KEGG   Neogale vison (American mink): 122918946
Entry
122918946         CDS       T08764                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
nvs  Neogale vison (American mink)
Pathway
nvs01521  EGFR tyrosine kinase inhibitor resistance
nvs01522  Endocrine resistance
nvs01524  Platinum drug resistance
nvs04012  ErbB signaling pathway
nvs04014  Ras signaling pathway
nvs04015  Rap1 signaling pathway
nvs04024  cAMP signaling pathway
nvs04062  Chemokine signaling pathway
nvs04066  HIF-1 signaling pathway
nvs04068  FoxO signaling pathway
nvs04070  Phosphatidylinositol signaling system
nvs04071  Sphingolipid signaling pathway
nvs04072  Phospholipase D signaling pathway
nvs04081  Hormone signaling
nvs04140  Autophagy - animal
nvs04150  mTOR signaling pathway
nvs04151  PI3K-Akt signaling pathway
nvs04152  AMPK signaling pathway
nvs04210  Apoptosis
nvs04211  Longevity regulating pathway
nvs04213  Longevity regulating pathway - multiple species
nvs04218  Cellular senescence
nvs04360  Axon guidance
nvs04370  VEGF signaling pathway
nvs04380  Osteoclast differentiation
nvs04510  Focal adhesion
nvs04550  Signaling pathways regulating pluripotency of stem cells
nvs04611  Platelet activation
nvs04613  Neutrophil extracellular trap formation
nvs04620  Toll-like receptor signaling pathway
nvs04625  C-type lectin receptor signaling pathway
nvs04630  JAK-STAT signaling pathway
nvs04650  Natural killer cell mediated cytotoxicity
nvs04660  T cell receptor signaling pathway
nvs04662  B cell receptor signaling pathway
nvs04664  Fc epsilon RI signaling pathway
nvs04666  Fc gamma R-mediated phagocytosis
nvs04668  TNF signaling pathway
nvs04670  Leukocyte transendothelial migration
nvs04722  Neurotrophin signaling pathway
nvs04725  Cholinergic synapse
nvs04750  Inflammatory mediator regulation of TRP channels
nvs04810  Regulation of actin cytoskeleton
nvs04910  Insulin signaling pathway
nvs04914  Progesterone-mediated oocyte maturation
nvs04915  Estrogen signaling pathway
nvs04917  Prolactin signaling pathway
nvs04919  Thyroid hormone signaling pathway
nvs04923  Regulation of lipolysis in adipocytes
nvs04926  Relaxin signaling pathway
nvs04929  GnRH secretion
nvs04930  Type II diabetes mellitus
nvs04931  Insulin resistance
nvs04932  Non-alcoholic fatty liver disease
nvs04933  AGE-RAGE signaling pathway in diabetic complications
nvs04935  Growth hormone synthesis, secretion and action
nvs04960  Aldosterone-regulated sodium reabsorption
nvs04973  Carbohydrate digestion and absorption
nvs05010  Alzheimer disease
nvs05017  Spinocerebellar ataxia
nvs05020  Prion disease
nvs05100  Bacterial invasion of epithelial cells
nvs05135  Yersinia infection
nvs05142  Chagas disease
nvs05146  Amoebiasis
nvs05160  Hepatitis C
nvs05161  Hepatitis B
nvs05162  Measles
nvs05163  Human cytomegalovirus infection
nvs05164  Influenza A
nvs05165  Human papillomavirus infection
nvs05166  Human T-cell leukemia virus 1 infection
nvs05167  Kaposi sarcoma-associated herpesvirus infection
nvs05168  Herpes simplex virus 1 infection
nvs05169  Epstein-Barr virus infection
nvs05170  Human immunodeficiency virus 1 infection
nvs05171  Coronavirus disease - COVID-19
nvs05200  Pathways in cancer
nvs05203  Viral carcinogenesis
nvs05205  Proteoglycans in cancer
nvs05206  MicroRNAs in cancer
nvs05207  Chemical carcinogenesis - receptor activation
nvs05208  Chemical carcinogenesis - reactive oxygen species
nvs05210  Colorectal cancer
nvs05211  Renal cell carcinoma
nvs05212  Pancreatic cancer
nvs05213  Endometrial cancer
nvs05214  Glioma
nvs05215  Prostate cancer
nvs05218  Melanoma
nvs05220  Chronic myeloid leukemia
nvs05221  Acute myeloid leukemia
nvs05222  Small cell lung cancer
nvs05223  Non-small cell lung cancer
nvs05224  Breast cancer
nvs05225  Hepatocellular carcinoma
nvs05226  Gastric cancer
nvs05230  Central carbon metabolism in cancer
nvs05231  Choline metabolism in cancer
nvs05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
nvs05415  Diabetic cardiomyopathy
nvs05417  Lipid and atherosclerosis
nvs05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:nvs00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    122918946 (PIK3R1)
   04015 Rap1 signaling pathway
    122918946 (PIK3R1)
   04630 JAK-STAT signaling pathway
    122918946 (PIK3R1)
   04668 TNF signaling pathway
    122918946 (PIK3R1)
   04066 HIF-1 signaling pathway
    122918946 (PIK3R1)
