Neogale vison (American mink): 122904294 Help Entry 122904294         CDS       T08764                                  Symbol ADCY8 Name (RefSeq) adenylate cyclase type 8   KO K08048   adenylate cyclase 8 [EC:4.6.1.1] Organism nvs  Neogale vison (American mink) Pathway nvs00230   Purine metabolism nvs01100   Metabolic pathways nvs01522   Endocrine resistance nvs04015   Rap1 signaling pathway nvs04020   Calcium signaling pathway nvs04022   cGMP-PKG signaling pathway nvs04024   cAMP signaling pathway nvs04062   Chemokine signaling pathway nvs04072   Phospholipase D signaling pathway nvs04081   Hormone signaling nvs04082   Neuroactive ligand signaling nvs04114   Oocyte meiosis nvs04211   Longevity regulating pathway nvs04213   Longevity regulating pathway - multiple species nvs04261   Adrenergic signaling in cardiomyocytes nvs04270   Vascular smooth muscle contraction nvs04371   Apelin signaling pathway nvs04540   Gap junction nvs04611   Platelet activation nvs04713   Circadian entrainment nvs04714   Thermogenesis nvs04720   Long-term potentiation nvs04723   Retrograde endocannabinoid signaling nvs04724   Glutamatergic synapse nvs04725   Cholinergic synapse nvs04727   GABAergic synapse nvs04742   Taste transduction nvs04750   Inflammatory mediator regulation of TRP channels nvs04911   Insulin secretion nvs04912   GnRH signaling pathway nvs04913   Ovarian steroidogenesis nvs04914   Progesterone-mediated oocyte maturation nvs04915   Estrogen signaling pathway nvs04916   Melanogenesis nvs04918   Thyroid hormone synthesis nvs04921   Oxytocin signaling pathway nvs04923   Regulation of lipolysis in adipocytes nvs04925   Aldosterone synthesis and secretion nvs04926   Relaxin signaling pathway nvs04927   Cortisol synthesis and secretion nvs04928   Parathyroid hormone synthesis, secretion and action nvs04934   Cushing syndrome nvs04935   Growth hormone synthesis, secretion and action nvs04970   Salivary secretion nvs04971   Gastric acid secretion nvs04972   Pancreatic secretion nvs04976   Bile secretion nvs05032   Morphine addiction nvs05163   Human cytomegalovirus infection nvs05166   Human T-cell leukemia virus 1 infection nvs05200   Pathways in cancer nvs05207   Chemical carcinogenesis - receptor activation nvs05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:nvs00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     122904294 (ADCY8)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     122904294 (ADCY8)    04371 Apelin signaling pathway     122904294 (ADCY8)    04020 Calcium signaling pathway     122904294 (ADCY8)    04072 Phospholipase D signaling pathway     122904294 (ADCY8)    04024 cAMP signaling pathway     122904294 (ADCY8)    04022 cGMP-PKG signaling pathway     122904294 (ADCY8)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     122904294 (ADCY8)    04081 Hormone signaling     122904294 (ADCY8)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     122904294 (ADCY8)   09144 Cellular community - eukaryotes    04540 Gap junction     122904294 (ADCY8)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     122904294 (ADCY8)    04062 Chemokine signaling pathway     122904294 (ADCY8)   09152 Endocrine system    04911 Insulin secretion     122904294 (ADCY8)    04923 Regulation of lipolysis in adipocytes     122904294 (ADCY8)    04912 GnRH signaling pathway     122904294 (ADCY8)    04913 Ovarian steroidogenesis     122904294 (ADCY8)    04915 Estrogen signaling pathway     122904294 (ADCY8)    04914 Progesterone-mediated oocyte maturation     122904294 (ADCY8)    04921 Oxytocin signaling pathway     122904294 (ADCY8)    04926 Relaxin signaling pathway     122904294 (ADCY8)    04935 Growth hormone synthesis, secretion and action     122904294 (ADCY8)    04918 Thyroid hormone synthesis     