Ornithorhynchus anatinus (platypus): 103170729 Help Entry 103170729         CDS       T01045                                  Symbol IRS1 Name (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism oaa  Ornithorhynchus anatinus (platypus) Pathway oaa04022   cGMP-PKG signaling pathway oaa04068   FoxO signaling pathway oaa04081   Hormone signaling oaa04140   Autophagy - animal oaa04150   mTOR signaling pathway oaa04151   PI3K-Akt signaling pathway oaa04152   AMPK signaling pathway oaa04211   Longevity regulating pathway oaa04213   Longevity regulating pathway - multiple species oaa04722   Neurotrophin signaling pathway oaa04910   Insulin signaling pathway oaa04920   Adipocytokine signaling pathway oaa04923   Regulation of lipolysis in adipocytes oaa04930   Type II diabetes mellitus oaa04931   Insulin resistance oaa04932   Non-alcoholic fatty liver disease oaa04935   Growth hormone synthesis, secretion and action oaa04960   Aldosterone-regulated sodium reabsorption oaa05010   Alzheimer disease oaa05206   MicroRNAs in cancer oaa05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:oaa00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     103170729 (IRS1)    04022 cGMP-PKG signaling pathway     103170729 (IRS1)    04151 PI3K-Akt signaling pathway     103170729 (IRS1)    04152 AMPK signaling pathway     103170729 (IRS1)    04150 mTOR signaling pathway     103170729 (IRS1)   09133 Signaling molecules and interaction    04081 Hormone signaling     103170729 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     103170729 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     103170729 (IRS1)    04923 Regulation of lipolysis in adipocytes     103170729 (IRS1)    04920 Adipocytokine signaling pathway     103170729 (IRS1)    04935 Growth hormone synthesis, secretion and action     103170729 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     103170729 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     103170729 (IRS1)   09149 Aging    04211 Longevity regulating pathway     103170729 (IRS1)    04213 Longevity regulating pathway - multiple species     103170729 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     103170729 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     103170729 (IRS1)   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     103170729 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     103170729 (IRS1)    04932 Non-alcoholic fatty liver disease     103170729 (IRS1)    04931 Insulin resistance     103170729 (IRS1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  103170729 NCBI-ProteinID:  XP_028924739 Ensembl:  ENSOANG00000041838 UniProt:  A0A6I8NQ80 LinkDB All DBs Position 7:complement(53928032..54019434) Genome browser AA seq 1232 aa AA seqDB search MASPPESDGFFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSGA PKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAVAADSESEQESWYQALLQLHNRAKG HHHPPHHETASAAFGAGGGAGGCTGSLGPGEAGEDGGYGEAAPGPAFREVWQVILKPKGL GQTKNLVGIYRLCLTDKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGP GEFWMQVDDSVVAQNMHETILEAMRAMSEEFRPRSKSQSSSNCSNPISVPLRRHHLGNPP PSQVGLSRRSRTESVTATSPAGGAGARPNSFRVRASSDGEGTMSRPASVDGSPVSPSANR THSHRHRGGSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLYPRRSS ASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELGNYICMGGKAA PGPTAPNGHHVPPRGGGGGGLRCPSGPAPGRAGDDAGDSEKGFRKRTHSAGTSPTICHQK TPSQSSVASIEEYIEMVPSCPGAGPGGRLPSHRHSAFVPTRSYPEGGLEAHPPEARGGSH HPHRAHPPGPHTDDGYMPMSPGVAPVPGGRRGGGDYMPMSPKSVSAPQQIVNPGRRHAQR VDPNGYMMMSPSGSCSPDGGGGSGGGGGAGGGGGYGKLWLNGGGNHHHPHHHHHHHHHHH HPKLPGESNDGKLLPGGGDYINMSPAGDSATGSPSDCYCGPGDPHHKPVYSYFSLPRSFK HTQRRGEAEDGGHHHLRLSVSSGRLLYAAAAEDSSSSTSSDSLGGGQEGGHPHQAAQQHQ LPRRVDTAVQTRGRPTRPTRLSLDGPKASTLPRAREQQQPPLLPPEPKSPGEYVNIEFVG DPPGFSRGSAVSLCSPAVRCQPQLHPAPREEEANSEEYMNMDLGPPRQPVRPEGRAAKPG RGGALPTGTGTGGVGRPGRAMAGGRDYVAMHVGGPCPGWAETPPAVLLGYPDSRAGCPVE TSSPPRSTSEAPSSSAASPSSSPQHRGQAELAGHAALLGGPQGPGAMSAFTRISLSPGRN QSAKVIRADPQGCRRRHSSETFSSASSAARGNGLAPAYAGGAGGGAAGGGGEDVKRHSSA