KEGG   Ornithorhynchus anatinus (platypus): 100078757
Entry
100078757         CDS       T01045                                 
Symbol
PLCG1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1
  KO
K01116  phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
Organism
oaa  Ornithorhynchus anatinus (platypus)
Pathway
oaa00562  Inositol phosphate metabolism
oaa01100  Metabolic pathways
oaa01521  EGFR tyrosine kinase inhibitor resistance
oaa04012  ErbB signaling pathway
oaa04014  Ras signaling pathway
oaa04015  Rap1 signaling pathway
oaa04020  Calcium signaling pathway
oaa04062  Chemokine signaling pathway
oaa04064  NF-kappa B signaling pathway
oaa04066  HIF-1 signaling pathway
oaa04070  Phosphatidylinositol signaling system
oaa04072  Phospholipase D signaling pathway
oaa04360  Axon guidance
oaa04370  VEGF signaling pathway
oaa04613  Neutrophil extracellular trap formation
oaa04650  Natural killer cell mediated cytotoxicity
oaa04658  Th1 and Th2 cell differentiation
oaa04659  Th17 cell differentiation
oaa04660  T cell receptor signaling pathway
oaa04664  Fc epsilon RI signaling pathway
oaa04666  Fc gamma R-mediated phagocytosis
oaa04670  Leukocyte transendothelial migration
oaa04722  Neurotrophin signaling pathway
oaa04750  Inflammatory mediator regulation of TRP channels
oaa04919  Thyroid hormone signaling pathway
oaa04933  AGE-RAGE signaling pathway in diabetic complications
oaa04935  Growth hormone synthesis, secretion and action
oaa05012  Parkinson disease
oaa05022  Pathways of neurodegeneration - multiple diseases
oaa05135  Yersinia infection
oaa05167  Kaposi sarcoma-associated herpesvirus infection
oaa05170  Human immunodeficiency virus 1 infection
oaa05171  Coronavirus disease - COVID-19
oaa05200  Pathways in cancer
oaa05205  Proteoglycans in cancer
oaa05206  MicroRNAs in cancer
oaa05214  Glioma
oaa05223  Non-small cell lung cancer
oaa05225  Hepatocellular carcinoma
oaa05231  Choline metabolism in cancer
oaa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
oaa05417  Lipid and atherosclerosis
Module
oaa_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:oaa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100078757 (PLCG1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    100078757 (PLCG1)
   04014 Ras signaling pathway
    100078757 (PLCG1)
   04015 Rap1 signaling pathway
    100078757 (PLCG1)
   04370 VEGF signaling pathway
    100078757 (PLCG1)
   04064 NF-kappa B signaling pathway
    100078757 (PLCG1)
   04066 HIF-1 signaling pathway
    100078757 (PLCG1)
   04020 Calcium signaling pathway
    100078757 (PLCG1)
   04070 Phosphatidylinositol signaling system
    100078757 (PLCG1)
   04072 Phospholipase D signaling pathway
    100078757 (PLCG1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    100078757 (PLCG1)
   04650 Natural killer cell mediated cytotoxicity
    100078757 (PLCG1)
   04660 T cell receptor signaling pathway
    100078757 (PLCG1)
   04658 Th1 and Th2 cell differentiation
    100078757 (PLCG1)
   04659 Th17 cell differentiation
    100078757 (PLCG1)
   04664 Fc epsilon RI signaling pathway
    100078757 (PLCG1)
   04666 Fc gamma R-mediated phagocytosis
    100078757 (PLCG1)
   04670 Leukocyte transendothelial migration
    100078757 (PLCG1)
   04062 Chemokine signaling pathway
    100078757 (PLCG1)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    100078757 (PLCG1)
   04919 Thyroid hormone signaling pathway
    100078757 (PLCG1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    100078757 (PLCG1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100078757 (PLCG1)
  09158 Development and regeneration
