Ornithorhynchus anatinus (platypus): 100087942
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Entry
100087942 CDS
T01045
Symbol
MAP2K2
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 2
KO
K04369
mitogen-activated protein kinase kinase 2 [EC:
2.7.12.2
]
Organism
oaa
Ornithorhynchus anatinus (platypus)
Pathway
oaa01521
EGFR tyrosine kinase inhibitor resistance
oaa01522
Endocrine resistance
oaa04010
MAPK signaling pathway
oaa04012
ErbB signaling pathway
oaa04014
Ras signaling pathway
oaa04015
Rap1 signaling pathway
oaa04022
cGMP-PKG signaling pathway
oaa04024
cAMP signaling pathway
oaa04066
HIF-1 signaling pathway
oaa04068
FoxO signaling pathway
oaa04071
Sphingolipid signaling pathway
oaa04072
Phospholipase D signaling pathway
oaa04140
Autophagy - animal
oaa04148
Efferocytosis
oaa04150
mTOR signaling pathway
oaa04151
PI3K-Akt signaling pathway
oaa04210
Apoptosis
oaa04218
Cellular senescence
oaa04270
Vascular smooth muscle contraction
oaa04370
VEGF signaling pathway
oaa04371
Apelin signaling pathway
oaa04540
Gap junction
oaa04550
Signaling pathways regulating pluripotency of stem cells
oaa04613
Neutrophil extracellular trap formation
oaa04620
Toll-like receptor signaling pathway
oaa04650
Natural killer cell mediated cytotoxicity
oaa04660
T cell receptor signaling pathway
oaa04662
B cell receptor signaling pathway
oaa04664
Fc epsilon RI signaling pathway
oaa04720
Long-term potentiation
oaa04722
Neurotrophin signaling pathway
oaa04730
Long-term depression
oaa04810
Regulation of actin cytoskeleton
oaa04910
Insulin signaling pathway
oaa04912
GnRH signaling pathway
oaa04915
Estrogen signaling pathway
oaa04916
Melanogenesis
oaa04917
Prolactin signaling pathway
oaa04919
Thyroid hormone signaling pathway
oaa04921
Oxytocin signaling pathway
oaa04926
Relaxin signaling pathway
oaa04929
GnRH secretion
oaa04934
Cushing syndrome
oaa04935
Growth hormone synthesis, secretion and action
oaa05010
Alzheimer disease
oaa05022
Pathways of neurodegeneration - multiple diseases
oaa05132
Salmonella infection
oaa05135
Yersinia infection
oaa05160
Hepatitis C
oaa05161
Hepatitis B
oaa05163
Human cytomegalovirus infection
oaa05164
Influenza A
oaa05165
Human papillomavirus infection
oaa05166
Human T-cell leukemia virus 1 infection
oaa05167
Kaposi sarcoma-associated herpesvirus infection
oaa05170
Human immunodeficiency virus 1 infection
oaa05200
Pathways in cancer
oaa05205
Proteoglycans in cancer
oaa05206
MicroRNAs in cancer
oaa05207
Chemical carcinogenesis - receptor activation
oaa05208
Chemical carcinogenesis - reactive oxygen species
oaa05210
Colorectal cancer
oaa05211
Renal cell carcinoma
oaa05213
Endometrial cancer
oaa05214
Glioma
oaa05215
Prostate cancer
oaa05216
Thyroid cancer
oaa05218
Melanoma
oaa05219
Bladder cancer
oaa05220
Chronic myeloid leukemia
oaa05221
Acute myeloid leukemia
oaa05223
Non-small cell lung cancer
oaa05224
Breast cancer
oaa05225
Hepatocellular carcinoma
oaa05226
Gastric cancer
oaa05230
Central carbon metabolism in cancer
oaa05231
Choline metabolism in cancer
oaa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
oaa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100087942 (MAP2K2)
04012 ErbB signaling pathway
100087942 (MAP2K2)
04014 Ras signaling pathway
