KEGG   Neomonachus schauinslandi (Hawaiian monk seal): 110591287
Entry
110591287         CDS       T08474                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
nsu  Neomonachus schauinslandi (Hawaiian monk seal)
Pathway
nsu01521  EGFR tyrosine kinase inhibitor resistance
nsu01522  Endocrine resistance
nsu01524  Platinum drug resistance
nsu04012  ErbB signaling pathway
nsu04014  Ras signaling pathway
nsu04015  Rap1 signaling pathway
nsu04024  cAMP signaling pathway
nsu04062  Chemokine signaling pathway
nsu04066  HIF-1 signaling pathway
nsu04068  FoxO signaling pathway
nsu04070  Phosphatidylinositol signaling system
nsu04071  Sphingolipid signaling pathway
nsu04072  Phospholipase D signaling pathway
nsu04081  Hormone signaling
nsu04140  Autophagy - animal
nsu04145  Phagocytosis
nsu04150  mTOR signaling pathway
nsu04151  PI3K-Akt signaling pathway
nsu04152  AMPK signaling pathway
nsu04210  Apoptosis
nsu04211  Longevity regulating pathway
nsu04213  Longevity regulating pathway - multiple species
nsu04218  Cellular senescence
nsu04360  Axon guidance
nsu04370  VEGF signaling pathway
nsu04380  Osteoclast differentiation
nsu04510  Focal adhesion
nsu04517  IgSF CAM signaling
nsu04518  Integrin signaling
nsu04550  Signaling pathways regulating pluripotency of stem cells
nsu04611  Platelet activation
nsu04613  Neutrophil extracellular trap formation
nsu04620  Toll-like receptor signaling pathway
nsu04625  C-type lectin receptor signaling pathway
nsu04630  JAK-STAT signaling pathway
nsu04650  Natural killer cell mediated cytotoxicity
nsu04660  T cell receptor signaling pathway
nsu04662  B cell receptor signaling pathway
nsu04664  Fc epsilon RI signaling pathway
nsu04666  Fc gamma R-mediated phagosome formation
nsu04668  TNF signaling pathway
nsu04670  Leukocyte transendothelial migration
nsu04722  Neurotrophin signaling pathway
nsu04725  Cholinergic synapse
nsu04750  Inflammatory mediator regulation of TRP channels
nsu04810  Regulation of actin cytoskeleton
nsu04910  Insulin signaling pathway
nsu04914  Progesterone-mediated oocyte maturation
nsu04915  Estrogen signaling pathway
nsu04917  Prolactin signaling pathway
nsu04919  Thyroid hormone signaling pathway
nsu04923  Regulation of lipolysis in adipocytes
nsu04926  Relaxin signaling pathway
nsu04929  GnRH secretion
nsu04930  Type II diabetes mellitus
nsu04931  Insulin resistance
nsu04932  Non-alcoholic fatty liver disease
nsu04933  AGE-RAGE signaling pathway in diabetic complications
nsu04935  Growth hormone synthesis, secretion and action
nsu04960  Aldosterone-regulated sodium reabsorption
nsu04973  Carbohydrate digestion and absorption
nsu05010  Alzheimer disease
nsu05017  Spinocerebellar ataxia
nsu05020  Prion disease
nsu05100  Bacterial invasion of epithelial cells
nsu05135  Yersinia infection
nsu05142  Chagas disease
nsu05146  Amoebiasis
nsu05160  Hepatitis C
nsu05161  Hepatitis B
nsu05162  Measles
nsu05163  Human cytomegalovirus infection
nsu05164  Influenza A
nsu05165  Human papillomavirus infection
nsu05166  Human T-cell leukemia virus 1 infection
nsu05167  Kaposi sarcoma-associated herpesvirus infection
nsu05168  Herpes simplex virus 1 infection
nsu05169  Epstein-Barr virus infection
nsu05170  Human immunodeficiency virus 1 infection
nsu05171  Coronavirus disease
nsu05200  Pathways in cancer
nsu05203  Viral carcinogenesis
nsu05205  Proteoglycans in cancer
nsu05206  MicroRNAs in cancer
nsu05207  Chemical carcinogenesis - receptor activation
nsu05208  Chemical carcinogenesis - reactive oxygen species
nsu05210  Colorectal cancer
nsu05211  Renal cell carcinoma
nsu05212  Pancreatic cancer
nsu05213  Endometrial cancer
nsu05214  Glioma
nsu05215  Prostate cancer
nsu05218  Melanoma
nsu05220  Chronic myeloid leukemia
nsu05221  Acute myeloid leukemia
nsu05222  Small cell lung cancer
nsu05223  Non-small cell lung cancer
nsu05224  Breast cancer
nsu05225  Hepatocellular carcinoma
nsu05226  Gastric cancer
nsu05230  Central carbon metabolism in cancer
nsu05231  Choline metabolism in cancer
nsu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
nsu05415  Diabetic cardiomyopathy
nsu05417  Lipid and atherosclerosis
nsu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:nsu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    110591287 (PIK3R1)
   04014 Ras signaling pathway
    110591287 (PIK3R1)
   04015 Rap1 signaling pathway
    110591287 (PIK3R1)
   04370 VEGF signaling pathway
    110591287 (PIK3R1)
   04630 JAK-STAT signaling pathway
    110591287 (PIK3R1)
   04668 TNF signaling pathway
    110591287 (PIK3R1)
   04066 HIF-1 signaling pathway
    110591287 (PIK3R1)
   04068 FoxO signaling pathway
    110591287 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    110591287 (PIK3R1)
