Nomascus leucogenys (northern white-cheeked gibbon): 100607873
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Entry
100607873 CDS
T03265
Symbol
IRS1
Name
(RefSeq) insulin receptor substrate 1
KO
K16172
insulin receptor substrate 1
Organism
nle
Nomascus leucogenys (northern white-cheeked gibbon)
Pathway
nle04022
cGMP-PKG signaling pathway
nle04068
FoxO signaling pathway
nle04081
Hormone signaling
nle04140
Autophagy - animal
nle04150
mTOR signaling pathway
nle04151
PI3K-Akt signaling pathway
nle04152
AMPK signaling pathway
nle04211
Longevity regulating pathway
nle04213
Longevity regulating pathway - multiple species
nle04722
Neurotrophin signaling pathway
nle04910
Insulin signaling pathway
nle04920
Adipocytokine signaling pathway
nle04923
Regulation of lipolysis in adipocytes
nle04930
Type II diabetes mellitus
nle04931
Insulin resistance
nle04932
Non-alcoholic fatty liver disease
nle04935
Growth hormone synthesis, secretion and action
nle04960
Aldosterone-regulated sodium reabsorption
nle05010
Alzheimer disease
nle05206
MicroRNAs in cancer
nle05415
Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:
nle00001
]
09130 Environmental Information Processing
09132 Signal transduction
04068 FoxO signaling pathway
100607873 (IRS1)
04022 cGMP-PKG signaling pathway
100607873 (IRS1)
04151 PI3K-Akt signaling pathway
100607873 (IRS1)
04152 AMPK signaling pathway
100607873 (IRS1)
04150 mTOR signaling pathway
100607873 (IRS1)
09133 Signaling molecules and interaction
04081 Hormone signaling
100607873 (IRS1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
100607873 (IRS1)
09150 Organismal Systems
09152 Endocrine system
04910 Insulin signaling pathway
100607873 (IRS1)
04923 Regulation of lipolysis in adipocytes
100607873 (IRS1)
04920 Adipocytokine signaling pathway
100607873 (IRS1)
04935 Growth hormone synthesis, secretion and action
100607873 (IRS1)
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
100607873 (IRS1)
09156 Nervous system
04722 Neurotrophin signaling pathway
100607873 (IRS1)
09149 Aging
04211 Longevity regulating pathway
100607873 (IRS1)
04213 Longevity regulating pathway - multiple species
100607873 (IRS1)
09160 Human Diseases
09161 Cancer: overview
05206 MicroRNAs in cancer
100607873 (IRS1)
09164 Neurodegenerative disease
05010 Alzheimer disease
100607873 (IRS1)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
100607873 (IRS1)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
100607873 (IRS1)
04932 Non-alcoholic fatty liver disease
100607873 (IRS1)
04931 Insulin resistance
100607873 (IRS1)
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Motif
Pfam:
IRS
PH
PH_11
Motif
Other DBs
NCBI-GeneID:
100607873
NCBI-ProteinID:
XP_003274751
Ensembl:
ENSNLEG00000013357
UniProt:
A0A2I3GVA0
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All DBs
Position
22a:complement(127376435..127443421)
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AA seq
1243 aa
AA seq
DB search
MASPPESDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH
HDGAGALGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI
GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV
DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT
RRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR
GSARLHPPLNHSRSIPMPASRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP
SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGPSTLTAPN
GHYILSRGGNGHRYAPGTGLGTSPALAGDEAASAADLDNRFRKRTHSAGTSPTITHQKTP
SQSSVASIEEYTEMMPAYPPGGGSGGRLPGHRHSAFVPTHSYPEEGLEMHPLERRGGHHR
PDSSTLHTDDGYMPMSPGVAPVPSSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN
GYMMMSPSGGCSPDIGGGPSSSSSNAVPSGSSYGKLWTNGVGGHHSHVLPHPKPPVESSG
GKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEE
GARHQHLRLSTSSGRLLYAATADDSSSSTSSDSLGGGYCGARLEPSLPHPHHQVLQPHLP
RKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQQQQQQPLLHPPEPKSPGEYVNIE
FGSDQPGYLSGLVASHSSPSVRCPSQLQPAPREEETGTEEYMKMDLGPGRRAAWQESTGV
EMGRLGPAPPGAASICRPTRAVPSSRGDYMTMQMSCPRQSYVDTSPAAPVSYADMRTGIA
AEEVSLPRATMAAASSSSAASASPTGPQGAAELAAHSSLLGGPQGPGGMSAFTRVNLSPN