122904294 (ADCY8)    04928 Parathyroid hormone synthesis, secretion and action     122904294 (ADCY8)    04916 Melanogenesis     122904294 (ADCY8)    04925 Aldosterone synthesis and secretion     122904294 (ADCY8)    04927 Cortisol synthesis and secretion     122904294 (ADCY8)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     122904294 (ADCY8)    04270 Vascular smooth muscle contraction     122904294 (ADCY8)   09154 Digestive system    04970 Salivary secretion     122904294 (ADCY8)    04971 Gastric acid secretion     122904294 (ADCY8)    04972 Pancreatic secretion     122904294 (ADCY8)    04976 Bile secretion     122904294 (ADCY8)   09156 Nervous system    04724 Glutamatergic synapse     122904294 (ADCY8)    04727 GABAergic synapse     122904294 (ADCY8)    04725 Cholinergic synapse     122904294 (ADCY8)    04720 Long-term potentiation     122904294 (ADCY8)    04723 Retrograde endocannabinoid signaling     122904294 (ADCY8)   09157 Sensory system    04742 Taste transduction     122904294 (ADCY8)    04750 Inflammatory mediator regulation of TRP channels     122904294 (ADCY8)   09149 Aging    04211 Longevity regulating pathway     122904294 (ADCY8)    04213 Longevity regulating pathway - multiple species     122904294 (ADCY8)   09159 Environmental adaptation    04713 Circadian entrainment     122904294 (ADCY8)    04714 Thermogenesis     122904294 (ADCY8)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     122904294 (ADCY8)    05207 Chemical carcinogenesis - receptor activation     122904294 (ADCY8)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     122904294 (ADCY8)    05163 Human cytomegalovirus infection     122904294 (ADCY8)   09165 Substance dependence    05032 Morphine addiction     122904294 (ADCY8)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     122904294 (ADCY8)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     122904294 (ADCY8)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     122904294 (ADCY8) Enzymes [BR:nvs01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      122904294 (ADCY8) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Guanylate_cyc AC_N Adcy_cons_dom TBK1_ULD Motif Other DBs NCBI-GeneID:  122904294 NCBI-ProteinID:  XP_044100870 UniProt:  A0A8C7EN25 LinkDB All DBs Position 4:10597365..10814683 Genome browser AA seq 1252 aa AA seqDB search MELSDVRCLSGSEELYTIHPTPPAGDGGSGSRPQRLLWQTAVRHITEQRFIHGHRGSGGG GGSRGSGKASDPASGGPNHHAAQLSSESALPLYSLGPGERAHSTGGTKVFPERSGSGSGS GSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRR KSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSH TYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGT SLLQVALQAAIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEA RLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFAD VKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHA HCCVEMGLSMIKTIRYVRSRTQHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANK LESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEESLLSLPE DIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALH VQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCA FIVLLFITAIQSLLPSSRVMPMAIQFSILIMLHSALVLITTAEDYKCLPLVLRKTCCWIN ETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFT GVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETIYAGLFLRYDNLNHSGEDFLGTKE ASLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHV ARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFD ELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINK HSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLI LKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGL VQSLNRQRQKQLLNENNNTGIIKGHYNRRTLLTPSGPEPGAQAEGTDKSDLP NT seq 3759 nt NT seq  +upstreamnt  +downstreamnt atggagctctccgatgtgcgctgcctaagcggcagcgaggaactctacaccatccacccg acgcccccggccggcgacggcgggagcggctctcggccgcagcggctgctgtggcagacg