Ornithorhynchus anatinus (platypus): 100681936 Help Entry 100681936         CDS       T01045                                  Symbol RYR1 Name (RefSeq) ryanodine receptor 1   KO K04961   ryanodine receptor 1 Organism oaa  Ornithorhynchus anatinus (platypus) Pathway oaa04020   Calcium signaling pathway oaa04371   Apelin signaling pathway oaa04713   Circadian entrainment oaa04730   Long-term depression oaa04921   Oxytocin signaling pathway oaa05017   Spinocerebellar ataxia oaa05020   Prion disease oaa05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:oaa00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     100681936 (RYR1)    04020 Calcium signaling pathway     100681936 (RYR1)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     100681936 (RYR1)   09156 Nervous system    04730 Long-term depression     100681936 (RYR1)   09159 Environmental adaptation    04713 Circadian entrainment     100681936 (RYR1)  09160 Human Diseases   09164 Neurodegenerative disease    05017 Spinocerebellar ataxia     100681936 (RYR1)    05020 Prion disease     100681936 (RYR1)    05022 Pathways of neurodegeneration - multiple diseases     100681936 (RYR1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:oaa01009]     100681936 (RYR1)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:oaa04147]     100681936 (RYR1)    04040 Ion channels [BR:oaa04040]     100681936 (RYR1) Protein phosphatases and associated proteins [BR:oaa01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      100681936 (RYR1) Exosome [BR:oaa04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    100681936 (RYR1) Ion channels [BR:oaa04040]  Voltage-gated cation channels   Ryanodine receptor    100681936 (RYR1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  100681936 NCBI-ProteinID:  XP_039768107 Ensembl:  ENSOANG00000047642 LinkDB All DBs Position 5:2780782..2851359 Genome browser AA seq 5027 aa AA seqDB search MAEGGEGEDDVQFLRTEDEVVLQCSATVLKEQLKLCLAAEGFGNRLCYLEPTSNAQNVPP DLAICCFVLEQSLSVRALQEMLANTMDASAESSQGGGHRTLLYGHAILLRHAHSRMYLSC LTTSRSLTDKLAFDVGLQEDASGEACWWTMHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSTASGDLQADASFMQTLWNMNPICSGGEEGYVTGGHVMRLFHGHMDECLTISPSDSDD QRRLVHYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPLRIRHVTTGRYLALTEEQGLV VVDAARAPTKASAFCFRASKEKLDVAPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYA ATDTKALRLGLLKRKAMLHQEGHMDDALSLTRCQQEESQAARMIYSTAGLYSLFIKGLDS LSGKPKGTGQSVSLPIEGVSLSLQDLISYFQPPRDDLQHEERQTKLRSLRNRQNLFQEEG MLSLVLNCIDRLNVYSTAAHFAEFAGEEAADSWKEIVNLLYELLASLIRGNRANCALFST NLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLDV LCSLCVCNGVAVRSNQDLITENLLPGRELLLQTCLVNYVTSIRPNIFVGRAEGSTQYRQW YFEVMVDSVQPFLTAQPTHLRVGWALSEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHLW AGRVARPVASPGQHLLAPEDVVSCCLDLNVPSISFRINGCPVQGMFEGFNLDGLFFPVVS FSAGVKLRFLLGGRHGDFKFLPPPGYAPCYEALLPRERMRLEPIKQYRQEGLRGAHLVGP ARCLSHTDFTPCPVDTVQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPVRDDNKR LHPCLLDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEENLKKTKLPKTYMMS NGYKPAPLDLAHVRLTPAQTTLVDRLAENGHNVWARDRVQQGWSYSTVQDIQARRNPRLV PYRLLDERTKRSNRDSLCQAVRTLLGYGYNIEPPDQEAAHTETRSRWDRVRIFRAERSYA VRSGRWYFEFEAVTTGEMRVGWARPDLRPDVELGADDLAYVFNGHRGQRWHVGSEPFGRT WQPGDVVGCMIDLTDNSIMFTLNGELLISDSGSEAAFKEIEIGDGFVPVCSLGPGQVGRL ELGQDVGNLRYFTICGLQEGFEPFAINMKRDITTWFSKSLPQFDPIPPDHPHYEVTRMDG TVDSPPCLRVTHRTWGSQNSVTEIIFLRLSLPVQFHQQFRCTPGATPLAPAGPPPPPEDE ARAAEPDSDYEQLCKSAGRKEAEGAGDKDGPGPKEPAAGGGRGEASRAENEKDVATEKSK KRGFLFKAKKAAMMSQTPATPTLPRLTEDVVPDDRDDPEIILNTTTYYYSVRVFAGQEPS AVWVGWVTPDYHQHDLAFELSKVRAVTVTMGDEQGNVHNSLKRSNCYMVWGGDFVSSGQQ SRVSHTDLVIGCLVDLATGLMTFTGNGKESNTFFQVEPNTKLFPAVFVLPTNQNLVQFEL GKLKNIMPLSAAMFLSERKNPVPQCPPRLVVQMLRPVTWSRMPNQFLRVNTQRQSERLGW AVECTEPLTMMALHIPEENRCIDILELAERLDLQRFHSHSLRLYCAVCALGNNRVAHALC SHVDQAQLLHTIEDHHLPGLLRAGYYDLLISIHLESARRARRSMQGEFIVPMTDATKGIT LYPPAGRGRHGLPGVGVSTSLRPPLHFAPPCFVAAPGGETSARLSPAVPLEVLKAKALHM LTEAVRESGQHARDPVGGSVEFQFVPVLKLVSALLVMGVFDDDDVKHILRMIEPDVFAEP EEEEVEEEEEEEEEEEEDEEEVEEEEEDEEKEEEEEKEDAEKEEEEGGEEKEEELEEGLL QMKLPESVKLQMCHLLEYFCDQELQHRVEALIAFSESYVERLQANQRGRYGQLMMAFTMS AAETARRTREFRSPPQEQINMLLHFKGGADEEDCPVPDDVRQDLLQFHEDLMTHCGVQLQ GEEEEQEEESSLGGRLLSLLEKVKLVKKKEPEQEEEPAQEEPKPTSLQELISHTMVHWAR EAFIQSPELVRAMFSLLHRQYDGVGEVLRALPRAYTISAGSVDDTMSLLESLGQIRSLLI VQMGPQEENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEIRFPK MVTSCCRFLCYFCRISRQNQRSMFDHLSYLLENSSIGLGMRGSTPLDVAAASVIDNNELA LALQEQDLEKVVSYLAGCGLQSCPMLLAKGYPDIGWNPCGGERYLDFLRFAVFVNGESVE ENANVVVRLLIRRPECFGPALRGEGGSGLLAAVEEAIRISEDPARDGPTHRKDRRREHFG GEEAPEENRVHLGNAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPLEDL VGVISLPLQIPAFGKDGNTVEPRMSASFVPDHKAPMVLFLDRVYGIDSQDFLLHVLEVGF LPDMRAAASLDTAAFSTTEMALALNRYLSLAVLPLITKCAPLFAGTEHRAIMVDSMLHTI YRLSRGRSLTKAQRDVIEDCLMALCRYIRPSMLQHLLRRLVFDVPILNEFAKMPLKLLTN HYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFESLAHKKFDAELYRIAMPCLCAI AGALPPDYVDASYSSKTEKKASVDAEGNFDPKPVETLNVIIPEKLDSFINKYAEYTHEKW AFDKIQNNWSFGENIDEDAKTHHMLRPYKTFSEKDKEIYRWPIKESLKAMIAWEWTVEKA REGEEEKGEKKTKTRKISQNAQATYDPSHGYNPQPVDLSTVTLSRELQAMAEQLAENYHN TWGRKKKLELEAKGGGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRGLKDM ELDTSSIEKRFAFSFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLP LISQYFTNHCLYFLSTPAKVLGSGGHASNKEKEMLTSLFCKLAALVRHRVSLFGTDAPAV VNCLHILARSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLKLGKVSQARTQVKG VGQNLTYTTVALLPVLTSLFQHIAQHQFGDDVILDDVQVSCYRTLCSIYSLGTTKNPYVE KQRPALGECLARLAAAMPVAFLEPQLNEFNACSVYTTKSPRERALLGLPNCVEEMCPDIP ELDRLMREIGGLAESGARYTEMPHVIEVTLPMLCNYLPRWWERGPETASSGTPPPCTSVT SDHLNSLLGNILRIIVNNLGIDEASWMKRLAVFAQPIVSRARPELLRSHFIPTVGRLRKR AGKVVSEEEQLRLEAKAEAEEGELLIRDEFSVLCRDLYALYPLLIRYVDNNRAHWLTEPN PDAEELFRMVGEIFIYWCKSHNFKREEQNFVVQNEINNMSFLTADSKSKMAKAGESQSGG SEQERTKKKRRGDRYSVQTSLIVATLKKMVPIGLNMCAPTDQELINQAKTRYAMKDTDEE