100087942 (MAP2K2)
04015 Rap1 signaling pathway
100087942 (MAP2K2)
04370 VEGF signaling pathway
100087942 (MAP2K2)
04371 Apelin signaling pathway
100087942 (MAP2K2)
04066 HIF-1 signaling pathway
100087942 (MAP2K2)
04068 FoxO signaling pathway
100087942 (MAP2K2)
04072 Phospholipase D signaling pathway
100087942 (MAP2K2)
04071 Sphingolipid signaling pathway
100087942 (MAP2K2)
04024 cAMP signaling pathway
100087942 (MAP2K2)
04022 cGMP-PKG signaling pathway
100087942 (MAP2K2)
04151 PI3K-Akt signaling pathway
100087942 (MAP2K2)
04150 mTOR signaling pathway
100087942 (MAP2K2)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
100087942 (MAP2K2)
04148 Efferocytosis
100087942 (MAP2K2)
09143 Cell growth and death
04210 Apoptosis
100087942 (MAP2K2)
04218 Cellular senescence
100087942 (MAP2K2)
09144 Cellular community - eukaryotes
04540 Gap junction
100087942 (MAP2K2)
04550 Signaling pathways regulating pluripotency of stem cells
100087942 (MAP2K2)
09142 Cell motility
04810 Regulation of actin cytoskeleton
100087942 (MAP2K2)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
100087942 (MAP2K2)
04620 Toll-like receptor signaling pathway
100087942 (MAP2K2)
04650 Natural killer cell mediated cytotoxicity
100087942 (MAP2K2)
04660 T cell receptor signaling pathway
100087942 (MAP2K2)
04662 B cell receptor signaling pathway
100087942 (MAP2K2)
04664 Fc epsilon RI signaling pathway
100087942 (MAP2K2)
09152 Endocrine system
04910 Insulin signaling pathway
100087942 (MAP2K2)
04929 GnRH secretion
100087942 (MAP2K2)
04912 GnRH signaling pathway
100087942 (MAP2K2)
04915 Estrogen signaling pathway
100087942 (MAP2K2)
04917 Prolactin signaling pathway
100087942 (MAP2K2)
04921 Oxytocin signaling pathway
100087942 (MAP2K2)
04926 Relaxin signaling pathway
100087942 (MAP2K2)
04935 Growth hormone synthesis, secretion and action
100087942 (MAP2K2)
04919 Thyroid hormone signaling pathway
100087942 (MAP2K2)
04916 Melanogenesis
100087942 (MAP2K2)
09153 Circulatory system
04270 Vascular smooth muscle contraction
100087942 (MAP2K2)
09156 Nervous system
04720 Long-term potentiation
100087942 (MAP2K2)
04730 Long-term depression
100087942 (MAP2K2)
04722 Neurotrophin signaling pathway
100087942 (MAP2K2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100087942 (MAP2K2)
05206 MicroRNAs in cancer
100087942 (MAP2K2)
05205 Proteoglycans in cancer
100087942 (MAP2K2)
05207 Chemical carcinogenesis - receptor activation
100087942 (MAP2K2)
05208 Chemical carcinogenesis - reactive oxygen species
100087942 (MAP2K2)
05230 Central carbon metabolism in cancer
100087942 (MAP2K2)
05231 Choline metabolism in cancer
100087942 (MAP2K2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
100087942 (MAP2K2)
09162 Cancer: specific types
05210 Colorectal cancer
100087942 (MAP2K2)
05225 Hepatocellular carcinoma
100087942 (MAP2K2)
05226 Gastric cancer
100087942 (MAP2K2)
05214 Glioma
100087942 (MAP2K2)
05216 Thyroid cancer
100087942 (MAP2K2)
05221 Acute myeloid leukemia
100087942 (MAP2K2)
05220 Chronic myeloid leukemia
100087942 (MAP2K2)
05218 Melanoma
100087942 (MAP2K2)
05211 Renal cell carcinoma
100087942 (MAP2K2)
05219 Bladder cancer
100087942 (MAP2K2)
05215 Prostate cancer
100087942 (MAP2K2)