gcggtgaggcatatcaccgagcagcgcttcattcacgggcaccggggtagcggcggcggc ggcgggagtagaggctccggcaaagcctcggaccctgcaagcggcggccccaaccatcac gcggcgcaactgtccagcgaatcggcgctgcccctctactcgctgggccccggggagaga gctcacagtaccggtggcaccaaagtcttcccggaacgcagcgggagcggcagcggcagc gggagcgggggcgggggtgatctgggcttcctgcacctcgactgtgccccgagcaactcg gatttcttcctgaacggaggctacagctaccgaggggtcattttccccactctgcgcaac tccttcaagtcccgggatctggagcgcctctaccagcgctatttcctgggccagaggcgc aaatccgaggtggtgatgaatgtgctggacgtgctgaccaaactcaccctgttggtcctc cacctgagcctggcttcggccccgatggaccctctcaagggcatcctcctgggcttcttc actggcatcgaggtggtgatctgcgccctggtggtggtcaggaaggacaccacctcgcac acgtacctgcagtacagtggcgtggtcacttgggtggccatgaccacccagatcttggca gcaggccttggctacgggcttctgggtgatggcatcggttacgttctcttcacactgttc gccacctacagcatgctgccgctgccgctcacctgggccatcctggccggcctgggcacc tctctgctgcaggtggccctgcaggcggccattcctcggctagctgtcatttccatcaac caggttgtggcccaggcagtgttattcatgtgtatgaacacagctggaatcttcatcagt tacctgtcagaccgggcccagcgccaagccttcctggagacgcggaggtgtgtggaggcc aggctacgcctggagacggaaaaccaaagacaggaacggcttgtgctgtctgtgctcccc cgctttgtcgtcctggaaatgatcaatgacatgaccaatgttgaagacgagcacttgcag caccagttccatcggatctacatccaccgttatgagaacgtcagtattctttttgcagat gttaaaggatttaccaacctctccacgaccttgtctgcccaggagctggtccggatgctc aacgagctctttgccagatttgatcgactggctcatgagcatcactgccttcgcattaaa atcctgggggactgttactactgtgtttcagggcttcctgagccccgccaggaccacgcc cactgctgcgttgaaatgggcctcagcatgatcaaaaccatcaggtatgtgaggtcaagg acacagcatgatgtggacatgaggattggaatccactcaggctcagttctatgtggagtg ctgggcctgcggaagtggcagtttgatgtctggtcctgggatgtggacatcgcgaacaag cttgaatctggaggaatccccgggaggattcacatttccaaagccacgctggactgcctc aacggtgactataatgtggaagagggtcatggtaaagagagaaacgaattcttgaggaag cataatatagagacctacttgattaagcagcctgaggagagtctgctgtcattgcccgaa gacattgtcaaggaatcggtgagctcctcagacaggagaaacagtggggcgacattcaca gaaggatcctggagccccgaactgccctttgataacatagtggggaaacagaacactctg gctgccctaacaagaaattcaataaatctacttccaaaccatcttgcacaagctttgcat gtccagtctgggcctgaggaaattaacaagagaatagaacataccatcgacttgcggagt ggcgataaattgagaagagagcatatcaagccattctcactgatgtttaaagactccagc ctggagcacaagtattctcaaatgagggatgaagtattcaagtcaaacttggtctgtgca tttatcgttcttctatttatcacggcgatacaaagtttgcttccttcttcaagggtgatg ccaatggccatccagttttccatcctgattatgctgcactcggctctcgtcctcatcacc acagcagaggattataagtgtttgcccctcgtcctccggaaaacttgctgttggattaat gagacctatttggcccggaacgtcatcatctttgcatccatcttgattaacttcctgggt gccatcttgaatatcctgtggtgtgattttgacaagtcgatacccttgaagaacctgact ttcaattcctcagctgtgtttacagatatctgctcctacccagagtacttcgtcttcacc ggggtgcttgccatggtgacttgtgcagttttcctccgcctgaactctgtcctgaaactg gctgtgctgctgattatgatcgccatctacgctctgctgaccgaaaccatctatgcgggc ctctttctgcgctacgacaacctgaaccacagtggagaagatttcctggggaccaaggag gcatcactgctgctgatggccatgttcctccttgctgtgttctaccatggacagcagcta gagtacacagcccgccttgacttcctttggcgagtacaggccaaagaggagatcaatgag atgaaggagctaagggaacacaatgagaacatgctccggaacattctacccagccacgtg gcccgccacttcctggagaaagaccgagacaatgaggagctgtattctcaatcctatgat gccgtcggggtgatgtttgcctccatcccggggtttgcagatttttactctcagactgaa atgaataaccaaggagtggagtgcctgcgcctgctgaatgaaatcattgctgacttcgat gagctcctcggtgaagaccggttccaagacattgaaaagattaagaccattggcagcacc tacatggctgtgtcaggcctgtcccctgaaaaacagcaatgtgaagacaagtgggggcat ttgtgcgccctggctgacttctccctcgccctgactgagagcatacaggagatcaacaaa cattccttcaacaatttcgaactccggattggcatcagccatggctccgtggtagctggc gttatcggcgctaagaaaccacagtatgacatttggggcaaaaccgtgaacctggcaagt cgaatggacagcacaggtgtcagtggcaggatccaagtccctgaggagacctatctcatc ctgaaggaccagggctttgcctttgactaccgaggggagatctatgtgaagggcatcagt gaacaagaaggaaaaatcaaaacgtactttctgctgggaagagtccaacccaatccattc atcttgcccccgagaagactgcccgggcagtactccttggccgcagttgtcctgggcctt gtccagtctctcaataggcaaaggcagaagcagctgctcaacgagaacaacaacacgggg attatcaagggtcattacaaccggcggactttgttgacacccagcgggccagagcctgga gcccaagccgaaggcaccgacaagtctgatttgccataa

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