KEGG   Ovis aries (sheep): 101112456
Entry
101112456         CDS       T03117                                 
Symbol
IRS4
Name
(RefSeq) insulin receptor substrate 4 isoform X2
  KO
K17446  insulin receptor substrate 4
Organism
oas  Ovis aries (sheep)
Pathway
oas04022  cGMP-PKG signaling pathway
oas04068  FoxO signaling pathway
oas04081  Hormone signaling
oas04140  Autophagy - animal
oas04152  AMPK signaling pathway
oas04211  Longevity regulating pathway
oas04213  Longevity regulating pathway - multiple species
oas04910  Insulin signaling pathway
oas04920  Adipocytokine signaling pathway
oas04923  Regulation of lipolysis in adipocytes
oas04930  Type II diabetes mellitus
oas04935  Growth hormone synthesis, secretion and action
oas05010  Alzheimer disease
Brite
KEGG Orthology (KO) [BR:oas00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    101112456 (IRS4)
   04022 cGMP-PKG signaling pathway
    101112456 (IRS4)
   04152 AMPK signaling pathway
    101112456 (IRS4)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    101112456 (IRS4)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101112456 (IRS4)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    101112456 (IRS4)
   04923 Regulation of lipolysis in adipocytes
    101112456 (IRS4)
   04920 Adipocytokine signaling pathway
    101112456 (IRS4)
   04935 Growth hormone synthesis, secretion and action
    101112456 (IRS4)
  09149 Aging
   04211 Longevity regulating pathway
    101112456 (IRS4)
   04213 Longevity regulating pathway - multiple species
    101112456 (IRS4)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101112456 (IRS4)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101112456 (IRS4)
SSDB
Motif
Pfam: IRS PH_11
Other DBs
NCBI-GeneID: 101112456
NCBI-ProteinID: XP_027819071
LinkDB
Position
X:126437486..126454354
AA seq 1256 aa
MASCSFARDQATRRLRAAAAATAAALAAAATTPFLSSGTPTAPIGTGSSCPGAMWLSTAT
GSRSDSESDEEDLPVGDEVCKRGYLRKQKHGRWRYFVLKLETADAPARLEYYENARKFRH
SVRTAAAAAAAAASGATVPALIAPRRVITLYQCFSVSQRADARYPHLIALFTQNEYFAMV
AENESEQESWYLLLSRLILESKRRRCGTLGAQPEGEPAALAAAAAVEPPFYKDVWQVIVK
PRGLGHRKELSGVFRLCLTDEEVLFVRLNTEVASVVVQLLSIRRCGHSEQYFFLEVGRST
VIGPGELWMQVDDCVVAQNMHELFLEKMRALCADEYRARCRSYSISIGGHLLTLLSTRRH
LDMLPLEPGGWLRRSRFEQFCHLWAIGDGEDEMLFARRYITPSEPVPRSRRGRLHLPRGR
RPRRATSVPASFFRHTAPSPVRILYPAEALHDRDPVSSEASGSGSGNSGEEGGPQGKEDQ
KENEGDYMPMNNWGSGNGRGSGSGQGSSGQGSSGQSSGGSQCSGRGHGSGGGQGSSSSHG
SSGSGSGDQSAGGNQCSGDGQGTAGHGSSSGQGAGGGHGSGRGQGPGDGHGSGGGKNSGG
GKGSGSGKGPEGNGDRGKSLKKRSYFGKLTQGKQQQMPPPPPLPPPPGAATGGKGKSGGR
FRLYFCADRGATKERKEAKEVKDTEPPEGAARGPHRARAFDEDEDDPYVPMRPGVAAPLA
SSSDYMPMAPQNVSVSKKRHSRSPFEDSRGYMMMFPRVSPPPVPSPPKAPDPAKEDDSKD
NDSDSDYMFMAPGAGAIPKNPRNPQGGSSSKSWSSYFSLPNPFRSSPLGQSDHSEYVPML
PGKFLGKGLEKEVLSNRGPKDTASKPSVEGSFSKPRDGGSPSKRSGDGPPKHKAKRPNRL
PFMTKGNKVKPKPQKPTQEQREADSPRGYVNIDFPKRGYNMPDPCLQRLPGAWGIITDPR
QFAFSNYVNIEFGVPFPNPAGNLSDLFRAIPGANPFFLDGATGSSANREEGDYIEVTFNP
AMTPAVPFADSAIRYDAETGRIYVVDPFSECCMNISLSPSRCSERPPVARLLLREELERR
RPQSRSQSFFAAARAAISAFPTDSLERDLSASFAAAAAAAAVPTLALGRALAVASALVAA
PGIGAAAAGLEAAAGFDSASVRWFLPVADAAGAAVRGAQDVAGGSNPRAPNPSADLAGGE
NGAGGAAAAVAAPPRSPGRGRVPRPPEREDSDEDDTYVRMDFARRDNRKFDSPQRE
NT seq 3771 nt   +upstreamnt  +downstreamnt
atggctagctgctccttcgctcgcgaccaagcgacaaggagactgcgagctgcagcagcg
gcaacagcagcggctctagctgcggcggcgaccaccccatttctttcctcgggaaccccc
accgcacccattgggaccgggtcgtcttgtccgggagccatgtggctctccacggccact
ggctcccggtcagactcggagtccgacgaggaggaccttcccgtcggggacgaagtctgc
aaacgcggctacctgcggaagcagaagcatgggcgctggcgctacttcgtgctcaaactc
gagaccgccgacgccccagctcggctggaatactacgaaaatgccaggaagttccggcac