   04068 FoxO signaling pathway
    122918946 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    122918946 (PIK3R1)
   04072 Phospholipase D signaling pathway
    122918946 (PIK3R1)
   04071 Sphingolipid signaling pathway
    122918946 (PIK3R1)
   04024 cAMP signaling pathway
    122918946 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    122918946 (PIK3R1)
   04152 AMPK signaling pathway
    122918946 (PIK3R1)
   04150 mTOR signaling pathway
    122918946 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    122918946 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    122918946 (PIK3R1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    122918946 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    122918946 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    122918946 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    122918946 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    122918946 (PIK3R1)
   04660 T cell receptor signaling pathway
    122918946 (PIK3R1)
   04662 B cell receptor signaling pathway
    122918946 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    122918946 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    122918946 (PIK3R1)
   04670 Leukocyte transendothelial migration
    122918946 (PIK3R1)
   04062 Chemokine signaling pathway
    122918946 (PIK3R1)
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    122918946 (PIK3R1)
   04929 GnRH secretion
    122918946 (PIK3R1)
   04915 Estrogen signaling pathway
    122918946 (PIK3R1)
   04917 Prolactin signaling pathway
    122918946 (PIK3R1)
   04926 Relaxin signaling pathway
    122918946 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    122918946 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    122918946 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    122918946 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    122918946 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    122918946 (PIK3R1)
   04722 Neurotrophin signaling pathway
    122918946 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    122918946 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    122918946 (PIK3R1)
   04380 Osteoclast differentiation
    122918946 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    122918946 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    122918946 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    122918946 (PIK3R1)
   05206 MicroRNAs in cancer
    122918946 (PIK3R1)
   05205 Proteoglycans in cancer
    122918946 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    122918946 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    122918946 (PIK3R1)
   05203 Viral carcinogenesis
    122918946 (PIK3R1)
   05230 Central carbon metabolism in cancer
    122918946 (PIK3R1)
   05231 Choline metabolism in cancer
    122918946 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    122918946 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    122918946 (PIK3R1)
   05212 Pancreatic cancer
    122918946 (PIK3R1)
   05225 Hepatocellular carcinoma
    122918946 (PIK3R1)
   05226 Gastric cancer
    122918946 (PIK3R1)
   05214 Glioma
    122918946 (PIK3R1)
   05221 Acute myeloid leukemia
    122918946 (PIK3R1)
   05220 Chronic myeloid leukemia
    122918946 (PIK3R1)
   05218 Melanoma
    122918946 (PIK3R1)
   05211 Renal cell carcinoma
    122918946 (PIK3R1)
   05215 Prostate cancer
    122918946 (PIK3R1)
   05213 Endometrial cancer
    122918946 (PIK3R1)
   05224 Breast cancer
    122918946 (PIK3R1)
   05222 Small cell lung cancer
    122918946 (PIK3R1)
   05223 Non-small cell lung cancer
    122918946 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    122918946 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    122918946 (PIK3R1)
   05161 Hepatitis B
    122918946 (PIK3R1)
   05160 Hepatitis C
    122918946 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    122918946 (PIK3R1)
   05164 Influenza A
    122918946 (PIK3R1)
   05162 Measles
    122918946 (PIK3R1)
   05163 Human cytomegalovirus infection
    122918946 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    122918946 (PIK3R1)
   05169 Epstein-Barr virus infection
    122918946 (PIK3R1)
   05165 Human papillomavirus infection
    122918946 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    122918946 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    122918946 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    122918946 (PIK3R1)
