KEGG   Nomascus leucogenys (northern white-cheeked gibbon): 100599301
Entry
100599301         CDS       T03265                                 
Symbol
PIK3R2
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit beta
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
nle  Nomascus leucogenys (northern white-cheeked gibbon)
Pathway
nle01521  EGFR tyrosine kinase inhibitor resistance
nle01522  Endocrine resistance
nle01524  Platinum drug resistance
nle04012  ErbB signaling pathway
nle04014  Ras signaling pathway
nle04015  Rap1 signaling pathway
nle04024  cAMP signaling pathway
nle04062  Chemokine signaling pathway
nle04066  HIF-1 signaling pathway
nle04068  FoxO signaling pathway
nle04070  Phosphatidylinositol signaling system
nle04071  Sphingolipid signaling pathway
nle04072  Phospholipase D signaling pathway
nle04081  Hormone signaling
nle04140  Autophagy - animal
nle04150  mTOR signaling pathway
nle04151  PI3K-Akt signaling pathway
nle04152  AMPK signaling pathway
nle04210  Apoptosis
nle04211  Longevity regulating pathway
nle04213  Longevity regulating pathway - multiple species
nle04218  Cellular senescence
nle04360  Axon guidance
nle04370  VEGF signaling pathway
nle04380  Osteoclast differentiation
nle04510  Focal adhesion
nle04550  Signaling pathways regulating pluripotency of stem cells
nle04611  Platelet activation
nle04613  Neutrophil extracellular trap formation
nle04620  Toll-like receptor signaling pathway
nle04625  C-type lectin receptor signaling pathway
nle04630  JAK-STAT signaling pathway
nle04650  Natural killer cell mediated cytotoxicity
nle04660  T cell receptor signaling pathway
nle04662  B cell receptor signaling pathway
nle04664  Fc epsilon RI signaling pathway
nle04666  Fc gamma R-mediated phagocytosis
nle04668  TNF signaling pathway
nle04670  Leukocyte transendothelial migration
nle04722  Neurotrophin signaling pathway
nle04725  Cholinergic synapse
nle04750  Inflammatory mediator regulation of TRP channels
nle04810  Regulation of actin cytoskeleton
nle04910  Insulin signaling pathway
nle04914  Progesterone-mediated oocyte maturation
nle04915  Estrogen signaling pathway
nle04917  Prolactin signaling pathway
nle04919  Thyroid hormone signaling pathway
nle04923  Regulation of lipolysis in adipocytes
nle04926  Relaxin signaling pathway
nle04929  GnRH secretion
nle04930  Type II diabetes mellitus
nle04931  Insulin resistance
nle04932  Non-alcoholic fatty liver disease
nle04933  AGE-RAGE signaling pathway in diabetic complications
nle04935  Growth hormone synthesis, secretion and action
nle04960  Aldosterone-regulated sodium reabsorption
nle04973  Carbohydrate digestion and absorption
nle05010  Alzheimer disease
nle05017  Spinocerebellar ataxia
nle05020  Prion disease
nle05100  Bacterial invasion of epithelial cells
nle05135  Yersinia infection
nle05142  Chagas disease
nle05146  Amoebiasis
nle05160  Hepatitis C
nle05161  Hepatitis B
nle05162  Measles
nle05163  Human cytomegalovirus infection
nle05164  Influenza A
nle05165  Human papillomavirus infection
nle05166  Human T-cell leukemia virus 1 infection
nle05167  Kaposi sarcoma-associated herpesvirus infection
nle05168  Herpes simplex virus 1 infection
nle05169  Epstein-Barr virus infection
nle05170  Human immunodeficiency virus 1 infection
nle05171  Coronavirus disease - COVID-19
nle05200  Pathways in cancer
nle05203  Viral carcinogenesis
nle05205  Proteoglycans in cancer
nle05206  MicroRNAs in cancer
nle05207  Chemical carcinogenesis - receptor activation
nle05208  Chemical carcinogenesis - reactive oxygen species
