KEGG   Neogale vison (American mink): 122916074
Entry
122916074         CDS       T08764                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
nvs  Neogale vison (American mink)
Pathway
nvs00562  Inositol phosphate metabolism
nvs01100  Metabolic pathways
nvs01521  EGFR tyrosine kinase inhibitor resistance
nvs04012  ErbB signaling pathway
nvs04014  Ras signaling pathway
nvs04015  Rap1 signaling pathway
nvs04020  Calcium signaling pathway
nvs04062  Chemokine signaling pathway
nvs04064  NF-kappa B signaling pathway
nvs04066  HIF-1 signaling pathway
nvs04070  Phosphatidylinositol signaling system
nvs04072  Phospholipase D signaling pathway
nvs04360  Axon guidance
nvs04370  VEGF signaling pathway
nvs04613  Neutrophil extracellular trap formation
nvs04650  Natural killer cell mediated cytotoxicity
nvs04658  Th1 and Th2 cell differentiation
nvs04659  Th17 cell differentiation
nvs04660  T cell receptor signaling pathway
nvs04664  Fc epsilon RI signaling pathway
nvs04666  Fc gamma R-mediated phagocytosis
nvs04670  Leukocyte transendothelial migration
nvs04722  Neurotrophin signaling pathway
nvs04750  Inflammatory mediator regulation of TRP channels
nvs04919  Thyroid hormone signaling pathway
nvs04933  AGE-RAGE signaling pathway in diabetic complications
nvs04935  Growth hormone synthesis, secretion and action
nvs05012  Parkinson disease
nvs05022  Pathways of neurodegeneration - multiple diseases
nvs05135  Yersinia infection
nvs05167  Kaposi sarcoma-associated herpesvirus infection
nvs05170  Human immunodeficiency virus 1 infection
nvs05171  Coronavirus disease - COVID-19
nvs05200  Pathways in cancer
nvs05205  Proteoglycans in cancer
nvs05206  MicroRNAs in cancer
nvs05214  Glioma
nvs05223  Non-small cell lung cancer
nvs05225  Hepatocellular carcinoma
nvs05231  Choline metabolism in cancer
nvs05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
nvs05417  Lipid and atherosclerosis
Module
nvs_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:nvs00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    122916074 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    122916074 (PLCG1)
   04014 Ras signaling pathway
    122916074 (PLCG1)
   04015 Rap1 signaling pathway
    122916074 (PLCG1)
   04370 VEGF signaling pathway
    122916074 (PLCG1)
   04064 NF-kappa B signaling pathway
    122916074 (PLCG1)
   04066 HIF-1 signaling pathway
    122916074 (PLCG1)
   04020 Calcium signaling pathway
    122916074 (PLCG1)
   04070 Phosphatidylinositol signaling system
    122916074 (PLCG1)
   04072 Phospholipase D signaling pathway
    122916074 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    122916074 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    122916074 (PLCG1)
   04660 T cell receptor signaling pathway
    122916074 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    122916074 (PLCG1)
   04659 Th17 cell differentiation
    122916074 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    122916074 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    122916074 (PLCG1)
   04670 Leukocyte transendothelial migration
    122916074 (PLCG1)
   04062 Chemokine signaling pathway
    122916074 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    122916074 (PLCG1)
   04919 Thyroid hormone signaling pathway
    122916074 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    122916074 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    122916074 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    122916074 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122916074 (PLCG1)
   05206 MicroRNAs in cancer
    122916074 (PLCG1)
   05205 Proteoglycans in cancer
    122916074 (PLCG1)
   05231 Choline metabolism in cancer
    122916074 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    122916074 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    122916074 (PLCG1)
   05214 Glioma
    122916074 (PLCG1)
   05223 Non-small cell lung cancer
    122916074 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    122916074 (PLCG1)
   05171 Coronavirus disease - COVID-19
    122916074 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122916074 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    122916074 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    122916074 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    122916074 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122916074 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    122916074 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122916074 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:nvs04131]
    122916074 (PLCG1)
Enzymes [BR:nvs01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     122916074 (PLCG1)
Membrane trafficking [BR:nvs04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    122916074 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    122916074 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH SH3_1 C2 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 PH_9 EF-hand_7