VREFLQSHLSLQGKNENSPSMRWQMALYRSMSGRAEDADDPDKIVRRVQEVSAVLYHLEQ TEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPRHRACNMFLEAYKLGWIVTEEHS FEDRMIDDLSKAGEEEEEEEAAEEQKEKQPDPLHQLVLHFSRTALTENSKLDEDYLYMAY ADIMAKSCHLEECSEEAEAAEDEQEASFEEKEMEKQKLLYQQSRLHSRGAAEMVLQMISA CKGEPGAMVSSTLKLGISILNGGNADVQQKMLDYLKDKKEVGFFQSLQALMQTCSVLDLN AFERQNKAEGLGMVTEDGTAIDRQNGEKVMADDEFTQDLFRFLQLLCEGHNNDFQNYLRT QTGNTTTINIIIATVDYLLRLQESISDFYWYYSGKDIVDEQGKRNFSKAMAVAKQVFNSL TEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIGLLKELLDLQKDMVV MLLSLLEGNVVNGMIARQMVDMLVESSSNVEMVLKFFDMFLKLKDIVAADAFRDYVTDPR GLISKKDFQKAMDSQKQFSGTEIQFLLSCSEADENEMIDCDEFASRFQEPAKDIGFNVAV LLTNLSEHVPHDPRLHTFLELAESILEYFRPYLGRIEIMGASKRIERIYFEISETNKAQW EMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISEPEGGPEEEEEEE EDGGEEEGAAEEEGPGGPAGAEGRSAFGELLGAATSCLRLFGYRALRRRVRRLRRMTVRE LSAALAGLVWTLLSRVARSLAGLARGVALLVWGSLFGGGLVEGAKKMTVTELLAGMPDPT QDEVHADQPAAPGAAPAQPRDGPEAEADFAEDGGDAPGDDGPEVAKDGAHYRPGGPDAPG GLGDMGDMTPVEPPTPEGSPILKRKPGDGEEEEEKEEREEEPPPEPEKADAENGEKGGPQ PEPEPPKKKAAAAPPPRKGEAGASAGLDFWGEMEVQRVKFLNYLSRNFYTLRFLALFLAF AINFILLFYKVSDSPPGEEELDGSGLEELSSGLGSGEGLGSGLGSGAGEEEDEEENMVYY FLEESTGYMQPALHFLSLLHTLIAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITE QPEDDDVKGQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIYGRERIAELLGMDLASLEI TAQNEKKPEPDKSFITWIMSIDIKYQIWKFGVIFTDNSFLYLAWYMVMSLLGHYNNFFFA CHLLDIAMGVKTLRTILSSVTHNGKQLAMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDED EPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLA IIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMF FLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 15084 nt NT seq  +upstreamnt  +downstreamnt atggccgaaggcggagaaggagaagatgatgtccagtttctccggactgaagatgaggtt gtcctgcagtgcagcgccaccgtactgaaggagcagctcaaactctgcctggcggccgaa ggctttggaaaccgactctgctacttggaacccaccagcaatgcccagaacgtgcccccc gatctcgccatctgctgcttcgtgctggagcagtccctgtcagtgcgggctctgcaagag atgctcgctaacaccatggacgccagcgctgagtcgtcccagggcggggggcaccgtaca cttctctacggtcacgccatcttgttgagacacgcccacagtcgcatgtacctgagttgc ctgaccacctcccgctccctgaccgacaaactggctttcgacgtggggctgcaggaagat gcctccggggaagcgtgctggtggaccatgcatccggcctccaagcagcggtcggaaggg gagaaggttcgtgttggagacgatctcatcttggtcagcgtctcctccgagcgctatctg catctgtctacagccagcggggacctgcaggccgacgcctccttcatgcagacgttgtgg aacatgaatcccatctgctccggtggcgaggaaggatatgttaccggaggccacgtgatg cgcctgtttcacggtcacatggacgagtgtctgaccatctccccgtctgacagcgatgac cagcgcaggttggtgcactacgaagggggggccgtgtgcacccacgcccgctctctctgg cggttggagcctctgcgtatcagctggagcggtagccacctgcgctggggtcagcccctg cggatccgtcacgtaaccacgggccgctacctggctctgacggaagagcaggggctggtg gtcgtggacgcagccagagctcctaccaaggcctccgctttctgcttccgcgcctccaag gagaagctggacgtggccccgaagagggacgtggaagggatgggccccccggagatcaag tacggggagtcgctctgcttcgtccagcacgtggcctcggggctgtggctcacctacgct gccaccgacaccaaggccttgagactcggcctgctcaagaggaaggccatgctgcaccag