nle05210  Colorectal cancer
nle05211  Renal cell carcinoma
nle05212  Pancreatic cancer
nle05213  Endometrial cancer
nle05214  Glioma
nle05215  Prostate cancer
nle05218  Melanoma
nle05220  Chronic myeloid leukemia
nle05221  Acute myeloid leukemia
nle05222  Small cell lung cancer
nle05223  Non-small cell lung cancer
nle05224  Breast cancer
nle05225  Hepatocellular carcinoma
nle05226  Gastric cancer
nle05230  Central carbon metabolism in cancer
nle05231  Choline metabolism in cancer
nle05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
nle05415  Diabetic cardiomyopathy
nle05417  Lipid and atherosclerosis
nle05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:nle00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100599301 (PIK3R2)
   04014 Ras signaling pathway
    100599301 (PIK3R2)
   04015 Rap1 signaling pathway
    100599301 (PIK3R2)
   04370 VEGF signaling pathway
    100599301 (PIK3R2)
   04630 JAK-STAT signaling pathway
    100599301 (PIK3R2)
   04668 TNF signaling pathway
    100599301 (PIK3R2)
   04066 HIF-1 signaling pathway
    100599301 (PIK3R2)
   04068 FoxO signaling pathway
    100599301 (PIK3R2)
   04070 Phosphatidylinositol signaling system
    100599301 (PIK3R2)
   04072 Phospholipase D signaling pathway
    100599301 (PIK3R2)
   04071 Sphingolipid signaling pathway
    100599301 (PIK3R2)
   04024 cAMP signaling pathway
    100599301 (PIK3R2)
   04151 PI3K-Akt signaling pathway
    100599301 (PIK3R2)
   04152 AMPK signaling pathway
    100599301 (PIK3R2)
   04150 mTOR signaling pathway
    100599301 (PIK3R2)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100599301 (PIK3R2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100599301 (PIK3R2)
  09143 Cell growth and death
   04210 Apoptosis
    100599301 (PIK3R2)
   04218 Cellular senescence
    100599301 (PIK3R2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100599301 (PIK3R2)
   04550 Signaling pathways regulating pluripotency of stem cells
    100599301 (PIK3R2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100599301 (PIK3R2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100599301 (PIK3R2)
   04613 Neutrophil extracellular trap formation
    100599301 (PIK3R2)
   04620 Toll-like receptor signaling pathway
    100599301 (PIK3R2)
   04625 C-type lectin receptor signaling pathway
    100599301 (PIK3R2)
   04650 Natural killer cell mediated cytotoxicity
    100599301 (PIK3R2)
   04660 T cell receptor signaling pathway
    100599301 (PIK3R2)
   04662 B cell receptor signaling pathway
    100599301 (PIK3R2)
   04664 Fc epsilon RI signaling pathway
    100599301 (PIK3R2)
   04666 Fc gamma R-mediated phagocytosis
    100599301 (PIK3R2)
   04670 Leukocyte transendothelial migration
    100599301 (PIK3R2)
   04062 Chemokine signaling pathway
    100599301 (PIK3R2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100599301 (PIK3R2)
   04923 Regulation of lipolysis in adipocytes
    100599301 (PIK3R2)
   04929 GnRH secretion
    100599301 (PIK3R2)
   04915 Estrogen signaling pathway
    100599301 (PIK3R2)
   04914 Progesterone-mediated oocyte maturation
    100599301 (PIK3R2)
   04917 Prolactin signaling pathway
    100599301 (PIK3R2)
   04926 Relaxin signaling pathway
    100599301 (PIK3R2)
   04935 Growth hormone synthesis, secretion and action
    100599301 (PIK3R2)
   04919 Thyroid hormone signaling pathway
    100599301 (PIK3R2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100599301 (PIK3R2)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100599301 (PIK3R2)