05213 Endometrial cancer
100087942 (MAP2K2)
05224 Breast cancer
100087942 (MAP2K2)
05223 Non-small cell lung cancer
100087942 (MAP2K2)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
100087942 (MAP2K2)
05170 Human immunodeficiency virus 1 infection
100087942 (MAP2K2)
05161 Hepatitis B
100087942 (MAP2K2)
05160 Hepatitis C
100087942 (MAP2K2)
05164 Influenza A
100087942 (MAP2K2)
05163 Human cytomegalovirus infection
100087942 (MAP2K2)
05167 Kaposi sarcoma-associated herpesvirus infection
100087942 (MAP2K2)
05165 Human papillomavirus infection
100087942 (MAP2K2)
09171 Infectious disease: bacterial
05132 Salmonella infection
100087942 (MAP2K2)
05135 Yersinia infection
100087942 (MAP2K2)
09164 Neurodegenerative disease
05010 Alzheimer disease
100087942 (MAP2K2)
05022 Pathways of neurodegeneration - multiple diseases
100087942 (MAP2K2)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
100087942 (MAP2K2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100087942 (MAP2K2)
01522 Endocrine resistance
100087942 (MAP2K2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
oaa01001
]
100087942 (MAP2K2)
Enzymes [BR:
oaa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
100087942 (MAP2K2)
Protein kinases [BR:
oaa01001
]
Serine/threonine kinases: STE group
STE7 family
100087942 (MAP2K2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Haspin_kinase
CAMSAP_CC1
Seadorna_VP7
Kdo
APH
Motif
Other DBs
NCBI-GeneID:
100087942
NCBI-ProteinID:
XP_028908616
Ensembl:
ENSOANG00000045918
UniProt:
A0A6I8NJJ1
LinkDB
All DBs
Position
X2:10608381..10628370
Genome browser
AA seq
400 aa
AA seq
DB search
MPPKRKPVLPALHITPTIAEGSSPTSESSSEANLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHKPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELAIGRYPIPPPDTKELEAIFGRPVVDGAEGEPSSISPRPRP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNPAERADL
KMLMNHAFIKRSEVEEVDFAGWLCKTLRLNQPSTPTRTAM
NT seq
1203 nt
NT seq
+upstream
nt +downstream
nt
atgccacccaagaggaagccggtgctgccggcgctccacatcactcctaccatcgccgaa
ggctcgtcccccacgagcgagagctcctccgaggcgaatctggttgacctccagaagaaa
ctggaggagctcgagctagatgaacagcagaagaagcggctggaggctttcctcacccag
aaagccaaggtgggagagctaaaggacgatgactttgaaaggatctcggagctgggagct
ggcaatggtggggtggtcaccaaagtacaacacaaaccctcagggctcatcatggcacga
aagttgattcacctggagatcaaacctgccattcgcaaccagatcattcgggaactccag
gtcctacacgagtgcaattcgccttacattgtgggcttctatggagccttttatagcgat
ggggaaatcagcatctgcatggagcacatggatggagggtctctggatcaggtgttaaaa
gaagccaagagaattcctgaagagatcttggggaaagtcagcattgcagttctgcgcggt
ttggcatatctgagagagaaacaccagattatgcacagagacgtgaaaccctccaacatc
cttgtcaactcccggggagagatcaagttgtgtgattttggggtgagcgggcagctcatc
gactccatggctaactccttcgtaggaacccgctcctacatgtctccggagcggttgcaa
ggcactcactactcagttcagtccgatatctggagtatgggcctgtccctagtagagctg
gccatcggaagatacccaatcccccctccagacaccaaggaattagaagcgatctttgga
cggcccgtggtcgatggggcagagggagagccctccagcatctctccgcggccacgaccc
ccaggacgcccaatcagtggccacgggatggatagtcgaccagccatggccatctttgaa
ctgttggactacattgttaacgagcctccacctaaacttccgaacggggttttcacgcaa
gacttccaggagtttgtaaataaatgcttaattaaaaatccagcagagcgggcagatctg
aagatgttgatgaatcatgcctttatcaaacggtcagaagtggaagaagtggattttgca
ggctggttatgtaaaacactgaggttaaaccaacccagcacccccacgcgcactgccatg
tga
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