Neomonachus schauinslandi (Hawaiian monk seal): 110574308
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Entry
110574308 CDS
T08474
Symbol
IRS1
Name
(RefSeq) insulin receptor substrate 1
KO
K16172
insulin receptor substrate 1
Organism
nsu
Neomonachus schauinslandi (Hawaiian monk seal)
Pathway
nsu04022
cGMP-PKG signaling pathway
nsu04068
FoxO signaling pathway
nsu04081
Hormone signaling
nsu04140
Autophagy - animal
nsu04150
mTOR signaling pathway
nsu04151
PI3K-Akt signaling pathway
nsu04152
AMPK signaling pathway
nsu04211
Longevity regulating pathway
nsu04213
Longevity regulating pathway - multiple species
nsu04722
Neurotrophin signaling pathway
nsu04910
Insulin signaling pathway
nsu04920
Adipocytokine signaling pathway
nsu04923
Regulation of lipolysis in adipocytes
nsu04930
Type II diabetes mellitus
nsu04931
Insulin resistance
nsu04932
Non-alcoholic fatty liver disease
nsu04935
Growth hormone synthesis, secretion and action
nsu04960
Aldosterone-regulated sodium reabsorption
nsu05010
Alzheimer disease
nsu05206
MicroRNAs in cancer
nsu05415
Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:
nsu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04068 FoxO signaling pathway
110574308 (IRS1)
04022 cGMP-PKG signaling pathway
110574308 (IRS1)
04151 PI3K-Akt signaling pathway
110574308 (IRS1)
04152 AMPK signaling pathway
110574308 (IRS1)
04150 mTOR signaling pathway
110574308 (IRS1)
09133 Signaling molecules and interaction
04081 Hormone signaling
110574308 (IRS1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
110574308 (IRS1)
09150 Organismal Systems
09152 Endocrine system
04910 Insulin signaling pathway
110574308 (IRS1)
04923 Regulation of lipolysis in adipocytes
110574308 (IRS1)
04920 Adipocytokine signaling pathway
110574308 (IRS1)
04935 Growth hormone synthesis, secretion and action
110574308 (IRS1)
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
110574308 (IRS1)
09156 Nervous system
04722 Neurotrophin signaling pathway
110574308 (IRS1)
09149 Aging
04211 Longevity regulating pathway
110574308 (IRS1)
04213 Longevity regulating pathway - multiple species
110574308 (IRS1)
09160 Human Diseases
09161 Cancer: overview
05206 MicroRNAs in cancer
110574308 (IRS1)
09164 Neurodegenerative disease
05010 Alzheimer disease
110574308 (IRS1)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
110574308 (IRS1)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
110574308 (IRS1)
04932 Non-alcoholic fatty liver disease
110574308 (IRS1)
04931 Insulin resistance
110574308 (IRS1)
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Motif
Pfam:
IRS
PH
PH_11
Motif
Other DBs
NCBI-GeneID:
110574308
NCBI-ProteinID:
XP_021538627
UniProt:
A0A2Y9GHR0
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Position
3:complement(181174683..181233839)
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AA seq
1236 aa
AA seq
DB search
MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH
HDGAAAPGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI
GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV
DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT
RRSRTESITATSPASMVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR
GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP
SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGSSTLTAPN
GHYILPRGGNGHRCVPGAGLGTSPALAGDEAASAVDLDNRFRKRTHSAGTSPTISHQKTP
SQSSVASIEEYTEMMMPPYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHPLDRRGGHH
RPDSSTLHTDDGYMPMSPGVAPVPSSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDP
NGYMMMSPSSSCSPDTGGGPSSSAAPSGSSYGKLWTNGVGGHHAHALPHPKLPMESGSGK
LLSCTGDYMNMSPVGGSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGELEEGA
RHQHLRLSSSSGRLLYATTAEDSSSSTSSDSLGGVYCGVRPDPGLPHVHHQVLQPHLPRK
VDTAAQTHSRLARPTRLSLGDPKASTLPRVREQQQLPPLLRPPPEPKSPGEYVNIEFGSD
QPAYLSGPVASHSSPSVRCPSQLQPAPREDETGTEEYMNMDLGPGRRATWQESAGVQPGS
AGPAPPGAASMCRPTRAVPSSREDYMTMQMGCPGQGYVDTSPVAPVSYADMRTGIVVEEA
SLPGATAAAPSSSSAASASPTAPQKAGELVARSSLLGGPQGPGGVSAFTRVNLSPNRTQS
AKVIRADPQGCRRRHSSETFSSTPSATRAGNAVPFGGGAAVGGSGAGSSTTEDMKRHSSA
