttctcagatgtcctgctcaccatcaaggagcat
gcctttgtggcctcagagtacccagtcatcctgtccattgaggaccactgcagcattgcc
cagcagaggaacatggcccagcacttcaagaaggtgctgggggacacactcctcaccaag
cccgtggagatctctgccgatgggctcccctcacccaaccagcttaagaggaagatcctc
atcaagcacaagaagctggctgagggcagtgcctacgaggaggtgcctacctccatgatg
tattctgagaacgacatcagcaactccatcaagaatggcatcctctacctggaggaccct
gtgaaccacgaatggtatccccactactttgttctgaccagcagcaagatctactactct
gaggagaccagcagtgaccagggcaacgaggatgaggaggagcccaaggaggtcagcagc
agcacagagctgcactccaatgagaagtggttccatgggaagctaggggcagggcgtgat
gggcgtcacatcgctgagcgcctgctcactgagtactgcatcgagaccggagcccctgat
ggctccttcctcgtgcgagagagtgagaccttcgtgggtgactacacgctctctttctgg
cggaacgggaaagtccagcactgccgtatccactcccggcaagatgctgggacccccaag
ttcttcttgacagacaacctcgtctttgactccctctatgacctcatcacgcactaccag
caggtgcccctgcgctgtaatgagtttgagatgagactttcagagcctgtcccacagacc
aacgcccatgagagcaaagagtggtaccacgcgagcctgaccagagcacaggctgagcac
atgctaatgcgcgtccctcgtgatggggccttcctggtgcggaagcggaatgagcccaac
tcatatgccatctctttccgggctgagggcaagatcaagcattgccgtgtccagcaagag
ggccagacagtgatgctagggaactcggagttcgacagccttgttgacctcatcagctac
tatgagaaacacccgctgtaccgcaagatgaagctgcgctatcccatcaacgaggaggca
ctggagaagattggcacagctgagcctgactacggggccctgtatgagggacgcaaccct
ggcttctatgtagaggcaaaccctatgccaactttcaagtgtgcggtcaaagccctcttt
gactacaaggcccagagggaggacgagctgaccttcaccaagagcgccatcatccagaat
gtggagaagcaagagggaggctggtggcgaggggactacggagggaagaagcagctgtgg
ttcccatcaaactacgtggaagagatggtcaaccccgtggccctggagccggagagggag
cacttggacgagaacagccccctaggggacttgctgcggggggtcctggatgtgccggct
tgtcagattgccatccgtcctgagggcaagaacaaccggctcttcgtcttctccatcagc
atggcgtcggtggcccactggtccctggatgttgctgccgactcacaggaggagctgcag
gactgggtgaaaaagatccgtgaagtggcccagaccgcagatgccaggctcactgaaggg
aagataatggaacggaggaagaagattgccctggagctctctgaacttgtcgtctactgc
cggcctgttcccttcgatgaagagaagattggcacagaacgtgcttgctaccgggacatg
tcatccttcccggaaaccaaggctgagaaatacgtgaacaaggccaaaggcaagaagttc
cttcagtacaatcgactgcagctctcccgcatctaccccaagggccagcgactggattcc
tccaactacgatcctttgcccatgtggatctgtggcagtcagctcgtggccctcaacttc
cagacccctgacaagcctatgcagatgaaccaggccctcttcatgacaggcaggcactgt
ggctatgtgctgcagccaagcaacatgcgggatgaggcctttgacccctttgacaagagc
agcctccgtgggctggagccatgtgccatctctattgaggtgctgggggcccgacatctg
ccaaagaatggccgaggcattgtgtgtccttttgtggagattgaggtggctggagctgag
tatgacagcaccaagcagaagacagagtttgtggtggacaatggactcaaccctgtatgg
ccagccaagcccttccacttccaaatcagtaaccctgaatttgcctttctgcgcttcgtg
gtgtatgaggaagacatgtttagtgaccagaatttcctggctcaggctactttcccggta
aaaggcctgaagacaggatacagagcagtgcctttgaagaacaactacagcgaggacctg
gagttggcctccctgctgatcaagattgatattttccctgccaagcaggagaatggtgac
ctcagtcccttcagtggtacgtccctgcgggagcggggctcagatgcctcaggccagctg
tttcacggccgaacccgggaaggctcctttgaatcccgctaccagcagccatttgaggac
ttccgcatctcccaggaacatctcgcagaccattttgacagccgagaacgaagggcccca
agaaggactcgggtcaatggagacaaccgcctctag

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