   05142 Chagas disease
    122918946 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    122918946 (PIK3R1)
   05017 Spinocerebellar ataxia
    122918946 (PIK3R1)
   05020 Prion disease
    122918946 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    122918946 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    122918946 (PIK3R1)
   05415 Diabetic cardiomyopathy
    122918946 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    122918946 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    122918946 (PIK3R1)
   04931 Insulin resistance
    122918946 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    122918946 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    122918946 (PIK3R1)
   01524 Platinum drug resistance
    122918946 (PIK3R1)
   01522 Endocrine resistance
    122918946 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:nvs04131]
    122918946 (PIK3R1)
Membrane trafficking [BR:nvs04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    122918946 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 AAA_13 SH3_9 SH3_2 CCDC113_CCDC96_CC Laminin_I
Other DBs
NCBI-GeneID: 122918946
NCBI-ProteinID: XP_044123756
LinkDB
Position
1:complement(220134844..220220255)
AA seq 725 aa
MSAEGYQYRALYDYKKERDEDIDLHLGDVLTVNKGSLVALGFSDGQEARPEEIGWLNGYN
ETTGERGDFPGTYVEYIGRKRISPPTPKPRPPRPLPVAPGSSKAEADSEQQQALALPDLA
EQFAPPDIAPPLLVKLLEAIEKKGLECSTLYRTQSSSNPAELRQLLDCDAASMDLEMIDV
QVLGDAFKRYLMDLPNPVIPVAVYNEMIYLAQEVQSSEDYIQLLKKLIRAPNIPHQYWLT
LQYLLKHFFKLCQTSSKNLLSARVLSELFSPLLFRFPAASSENTEHLIKVIEILISTEWN
ERQPAPALPPKPPKPTSVANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRD
ASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPK
LDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEDYTRTSQEIQM
KRTAIEAFNETIKIFEEQCQSQERYSKEYIEKFKREGNEKEIQRIMHNYEKLKSRISEIV
DSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLG
NENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYAC
SVVVDGEVKHCVINKTATGYGFAEPYNLYGSLKELVLHYQHTSLVQHNDSLNVTLAYPVY
AQQRR
NT seq 2178 nt   +upstreamnt  +downstreamnt
atgagtgccgagggctaccagtaccgagcactgtatgattacaaaaaggaacgagacgaa
gatattgacttgcacttgggtgatgtcttgactgtgaataaagggtccttagtagctctt
ggattcagtgatggacaggaagccaggcctgaagaaatcggctggttaaatggttataat
gaaaccacaggggaaagaggggactttccgggaacttacgttgaatatattggaaggaaa
agaatctcgcctcccacaccaaagccccgaccacctcgaccccttcctgttgcaccaggt
tcttcgaaagctgaagcagatagtgaacaacagcaagctttggctcttccagatctcgct
gagcagtttgcccctcccgacattgctccgcctcttctcgtgaaactcctggaagccatt
gaaaagaaaggtctggaatgttcaactctatacagaacacagagctccagcaacccggcc
gaattgcgacagcttcttgattgtgatgccgcctccatggacttggagatgatcgatgtg
caagttttgggagacgctttcaaacgctatcttatggacttaccgaatcctgtcattcca
gtagcagtttacaatgaaatgatttatttagcccaagaagtacaaagctctgaggactac
atccagctgttgaagaagctcattagggcacctaacatacctcatcagtattggctgacg
cttcagtatttgctaaaacatttcttcaagctctgtcagacctccagcaagaatctcctg
agtgcgagagtgctctctgaacttttcagccctctgcttttcagattcccagcagccagc
tctgagaatactgaacacctcattaaagttatagaaattttaatctcaacggagtggaat
gagcgacagcctgcaccagcattgcctcctaaaccaccaaaacccactagtgtagccaac
aacggtatgaataacaatatgtccttacaagatgctgagtggtactggggagatatctca
agggaagaagtgaatgaaaaacttcgagatacagctgatgggacctttttggtacgagac
gcatctactaaaatgcatggggattatactcttacactaaggaaaggaggaaataacaaa
ttaatcaaaatatttcaccgagatgggaaatatggcttctctgacccactgaccttcaac
tctgtggttgaactaataaaccactaccggaatgagtctctagctcagtataatcccaaa
ctggacgtgaaattactttatccagtgtccaaataccaacaggatcaagttgtcaaagaa
gataatattgaagctgtagggaaaaaattacatgaatataacactcaatttcaagaaaaa
agccgggaatatgatagattatatgaagattatacccgtacttcccaggaaatccaaatg
aaaagaacagctattgaagcatttaatgaaaccataaaaatatttgaagaacagtgccaa
agccaggaacggtacagcaaagaatacatagaaaaatttaaacgcgaaggcaatgagaaa
gaaatacaaaggattatgcataattatgagaagttaaagtcccgaatcagtgaaattgtg
gacagtagaaggcgactggaggaagacctgaagaagcaggcagctgagtaccgggagatc
gacaaacgcatgaacagcattaaaccagacctcattcagctgagaaagacaagagaccaa
tacttgatgtggttgactcagaaaggtgttcggcagaagaagctgaatgagtggctgggc
aatgaaaatacggaagaccaatattcgctggtggaagatgatgaggatttgccgcaccac
gacgagaagacctggaacgtgggcagcagcaacaggaacaaagcggagaacctcctccga
gggaaacgagacggcaccttcctggtccgggagagcagcaaacagggctgctacgcctgc
tctgtcgtggtggacggcgaggtcaagcattgtgtcatcaacaaaacggccaccggctat
ggcttcgccgaaccctataacttgtacggctccctgaaagaactggtgctacattaccaa
cacacgtccctcgtgcagcacaatgactcgctcaacgtcacactagcctacccggtatac
gcacagcagaggcgatga

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