SFENVWLRPGELGGAPKEPAQVCGAAGGLENGLNYIDLDLVKDFKQRPQERPPQPPLPPP
PHQPLGSRESRSSSRSSEDLSAYASLSFQKQPEDLQ
NT seq
3711 nt
NT seq
+upstream
nt +downstream
nt
atggcgagccctccggagaccgacggcttctcggacgtgcgcaaggtgggctacctgcgc
aaacccaagagcatgcacaagcgcttcttcgtgctgcgggcggccagcgaggcggggggc
ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc
aaacgctcgatccccctcgagagctgcttcaacatcaacaagcgggcggactccaagaac
aagcacctggtggccctttacacccgggacgagcattttgccatcgcggcggacagcgag
gccgagcaggacagctggtaccaggccctcctgcagctgcacaaccgggccaagggccac
cacgacggggccgcggcccccggggcaggaggcggcgggggcagctgcagcggcagctcg
ggccttggggaggctggggaggacttgagctacggggacgtgcccccaggacctgcgttc
aaggaggtctggcaggtgatcctgaaacccaagggcctgggtcagacaaagaacttgatt
ggcatctaccgtctctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag
gcggcggccgtggtgctgcagctgatgaacatcagacgctgcggccattcagagaacttc
ttcttcatcgaagtgggccgttccgcagtgacaggacctggggagttctggatgcaggtg
gatgactctgtggtggcccagaacatgcacgagaccatcctggaggccatgcgggccatg
agcgatgagttccgtcctcgaagtaagagccagtcctcctccaactgctccaaccccatc
agcgtccccctgcgcaggcaccacctcaacaaccccccgcccagccaggtggggctgacg
cgccgctcgcggaccgagagcatcaccgccacctcaccggccagcatggtgggcggcaag
cagggctccttccgtgtgcgcgcgtccagcgacggcgaaggcaccatgtcccgcccggcc
tcggtggacggcagccccgtgagtcccagcaccaacaggacccacgcccaccggcatcgc
ggcagctcccggctgcacccccctctcaaccacagccgctccatccccatgccttcttcc
cgctgctcgccttccgccaccagcccggtcagcctgtcgtccagcagcaccagcggccac
ggctccacctcggactgtctcttcccgcggcggtctagtgcttctgtgtcgggttccccc
agcgatggcggcttcatctcctccgatgagtacggctccagcccttgcgatttccgaagt
tccttccgcagtgtcaccccggattccctgggccacacgccaccggcccgcggtgaggag
gagctgagcaactacatctgcatgggaggcaaagggtcctccaccctcaccgcccccaat
ggtcactacattttgcctcggggtggcaacggtcaccgctgcgtcccaggagctggcttg
ggtacgagcccagccctggctggggatgaagcagccagtgctgtagatctggataatcgg
ttccgcaagcggactcactccgcgggcacatcccctaccatttcccaccagaagacccca
tcccagtcatctgtggcttccattgaggaatacacagagatgatgatgcctccctacccg
ccaggaggtggcagtggaggccggctgcctggctaccggcactctgctttcgtgcccacc
cactcctaccctgaggagggtctggaaatgcaccctttggacaggcgtgggggccaccac
cgcccagactcctccactctccacacggatgatggttacatgcctatgtccccaggagtg
gcgccagtgcccagcagccgaaagggcagtggcgactatatgcccatgagccccaagagc
gtgtcggcgccgcagcagatcatcaacccgatcagacgccatccccagagagtggacccc
aatggctacatgatgatgtccccaagcagcagctgctccccggacactggaggtggaccc
agcagcagcgccgccccttctgggagcagctacggcaagctgtggacaaatggggtaggg
ggccaccacgctcacgccctgccgcatcccaaactgcccatggagagcgggagtggcaag
ctcttgtcttgtactggtgactacatgaacatgtcgccagtggggggctccaacaccagc
agcccctccgactgctactacggcccggaggacccccagcacaagccagttctctcctac
tactcattgccaaggtcctttaagcacacccagcggcctggggagctggaggagggtgct
cggcaccagcacctccgcctttcctccagctctggccgccttctctatgctacaacggcg
gaagattcctcctcgtccaccagcagcgacagcctgggcggggtatactgtggggtgagg
ccggatcctggcctcccgcatgtccaccatcaggtcctgcagccccatctgcctcgaaag
gtggacacagctgcccagacccacagccgcctggctcggcccacgaggctgtccctgggg
gaccccaaggccagcaccttacctcgggtcagggagcaacagcagctcccgcccctgctg
cgccctcccccggagcccaagagccccggcgaatatgtgaatattgaatttgggagtgat
cagccagcttatttatctggtcctgtggcttcccacagctcgccttctgtcaggtgccca
tcccagctccagccagctccccgagaggacgagactggcaccgaggaatacatgaacatg
gacctggggccaggccggagggcgacctggcaggagagcgctggggtccagccaggcagt
gcgggccctgcacctcccggtgctgctagcatgtgcaggcctacccgggcagtgcccagc
agccgggaggactacatgaccatgcagatgggctgccctgggcagggctacgtggacacc
tcaccagttgcccccgtcagctatgccgacatgcggacaggcattgttgtggaggaggcc
agccttccaggggccacagcggccgctccctcctcatcctctgcagcctctgcttccccc
accgcgcctcaaaaagcaggggagctggtggcccgctcttcccttctggggggcccccag
ggacctgggggcgtgagcgccttcacccgggtgaacctcagtcccaaccgtacgcagagt
gccaaagtgatccgtgcggacccacaagggtgccggaggcggcatagctctgagaccttc
tcgtccacaccgagtgccacccgggcgggcaacgcggtgccctttggagggggggctgct
gtagggggcagcggtgctggcagcagcaccacagaggatatgaaacgccacagttctgct
tcttttgagaatgtgtggctgaggcctggggagctcgggggagcccccaaggagccggcc
caagtgtgcggggctgctgggggtttggagaatgggcttaactacatagacctggatttg
gtcaaggacttcaaacagcgccctcaggagcgcccccctcaaccgcccctgcccccgccc
cctcatcagcctctgggcagcagggagagccgctccagcagccgctccagcgaggattta
agcgcgtatgccagcctcagtttccagaagcagccagaggacctccagtag
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