Other DBs
NCBI-GeneID: 122916074
NCBI-ProteinID: XP_044118966
LinkDB
Position
8:complement(18377613..18413873)
AA seq 1290 aa
MAGAASPCANGCGPGAPSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRSSDITYGQFAQLYRSLMYSAQKTMDLPFLEASALRA
GERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSSEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGAPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKNAIIQNVEKQDGGWWRGDYGGKKQLW
FPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMAGGRCGYVLQPSTMRDEAFDPFDKS
SLRGLEPYAVCIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSVKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDL
ELASLLVKIEVFPAKQENGDLSPFGMSLRERGSDASGQLFHGRAREGSFEARYQQPFEDF
RISQEHLADHFDSRERRAPRRTRVNGDNRL
NT seq 3873 nt   +upstreamnt  +downstreamnt
atggcgggcgctgcgtccccctgcgccaatggctgcgggcccggcgcgccctcggacgcc
gaggtgctgcacctctgccgcagcctcgaggtgggcaccgtcatgactttgttctactcc
aagaagtcgcagcgaccggagcggaagaccttccaggtcaagctggaaacgcggcagatc
acgtggagccgtggagccgacaagatcgagggggccattgacattcgggaaatcaaggag
atccgcccaggcaagacgtcacgggattttgatcgctaccaagaggaccctgctttccga
ccagaccagtcacactgctttgtcatcctgtatgggatggagttccgcctgaagaccctg
agcctgcaggctacatctgaggatgaagtgaacatgtggatcaagggtttaacgtggctg
atggaggacaccctgcaggcggccacgcctctgcagatcgagaggtggctgcggaagcag
ttctactccgtggatcggaaccgtgaggatcgtatatcagccaaggacctgaagaacatg
ctgtcccaggtcaactaccgggtccccaacatgcgcttcctccgagagcgtctgacggac
ctggagcagcgcagcagcgacatcacctacgggcagtttgctcagctgtaccgcagcctc
atgtacagcgcccagaagacgatggacctccccttcttggaagccagtgccctgagggcg
ggggagcggccggagctctgtcgagtatcccttcccgagttccagcagttcctcctcgag
taccagggggagctgtgggctgttgaccggcttcaggtgcaggagttcatgctcagcttc
cttcgagaccccttgcgggaaattgaagagccatacttcttcctggacgagtttgtcacc
ttcctgttctccaaagagaacagtgtgtggaactcgcagctggatgccgtgtgcccggac
accatgaacaaccctctctcccactactggatctcctcctcccacaacacgtacctgact
ggggaccagttctccagcgagtcctccctagaagcctacgcccgctgcctgcgaatgggc
tgtcgctgcattgagttggactgctgggatggcccagatgggatgccggtcatttaccat
ggacacacccttaccaccaagattaagttctcagatgttctgcacaccatcaaggagcac
gccttcgtggcctcagagtacccggtcatcctatccatcgaggaccactgcagcattgcc
cagcagagaaacatggcacagtacttcaagaaggtgcttggggacaccctcctcaccaag
cccgtggacatcgctgcagacgggctcccctcacccaaccagctcaagaggaagatcctc
atcaagcacaagaagctggcagagggcagcgcctatgaagaggtgcccacgtcggtgatg
tactccgagaacgacatcagcaactccatcaagaacggcatcctctacctggaggacccc
gtgaaccatgagtggtacccgcactacttcgttctgaccagcagcaagatctactactcc
gaggagaccagcagtgaccagggcaatgaggatgaggaggagcccaaggaggccagtggc
agcacggagctgcactccagtgagaagtggttccacgggaagctcggcgcgggacgggat
ggacggcacatcgccgagcgcctgctcaccgagtactgcatcgagaccggggcccctgac
ggctccttccttgtacgggagagcgagaccttcgtgggcgactacaccctctccttctgg
aggaacgggaaagtccagcactgccggatccactcccgccaggacgctggggcccccaag
ttcttcttgacagacaacttggtctttgactcactctatgacctcatcacgcactaccag
caggtgcccctgcgctgcaatgaatttgagatgcgcctctcagagcctgtcccgcagacc
aatgcccacgagagcaaagagtggtaccacgccagcctgaccagagctcaggccgagcac
atgctgatgcgtgtaccccgggacggggccttcctggtgagaaaacggaacgaacccaac
tcctacgccatctccttccgggccgagggcaagatcaagcattgccgtgtccagcaggag
ggccagaccgtgatgctgggcaactcggagtttgacagccttgtggacctgatcagctac
tacgagaagcacccactataccgcaaaatgaagctgcgctaccccatcaatgaggaggcg
ctggagaagatcggcaccgctgagcctgactatggagccctgtatgagggacgcaaccct
ggcttctacgtggaggcaaatcctatgccaactttcaagtgcgccgtcaaggccctcttt
gactacaaggcccagagggaggacgagctgacgttcacgaagaatgccatcatccagaac
gtggagaagcaggacggtggctggtggcggggggactacggggggaagaagcagctgtgg
ttcccgtcgaactatgtggaggagatggtcagccccgcagccctggagcccgagagggag
cacttggacgagaacagccccctgggggacttgctccggggggtcttggatgtgccggct
tgtcagattgccatccgtcctgaaggcaagaacaaccggctgttcgtcttctccatcagc
atggcttcagtggcgcactggtccttggatgtcgctgccgactcgcaggaggagctgcag
gactgggtgaagaagatccgagaagtggcccagacggcagatgccaggctcacggagggg
aagatgatggagcgcaggaagaagatcgccctggagctctccgagctggttgtctactgt
cggcctgttcccttcgatgaagagaagatcggcacagaacgtgcctgctaccgggacatg
tcgtcctttccggaaaccaaggctgagaaatacgtgaacaaggccaaaggcaagaaattc
ctccagtacaaccggctgcagctctcccgcatataccccaagggccagcggctggactcc
tccaattacgaccccttgcccatgtggatctgcggcagtcagctcgtggccctcaacttc
cagaccccagacaagccgatgcagatgaaccaggccctgttcatggccggcggccgctgc
ggctacgtactacagcccagtaccatgcgggatgaggccttcgatcccttcgacaagagc
agcctccggggcctggagccgtatgcggtctgcattgaggtactgggggcccggcacctg
ccaaagaacggccgaggcatcgtgtgtccttttgtggagattgaggtggctggagcggag
tatgacagcgtcaagcagaagacagagttcgtggtggacaatggactgaaccctgtgtgg
cctgccaagcccttccacttccagatcagtaacccggaattcgcctttctgcgcttcgtg
gtgtatgaggaagacatgttcagtgaccagaacttcctggctcaggctaccttcccggtg
aaaggcctgaagacagggtacagagccgtgcctttgaagaacaactacagcgaggacctg
gagctggcctccctgctcgtcaagatcgaggttttccctgccaagcaggagaacggggac
ctcagtcccttcgggatgtctctgcgggagcggggctctgatgcctcaggccagctgttc
catggccgggcccgggaaggttcctttgaagcccgctatcagcagccatttgaggacttt
cgaatctcccaggagcatctggcagaccattttgacagtcgggaacggagggccccacga
aggactcgggtcaacggagacaaccgcctctag

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