gaaggccacatggacgacgctctgtcgctgacccgttgccagcaggaggaatcccaggct gcccgcatgatctacagcaccgccggcctctacagcctcttcatcaagggcttggacagc ctgagtgggaagccgaagggcacgggacagagcgtgtcgctgcccatcgaaggggtgagc ctcagcctgcaggatctcatcagctacttccagccgccccgcgacgacctgcagcacgaa gagcgacagaccaagctgcgctccctccgcaaccgacagaacctcttccaggaggagggc atgctatcgctggtgctgaactgcatcgacaggctcaacgtctactccaccgccgcccac ttcgccgaattcgccggcgaggaggccgccgactcctggaaggagatcgtcaacctgctc tatgaacttctggcctctttgattcgtgggaaccgcgccaactgtgccctcttctccacc aacctggactggcttgtcagcaagctagatcggctggaggcctcctcggggatcctggag gtgctctactgcgtgctcatcgagagccccgaggttctcaacatcatccaggagaaccac atcaaatccatcatctccctgctggacaagcatggacgcaaccacaaggtgctggacgtg ctgtgctcgctgtgcgtgtgcaacggcgtggccgtgcgctccaaccaggacctcatcacg gaaaacctgctccccggccgggagctgctgctgcagacctgccttgtcaactatgtgacc agcatccgccccaacatctttgtgggccgggcggagggctccacgcagtatcgccagtgg tacttcgaggtgatggtggactccgtgcagcccttcctgacggcccagcccacccacctg cgggtgggctgggcgctcagcgagggctacagcccctaccccgggggcggcgagggctgg ggaggcaacggcgtcggcgacgacctctactcctacggcttcgacgggctgcacctctgg gcagggcgggtggcacggccggtggcctcccccgggcagcacctgctggcgcccgaggac gtggtgagctgctgtctggatctcaacgtcccgtccatctcgttccgcatcaacggctgc cccgtgcagggcatgttcgagggcttcaacctcgacggcctcttcttccccgtcgtcagc ttctcggccggcgtcaagttgcgtttcctgctgggggggcgtcacggagacttcaagttc ctgcccccgcccggctacgcgccctgctacgaggccctgctgccgcgggagcgtatgcgc ctggagcccatcaagcagtatcggcaggagggtctgcggggagcccacctggtgggcccg gctcgttgcctctcccacaccgacttcaccccctgccccgtcgacaccgtccagatcgtc ctccctccgcacctggagcgcatccgcgagaagctggcggagaacatccacgagctgtgg gcgctgacccggatcgagcaaggctggacctacgggcctgtccgggatgacaataagcgg ctccacccgtgtctgctcgacttccacagcctccccgagccagagcgcaactacaacctg cagatgtccggggagaccctcaagacgctgttggccttgggttgccacgtaggcatggcg gacgagaaggctgaagaaaacctcaaaaagaccaagctccccaaaacgtacatgatgagc aacgggtacaagccggcccccctggacctggcccacgtgcggctgacaccggcgcagacg acgctggtggaccggctggcggagaacgggcacaacgtgtgggcgagggaccgggtgcag cagggctggagctacagcaccgtgcaggacatccaggcccgccgcaacccccgcctcgtg ccctaccgcctgctcgacgagcgcaccaagcgcagcaaccgcgacagcctctgccaggcc gtgcgaaccctcctgggctacggctacaacatcgagccccccgaccaggaagccgcccac acggagacccgatcgcgctgggaccgggtgcgaatcttccgggccgagcgatcgtacgcc gtgcgcagcggccgctggtacttcgagttcgaggcggtgaccaccggggagatgcgcgtc ggctgggcccggccggacctgcggcctgacgtggagctcggcgccgacgatctggcctac gtcttcaacggacaccgggggcagcgctggcatgtgggcagcgagccgtttgggcgcacc tggcagccgggcgacgtggtcggctgcatgatcgatctgacggacaacagcatcatgttc accctcaacggcgagttgctcatcagcgactcgggctcggaggcggccttcaaggagatc gagatcggcgacggcttcgtcccggtgtgcagcctgggccccggccaggtggggcggctg gagctgggccaggacgtgggcaacctgcgttacttcaccatctgcgggctccaggagggc ttcgagcccttcgccatcaacatgaagcgagacatcaccacctggttcagcaagagcctg cctcagttcgaccccatcccgcccgaccacccccactacgaggtgacgcggatggacggc acggtggacagtcccccctgcctgcgggtgacccaccggacctggggctcgcagaacagc gtcacggagatcatcttcctgcgcctcagtctacccgtccagttccaccagcagttccgc tgcacccccggggccaccccgctggccccggccggacccccgcccccgcccgaggacgag