KEGG   Ovis aries (sheep): 101121455
Entry
101121455         CDS       T03117                                 
Symbol
PIK3R1
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
oas  Ovis aries (sheep)
Pathway
oas01521  EGFR tyrosine kinase inhibitor resistance
oas01522  Endocrine resistance
oas01524  Platinum drug resistance
oas04012  ErbB signaling pathway
oas04014  Ras signaling pathway
oas04015  Rap1 signaling pathway
oas04024  cAMP signaling pathway
oas04062  Chemokine signaling pathway
oas04066  HIF-1 signaling pathway
oas04068  FoxO signaling pathway
oas04070  Phosphatidylinositol signaling system
oas04071  Sphingolipid signaling pathway
oas04072  Phospholipase D signaling pathway
oas04081  Hormone signaling
oas04140  Autophagy - animal
oas04150  mTOR signaling pathway
oas04151  PI3K-Akt signaling pathway
oas04152  AMPK signaling pathway
oas04210  Apoptosis
oas04211  Longevity regulating pathway
oas04213  Longevity regulating pathway - multiple species
oas04218  Cellular senescence
oas04360  Axon guidance
oas04370  VEGF signaling pathway
oas04380  Osteoclast differentiation
oas04510  Focal adhesion
oas04550  Signaling pathways regulating pluripotency of stem cells
oas04611  Platelet activation
oas04613  Neutrophil extracellular trap formation
oas04620  Toll-like receptor signaling pathway
oas04625  C-type lectin receptor signaling pathway
oas04630  JAK-STAT signaling pathway
oas04650  Natural killer cell mediated cytotoxicity
oas04660  T cell receptor signaling pathway
oas04662  B cell receptor signaling pathway
oas04664  Fc epsilon RI signaling pathway
oas04666  Fc gamma R-mediated phagocytosis
oas04668  TNF signaling pathway
oas04670  Leukocyte transendothelial migration
oas04722  Neurotrophin signaling pathway
oas04725  Cholinergic synapse
oas04750  Inflammatory mediator regulation of TRP channels
oas04810  Regulation of actin cytoskeleton
oas04910  Insulin signaling pathway
oas04914  Progesterone-mediated oocyte maturation
oas04915  Estrogen signaling pathway
oas04917  Prolactin signaling pathway
oas04919  Thyroid hormone signaling pathway
oas04923  Regulation of lipolysis in adipocytes
oas04926  Relaxin signaling pathway
oas04929  GnRH secretion
oas04930  Type II diabetes mellitus
oas04931  Insulin resistance
oas04932  Non-alcoholic fatty liver disease
oas04933  AGE-RAGE signaling pathway in diabetic complications
oas04935  Growth hormone synthesis, secretion and action
oas04960  Aldosterone-regulated sodium reabsorption
oas04973  Carbohydrate digestion and absorption
oas05010  Alzheimer disease
oas05017  Spinocerebellar ataxia
oas05020  Prion disease
oas05100  Bacterial invasion of epithelial cells
oas05135  Yersinia infection
oas05142  Chagas disease
oas05146  Amoebiasis
oas05160  Hepatitis C
oas05161  Hepatitis B
oas05162  Measles
oas05163  Human cytomegalovirus infection
oas05164  Influenza A
oas05165  Human papillomavirus infection
oas05166  Human T-cell leukemia virus 1 infection
oas05167  Kaposi sarcoma-associated herpesvirus infection
oas05168  Herpes simplex virus 1 infection
oas05169  Epstein-Barr virus infection
oas05170  Human immunodeficiency virus 1 infection
oas05171  Coronavirus disease - COVID-19
oas05200  Pathways in cancer
oas05203  Viral carcinogenesis
oas05205  Proteoglycans in cancer
oas05206  MicroRNAs in cancer
oas05207  Chemical carcinogenesis - receptor activation
oas05208  Chemical carcinogenesis - reactive oxygen species
oas05210  Colorectal cancer
oas05211  Renal cell carcinoma
oas05212  Pancreatic cancer
oas05213  Endometrial cancer
oas05214  Glioma
oas05215  Prostate cancer
oas05218  Melanoma
oas05220  Chronic myeloid leukemia
