KEGG   Nomascus leucogenys (northern white-cheeked gibbon): 100605788
Entry
100605788         CDS       T03265                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
nle  Nomascus leucogenys (northern white-cheeked gibbon)
Pathway
nle01521  EGFR tyrosine kinase inhibitor resistance
nle01522  Endocrine resistance
nle01524  Platinum drug resistance
nle04012  ErbB signaling pathway
nle04014  Ras signaling pathway
nle04015  Rap1 signaling pathway
nle04024  cAMP signaling pathway
nle04062  Chemokine signaling pathway
nle04066  HIF-1 signaling pathway
nle04068  FoxO signaling pathway
nle04070  Phosphatidylinositol signaling system
nle04071  Sphingolipid signaling pathway
nle04072  Phospholipase D signaling pathway
nle04081  Hormone signaling
nle04140  Autophagy - animal
nle04150  mTOR signaling pathway
nle04151  PI3K-Akt signaling pathway
nle04152  AMPK signaling pathway
nle04210  Apoptosis
nle04211  Longevity regulating pathway
nle04213  Longevity regulating pathway - multiple species
nle04218  Cellular senescence
nle04360  Axon guidance
nle04370  VEGF signaling pathway
nle04380  Osteoclast differentiation
nle04510  Focal adhesion
nle04517  IgSF CAM signaling
nle04518  Integrin signaling
nle04550  Signaling pathways regulating pluripotency of stem cells
nle04611  Platelet activation
nle04613  Neutrophil extracellular trap formation
nle04620  Toll-like receptor signaling pathway
nle04625  C-type lectin receptor signaling pathway
nle04630  JAK-STAT signaling pathway
nle04650  Natural killer cell mediated cytotoxicity
nle04660  T cell receptor signaling pathway
nle04662  B cell receptor signaling pathway
nle04664  Fc epsilon RI signaling pathway
nle04666  Fc gamma R-mediated phagocytosis
nle04668  TNF signaling pathway
nle04670  Leukocyte transendothelial migration
nle04722  Neurotrophin signaling pathway
nle04725  Cholinergic synapse
nle04750  Inflammatory mediator regulation of TRP channels
nle04810  Regulation of actin cytoskeleton
nle04910  Insulin signaling pathway
nle04914  Progesterone-mediated oocyte maturation
nle04915  Estrogen signaling pathway
nle04917  Prolactin signaling pathway
nle04919  Thyroid hormone signaling pathway
nle04923  Regulation of lipolysis in adipocytes
nle04926  Relaxin signaling pathway
nle04929  GnRH secretion
nle04930  Type II diabetes mellitus
nle04931  Insulin resistance
nle04932  Non-alcoholic fatty liver disease
nle04933  AGE-RAGE signaling pathway in diabetic complications
nle04935  Growth hormone synthesis, secretion and action
nle04960  Aldosterone-regulated sodium reabsorption
nle04973  Carbohydrate digestion and absorption
nle05010  Alzheimer disease
nle05017  Spinocerebellar ataxia
nle05020  Prion disease
nle05100  Bacterial invasion of epithelial cells
nle05135  Yersinia infection
nle05142  Chagas disease
nle05146  Amoebiasis
nle05160  Hepatitis C
nle05161  Hepatitis B
nle05162  Measles
nle05163  Human cytomegalovirus infection
nle05164  Influenza A
nle05165  Human papillomavirus infection
nle05166  Human T-cell leukemia virus 1 infection
nle05167  Kaposi sarcoma-associated herpesvirus infection
nle05168  Herpes simplex virus 1 infection
nle05169  Epstein-Barr virus infection
nle05170  Human immunodeficiency virus 1 infection
nle05171  Coronavirus disease - COVID-19
nle05200  Pathways in cancer
nle05203  Viral carcinogenesis
nle05205  Proteoglycans in cancer
nle05206  MicroRNAs in cancer
nle05207  Chemical carcinogenesis - receptor activation
nle05208  Chemical carcinogenesis - reactive oxygen species
nle05210  Colorectal cancer
nle05211  Renal cell carcinoma
nle05212  Pancreatic cancer
nle05213  Endometrial cancer
nle05214  Glioma
nle05215  Prostate cancer
nle05218  Melanoma
nle05220  Chronic myeloid leukemia
nle05221  Acute myeloid leukemia
nle05222  Small cell lung cancer
nle05223  Non-small cell lung cancer
nle05224  Breast cancer
nle05225  Hepatocellular carcinoma
nle05226  Gastric cancer
nle05230  Central carbon metabolism in cancer
nle05231  Choline metabolism in cancer
nle05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
nle05415  Diabetic cardiomyopathy
nle05417  Lipid and atherosclerosis
nle05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:nle00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100605788 (PIK3R1)
   04014 Ras signaling pathway
    100605788 (PIK3R1)
   04015 Rap1 signaling pathway
    100605788 (PIK3R1)
   04370 VEGF signaling pathway
    100605788 (PIK3R1)
   04630 JAK-STAT signaling pathway
    100605788 (PIK3R1)