gcccgggccgccgagcccgactccgactacgagcagctgtgcaagtcggccggcaggaag gaggccgaaggggccggcgacaaggacgggcccgggcccaaggagccggcggccgggggt gggcgtggggaggcgtccagggccgagaacgagaaggacgtggccacggagaagagcaag aagagggggttcctcttcaaggccaagaaggctgccatgatgtcccagacgcccgctacc ccgacgctgccccgtctgacagaggatgtggtccccgatgatcgcgatgaccccgagatc atcctcaacaccaccacgtactactactcggtgcgggtgttcgcggggcaggagcccagc gccgtctgggtgggctgggtcacccccgattaccaccagcacgacctggccttcgagctg agcaaggtccgggcggtgaccgtcaccatgggagacgagcagggcaacgtgcacaacagc ctgaaacgcagtaactgctacatggtgtggggaggcgactttgtgagcagcggtcagcag agccgggtcagccacacggacctggtcatcggctgcctggtggacctggccaccggcctc atgaccttcacgggcaacggcaaagagagcaacactttcttccaggtggagcccaacacc aagctgtttcctgccgtcttcgtgctgcccaccaaccagaacctggtccagttcgagctg gggaagctgaagaacatcatgccgctgtcggccgccatgttcctgagcgagcggaagaac ccggtgccccagtgcccgccgcgcctggtggtgcagatgctgcggccggtgacctggagc cgaatgcccaaccagttcctgcgcgtcaacacgcagcgccagagcgagcgactcggctgg gccgtcgagtgcacggaaccgctcaccatgatggcgctgcacatccccgaggagaaccgg tgcatcgacatcctggagctggccgagcggctggacctgcagcgcttccactcgcactct ctgcgtctgtactgcgccgtgtgcgcgctgggcaacaaccgcgtggctcacgcactgtgc agccacgtggaccaggcgcagctgctgcacaccatcgaggaccaccacctgcccggcctg ctgcgcgctggctactacgacctgctcatctccatccacctggagagcgcccgccgcgcc cgccgctccatgcagggcgagttcatcgtgcccatgacggacgccaccaagggcatcacc ctgtacccgccggccgggcgcggacggcacgggctgcccggcgtgggtgtgtccacctcc ctgcgcccccccctgcacttcgcgcccccctgcttcgtggcggccccggggggcgagacc tcggcccggctcagccccgccgtgcccctcgaggtgctcaaggccaaggccctgcacatg ctgaccgaggccgtgcgggagagcggccagcacgcccgggaccccgtgggcggttccgtc gagttccagttcgtgccggtgctcaagctggtctcggccctgctggtcatgggcgtgttc gacgacgacgacgtcaaacacatcctgaggatgatcgagcccgacgtcttcgccgagccc gaggaggaagaggtggaggaggaggaggaggaggaggaggaggaagaagaggacgaggag gaggtggaggaggaagaggaggacgaggagaaggaggaggaagaggagaaagaggacgcc gagaaggaggaggaggaaggaggggaagagaaggaggaggagctggaggaggggctgctg cagatgaaactgcccgaatccgtcaagctgcagatgtgccacctcctggagtatttctgc gaccaggagctgcagcaccgcgtggaggccctgatcgccttctcggagagctacgtggag cggctgcaggccaaccagcgcggccgctacgggcagctcatgatggccttcaccatgtcg gccgccgagacggcccgccgcacccgcgagttccgttcgccgccccaggagcagatcaac atgctgctgcacttcaaggggggcgcggacgaggaggactgtccggtgcccgacgacgtg cgccaggacctgctgcagtttcacgaggatctgatgacgcactgtggtgtgcagctgcag ggggaggaagaggagcaggaggaggagagctccctgggcggtcggctgctcagcctcctg gagaaggtgaaactggtgaagaagaaggaaccggagcaagaagaggagccggcccaggag gaacccaagcctacctccctgcaggagctgatttcgcacaccatggtgcactgggctcgg gaggccttcatccagagcccggagctggtgcgggccatgttcagtctcctgcaccgccag tacgacggcgtcggggaggtgctgcgggccctgccccgcgcctacaccatctccgccggc tccgtggacgacaccatgagcctcctggagagcctgggccagatccgctccctgctcatc gtgcagatgggaccccaggaggagaacctcatgatccagagcatcgggaacatcatgaac aacaaagtgttctaccagcaccccaacctgatgcgggccctgggcatgcacgagacggtc atggaggtcatggtcaacgtcctcgggggcggagagtccaaggagatccgcttccccaag atggtgaccagctgctgccgtttcctctgctacttctgccgcatcagccgccagaatcag