RNQSAKVIRADPQGCRRRHSSETFSSTPSATRVSNTVPFGAGAAVGGGGGSSSSSSEDVK
RHSSASFENVWLRPGELGGAPKEPAQLCGAAGGLENGLNYIDLDLVKDFKQRPQECTPEP
QPPPPPPPHQPLGSGESSSTRCSSEDLSAYASISFQKQPEDRQ
NT seq
3732 nt
NT seq
+upstream
nt +downstream
nt
atggcgagccctccggagagcgatggcttctcggacgtgcgcaaggtgggctacctgcgc
aaacccaagagcatgcacaaacgcttcttcgtactgcgcgcggccagcgaggctgggggc
ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc
aaacgctcgatcccccttgagagctgcttcaacatcaacaagcgggctgactccaagaac
aagcacctggtggctctctacacccgggacgagcactttgccatcgcggcggatagcgag
gccgagcaagacagctggtaccaggctctcctacagctgcacaaccgtgctaagggccac
cacgacggagctggggccctcggggcgggaggtggcgggggcagctgcagcggcagctcc
ggccttggtgaggctggggaggacttgagctacggtgacgtgcccccaggacccgcattc
aaagaggtctggcaggtgatcctgaagcccaagggcctgggtcagacaaagaacctgatt
ggtatctaccgcctctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag
gcagccgccgtggtgctgcagctgatgaacatcaggcgctgtggccactcggagaacttc
ttcttcatcgaggtgggccgttctgctgtgacggggcccggggagttctggatgcaggtg
gatgactccgtggtggcccagaacatgcatgagaccatcctggaggccatgcgggccatg
agtgacgagttccgccctcgcagcaagagccagtcctcgtccaactgctctaaccccatc
agcgtgcccctgcgccggcaccatctcaacaaccccccgcccagccaggtggggctgacc
cgcagatcgcgcactgagagcattactgccacctccccggccagcatggtgggcgggaag
ccaggctccttccgtgtccgcgcctccagtgacggcgaaggcaccatgtcccgcccagcc
tcggtggacggcagccctgtgagtcccagcaccaacagaacccacgcccaccggcatcgg
ggcagcgcccggctgcatcccccgctcaaccacagccgctccatccccatgccggcttcc
cgctgctcgccttcggccaccagcccggtcagtctgtcgtccagcagcaccagtggccat
ggctccacctcggattgtctcttcccacggcgatctagtgcttcggtgtctggttccccc
agcgatggcggtttcatctcctcggatgagtatggctccagtccctgcgatttccggagt
tccttccgcagtgtcactccggattccctgggccacaccccaccagcccgcggtgaggag
gagctaagcaactatatctgcatgggtggcaaggggccttccaccctgaccgcccccaac
ggtcactatattttgtctcggggtggcaatggccaccgctacgccccaggaacaggcttg
ggcacgagtccagccttggctggggatgaagcagccagtgctgcagatctggataatcgg
ttccgaaagagaactcactcggcaggcacatcccctaccattacccaccagaagaccccg
tcccagtcctcagtggcttccattgaggagtatacagagatgatgcctgcctacccacca
ggaggtggcagtggaggccgactgccgggacacaggcactccgccttcgtgcccacccac
tcctacccagaggagggtctggaaatgcaccccttggagcgtcgggggggccaccaccgc
ccagacagctccaccctccacactgatgatggctacatgcccatgtccccaggggttgcc
ccagtgcccagcagccgaaagggcagtggagactatatgcccatgagccccaagagtgtg
tctgccccacagcagatcatcaatcccatcagacgccatccccagagagtggaccccaat
ggctacatgatgatgtctcccagtggcggctgctctcctgacattggaggtggccccagc
agcagcagcagcaatgccgtcccttccgggagcagctatggaaagctgtggacaaacggg
gtagggggccaccactctcatgtcttgcctcaccccaaacccccagtggagagcagtggt
ggtaagctcttaccttgcacaggtgactacatgaacatgtcaccagtgggggactccaac
accagcagcccctccgactgctactatggccctgaggacccccagcacaagccagtcctc
tcctactactcattgccaagatcctttaagcacacccagcgccctggagagccggaggag
ggtgcccggcatcagcacctccgtctttccactagctctggtcgccttctctatgctgca
acagcggatgattcttcctcttccaccagcagtgacagcctgggtgggggatactgtggg
gctaggctggagcccagccttccacatccccaccatcaggttctgcagccccatctgcct
cgaaaggtggacacagctgctcagaccaatagccgcctggcccggcccacgaggctgtcc
ctgggggatcccaaggccagcaccttacctcgggcccgagagcagcagcagcagcagcag
cagcagcccctgctgcaccctccagaacccaagagcccaggggaatatgtcaatattgaa
ttcgggagtgatcagcctggctacttgtctggcctggtggcttcccacagctcaccttct
gtcaggtgtccatcccagctccagccagctcccagagaggaagagactggcactgaggag
tacatgaagatggacctggggccgggccggagggcagcctggcaggagagcactggggtc
gagatgggcagactgggccccgcacctcctggggctgctagcatttgcaggcctacccgg
gcagtgcccagcagccggggtgactacatgaccatgcagatgagttgtccccgtcagagc
tacgtggacacctcgccagctgcccctgtaagctatgctgacatgcggacaggcattgct
gccgaggaagtgagcctgcccagggccaccatggctgctgcctcctcatcctcagcagcc
tctgcttccccgactgggcctcaaggggcagcagagctggctgcccactcgtccctgctg
gggggcccacaaggacctgggggcatgagcgccttcacccgggtgaacctcagtcctaac
cgcaaccagagtgccaaagtgatccgtgcagacccacaagggtgccggcggaggcatagc
tctgagaccttctcctcaacacccagtgccacccgggtgagcaacacagtgccctttgga
gcgggggcagcagtagggggtggtggcggtagcagcagcagcagcagcgaggatgtgaaa
cgccacagctctgcttcctttgagaatgtgtggctgaggcctggggagcttgggggagcc
cccaaggagccagcccaactgtgtggggctgctgggggtttggagaatggtctcaactac
atagacctggatttggtcaaggacttcaaacagcgccctcaggagtgcacccctgaaccg
cagcctcccccacccccaccccctcatcaacccctgggcagcggtgagagcagctccacc
cgctgctcaagtgaggatttaagcgcctatgccagcatcagtttccagaagcagccagag
gaccgtcagtag
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