   04072 Phospholipase D signaling pathway
    110591287 (PIK3R1)
   04071 Sphingolipid signaling pathway
    110591287 (PIK3R1)
   04024 cAMP signaling pathway
    110591287 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    110591287 (PIK3R1)
   04152 AMPK signaling pathway
    110591287 (PIK3R1)
   04150 mTOR signaling pathway
    110591287 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    110591287 (PIK3R1)
   04517 IgSF CAM signaling
    110591287 (PIK3R1)
   04518 Integrin signaling
    110591287 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    110591287 (PIK3R1)
   04140 Autophagy - animal
    110591287 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    110591287 (PIK3R1)
   04218 Cellular senescence
    110591287 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    110591287 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    110591287 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    110591287 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    110591287 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    110591287 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    110591287 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    110591287 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    110591287 (PIK3R1)
   04660 T cell receptor signaling pathway
    110591287 (PIK3R1)
   04662 B cell receptor signaling pathway
    110591287 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    110591287 (PIK3R1)
   04666 Fc gamma R-mediated phagosome formation
    110591287 (PIK3R1)
   04670 Leukocyte transendothelial migration
    110591287 (PIK3R1)
   04062 Chemokine signaling pathway
    110591287 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    110591287 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    110591287 (PIK3R1)
   04929 GnRH secretion
    110591287 (PIK3R1)
   04915 Estrogen signaling pathway
    110591287 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    110591287 (PIK3R1)
   04917 Prolactin signaling pathway
    110591287 (PIK3R1)
   04926 Relaxin signaling pathway
    110591287 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    110591287 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    110591287 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    110591287 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    110591287 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    110591287 (PIK3R1)
   04722 Neurotrophin signaling pathway
    110591287 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    110591287 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    110591287 (PIK3R1)
   04380 Osteoclast differentiation
    110591287 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    110591287 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    110591287 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    110591287 (PIK3R1)
   05206 MicroRNAs in cancer
    110591287 (PIK3R1)
   05205 Proteoglycans in cancer
    110591287 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    110591287 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    110591287 (PIK3R1)
   05203 Viral carcinogenesis
    110591287 (PIK3R1)
   05230 Central carbon metabolism in cancer
    110591287 (PIK3R1)
   05231 Choline metabolism in cancer
    110591287 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    110591287 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    110591287 (PIK3R1)
   05212 Pancreatic cancer
    110591287 (PIK3R1)
   05225 Hepatocellular carcinoma
    110591287 (PIK3R1)
   05226 Gastric cancer
    110591287 (PIK3R1)
   05214 Glioma
    110591287 (PIK3R1)
   05221 Acute myeloid leukemia
    110591287 (PIK3R1)
   05220 Chronic myeloid leukemia
    110591287 (PIK3R1)
   05218 Melanoma
    110591287 (PIK3R1)
   05211 Renal cell carcinoma
    110591287 (PIK3R1)
   05215 Prostate cancer
    110591287 (PIK3R1)
   05213 Endometrial cancer
    110591287 (PIK3R1)
   05224 Breast cancer
    110591287 (PIK3R1)
   05222 Small cell lung cancer
    110591287 (PIK3R1)
   05223 Non-small cell lung cancer
    110591287 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    110591287 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    110591287 (PIK3R1)
   05161 Hepatitis B
    110591287 (PIK3R1)
   05160 Hepatitis C
    110591287 (PIK3R1)
   05171 Coronavirus disease
    110591287 (PIK3R1)
   05164 Influenza A
    110591287 (PIK3R1)
   05162 Measles
    110591287 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    110591287 (PIK3R1)
   05163 Human cytomegalovirus infection
    110591287 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    110591287 (PIK3R1)