   04360 Axon guidance
    100078757 (PLCG1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100078757 (PLCG1)
   05206 MicroRNAs in cancer
    100078757 (PLCG1)
   05205 Proteoglycans in cancer
    100078757 (PLCG1)
   05231 Choline metabolism in cancer
    100078757 (PLCG1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100078757 (PLCG1)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    100078757 (PLCG1)
   05214 Glioma
    100078757 (PLCG1)
   05223 Non-small cell lung cancer
    100078757 (PLCG1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100078757 (PLCG1)
   05171 Coronavirus disease - COVID-19
    100078757 (PLCG1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100078757 (PLCG1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100078757 (PLCG1)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    100078757 (PLCG1)
   05022 Pathways of neurodegeneration - multiple diseases
    100078757 (PLCG1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100078757 (PLCG1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    100078757 (PLCG1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100078757 (PLCG1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:oaa04131]
    100078757 (PLCG1)
Enzymes [BR:oaa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     100078757 (PLCG1)
Membrane trafficking [BR:oaa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    100078757 (PLCG1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    100078757 (PLCG1)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 PH SH3_1 C2 EF-hand_PLCG1 SH3_9 SH3_2 PH_12 GDPD EF-hand_6 EF-hand_7
Other DBs
NCBI-GeneID: 100078757
NCBI-ProteinID: XP_028926852
Ensembl: ENSOANG00000047399
LinkDB
Position
8:complement(22860295..22942785)
AA seq 1291 aa
MAAAAGAVGAFNGFAPCIQSEAQAAHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETR
QITWSRGSDKIEGGIDIREIKEIRPGKSSRDFDRYQEDPSFRPDQSHCFVILYGMEFRLK
TLSLQATSEEEVNMWIRGLNWLVTDTVKAATPLQIERWLRKQFYSVDRNREDRISAKDLK
NMLSQVNYRVPNMRFLRERLTDLEQRNGDITYGQFAQLYRTLMYSAQKAIEHPLIEAKII
RTGEHPELCKLSLPEFQQFLEEHQKEPWASDRSLVQEFMLSFLRDPLREIEEPYFSLDEF
LTFLFSKENSVWNAQLDAVCPESMNNPLSQYWISSSHNTYLTGDQFSSESSLEAYARCLR
MGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVTSEYPVILSIEDHCS
IAQQRNMAHYFKKVFGDMLLTKPVDVSADGLPAPNQLKRKILIKHKKLAEGSAYEEVPTS
AMYSENDISNSIKNGILYLEDPINHEWYPHYFVLTSSKIYYSEETTNDQGNEDEEEQKEA
SNSTELHSAEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLS
FWRNGKVQHCRIHSRQDAGSPKFFLTDNLVFDSLYALITHYQQVPLRCNEFEMRLTEPVP
QTNAHESKEWYHASLTRTQAEHMLMRVPRDGAFLVRKRSEPNSYAISFRAEGKIKHCRVQ
QEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMRLRYPINEETLEKIGTAEPDYGALYEGR
NPGFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQ
LWFPSNYVEEMASPALEPEREQLDENSPLGDLLRGVLDVPSCQIAIRPEGKNSRLYVFSV
SMASLSHWSLDVAADTQEDLQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVY
CRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKSKGKKFLQYNRLQLSRIYPKGQRLD
SSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMSGGRCGYVMQPCSMRDDVFDPFDK
NSLRGLESWTINIEVLGARHLPKNGRGIVCPFVEIEVSGADYDNAKQKTEFVVDNGLNPV
WPPKPFQFQIINPEFAFLRFVVYEEDMFSDQNFLAQATFLVKGLKSGYRAVPLKNNYSED
LELASLLIKINIHPAKQENGELSQFSPASLRERGSDSGQLLNSRPRVGSFEARYQQPFED
FRLSPEQLAEHFEVRERRALRRTRVNGDNRL
NT seq 3876 nt   +upstreamnt  +downstreamnt
atggcagcggcggcaggggctgtgggcgccttcaacggtttcgcgccctgcatccagtcc
gaggcccaggccgcccacctctgccggagcctggaggtgggcaccgtgatgactttgttt
tactcgaaaaaatctcagcggccggagaggaaaactttccaggtcaaactggaaaccagg
cagatcacatggagcagaggctcggataaaatcgaaggaggcattgacatccgtgagatc
aaggaaatccggcctgggaagagctcccgggattttgaccgctatcaggaggacccttcg
ttccggccagaccagtcccactgcttcgtcattctgtacgggatggagttccgactgaaa