cgctccatgtttgaccacctcagctacctgctggagaacagcagcatcggcttgggcatg cggggctccacacccctggacgtcgccgccgcctccgtcatcgacaacaacgaactggcc ctggctctgcaagagcaggacttggagaaggtggtgtcatatctggccggttgcgggctg cagagttgccccatgctgctggccaagggctaccctgacatcggctggaacccctgcggc ggggagcgatacctcgacttcttgcgcttcgccgtcttcgtcaacggggagagcgtggag gagaatgccaacgtggtggtgcggctgctgatccgcagacccgaatgcttcgggcccgca ctgcggggcgaggggggctcgggcctacttgccgccgtggaggaggccatccgcatctcc gaggacccggcccgcgacggacccacccaccgcaaggaccgacggcgagagcactttggc ggggaagaggcaccagaggagaaccgcgtccacctggggaacgccatcatgtccttctac gcggccctcattgacctgctgggccgctgcgcccccgagatgcatctgatccaggccggg aagggcgaagcgctgcggatccgggccatcctgcgctccctggtgccgctggaggacctg gtgggcgtcatcagcctcccgctgcagatccccgcctttggcaaggacgggaacacggtg gagccccgcatgtcggccagcttcgtgcccgaccacaaggcgcccatggtcctcttcctc gaccgggtgtacggcatcgacagccaggacttcctgctgcacgtactggaggtcggcttc ctgcccgacatgcgggccgcggcctcgctggacacggcggcgttcagcacaacggagatg gccctggccttgaaccgctacctgagcctggcggtgctgcccctgatcaccaagtgcgcc ccgctgttcgccggcaccgagcaccgcgccatcatggtggactccatgctgcacaccatc taccgcctgtcccgaggccgctcgctcaccaaggcgcagcgcgacgtcatcgaggactgc ctcatggccctctgcaggtacatccggccgtccatgctccagcacctgctgcgacgcctc gtgttcgacgtgcccatcctcaacgagtttgccaagatgccccttaaactgctgaccaat cactacgagcgctgctggaagtattactgcctccctacgggctgggccaacttcggggtc acctcggaggaggagctgcacctcacccgcaagctcttctgggggatctttgagtctctg gctcacaagaagttcgacgccgagctgtaccgcatcgccatgccctgcctgtgtgccatc gcgggcgctctgccccccgactacgtcgacgcctcctactcctccaagactgagaagaag gccagtgtggatgccgagggaaacttcgaccccaaacccgtggagacgctcaatgtgatc atcccagagaagctggattcgttcatcaacaagtacgcagagtacacccacgagaaatgg gcgttcgacaagatccagaacaattggtcatttggggagaacattgacgaggacgccaag actcatcacatgctgcggccctacaagaccttctctgaaaaggacaaggagatctaccga tggcccatcaaggaatctctcaaagccatgatcgcgtgggagtggacagtggagaaagcc cgggagggggaggaggaaaaaggcgaaaagaagacgaagacacgcaagatctcccagaat gctcaggctacctatgaccccagccatggctacaatccacagcccgtcgatctctctact gtcaccctgtcccgggagctgcaggccatggctgagcagctggcagagaattatcacaac acttggggacgcaagaagaagctggagctggaggccaaaggcgggggcacccacccgctg ctggtcccctacgacaccctgacggccaaggagaaggctcgcgaccgcgagaaggcccag gaactactcaaattcctacagatgaacggttacgccgtcacccggggtctgaaggatatg gagctggacacttcctctatcgagaagcgctttgccttcagtttcctgcagcagcttctg cgttggatggacatttcccaggaattcattgcccacttggaggccgtggtgagcagcggc cgagtggagaagtcgcctcatgagcaagagatcaagttttttgccaagatcctactgccg ctcatcagtcaatatttcaccaatcactgcctctacttcctgtccacgccagccaaggtg ctgggcagtggcggccacgcctccaacaaggagaaggagatgctcaccagtctgttctgt aaactggccgccctggttcgccaccgagtctctctcttcgggacggacgctccggccgtg gtcaactgtctccacatcctcgcccgctccttggacgcccggacggtgatgaagtcgggg ccggagatcgtcaaggccgggctgcgctccttcttcgagagcgcctccgaggacatcgag aagatggtggagaacctgaagctggggaaggtgtcccaggcgcggacccaggtcaagggg gtcgggcagaacctcacctacaccaccgtggcccttctcccggtcctcacctccctcttc cagcacatcgcccagcaccagttcggggacgatgtcatactggacgacgtccaggtgtcc tgctatcggactctgtgcagcatttactcgctgggcaccaccaagaacccgtatgtggaa