  09156 Nervous system
   04725 Cholinergic synapse
    100599301 (PIK3R2)
   04722 Neurotrophin signaling pathway
    100599301 (PIK3R2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100599301 (PIK3R2)
  09158 Development and regeneration
   04360 Axon guidance
    100599301 (PIK3R2)
   04380 Osteoclast differentiation
    100599301 (PIK3R2)
  09149 Aging
   04211 Longevity regulating pathway
    100599301 (PIK3R2)
   04213 Longevity regulating pathway - multiple species
    100599301 (PIK3R2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100599301 (PIK3R2)
   05206 MicroRNAs in cancer
    100599301 (PIK3R2)
   05205 Proteoglycans in cancer
    100599301 (PIK3R2)
   05207 Chemical carcinogenesis - receptor activation
    100599301 (PIK3R2)
   05208 Chemical carcinogenesis - reactive oxygen species
    100599301 (PIK3R2)
   05203 Viral carcinogenesis
    100599301 (PIK3R2)
   05230 Central carbon metabolism in cancer
    100599301 (PIK3R2)
   05231 Choline metabolism in cancer
    100599301 (PIK3R2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100599301 (PIK3R2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100599301 (PIK3R2)
   05212 Pancreatic cancer
    100599301 (PIK3R2)
   05225 Hepatocellular carcinoma
    100599301 (PIK3R2)
   05226 Gastric cancer
    100599301 (PIK3R2)
   05214 Glioma
    100599301 (PIK3R2)
   05221 Acute myeloid leukemia
    100599301 (PIK3R2)
   05220 Chronic myeloid leukemia
    100599301 (PIK3R2)
   05218 Melanoma
    100599301 (PIK3R2)
   05211 Renal cell carcinoma
    100599301 (PIK3R2)
   05215 Prostate cancer
    100599301 (PIK3R2)
   05213 Endometrial cancer
    100599301 (PIK3R2)
   05224 Breast cancer
    100599301 (PIK3R2)
   05222 Small cell lung cancer
    100599301 (PIK3R2)
   05223 Non-small cell lung cancer
    100599301 (PIK3R2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100599301 (PIK3R2)
   05170 Human immunodeficiency virus 1 infection
    100599301 (PIK3R2)
   05161 Hepatitis B
    100599301 (PIK3R2)
   05160 Hepatitis C
    100599301 (PIK3R2)
   05171 Coronavirus disease - COVID-19
    100599301 (PIK3R2)
   05164 Influenza A
    100599301 (PIK3R2)
   05162 Measles
    100599301 (PIK3R2)
   05168 Herpes simplex virus 1 infection
    100599301 (PIK3R2)
   05163 Human cytomegalovirus infection
    100599301 (PIK3R2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100599301 (PIK3R2)
   05169 Epstein-Barr virus infection
    100599301 (PIK3R2)
   05165 Human papillomavirus infection
    100599301 (PIK3R2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100599301 (PIK3R2)
   05100 Bacterial invasion of epithelial cells
    100599301 (PIK3R2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100599301 (PIK3R2)
   05142 Chagas disease
    100599301 (PIK3R2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100599301 (PIK3R2)
   05017 Spinocerebellar ataxia
    100599301 (PIK3R2)
   05020 Prion disease
    100599301 (PIK3R2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100599301 (PIK3R2)
   05418 Fluid shear stress and atherosclerosis
    100599301 (PIK3R2)
   05415 Diabetic cardiomyopathy
    100599301 (PIK3R2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100599301 (PIK3R2)
   04932 Non-alcoholic fatty liver disease
    100599301 (PIK3R2)
   04931 Insulin resistance
    100599301 (PIK3R2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100599301 (PIK3R2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100599301 (PIK3R2)
   01524 Platinum drug resistance
    100599301 (PIK3R2)
   01522 Endocrine resistance