accctgagtcttcaagccacgtcggaggaagaagtgaacatgtggatcagaggcctgaac
tggctggtgactgatactgtcaaggcggccaccccactgcagatcgagaggtggctccga
aagcagttctactcggtggatcgcaacagggaagacaggatttccgctaaggacttgaaa
aacatgctgtcccaggtcaactaccgtgtccctaacatgcggttcctgagggagcggctg
acggacctggagcaacgcaatggggacatcacctacggacagtttgctcagctgtaccgc
accctgatgtacagcgctcagaaagcgattgagcaccctctcatcgaagccaaaatcatc
aggactggggagcatcccgagctctgtaagttgtcgctcccagagttccagcagttcctc
gaggaacaccagaaggagccctgggcctcggacaggagcctggtgcaggagttcatgctc
agcttcctccgggaccccctgcgggagatcgaggagccgtacttctcgctggacgagttt
ctcaccttcctgttctccaaagaaaacagcgtttggaacgcccaactcgacgctgtgtgc
ccagaaagtatgaacaatcccctgtcacagtactggatctcctcatcacacaatacgtac
ctaacgggcgaccagttctccagtgagtcgtcgctagaagcctatgcccgctgcctgcgc
atgggctgccgctgcatcgagctggactgctgggacgggccggacggcatgccggtcatc
taccacgggcacacgctgaccaccaagatcaagttctctgacgtcctgcacaccatcaag
gagcacgccttcgtgacctcggagtatcccgtgatcctgtcgatcgaggaccactgtagc
atcgcccagcagcggaacatggctcactacttcaagaaggtgttcggggacatgctgctc
accaagccggtggacgtctcggctgacgggctgccggcccccaatcagctcaagaggaag
attctcattaagcacaagaagctggcagagggcagcgcctacgaggaggtgccaacgtca
gctatgtactcggaaaatgacatcagcaactccatcaagaacggaattctctacctggag
gaccccatcaaccacgaatggtacccccactactttgtcctgaccagcagcaagatctac
tactcagaggagaccaccaatgaccaggggaatgaggatgaggaggaacagaaggaggca
agcaacagcacggagctgcactcggccgaaaagtggttccacgggaagctgggcgcggga
cgggatggccggcacatcgccgagcggctgctcaccgagtactgcatcgagaccggcgcc
cccgacggctccttcctggtgcgcgagagcgagaccttcgtgggagactacaccctctcc
ttctggcgcaacggaaaggtgcagcactgccgcatccactcccgccaggacgccggcagc
cccaagttcttcctcaccgacaacctggtgttcgacagcctgtacgccctcatcacccac
taccagcaggtgcccctgcgctgcaatgagtttgagatgcgcctgacggagcccgtgccc
cagaccaacgcccacgagagcaaggagtggtaccacgccagcctaacgcggacccaggcg
gagcacatgctcatgagggtcccgcgggatggggccttccttgtgcgcaagaggagcgag
cccaactcctacgccatttccttccgggcggaagggaagatcaagcactgccgcgtccag
caggagggccagacggtcatgctgggcaactcggagttcgacagcctcgtggacctcatc
agctactacgagaagcacccgctgtaccgcaagatgagactgcgttatcctatcaatgag
gagacgctggagaagataggcaccgcggagccggactacggagccctgtacgaaggccgc
aaccccggcttctacgtggaggccaacccgatgcccacttttaagtgtgcagtcaaggcc
ctgttcgactacaaggcccagcgggaggatgagctgacgttcaccaagagtgccatcatc
cagaatgtggaaaagcaggaggggggctggtggaggggagactatggaggcaagaaacag
ctctggttcccttccaactacgtggaggaaatggccagtccggccctggagcccgagaga
gagcagctggacgagaacagccccctgggggacctgttgagaggagtcttggatgtgccc
tcctgtcagatcgccatccgcccggaggggaagaacagccggctgtacgtattctccgtg
agcatggcctcgttgtcgcactggtctctggacgtggcggccgacacgcaggaggacctg
caggactgggtgaagaagattcgcgaggtggcccagaccgcagacgccaggctcacagaa
gggaagatgatggaacgaaggaagaagatcgccttggagctgtccgagctggtcgtctac
tgccggccggtgcctttcgatgaagagaagatcggcacggagagagcctgctaccgggac
atgtcctccttccccgagaccaaagccgagaagtatgtgaacaagagcaaaggcaagaag
ttcctgcaatacaaccggctgcagctatcccgtatataccccaaaggccagcgtctcgac
tcttccaactacgaccccctgcccatgtggatctgtggcagccagctggtcgccctcaac
ttccagaccccagacaagcccatgcagatgaaccaggcgctgttcatgtccggcggccgc
tgtggctacgtgatgcagccctgcagcatgcgcgacgacgtcttcgaccccttcgacaag
aacagcctccgcggtctcgagtcgtggaccattaacatcgaggtcctgggggctcggcat
ctgcccaagaacggcaggggcatcgtgtgcccatttgtggagatcgaggtgtctggggcc
gactatgacaacgccaagcagaagaccgaatttgtggtggacaacggtctgaaccccgta
tggccccccaagcccttccagttccagatcatcaaccctgagtttgccttcctgcgcttc
gtcgtgtatgaagaggacatgttcagtgaccaaaacttcctggcccaggccacattcctg
gtgaaaggactgaaatcaggatacagagcggtgcccctgaagaacaactacagcgaggac
ttggagttggcttctctcctcattaagatcaacatccacccggccaagcaggagaacggc
gagctgagccagttcagccccgcgtccctgcgagagcggggtagcgactcgggccagctc
ctcaatagccgcccccgcgtgggctccttcgaagcccgctaccagcagccgttcgaggac
ttccgtctttccccggagcagctagccgagcacttcgaggtccgggagcgaagggccttg
cggaggaccagagtcaacggagacaatcgcctctag

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