   05169 Epstein-Barr virus infection
    110591287 (PIK3R1)
   05165 Human papillomavirus infection
    110591287 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    110591287 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    110591287 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    110591287 (PIK3R1)
   05142 Chagas disease
    110591287 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    110591287 (PIK3R1)
   05017 Spinocerebellar ataxia
    110591287 (PIK3R1)
   05020 Prion disease
    110591287 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    110591287 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    110591287 (PIK3R1)
   05415 Diabetic cardiomyopathy
    110591287 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    110591287 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    110591287 (PIK3R1)
   04931 Insulin resistance
    110591287 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    110591287 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    110591287 (PIK3R1)
   01524 Platinum drug resistance
    110591287 (PIK3R1)
   01522 Endocrine resistance
    110591287 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:nsu04131]
    110591287 (PIK3R1)
Membrane trafficking [BR:nsu04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    110591287 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 AAA_13 CEP135_TSGA10_CC SH3_9 SH3_2 CCDC113_CCDC96_CC ODF2_C Laminin_I ACDC Exonuc_VII_L
Other DBs
NCBI-GeneID: 110591287
NCBI-ProteinID: XP_021557843
UniProt: A0A2Y9I1U1
LinkDB
Position
7:49279197..49353364
AA seq 725 aa
MSAEGYQYRALYDYKKERDEDIDLHLGDVLTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKKISPPTPKPRPPRPLPVAPGSSKAEADSEQQQALALPDLA
EQFAPPDIAPPLLVKLVEAIEKKGLECSTLYRTQSSSNPAELRQLLDCDAASMDLEMIDV
QVLGDAFKRYLVDLPNPVIPVAVYNEMIYLAQEVQSPEEYIQLLKKLIRAPNIPHQYWLT
LQYLLKHFFKLSQTSSKNLLSARVLSELFSPLLFRFPAASSENTEHLIKVIEILISTEWN
ERQPAPALPPKPPKPTTVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRD
ASTKMHGDYTLTLRKGGNNKLIKIFHQDGKYGFSDPLTFNSVVELINHYRNESLAQYNPK
LDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEDYTRTSQEIQM
KRTAIEAFNETIKIFEEQCQSQERYSKEYIEKFKREGNEKEIQRIMHNYEKLKSRISEIV
DSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLG
NENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYAC
SVVVDGEVKHCVINKTATGYGFAEPYNLYGSLKELVLHYQHTSLVQHNDSLNVTLAYPVY
AQQRR
NT seq 2178 nt   +upstreamnt  +downstreamnt
atgagtgccgagggctatcagtaccgagcgctgtatgattacaagaaggaacgagacgaa
gatattgacttgcacttgggtgatgtcttgactgtgaataaagggtccttagtagctctt
ggattcagtgacggacaggaagccaggcctgaagaaatcggctggttaaatggttataat
gaaaccacaggggaaagaggggactttccaggaacttatgttgaatatattggaaggaaa
aaaatctcgcctcccacaccaaagccccgaccacctcgaccccttcctgttgcaccaggt
tcttcgaaagctgaagcagacagtgagcaacagcaagctttggcccttccagatctcgcc
gagcagtttgcccctcctgacattgccccgcctcttctcgtgaagctagtggaagccatt
gaaaagaaaggtctggaatgttcaactctatacagaacacagagctccagcaacccagca
gaattacgacagcttcttgattgtgatgccgcctccatggacttggaaatgatcgatgtg
caagttttaggagacgcttttaaacgctatcttgtggacttaccgaatcctgtcattcca
gtagccgtttacaatgaaatgatttatttagcccaagaagtacagagccctgaagaatat
atccagctgttgaagaagctcattagggcacctaacatacctcatcagtattggcttacg
cttcagtatttgctaaaacatttcttcaagctctctcaaacctccagcaagaatcttctg
agtgcaagagtactctctgaacttttcagccctctgcttttcagattcccggcagccagc
tctgagaatactgaacacctcataaaagttatagaaattttaatctcaactgagtggaat
gaacgacagcctgcaccagcattgcctcctaaaccaccaaaacccactactgtagccaac
aacggtatgaataacaatatgtccttacaagatgctgaatggtactggggagatatctca
agggaagaagtgaatgaaaaacttcgagatacagctgatgggacctttttggtacgagac
gcatctactaaaatgcatggtgattatactcttacactaaggaaaggaggaaataacaaa
ttaatcaaaatatttcaccaagatgggaaatatggcttctctgacccactgaccttcaac
tctgtggttgaactaataaaccactaccggaatgagtctctagctcagtataatcccaaa
ctggacgtaaagttactttatccagtatccaaataccaacaggatcaagttgtcaaagaa
gataatattgaagctgtaggaaaaaagttacatgaatataacactcaatttcaagaaaaa
agtcgggaatatgatagattatatgaagattatacccgtacttcccaggaaatccaaatg
aaaagaacagctattgaagcctttaatgaaaccataaaaatatttgaagaacagtgccaa
agtcaggaacggtacagcaaagaatacatagaaaaatttaaacgtgaaggcaatgagaaa
gaaatacaaaggattatgcataattatgagaagttaaagtcccgaatcagtgaaattgtg
gacagtcgaagaagactggaggaagacttgaagaagcaggcagctgagtaccgggagatt
gacaaacgcatgaacagcattaaaccagacctcattcagctgagaaagacaagagaccaa
tacttgatgtggttgactcagaaaggtgttcggcagaagaagctgaatgagtggttgggc
aatgaaaatacggaagaccaatattcgctggtggaagatgatgaggatttgccgcaccac
gacgagaagacctggaatgtgggcagcagcaacagaaacaaagctgagaacctactccga
gggaaacgagacggcaccttcctggtccgggagagcagcaaacagggctgctacgcctgc
tccgtagtggtggacggcgaagtcaagcactgtgtcatcaacaaaacggccaccggctac
ggcttcgccgagccctataacctgtacggctctctgaaagaactggtgcttcattaccag
cacacgtccctcgtgcagcacaatgactcgctcaacgtcacactggcctacccggtatac
gcacagcagagacgatga

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