    100599301 (PIK3R2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:nle04131]
    100599301 (PIK3R2)
Membrane trafficking [BR:nle04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100599301 (PIK3R2)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH3_1 SH2_1 Ribosomal_L22e SH3_9
Other DBs
NCBI-GeneID: 100599301
NCBI-ProteinID: XP_003275871
Ensembl: ENSNLEG00000005931
UniProt: G1R1V3
LinkDB
Position
10:complement(52990392..53007728)
AA seq 727 aa
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGL
NERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSP
PDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDAAALADGIKSFLLA
LPAPLVTPEALAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVARRAPALG
PAVRALGATFGPLLLRAPPPSSPPPGGAPDGSEPSPDFPALLLEKLLQEHLEEQEVAPPA
LPPKPPKAKPAPTGLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKI
QGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRL
LYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAI
EAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTK
LEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNET
EDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVV
DGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGP
GPPPAAR
NT seq 2184 nt   +upstreamnt  +downstreamnt
atggcgggccctgagggcttccagtaccgcgctctgtacccgttccgccgggagcggccg
gaggacctggagctgctgcccggcgacgtgctggtagtgagccgggcggccttgcaggca
ctgggcgtggccgagggtggcgagcgctgcccacagagcgtgggctggatgcccggcctc
aacgagcgcacacggcagcgaggtgacttccctggcacctacgtggagttcctggggccc
gtggccctggcccggcccggccctcgcccacggggcccccgcccactgcccgccaggccc
cgtgatggggcccctgagccaggcctcacactccccgacttgcccgagcagttctcccca
cctgatgtggcgccccctcttctggtgaagcttgtggaggccattgaaaggacagggctg
gacagcgaatctcactaccggccggagctgcccgcaccgcgtacagactggtccctgagc
gacgtggatcagtgggacgcggcagccctggctgacggcattaagagcttcctgctggca
ctgcccgcgccgctcgtgacccccgaggccttggccgaggcgcgccgggccctgcgggag
gccgcggggcccgtggggccggcgctggagccaccgacgctgccgctgcaccgtgcgctc
acgctgcgcttcctgctccagcacctgggccgcgtggcccgccgcgccccggccctgggt
cccgcggtccgggccctgggcgccacctttgggccgctgctgctgcgcgcgccgccgccg
tcctcgccgccaccagggggcgctcccgacgggagtgagcccagccctgacttcccggcg
ctgctgttagagaagctgcttcaggaacacttggaagagcaggaggttgcgcccccagcg
ctgccgcctaaaccccccaaggcaaagccggcccccacaggcctggccaatggagggagc
ccaccctccctgcaggatgctgagtggtactggggggacatttcaagggaggaggtgaac
gagaaactccgggacactcccgatggcaccttcctagtccgagatgcttctagcaagatc
cagggcgagtacacgctgaccctcaggaaaggcgggaacaataagctgatcaaggtcttc
caccgagatgggcactatggcttctcagagccactcaccttctgctccgtcgtggacctc
atcaatcactaccgccacgagtcgctggcccagtacaacgccaagctggacacacggctc
ctctaccctgtgtccaaataccagcaggaccagattgtcaaggaggatagcgtggaggcg
gtgggtgcccagctcaaggtctatcaccagcaataccaggacaagagccgcgagtatgac
cagctctatgaagagtacacaaggacctcccaggagctgcagatgaagcgtaccgcaatt
gaggccttcaatgagactatcaagatctttgaagagcagggccagactcaagagaagtgc
agcaaggaatacctggagcgcttccggcgtgagggcaatgagaaagagatgcagaggatc
ctgctgaactccgagcggctcaagtcccgcattgccgagatccatgagagccgcacgaag
ctggagcagcagctgcgggcccaggcctcggacaaccgggagatcgacaagcgaatgaac
agcctcaagccggacctcatgcagctgcgcaagatccgagaccagtacctcgtgtggctc
acccagaaaggcgcccggcagaagaaaatcaacgagtggctggggattaaaaatgagact
gaggaccagtacgcgctgatggaggacgaggacgatctcccgcaccacgaggaacgcact
tggtacgtgggcaagatcaatcgcacgcaggcagaggagatgctgagcggcaagcgagat
ggcaccttcctcatccgcgagagcagccagcggggctgctacgcctgctccgtagtagtg
gacggcgacaccaagcactgcgtcatctaccgcacggccaccggcttcggcttcgcggag
ccctacaacctgtacgggtcgctgaaggagctggtgctgcactaccagcacgcctcgctc
gtgcagcacaacgacgcgctcaccgtcaccctggcgcacccagtgcgcgcccccggcccc
gggccgccgcctgccgcccgctga

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