aagcagcggccggccctgggggagtgcctggcccggttggcggcggccatgccagtggcc tttctggaaccccagctcaacgagttcaacgcgtgctccgtctacaccaccaagtccccg cgggagcgagcgctgctggggctccctaactgcgtggaggagatgtgccccgacatcccg gagctggaccggctgatgcgtgaaatcggggggctggccgagtcgggtgcccgttatacc gagatgccccacgtgatcgaggtgacgctgcccatgctgtgcaactatctgccgcgctgg tgggagcgggggcccgagaccgcctcctccgggacgcccccgccctgcaccagcgtcacc tccgaccacctcaactccctcctgggaaacattctgcgcatcatcgtcaacaacctgggc atcgacgaggcctcgtggatgaagaggctggcagtgttcgcccagcccatcgtgagccgg gcgcggcccgagctgctgcgatcgcacttcatccccaccgtggggcggctgcggaaacgc gcggggaaggtggtgtccgaggaggagcagctgcgcctggaggccaaggccgaggcggag gagggcgagctgctcatccgggacgagttctccgtgctctgccgcgacctctacgccctc tacccgctgctcatccgctacgtggacaacaatcgggcgcactggctgaccgagcccaat ccggacgcggaagagctgttccgcatggtcggagagatctttatctactggtgcaagtct cacaacttcaaacgagaagagcagaacttcgtggttcagaacgagataaacaacatgtct ttcctgactgccgacagcaagagcaagatggccaaggcgggagaaagtcagtcgggcggc tcggagcaggaacggacgaagaagaagcggcggggcgaccgttactcggtgcagacctcc ctcatcgtggccacgctcaaaaagatggtccccatcggtctcaacatgtgcgcccccacg gatcaggagctcatcaaccaggccaagacccgctacgctatgaaagacacggacgaggag gtgcgggagtttctccagagccacctatccctgcaagggaagaacgaaaactcgccgtcc atgcgctggcagatggccctgtaccggagcatgtccggccgggccgaggacgccgacgac cccgacaagatcgtccgccgcgtccaggaggtgtccgccgtgctctatcacctggagcag acggagcacccgtacaagtccaagaaggcggtgtggcacaagctgctgtcgaagcagagg cggcgggccgtcgtggcctgcttccggatgacgcccttgtacaacctcccccggcaccgg gcatgcaacatgttcctagaggcctacaaactgggttggatcgtgactgaagagcacagc ttcgaggaccggatgatcgacgacctgtcgaaagcaggggaggaggaggaggaggaggag gcggcagaggagcagaaagagaagcagccggatccgctccaccagctcgtgctacacttc agtcggacggcgctcaccgagaacagcaaactggacgaggactacctgtacatggcctac gctgacatcatggccaaaagctgtcacctggaggagtgttcagaggaggcggaagctgcg gaggatgaacaggaggcatcctttgaggagaaggaaatggagaaacagaagttgctttat cagcagtctcggctgcacagccgaggagccgctgaaatggtcctgcagatgatcagcgcc tgcaaaggggaaccgggcgccatggtgtcctccaccctgaaactgggcatctccatcctc aacgggggcaacgctgatgttcaacagaagatgctggattacctgaaggacaagaaggaa gttggttttttccagagtctgcaggccttgatgcagacgtgcagcgtcctggatctcaac gcctttgagcggcagaacaaggcagagggtcttggcatggtgacggaggacgggacggcc atcgaccggcagaatggagagaaagtgatggcggacgacgagttcactcaggacctgttc cgcttcctgcagctcctatgcgaggggcacaacaacgacttccagaactacctgcggacc cagacggggaacaccaccaccatcaacatcatcatcgccaccgtggactacctgctgagg ctgcaggagtccatcagcgacttttactggtactactcggggaaggacatcgtcgatgag cagggcaagagaaacttctccaaggccatggccgtggccaagcaggtttttaacagcctc accgagtacatccagggcccgtgcacggggaaccagcagagcctggcacacagccgcctg tgggacgccgtcgtcggcttcctgcacgtgttcgcgcacatgatgatgaagctggcacag gactccagtcagatcgggctgctcaaggaactgctggacctgcagaaggacatggtggtg atgctcctgtccctgctggagggcaacgtggtgaacgggatgatcgcgcggcagatggtg gacatgctggtggagtcatccagcaacgtggagatggtgctgaagttcttcgacatgttc ctcaagctcaaggacatcgtggccgcagacgccttccgggactatgtcaccgacccccgg gggctcatctccaagaaggacttccagaaggccatggacagccagaagcagttctctggg acggagatccagttcctgctttcctgctcggaggcggacgagaacgagatgatcgactgc