KEGG   Neogale vison (American mink): 122909871
Entry
122909871         CDS       T08764                                 
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2
  KO
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
Organism
nvs  Neogale vison (American mink)
Pathway
nvs01521  EGFR tyrosine kinase inhibitor resistance
nvs01522  Endocrine resistance
nvs04010  MAPK signaling pathway
nvs04012  ErbB signaling pathway
nvs04014  Ras signaling pathway
nvs04015  Rap1 signaling pathway
nvs04022  cGMP-PKG signaling pathway
nvs04024  cAMP signaling pathway
nvs04066  HIF-1 signaling pathway
nvs04068  FoxO signaling pathway
nvs04071  Sphingolipid signaling pathway
nvs04072  Phospholipase D signaling pathway
nvs04140  Autophagy - animal
nvs04148  Efferocytosis
nvs04150  mTOR signaling pathway
nvs04151  PI3K-Akt signaling pathway
nvs04210  Apoptosis
nvs04218  Cellular senescence
nvs04270  Vascular smooth muscle contraction
nvs04370  VEGF signaling pathway
nvs04371  Apelin signaling pathway
nvs04517  IgSF CAM signaling
nvs04519  Cadherin signaling
nvs04540  Gap junction
nvs04550  Signaling pathways regulating pluripotency of stem cells
nvs04613  Neutrophil extracellular trap formation
nvs04620  Toll-like receptor signaling pathway
nvs04650  Natural killer cell mediated cytotoxicity
nvs04660  T cell receptor signaling pathway
nvs04662  B cell receptor signaling pathway
nvs04664  Fc epsilon RI signaling pathway
nvs04720  Long-term potentiation
nvs04722  Neurotrophin signaling pathway
nvs04730  Long-term depression
nvs04810  Regulation of actin cytoskeleton
nvs04910  Insulin signaling pathway
nvs04912  GnRH signaling pathway
nvs04915  Estrogen signaling pathway
nvs04916  Melanogenesis
nvs04917  Prolactin signaling pathway
nvs04919  Thyroid hormone signaling pathway
nvs04921  Oxytocin signaling pathway
nvs04926  Relaxin signaling pathway
nvs04929  GnRH secretion
nvs04934  Cushing syndrome
nvs04935  Growth hormone synthesis, secretion and action
nvs05010  Alzheimer disease
nvs05022  Pathways of neurodegeneration - multiple diseases
nvs05132  Salmonella infection
nvs05135  Yersinia infection
nvs05160  Hepatitis C
nvs05161  Hepatitis B
nvs05163  Human cytomegalovirus infection
nvs05164  Influenza A
nvs05165  Human papillomavirus infection
nvs05166  Human T-cell leukemia virus 1 infection
nvs05167  Kaposi sarcoma-associated herpesvirus infection
nvs05170  Human immunodeficiency virus 1 infection
nvs05200  Pathways in cancer
nvs05205  Proteoglycans in cancer
nvs05206  MicroRNAs in cancer
nvs05207  Chemical carcinogenesis - receptor activation
nvs05208  Chemical carcinogenesis - reactive oxygen species
nvs05210  Colorectal cancer
nvs05211  Renal cell carcinoma
nvs05213  Endometrial cancer
nvs05214  Glioma
nvs05215  Prostate cancer
nvs05216  Thyroid cancer
nvs05218  Melanoma
nvs05219  Bladder cancer
nvs05220  Chronic myeloid leukemia
nvs05221  Acute myeloid leukemia
nvs05223  Non-small cell lung cancer
nvs05224  Breast cancer
nvs05225  Hepatocellular carcinoma
nvs05226  Gastric cancer
nvs05230  Central carbon metabolism in cancer
nvs05231  Choline metabolism in cancer
nvs05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:nvs00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    122909871 (MAP2K2)
   04012 ErbB signaling pathway
    122909871 (MAP2K2)
   04014 Ras signaling pathway
    122909871 (MAP2K2)
