KEGG   Neomonachus schauinslandi (Hawaiian monk seal): 110580487
Entry
110580487         CDS       T08474                                 
Symbol
HSD3B2
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
nsu  Neomonachus schauinslandi (Hawaiian monk seal)
Pathway
nsu00140  Steroid hormone biosynthesis
nsu01100  Metabolic pathways
nsu04913  Ovarian steroidogenesis
nsu04925  Aldosterone synthesis and secretion
nsu04927  Cortisol synthesis and secretion
nsu04934  Cushing syndrome
Module
nsu_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
nsu_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
nsu_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:nsu00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    110580487 (HSD3B2)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    110580487 (HSD3B2)
   04925 Aldosterone synthesis and secretion
    110580487 (HSD3B2)
   04927 Cortisol synthesis and secretion
    110580487 (HSD3B2)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    110580487 (HSD3B2)
Enzymes [BR:nsu01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     110580487 (HSD3B2)
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     110580487 (HSD3B2)
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 GDP_Man_Dehyd Polysacc_synt_2 NAD_binding_10 NmrA RmlD_sub_bind KR Sacchrp_dh_NADP
Other DBs
NCBI-GeneID: 110580487
NCBI-ProteinID: XP_021545875
UniProt: A0A2Y9H7N6
LinkDB
Position
4:99470787..99479001
AA seq 373 aa
MAGWSCLVTGAGGFLGQRIVRLLVEEKELQEIRALDKVFRPEQREEFSKLQSKTKVIMVE
GDILDEQCLKRACQGTSVVIHTASVIDVMNVIHRETIMNVNLKGTQLLLEACAQANVPTF
IYTSTIEVAGPNSYREIIQNGHEEEHLESRWSAPYPYSKKLAEKAVLAANGWALKNGGTL
HTCALRPMYIYGEGSIFLYDYIYKALRNNGILTHHSKFSVVNPVYVGNVAWAHILALRAL
RDPKKAPSVRGQFYYISDDTPHQSYDDLNYTLSKEWGFSLDSRMSLPIFLEYWLAFLLEI
VSFLLSPIYKYQPPFNRHTVTLLNSVFTFSYKKAQRDLGYKPLFSWEEAKQKTMEWIGSL
VKQHRETLKTKTH
NT seq 1122 nt   +upstreamnt  +downstreamnt
atggctgggtggagctgccttgtgacaggtgcaggagggtttctgggtcaaaggatcgtt
cgcttgttggtggaggagaaggagctgcaggagatccgggcactggacaaagtcttcaga
ccggaacagcgggaggaattttctaagctccagagcaagaccaaggtgatcatggtggaa
ggagacattctggatgagcagtgcctgaagagagcctgccagggcacttcagttgtcatt
cacaccgcttctgtcattgacgtcatgaatgtcattcaccgagagaccatcatgaatgtc
aatctgaagggtacccagctgctgttggaagcctgtgcccaggctaatgtgccgaccttc
atctataccagcaccatagaggtggctgggcccaactcctacagggagatcatccagaat
ggccacgaagaagagcatctcgaatcaagatggtctgctccatacccctacagcaaaaag
ctcgcagagaaggcagtgctggctgctaacgggtgggctcttaaaaacggcggcaccctg
catacctgtgccttaaggcccatgtatatctatggggaaggaagcatattcctttatgac
tatatatacaaggccctgaggaacaatggcatcctgacacatcatagcaagttctctgta
gtcaaccctgtctatgttggcaatgtggcctgggctcacattctggccttgagggcccta
cgggaccccaagaaggccccaagtgtccgaggacagttctattacatctcagatgacaca
cctcaccaaagctatgatgacctcaattacactttgagcaaggaatggggcttctccctg
gattccagaatgagccttcctatatttctggagtactggcttgccttcctactggaaata
gtgagcttcctgctcagtccaatttacaaatatcaaccccccttcaaccgccacacagtg
acattgttaaatagtgtatttaccttctcctataagaaagctcagagggatctggggtat
aagccactcttcagctgggaggaagccaagcagaaaaccatggagtggattggctccctg
gtgaaacagcacagagagaccctaaaaacgaagactcactga

DBGET integrated database retrieval system