   04668 TNF signaling pathway
    100605788 (PIK3R1)
   04066 HIF-1 signaling pathway
    100605788 (PIK3R1)
   04068 FoxO signaling pathway
    100605788 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    100605788 (PIK3R1)
   04072 Phospholipase D signaling pathway
    100605788 (PIK3R1)
   04071 Sphingolipid signaling pathway
    100605788 (PIK3R1)
   04024 cAMP signaling pathway
    100605788 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    100605788 (PIK3R1)
   04152 AMPK signaling pathway
    100605788 (PIK3R1)
   04150 mTOR signaling pathway
    100605788 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100605788 (PIK3R1)
   04517 IgSF CAM signaling
    100605788 (PIK3R1)
   04518 Integrin signaling
    100605788 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100605788 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    100605788 (PIK3R1)
   04218 Cellular senescence
    100605788 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100605788 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    100605788 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100605788 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100605788 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    100605788 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    100605788 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    100605788 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    100605788 (PIK3R1)
   04660 T cell receptor signaling pathway
    100605788 (PIK3R1)
   04662 B cell receptor signaling pathway
    100605788 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    100605788 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    100605788 (PIK3R1)
   04670 Leukocyte transendothelial migration
    100605788 (PIK3R1)
   04062 Chemokine signaling pathway
    100605788 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100605788 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    100605788 (PIK3R1)
   04929 GnRH secretion
    100605788 (PIK3R1)
   04915 Estrogen signaling pathway
    100605788 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    100605788 (PIK3R1)
   04917 Prolactin signaling pathway
    100605788 (PIK3R1)
   04926 Relaxin signaling pathway
    100605788 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    100605788 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    100605788 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100605788 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100605788 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    100605788 (PIK3R1)
   04722 Neurotrophin signaling pathway
    100605788 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100605788 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    100605788 (PIK3R1)
   04380 Osteoclast differentiation
    100605788 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    100605788 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    100605788 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100605788 (PIK3R1)
   05206 MicroRNAs in cancer
    100605788 (PIK3R1)
   05205 Proteoglycans in cancer
    100605788 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    100605788 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    100605788 (PIK3R1)
   05203 Viral carcinogenesis
    100605788 (PIK3R1)
   05230 Central carbon metabolism in cancer
    100605788 (PIK3R1)
   05231 Choline metabolism in cancer
    100605788 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100605788 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100605788 (PIK3R1)
   05212 Pancreatic cancer
    100605788 (PIK3R1)
   05225 Hepatocellular carcinoma
    100605788 (PIK3R1)
   05226 Gastric cancer
    100605788 (PIK3R1)
   05214 Glioma
    100605788 (PIK3R1)
   05221 Acute myeloid leukemia
    100605788 (PIK3R1)
   05220 Chronic myeloid leukemia
    100605788 (PIK3R1)
   05218 Melanoma
    100605788 (PIK3R1)
   05211 Renal cell carcinoma
    100605788 (PIK3R1)
   05215 Prostate cancer
    100605788 (PIK3R1)
   05213 Endometrial cancer
    100605788 (PIK3R1)
   05224 Breast cancer
    100605788 (PIK3R1)
   05222 Small cell lung cancer
    100605788 (PIK3R1)
   05223 Non-small cell lung cancer
    100605788 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100605788 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    100605788 (PIK3R1)
   05161 Hepatitis B
    100605788 (PIK3R1)
   05160 Hepatitis C
