KEGG   Ovis aries (sheep): 101103800
Entry
101103800         CDS       T03117                                 
Symbol
ROCK2
Name
(RefSeq) rho-associated protein kinase 2
  KO
K17388  Rho-associated protein kinase 2 [EC:2.7.11.39]
Organism
oas  Ovis aries (sheep)
Pathway
oas04022  cGMP-PKG signaling pathway
oas04024  cAMP signaling pathway
oas04062  Chemokine signaling pathway
oas04071  Sphingolipid signaling pathway
oas04270  Vascular smooth muscle contraction
oas04310  Wnt signaling pathway
oas04360  Axon guidance
oas04510  Focal adhesion
oas04520  Adherens junction
oas04530  Tight junction
oas04611  Platelet activation
oas04670  Leukocyte transendothelial migration
oas04810  Regulation of actin cytoskeleton
oas04921  Oxytocin signaling pathway
oas05132  Salmonella infection
oas05135  Yersinia infection
oas05163  Human cytomegalovirus infection
oas05200  Pathways in cancer
oas05205  Proteoglycans in cancer
oas05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:oas00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    101103800 (ROCK2)
   04071 Sphingolipid signaling pathway
    101103800 (ROCK2)
   04024 cAMP signaling pathway
    101103800 (ROCK2)
   04022 cGMP-PKG signaling pathway
    101103800 (ROCK2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101103800 (ROCK2)
   04520 Adherens junction
    101103800 (ROCK2)
   04530 Tight junction
    101103800 (ROCK2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101103800 (ROCK2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101103800 (ROCK2)
   04670 Leukocyte transendothelial migration
    101103800 (ROCK2)
   04062 Chemokine signaling pathway
    101103800 (ROCK2)
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    101103800 (ROCK2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    101103800 (ROCK2)
  09158 Development and regeneration
   04360 Axon guidance
    101103800 (ROCK2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101103800 (ROCK2)
   05205 Proteoglycans in cancer
    101103800 (ROCK2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    101103800 (ROCK2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101103800 (ROCK2)
   05135 Yersinia infection
    101103800 (ROCK2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101103800 (ROCK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:oas01001]
    101103800 (ROCK2)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:oas03036]
    101103800 (ROCK2)
Enzymes [BR:oas01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.39  ROCK-subfamily protein kinase
     101103800 (ROCK2)
Protein kinases [BR:oas01001]
 Serine/threonine kinases: AGC group
  DMPK family [OT]
   101103800 (ROCK2)
Chromosome and associated proteins [BR:oas03036]
 Eukaryotic type
  Centrosome formation proteins
   Kinases and associated factors
    101103800 (ROCK2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Rho_Binding PH C1_1 APH Pkinase_C Irp3-like_C
Other DBs
NCBI-GeneID: 101103800
NCBI-ProteinID: XP_060269801
LinkDB
Position
3:complement(20178720..20313674)
AA seq 1416 aa
MSRPPPTGKMPGAPEAVSGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFP
ALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAM
KLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDDKYLYMVMEYMPGGDLVNL
MSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMD
ETGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLV
GTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIKQHPFFKNDQWN
WDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENL
LLSDSPSCKENDSIQSRKNEESQEIQKKLYTLEEHLSTEIQAKEELEQKCKSVNTRLEKV
AKELEEEITLRKNVESTLRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQL
EDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNR
DLQDKNCLLETAKLKLEKEFINLQSVLESERRDRTHGSEIINDLQGRISGLEEDVKNGKI
LLAKVELEKRQLQERFTDLEKEKNNMEIDMTYQLKVIQQSLEQEETEHKATKARLADKNK
IYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSILDCDLKQSQQKINELLK
QKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLLEMKMS
LEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLCKELQQK
KQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQE
LTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKEAQEQLSRLKDEEISAAAIKAQF
EKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQ
MIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPG
DTEADDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVL
DIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKG
HEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYD
ISSAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSR
QLAPNKPRLLDLAFKDWDWSFDDVDGGDDDDDVFDF
NT seq 4251 nt   +upstreamnt  +downstreamnt
atgagccggcccccgccgacggggaagatgcccggcgcccccgaggccgtgtcgggggac
ggcgcgggcgcgagccgccagaggaagctggaggcgctgatccgagaccctcgctcgccc
attaacgtggagagcttgctggatggcttaaattctttggtccttgatttggattttcca
gctttgaggaaaaacaaaaatatagataatttcttaaatagatatgagaaaattgtgaaa
aagataagaggtttacagatgaaggcagaagactacgatgttgtaaaagttatcggaaga
ggtgcttttggtgaagtccagttggttcgtcataaggcatcacagaaagtttatgctatg
aagcttcttagtaagtttgaaatgataaaaagatcagattctgcttttttctgggaggaa
agagatattatggcctttgccaacagtccctgggtggttcagctcttttgtgcctttcaa
gatgataagtatctgtacatggtaatggagtacatgcctggtggagaccttgtaaacctt
atgagtaactatgatgtacctgaaaaatgggccaaattttatactgctgaagttgttctt
gctttggatgccatacactccatgggtttaattcacagagatgtgaagcctgacaacatg
ctcttggataaacatgggcatctaaaattagcagattttggcacatgtatgaagatggat
gaaacaggcatggtgcattgtgatacagcagttggaacacccgattatatatcacctgag
gtcctgaaatcacaagggggtgatggttactatgggcgagaatgtgattggtggtccgtg
ggtgttttcctttttgagatgctggtgggggatactccattttatgcagattcacttgta
ggaacatacagcaaaattatggatcataaaaactcactatgtttccctgaagatgcagaa
atttctaaacatgcgaagaatctcatctgtgccttcttaacagatagggaggtacgcctt
ggaagaaatggagtagaagaaatcaaacaacatcctttctttaagaatgatcagtggaat
tgggataacataagagagactgctgctcctgtggtacctgaactcagcagtgacatagac
agcagcaattttgatgacattgaagatgataaaggagatgtagaaaccttcccaattcct
aaggcttttgtgggaaatcagctaccttttataggatttacctactatagagaaaatttg
ttactaagtgattctccatcttgtaaagaaaatgactcaatacaatcaaggaagaatgaa
gagagtcaagagattcagaaaaaactgtacacattagaagaacaccttagcactgagatt
caagccaaagaggaactagagcagaagtgcaaatctgttaatactcgcttagagaaagtg
gcaaaggagttagaagaagagattaccttaaggaaaaatgtggaatcaacattaagacaa
ttagaaagagaaaaagcacttcttcagcacaaaaatgcagaatatcagcggaaagctgat
catgaagcagacaagaagcgaaatttggagaatgatgttaacagtttaaaagatcagctt
gaagatttgaaaaaaagaaatcagaactctcagatatccactgagaaagtgaatcaactc
cagagacaactggatgaaaccaatgctttgctgcgaacagaatctgatactgcagcccgg
ttaaggaaaacacaggcagaaagttcaaaacagattcagcaattggaatctaacaataga
gatctacaagacaaaaattgcctgctggagaccgccaagttaaaacttgaaaaggaattt
atcaatcttcagtcagttctagaatctgaaaggagggaccgaacccatggatcagagatt
attaatgatttacaaggtagaatatctggcctagaagaagatgttaagaatggtaaaatc
ttactagcaaaagtagagctggagaagagacaactacaggagagatttactgatttggaa
aaggaaaagaacaacatggaaatagatatgacataccaactaaaagttatacagcaaagt
ttagaacaagaagaaactgaacataaggctacaaaagcacggcttgcagacaaaaacaaa
atttatgaatccattgaagaagccaaatcagaagccatgaaagaaatggagaaaaagctc
ttggaggaaagaactttaaaacagaaagtagagaacttgttgctggaggctgagaaaaga
tgctctatattagactgtgacctcaaacagtcacagcagaaaataaatgaactcctcaaa
cagaaagatgtgctaaatgaggatgttagaaacttgacattaaaaatagaacaggaaact
cagaagcgctgccttacacaaaatgacttgaagatgcaaacacagcaagttaatacacta
aaaatgtcagaaaagcagttaaagcaagagaataatcatctcctagaaatgaaaatgagc
ttggaaaaacagaatgctgaacttcgaaaagaacgtcaagatgcagatggacaaatgaaa
gagctccaggatcagcttgaagcagagcagtatttctcaaccctctataaaacacaggtt
agggaacttaaggaagaatgtgaagaaaagaccaaactttgtaaagaattacagcagaag
aagcaggaattacaggatgaaagggactccttggctgctcaactggagattaccttaacc
aaagcagattctgagcaattggctcgttcaattgctgaggaacagtattctgatttggaa
aaagagaagatcatgaaagagctggagatcaaagagatgatggctcggcacaaacaggaa
ctcaccgaaaaagatgctactattgcatctcttgaagaaactaataggacactaactagt
gatgttgccaatcttgcaaatgagaaagaagaattaaataacaaattgaaagaagcccaa
gagcaactatcaaggttgaaagatgaagaaataagtgcagcagctattaaagcacaattt
gagaagcagctgttaacagagaggacactcaaaactcaagctgtgaacaagttggctgag
atcatgaatcgaaaggaacctgttaagcgtggtaatgacacagatgtgcggagaaaagaa
aaggagaatagaaagctacatatggaacttaaatctgaacgtgaaaaactgacccagcag
atgatcaagtatcagaaagaactgaatgaaatgcaggctcaaatagctgaagagagtcag
attcgaattgaactacagatgacactggacagtaaggacagtgacattgagcagctgcgc
tcccagctccaggccttgcacattggtttggatagttccagtataggcagtggaccaggg
gatactgaagctgatgatgggtttccagaatcaagactagaaggatggctttcattgcct
gtgcgaaacaacactaagaaatttggatgggttaaaaagtatgtgattgtaagcagtaag
aagatccttttctatgacagtgaacaagataaagaacaatctaatccttacatggtttta
gatatagacaagttatttcatgtccgaccagttacacagacagatgtatatagagcagat
gctaaagaaattccaaggatattccagattctgtatgccaacgaaggagaaagtaagaag
gaacaagaatttccagtggagccagtgggagaaaaatcaaattatatttgccacaaggga
catgaatttattcccactctctatcatttcccaaccaactgtgaggcatgtatgaagcca
ttgtggcacatgtttaaaccccctcctgctttagagtgccgtcgctgtcatattaaatgt
cataaagaccacatggacaaaaaggaggaaattatagcgccttgcaaagtgtattatgat
atttcatcggcaaagaatctattgttattagcaaattctacagaagagcagcagaagtgg
gttagtcggttagtgaaaaagatacctaaaaagcctccagctccagacccttttgcacgg
tcgtctcctagaacatcaatgaaaatacaacaaaaccagtctattcgacggccaagtcga
caacttgctccaaacaaaccaagattgcttgatttggcatttaaagactgggattggtca
tttgatgatgttgatggtggtgatgatgatgacgatgtttttgatttctga

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