SFENVWLKPGELGGPPTRREPPQPCAGGGLENGLNYIDLDLAKDFNHRPQECLPGLQPPP PRQPCGSGSSRSSEDLSAYASISFQKPPEDLQ NT seq 3699 nt NT seq  +upstreamnt  +downstreamnt atggccagccctccggagagcgacggcttcttctccgacgtgcggaaggtgggttacctg cgcaaacccaagagcatgcacaaacgcttcttcgtgctgcgggcggccagcgaggccgga ggcccggcccggctggagtactacgagaacgagaagaagtggaggcacaagtccggggcc cccaagcgctccatccccctggagagctgcttcaacatcaacaagcgggccgactccaag aacaagcacctggtggccctctacacccgggacgagcacttcgccgtcgccgccgacagc gagtcggagcaggagagttggtaccaggccctgctgcagctgcacaaccgggccaagggc caccaccacccgcctcaccacgaaacggcctccgccgccttcggggcgggcggcggggcc ggcggctgcaccgggagcctggggccgggggaggccggggaggacggcggctacggggag gcggccccgggaccggccttcagagaggtctggcaggtgatcctcaagcccaagggcctg ggccagaccaagaacctcgtcggcatctaccggctgtgcctgaccgacaagaccatcagc ttcgtcaagctcaactcggaggcggcggccgtggtcctgcagctgatgaacatccgacgc tgcggccactcggagaacttcttcttcatcgaggtggggcgctcggccgtgaccggcccg ggggagttctggatgcaggtggatgactcggtggtggcccagaacatgcacgagaccatc ctggaggccatgcgggccatgagcgaagagttccggccccgcagcaagagccagtcgtcg tccaactgctccaaccccatctcggtgcccctgcgccgccaccacctgggcaaccccccg cccagccaggtggggctcagccgtcgctcccgcaccgagagcgtcacggccacgtcgccc gccggcggggccggggccaggcccaactctttccgcgtccgcgcctccagcgacggcgag ggcaccatgtcgcgcccggcctcggtggacgggagccccgtgagccccagcgccaaccgg actcactcgcaccggcaccggggcggttcccgcctgcacccgcccctcaaccacagccgt tccatccccatgccctcgtcgcgctgctctccctcggccacgagccccgtcagcctgtcg tccagcagcaccagcggccacggctccacctcggactgcctctacccgcggaggtccagc gcctcggtgtcgggctcccccagcgacgggggcttcatctcctccgacgagtacggctcc agcccctgcgacttccgcagctccttccgcagcgtcaccccggattccctcggccacacc cccccggcccggggggaggaggagctgggcaactacatctgcatggggggcaaggccgcg cccggcccgacggcccccaacggccaccacgtcccgccccgggggggcggcggcggcggc ctccgctgcccctccgggccggcgccgggccgggcgggcgacgacgccggcgactcggag aagggtttccggaagaggactcactcggcgggcacgtccccgaccatctgccaccagaag acgccctctcagtcctccgtggcctccatcgaggagtacatcgagatggtgccctcctgc ccgggggccggcccggggggccggctgccctctcaccgccactcggccttcgtgcccacc cgttcctaccccgaagggggtctggaggcgcaccctccggaggcacgcggcggcagccac cacccccaccgggcccaccccccggggccccacacggacgacggctacatgcccatgtcc cccggggtggccccggtgcccggtggccgcagagggggcggggattacatgcccatgagc cccaagagcgtgtcggccccgcagcagatcgtcaaccccggcaggcgtcacgcccagcgg gtggaccccaacggctacatgatgatgtccccgagcggcagctgttcgcccgacgggggc ggcgggtccggcggcggcggcggcgccgggggcggcggcggctacgggaagctgtggctg aacgggggcggaaaccaccaccacccccatcaccaccaccaccatcaccaccaccaccac cacccgaagctccccggagagagcaacgacgggaagctgttacccggcggcggcgactac atcaacatgtccccggcgggggactccgccaccggcagcccctcggactgctactgcggg cccggcgacccgcaccacaagcccgtctattcctacttctccttgccccgctccttcaag cacacccagcggcggggcgaggccgaggacggcggccaccatcacttgcgcctctcggtc agctccggccgccttctctacgcggcggcagccgaagactcctcctcgtccaccagcagc gacagcctgggagggggccaggagggcggccacccccaccaggcagcgcagcagcaccag ctgcctcgccgagtggacacggccgtgcagaccaggggccgcccgaccaggcctacccga ctgtcactggacgggcccaaggccagcacgttgcccagggcgcgggagcagcagcagccg ccgctgctccctccggagcccaagagcccaggggagtacgtcaacatcgagttcgtgggc gacccgcccggcttctcgcggggttccgccgtctccctctgctcccccgccgtccggtgc cagccccagctgcaccccgccccgcgggaggaagaggctaactccgaggaatacatgaac atggacctggggcctccccggcagcccgtccgcccggaaggccgcgcggctaaaccgggc cgagggggagccctcccgacggggacggggacgggaggcgtcggccggcccggccgagcg atggcgggcggccgggattacgtggccatgcacgtgggcgggccttgcccgggctgggcg gagacgcccccggccgtcctgctcggctaccccgactcgcgggcgggctgccccgtggag acgtcgagtccccctcgttcgacgtccgaggccccgtcttcctccgccgcttccccttcg tcctccccccagcaccggggccaggccgagctggccgggcacgccgctctgcttggcggc ccccaggggccgggggcgatgagcgccttcacccggatcagcctcagccccggccgcaac cagagcgccaaggtcatccgggccgaccctcaagggtgccggaggcggcacagctcggag accttctcctccgcctcgagcgccgcccggggcaacggcctcgccccggcctacgcgggg ggtgccggcggcggggccgcggggggcggcggcgaggacgtgaagcgccacagctctgcc tccttcgagaacgtgtggctcaagcccggtgagctggggggccctcccaccaggagggag ccgccccagccctgtgccggtggaggattggagaacggactcaactacatcgacctggac ttggccaaggattttaatcaccgcccccaggagtgtctccctgggctccagcctcctcct cctcgtcagccttgcggcagcgggagcagccgctccagtgaggatttaagcgcctacgcg agcatcagcttccagaagccacccgaggacctccagtag

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