agtgtccgcaccgcggcggctgcagcggcggcggccgcctccggcgccacggtccccgcg
ctcattgcaccgcggcgcgtgatcaccctgtaccagtgcttctcggtgagccagcgggcc
gacgcaaggtacccacacctcatcgctcttttcacccaaaacgagtatttcgcgatggtg
gccgagaatgagtcggagcaagagagctggtacttgctgctcagccgcctcatcctcgag
agcaagcgccgccgctgcggcacgctcggcgcgcagccggagggagagccggccgcgcta
gcggctgcagcggcggtggagccacccttctacaaagatgtgtggcaagtaatagtcaaa
cccagggggctggggcaccgaaaagagctgagcggcgtgttccggctctgtcttaccgac
gaggaagttctgttcgtgaggttaaatacagaagtggccagcgtggtcgtccagctcctg
agcatccgtcgctgtgggcactcggagcagtatttcttcttggaagtcggtaggtccacc
gtcatcggtccgggggagctctggatgcaagtggatgactgtgtggtggcccaaaacatg
cacgagctgtttttggagaagatgagagccttgtgtgcagacgaatacagagcccgctgc
cgcagctacagcatcagcatcggcggccacctgttaaccctgctgtccactaggaggcac
ctggacatgctgccgctcgagcccggcggctggctccgaaggtcccgctttgagcagttt
tgccacctttgggccatcggtgatggggaagacgagatgctcttcgccaggcgctacata
acacccagtgagcctgtgccccgctccagacgaggaagactacacctgcccagagggcgc
agacccaggagagcgacttcagtgccagccagctttttccgccacaccgcacccagccct
gtgcgcatcctgtaccctgcagaagccctccacgaccgagatcccgtgtcttctgaagcc
tctggctctggctctggcaactcaggtgaagaaggtggtcctcagggcaaagaggatcag
aaagaaaacgaaggtgactatatgcccatgaacaactggggctcgggaaatggccggggc
tcaggaagtggacagggttcaagtgggcaaggctccagtggccaaagctccgggggaagt
cagtgctcaggcagggggcatggctctggaggtggtcagggctcaagtagcagccatggc
tcaagtggcagcggctccggggaccagagtgcaggaggaaaccagtgctccggggacggc
cagggcaccgctgggcatggctcaagcagtggccagggagctggaggtgggcatggctca
ggccgtggccagggacccggagatggccatggctcaggcggtggcaagaactccggaggt
ggcaaaggctcaggaagtgggaaggggcccgaaggcaatggtgatcgtgggaaatctctg
aagaaaagatcctactttggcaaattaactcaaggcaagcaacagcaaatgccaccacct
ccgccccttccacccccaccaggtgcagcaactggtgggaaagggaagtctgggggaagg
ttccgactttatttttgtgcagacagaggggccacaaaagaacgcaaagaagccaaagaa
gtgaaagacacggagcccccagaaggtgcagctcggggtccccacagagccagagctttt
gatgaagacgaggatgatccgtatgtgccaatgaggccaggcgtggctgctcctctcgca
agctccagtgactacatgcccatggctcctcaaaatgtctctgtgtccaaaaagcgccac
tctcgatcacctttcgaagattctagagggtacatgatgatgtttcccagagtgagccca
ccacctgtgccaagtcctccaaaagcacctgatcctgctaaagaggatgactcaaaggac
aatgacagtgacagtgactatatgttcatggcccctggagctggtgccattcctaaaaac
cccagaaatcctcagggaggctcttcctccaaaagttggagctcctacttctctctgcca
aatccttttcggagctccccattgggacagagtgaccatagtgagtatgtaccaatgtta
cctggaaaattcctaggaaagggcctagagaaggaagtcttatctaacagaggccccaaa
gatacagcttcaaagccttcagttgaagggtctttctcaaagcctagagatgggggatca
ccttccaagcgttcaggtgatgggccccccaagcacaaggctaagagacctaatcgactt
ccttttatgacaaaaggaaacaaagtcaagccaaaaccacaaaagcccacacaggagcag
agagaagccgacagccctaggggctacgtcaacattgacttccctaagagaggttataat
atgccagatccatgtcttcaaagacttccaggtgcgtggggcataattaccgaccccaga
cagtttgccttttccaattatgtgaatattgagttcggagtgccatttccaaatccagca
ggcaacctctcagatctcttcagagctatcccaggtgccaatcccttctttctggacggt
gctacagggagcagtgctaatagagaagaaggtgactacatcgaagtgactttcaaccca
gcgatgacaccagccgtgccttttgctgacagtgccattcgctacgatgccgaaactggt
cgcatctatgtggtcgatccattttctgagtgctgtatgaacatttctctctcccccagc
cgctgctccgaacgaccacctgtagcgaggctgctactgcgagaagagctcgagcgaagg
cgcccacaaagccgttcgcaaagtttctttgcagccgccagagccgccatctctgctttt
ccgaccgacagcctcgagagagacctgtccgcttccttcgccgcggccgcggccgcggcc
gccgtgccaaccttagctctcggccgggctttagccgtcgcctccgctttggtcgcggct
cccggcatcggcgcagcagccgccggcctcgaggctgccgctggatttgactccgcctcc
gtccgctggttcctacctgttgccgatgctgctggtgccgctgtcaggggggcccaagac
gttgcgggtggctcgaaccccagagccccaaacccatcagcagacctggccggaggtgag
aacggagccggtggggctgccgctgcagtcgccgctccgcctcgatcacctggccgcggc
cgggtgcccagacccccagaaagagaagattctgacgaagacgacacgtacgtgagaatg
gactttgcaagacgtgacaacaggaagttcgactctccccaaagagagtga

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