gatgagttcgccagccgcttccaggagccggccaaggacatcggcttcaacgtggccgtg ctgctgaccaacctgtcggagcacgtgccccacgatccccggctccacaccttcctggag ctggccgagagcatcctggagtacttccgcccctacctgggccgcatcgagatcatgggg gcctccaagcgcatcgagcgcatctacttcgagatctccgagaccaacaaggcccagtgg gagatgccccaggtgaaggagtcgaagcgtcagttcatcttcgacgtggtgaacgagggc ggggaggcggagaagatggagctgttcgtcagcttctgcgaggacaccatcttcgagatg caaatcgcggcgcagatctcggagcccgagggcgggccggaggaggaggaggaggaggag gaggacgggggggaggaggagggggcggcggaggaagaggggccgggcgggccggcgggg gccgagggccggtccgccttcggggagctgctgggggcggcgacctcctgcctccgcctc ttcggctaccgggccctgcggcgccgggtccgccggctgcggcggatgacggtgcgggag ctgagcgcggccctggcggggctggtctggacgctgctgagccgggtggcccgcagcctg gccgggctggcccggggggtggccctcctcgtctgggggtccctgttcggcggcggcctg gtggagggggccaagaagatgacggtgaccgagctgctggccggcatgcccgaccccacg caggacgaggtccacgccgaccagccggccgccccgggcgccgcgcccgcccagccccgg gacgggcccgaggcggaggcggacttcgccgaggacgggggcgacgccccgggcgacgac ggccccgaggtggccaaggacggggcccactaccggcccggcggccccgacgcccccggg gggctgggggacatgggcgacatgacgcccgtggagccgcccacgcccgaggggtccccc atcctcaagaggaagccgggggacggcgaggaagaggaggagaaggaggagcgggaggaa gagcccccgccggagcccgagaaggccgatgccgagaacggggagaaggggggtccccag ccggagcccgaacccccgaagaagaaggcggcggcggcccccccgccgcggaaaggggag gccggagcctccgccggactggacttctggggggaaatggaggtccagagggtcaaattc ctgaactacctgtcccgaaacttctacacgctgcgtttcctggccctcttcctcgccttc gccatcaacttcatcctcctcttctacaaggtgtctgactccccgccgggggaggaggag ctggacggctcgggactggaggagctgtcgagcggcttgggatccggcgagggtttgggc agcgggctgggctccggggccggcgaggaggaagacgaggaggagaatatggtctactat ttcttggaggagagcaccggctacatgcagcccgccctgcacttcctcagcctcctgcac acgctcatcgccttcctctgcattatcggctacaactgcctcaaggtgcccctggtgatc ttcaagcgtgaaaaggagctggctcggaaactggagttcgacggcctctacatcaccgag cagcccgaggacgatgacgtgaagggccagtgggatcgcctggtcctcaacacaccatcg ttccccagcaactactgggacaagttcgtgaagcgaaaggtgctggataaacacggtgac atctacgggcgggagcggatcgccgagctgctgggaatggacctggccagcctggagatc accgcccagaacgagaagaagcccgagcccgacaagagcttcatcacctggatcatgtcc attgacatcaaataccaaatctggaaattcggagtcatcttcactgacaattcgttcctc tacctggcctggtacatggtcatgtccctgctcggccattacaacaacttcttcttcgct tgccatctcttggacatcgccatgggggtcaagacgttgcggaccatcctttcctccgtc acccacaacggcaaacagctggcgatgacggtgggattgctggccgtggtcgtttacctg tacaccgtggtggccttcaatttcttccgcaagttctacaacaagagcgaagacgaggac gagccggacatgaagtgtgacgacatgatgacgtgctacctgtttcacatgtatgtgggg gtgcgagccggcgggggcatcggggacgagattgaagacccggcgggggacgagtacgag ctgtaccgcgtcgtcttcgacatcaccttcttcttcttcgtcatcgtcatcctgctggcc atcatccagggtctgatcatcgacgccttcggggagctgagagaccagcaggagcaggtc aaggaggacatggagaccaagtgtttcatctgcggcatcggcagcgactacttcgacacg accccacacggctttgaaacccacaccctggaggagcacaatttagccaactacatgttc ttcctgatgtatctcatcaacaaggacgagacagagcacacggggcaggagtcctacgtc tggaagatgtaccaggaacgttgctgggacttctttccggccggtgactgtttccgcaaa cagtacgaggaccaactgggctga

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