    100605788 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    100605788 (PIK3R1)
   05164 Influenza A
    100605788 (PIK3R1)
   05162 Measles
    100605788 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    100605788 (PIK3R1)
   05163 Human cytomegalovirus infection
    100605788 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100605788 (PIK3R1)
   05169 Epstein-Barr virus infection
    100605788 (PIK3R1)
   05165 Human papillomavirus infection
    100605788 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100605788 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    100605788 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100605788 (PIK3R1)
   05142 Chagas disease
    100605788 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100605788 (PIK3R1)
   05017 Spinocerebellar ataxia
    100605788 (PIK3R1)
   05020 Prion disease
    100605788 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100605788 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    100605788 (PIK3R1)
   05415 Diabetic cardiomyopathy
    100605788 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100605788 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    100605788 (PIK3R1)
   04931 Insulin resistance
    100605788 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100605788 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100605788 (PIK3R1)
   01524 Platinum drug resistance
    100605788 (PIK3R1)
   01522 Endocrine resistance
    100605788 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:nle04131]
    100605788 (PIK3R1)
Membrane trafficking [BR:nle04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100605788 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 SH3_2 CEP135_TSGA10_CC Laminin_I SH3_9 ODF2_C Nucleopor_Nup85 DicA_C FANCI_S2 Exonuc_VII_L
Other DBs
NCBI-GeneID: 100605788
NCBI-ProteinID: XP_030653598
Ensembl: ENSNLEG00000003893
LinkDB
Position
18:78395089..78480864
AA seq 724 aa
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKTEADVEQQALTLPDLAE
QFAPPDVAPPLLIKLVEAIEKKGLECSTLYRTQSSSNLAELRQLLDCDAASVDLEMIDVH
VLADAFKRYLLDLPNPVIPAAVYSEMISLAQEVQSSEEYIQLLKKLIRSPSIPHQYWLTL
QYLLKHFFKLSQTSSKNLLNARVLSEIFSPMLFRFSAASSDNTENLIKVIEILISTEWNE
RQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atgagtgctgaggggtaccagtatagagcgctgtatgattacaaaaaggaaagagaagaa
gatattgatttgcacttgggtgacatattgactgtgaataaagggtccttagtagctctt
ggattcagtgatggacaggaagccaggcctgaagaaattggctggttaaatggctataat
gaaaccacaggggaaaggggggactttccgggaacttatgtagaatatattggaaggaaa
aaaatctcgcctcccacaccaaagccccggccacctcggcctcttcctgttgcaccaggt
tcttcgaaaactgaagcagatgttgaacaacaagctttgactctcccggatcttgcagag
cagtttgcccctcctgacgttgccccgcctcttcttatcaagctcgtggaagccattgaa
aagaaaggtctggaatgttcaactctatacagaacacagagctccagcaacctggcagaa
ttacgacagcttcttgattgtgatgcagcctctgtggacttggaaatgatcgatgtgcac
gttttggccgacgctttcaaacgctatctcctggacttaccaaatcctgtcattccagca
gccgtttacagtgaaatgatttctttagctcaagaagtacaaagctccgaagaatatatt
cagctattgaagaagcttattaggtcgcctagcatacctcatcagtattggcttacgctt
cagtatttgttaaaacatttcttcaagctctctcagacctccagcaaaaatctgttgaat
gcaagagtactctctgaaattttcagccctatgcttttcagattctcagcagccagctct
gataatactgaaaacctcataaaagttatagaaattttaatctcaactgaatggaatgaa
cgacagcctgcaccagcactgcctcctaagccaccaaaacccactactgtagccaacaac
ggtatgaataacaatatgtccttacaagatgctgaatggtactggggagatatctcgagg
gaagaagtgaatgaaaaacttcgagatacagcagatgggacctttttggtacgagacgcg
tctactaaaatgcatggtgattatactcttacactaaggaaagggggaaataacaaatta
atcaaaatatttcatcgagatgggaaatatggcttctctgacccattaaccttcaattct
gtggttgagttaataaaccactaccggaatgaatctctagcgcagtataatcccaaattg
gatgtgaaattactttatccagtatccaaataccaacaggatcaagttgtcaaagaagat
aatattgaagctgtagggaaaaaattacatgaatataacactcagtttcaagaaaaaagt
cgagaatatgatagattatatgaagaatatacccgtacatcccaggaaatccaaatgaaa
aggacagctattgaagcatttaatgagaccataaaaatatttgaagaacagtgccagacc
caagagcggtacagcaaagaatacatagaaaagtttaaacgtgaaggcaatgagaaagaa
atacaaaggattatgcataattatgataagctgaagtctcgaatcagtgaaattattgac
agtagaagaagattggaagaagacttgaagaagcaggcagctgagtatcgagaaattgac
aaacgtatgaacagcattaaaccagaccttatccagctgagaaagacgagagaccaatac
ttgatgtggttgactcaaaaaggtgttcggcaaaagaagttgaacgagtggttgggcaat
gaaaacactgaagaccaatattcacttgtggaagatgatgaagatttgccccatcatgat
gagaagacgtggaatgttggaagcagcaaccgaaacaaagctgaaaacctgttgcgaggg
aagcgagatggcacttttcttgtccgggagagcagtaaacagggctgctacgcctgctct
gtagtggtggacggcgaagtaaagcattgtgtcataaacaaaacagcgactggctatggc
tttgccgagccctataacttgtacagctctctgaaagaactggtgctacattaccaacac
acctccctcgtgcagcacaacgactccctcaatgtcacactagcctacccagtatatgca
cagcagaggcgatga

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