   04015 Rap1 signaling pathway
    122909871 (MAP2K2)
   04370 VEGF signaling pathway
    122909871 (MAP2K2)
   04371 Apelin signaling pathway
    122909871 (MAP2K2)
   04066 HIF-1 signaling pathway
    122909871 (MAP2K2)
   04068 FoxO signaling pathway
    122909871 (MAP2K2)
   04072 Phospholipase D signaling pathway
    122909871 (MAP2K2)
   04071 Sphingolipid signaling pathway
    122909871 (MAP2K2)
   04024 cAMP signaling pathway
    122909871 (MAP2K2)
   04022 cGMP-PKG signaling pathway
    122909871 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    122909871 (MAP2K2)
   04150 mTOR signaling pathway
    122909871 (MAP2K2)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    122909871 (MAP2K2)
   04519 Cadherin signaling
    122909871 (MAP2K2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    122909871 (MAP2K2)
   04148 Efferocytosis
    122909871 (MAP2K2)
  09143 Cell growth and death
   04210 Apoptosis
    122909871 (MAP2K2)
   04218 Cellular senescence
    122909871 (MAP2K2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    122909871 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    122909871 (MAP2K2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    122909871 (MAP2K2)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    122909871 (MAP2K2)
   04620 Toll-like receptor signaling pathway
    122909871 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    122909871 (MAP2K2)
   04660 T cell receptor signaling pathway
    122909871 (MAP2K2)
   04662 B cell receptor signaling pathway
    122909871 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    122909871 (MAP2K2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    122909871 (MAP2K2)
   04929 GnRH secretion
    122909871 (MAP2K2)
   04912 GnRH signaling pathway
    122909871 (MAP2K2)
   04915 Estrogen signaling pathway
    122909871 (MAP2K2)
   04917 Prolactin signaling pathway
    122909871 (MAP2K2)
   04921 Oxytocin signaling pathway
    122909871 (MAP2K2)
   04926 Relaxin signaling pathway
    122909871 (MAP2K2)
   04935 Growth hormone synthesis, secretion and action
    122909871 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    122909871 (MAP2K2)
   04916 Melanogenesis
    122909871 (MAP2K2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    122909871 (MAP2K2)
  09156 Nervous system
   04720 Long-term potentiation
    122909871 (MAP2K2)
   04730 Long-term depression
    122909871 (MAP2K2)
   04722 Neurotrophin signaling pathway
    122909871 (MAP2K2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122909871 (MAP2K2)
   05206 MicroRNAs in cancer
    122909871 (MAP2K2)
   05205 Proteoglycans in cancer
    122909871 (MAP2K2)
   05207 Chemical carcinogenesis - receptor activation
    122909871 (MAP2K2)
   05208 Chemical carcinogenesis - reactive oxygen species
    122909871 (MAP2K2)
   05230 Central carbon metabolism in cancer
    122909871 (MAP2K2)
   05231 Choline metabolism in cancer
    122909871 (MAP2K2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    122909871 (MAP2K2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122909871 (MAP2K2)
   05225 Hepatocellular carcinoma
    122909871 (MAP2K2)
   05226 Gastric cancer
    122909871 (MAP2K2)
   05214 Glioma
    122909871 (MAP2K2)
   05216 Thyroid cancer
    122909871 (MAP2K2)
   05221 Acute myeloid leukemia
    122909871 (MAP2K2)
