KEGG   Nomascus leucogenys (northern white-cheeked gibbon): 100606563
Entry
100606563         CDS       T03265                                 
Name
(RefSeq) LOW QUALITY PROTEIN: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
nle  Nomascus leucogenys (northern white-cheeked gibbon)
Pathway
nle00140  Steroid hormone biosynthesis
nle01100  Metabolic pathways
nle04913  Ovarian steroidogenesis
nle04925  Aldosterone synthesis and secretion
nle04927  Cortisol synthesis and secretion
nle04934  Cushing syndrome
Module
nle_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
nle_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
nle_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
nle_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:nle00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    100606563
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    100606563
   04925 Aldosterone synthesis and secretion
    100606563
   04927 Cortisol synthesis and secretion
    100606563
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100606563
Enzymes [BR:nle01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     100606563
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     100606563
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 Polysacc_synt_2 GDP_Man_Dehyd NAD_binding_10 NmrA RmlD_sub_bind KR Sacchrp_dh_NADP
Other DBs
NCBI-GeneID: 100606563
NCBI-ProteinID: XP_004093339
LinkDB
Position
12:complement(56558615..56565780)
AA seq 373 aa
MTGWSCLVTGAGGFLGQRIICLLVEETELKEIRALDRAFRPGLREEFSKLQNKTKLTVLE
GDILDEPFLKRACQDVSVVIHTACIIDIFGVTHXESIMNVNVKGTQLLLEACVQASVPVF
IYTSTLQXAGPNSYKEIIENAHEEDFLENAWPAPYPYSKXLAEKAVLAANGWTLKNGDTL
YSCALRPMYIYGEGSPFLSANINEALNNNGILSSVSKFSTVNPVYVGNVAWTHILALRAL
RDPKKAPSVQGQFYYISDDMPHQSXDNLNYILSKEFGLCLDSRWSLPLSLMYWIGFLLEI
VSLLLRPICTYLPPFDCHTVTLSNSMFTSSYKNAQRDLAYKPLYSWEGAKQKTMEWVGSL
VDRHKETLKSKTQ
NT seq 1122 nt   +upstreamnt  +downstreamnt
atgacaggctggagctgtcttgtgacaggagcaggagggtttctgggtcagaggatcatc
tgcctgttagtggaggagacagagctgaaggagatcagggccttggacagggccttcaga
ccaggattgagggaggaattttctaaactccagaacaagaccaagctgacagtgctggaa
ggagacattctggatgagccattcctgaagagagcctgccaggacgtctcggtcgtcatc
cacaccgcttgtatcattgatatcttcggagtcactcacnnagagtctatcatgaatgtc
aacgtgaaaggtacccagctcctgttggaggcctgtgtccaagctagtgtgccagtcttc
atctacaccagtaccctgcagtaagccgggcccaactcctacaaggaaatcattgagaat
gcccatgaagaggactttctggaaaatgcatggcccgctccatatccatacagcaaantg
cttgctgagaaggctgtgctggcagctaatgggtggactctgaaaaatggtgataccttg
tacagttgtgccttaagacccatgtatatctatggggaaggaagcccatttctttctgcc
aatataaatgaggccctgaacaacaatgggatcctgtcgagtgtcagcaagttctccaca
gtcaacccagtctatgttggcaacgtggcctggacccacattctggccttgagggccctg
cgggaccccaagaaggccccaagtgtccaaggacagttctactatatctcagatgacatg
cctcaccaaagctaagataatcttaattacatcctgagcaaagagtttggcctctgcctt
gattccagatggagccttcctttatccctgatgtactggattggcttcctgctggaaata
gtgagcctcctgctcaggccaatttgcacctatctaccgcccttcgactgccacacagtg
acattgtcaaatagcatgtttacctcctcttacaagaacgctcagagagatctggcatat
aagccactttacagctgggagggagccaagcagaaaaccatggagtgggttggttccctt
gtggatcggcacaaggagaccctaaagtccaagactcagtga

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