   05220 Chronic myeloid leukemia
    122909871 (MAP2K2)
   05218 Melanoma
    122909871 (MAP2K2)
   05211 Renal cell carcinoma
    122909871 (MAP2K2)
   05219 Bladder cancer
    122909871 (MAP2K2)
   05215 Prostate cancer
    122909871 (MAP2K2)
   05213 Endometrial cancer
    122909871 (MAP2K2)
   05224 Breast cancer
    122909871 (MAP2K2)
   05223 Non-small cell lung cancer
    122909871 (MAP2K2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    122909871 (MAP2K2)
   05170 Human immunodeficiency virus 1 infection
    122909871 (MAP2K2)
   05161 Hepatitis B
    122909871 (MAP2K2)
   05160 Hepatitis C
    122909871 (MAP2K2)
   05164 Influenza A
    122909871 (MAP2K2)
   05163 Human cytomegalovirus infection
    122909871 (MAP2K2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122909871 (MAP2K2)
   05165 Human papillomavirus infection
    122909871 (MAP2K2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    122909871 (MAP2K2)
   05135 Yersinia infection
    122909871 (MAP2K2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122909871 (MAP2K2)
   05022 Pathways of neurodegeneration - multiple diseases
    122909871 (MAP2K2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    122909871 (MAP2K2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122909871 (MAP2K2)
   01522 Endocrine resistance
    122909871 (MAP2K2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:nvs01001]
    122909871 (MAP2K2)
Enzymes [BR:nvs01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     122909871 (MAP2K2)
Protein kinases [BR:nvs01001]
 Serine/threonine kinases: STE group
  STE7 family
   122909871 (MAP2K2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7 APH
Other DBs
NCBI-GeneID: 122909871
NCBI-ProteinID: XP_044110485
UniProt: A0A8C7ALL1
LinkDB
Position
6:221639339..221659670
AA seq 400 aa
MLARRKPVLPALTINPAIAEGPSPTSEGASEANLVDLQKKLAELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPVVDGVEGEPHSISPRPRP
PGRPISGHGTDSRPAMAIFELLDYIVNEPPPKLPSGVFTQDFQEFVNKCLIKNPAERADL
KMLTSHAFIKRSEVEEVDFAGWLCKTLRLKQPSTPTRTAV
NT seq 1203 nt   +upstreamnt  +downstreamnt
atgctggcccggaggaagccggtgctgccggcgctcactatcaaccccgccatcgccgag
ggcccgtcccccaccagcgagggcgcctccgaagcaaacttggtggacctccagaagaag
ctggcagagctagaactggatgagcagcagaagaagcgactggaagccttcctcacccag
aaggccaaggtcggggagctcaaggacgatgactttgaacggatctcggagctgggagct
gggaacggcggggtggtcaccaaggtccagcacagaccatccggactcatcatggcgaga
aagctgatccacctggagatcaagccggccatccggaaccagatcatccgcgagctgcag
gtgctacacgagtgtaactccccgtacatcgtgggcttctatggggccttctacagcgac
ggcgagatcagcatctgcatggagcacatggacggtggttccctggaccaggtgttgaaa
gaagccaagagaattcctgaggagatcctggggaaggtcagcattgcggttctccggggt
ttggcgtatctccgggaaaagcaccagatcatgcaccgagatgtgaaaccttccaacatc
ctcgtcaactcccgaggggagatcaagctgtgcgattttggggtgagcggacagctcatc
gactccatggccaactccttcgtgggaactcggtcctacatgtctccggagcggctgcag
ggcacgcactactccgtgcagtcggacatctggagcatggggctgtccctggtggagctg
tccatcggaaggtaccccatccccccgccagacgccaaggagctggaggccatatttggc
cggcccgtggtggacggggtagaaggagagcctcacagcatctcgccgcggccgagaccc
cccggacgccccatcagcggtcacgggacagacagccggccggccatggccatcttcgag
ctgctggactatattgtgaacgagccgcctcccaagctccccagtggcgtcttcacccag
gatttccaggagtttgtaaataaatgcctaataaagaacccagcggagcgagcagatctg
aagatgctcacgagccacgccttcatcaagcgctccgaggtggaagaagtggattttgcc
ggctggttgtgtaaaacgctgcggctgaagcagcccagcacacccacgcgcacggccgtg
tga

DBGET integrated database retrieval system