oas05221  Acute myeloid leukemia
oas05222  Small cell lung cancer
oas05223  Non-small cell lung cancer
oas05224  Breast cancer
oas05225  Hepatocellular carcinoma
oas05226  Gastric cancer
oas05230  Central carbon metabolism in cancer
oas05231  Choline metabolism in cancer
oas05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
oas05415  Diabetic cardiomyopathy
oas05417  Lipid and atherosclerosis
oas05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:oas00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101121455 (PIK3R1)
   04014 Ras signaling pathway
    101121455 (PIK3R1)
   04015 Rap1 signaling pathway
    101121455 (PIK3R1)
   04370 VEGF signaling pathway
    101121455 (PIK3R1)
   04630 JAK-STAT signaling pathway
    101121455 (PIK3R1)
   04668 TNF signaling pathway
    101121455 (PIK3R1)
   04066 HIF-1 signaling pathway
    101121455 (PIK3R1)
   04068 FoxO signaling pathway
    101121455 (PIK3R1)
   04070 Phosphatidylinositol signaling system
    101121455 (PIK3R1)
   04072 Phospholipase D signaling pathway
    101121455 (PIK3R1)
   04071 Sphingolipid signaling pathway
    101121455 (PIK3R1)
   04024 cAMP signaling pathway
    101121455 (PIK3R1)
   04151 PI3K-Akt signaling pathway
    101121455 (PIK3R1)
   04152 AMPK signaling pathway
    101121455 (PIK3R1)
   04150 mTOR signaling pathway
    101121455 (PIK3R1)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    101121455 (PIK3R1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101121455 (PIK3R1)
  09143 Cell growth and death
   04210 Apoptosis
    101121455 (PIK3R1)
   04218 Cellular senescence
    101121455 (PIK3R1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101121455 (PIK3R1)
   04550 Signaling pathways regulating pluripotency of stem cells
    101121455 (PIK3R1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101121455 (PIK3R1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101121455 (PIK3R1)
   04613 Neutrophil extracellular trap formation
    101121455 (PIK3R1)
   04620 Toll-like receptor signaling pathway
    101121455 (PIK3R1)
   04625 C-type lectin receptor signaling pathway
    101121455 (PIK3R1)
   04650 Natural killer cell mediated cytotoxicity
    101121455 (PIK3R1)
   04660 T cell receptor signaling pathway
    101121455 (PIK3R1)
   04662 B cell receptor signaling pathway
    101121455 (PIK3R1)
   04664 Fc epsilon RI signaling pathway
    101121455 (PIK3R1)
   04666 Fc gamma R-mediated phagocytosis
    101121455 (PIK3R1)
   04670 Leukocyte transendothelial migration
    101121455 (PIK3R1)
   04062 Chemokine signaling pathway
    101121455 (PIK3R1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101121455 (PIK3R1)
   04923 Regulation of lipolysis in adipocytes
    101121455 (PIK3R1)
   04929 GnRH secretion
    101121455 (PIK3R1)
   04915 Estrogen signaling pathway
    101121455 (PIK3R1)
   04914 Progesterone-mediated oocyte maturation
    101121455 (PIK3R1)
   04917 Prolactin signaling pathway
    101121455 (PIK3R1)
   04926 Relaxin signaling pathway
    101121455 (PIK3R1)
   04935 Growth hormone synthesis, secretion and action
    101121455 (PIK3R1)
   04919 Thyroid hormone signaling pathway
    101121455 (PIK3R1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    101121455 (PIK3R1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101121455 (PIK3R1)
  09156 Nervous system
   04725 Cholinergic synapse
    101121455 (PIK3R1)
   04722 Neurotrophin signaling pathway
    101121455 (PIK3R1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101121455 (PIK3R1)
  09158 Development and regeneration
   04360 Axon guidance
    101121455 (PIK3R1)
   04380 Osteoclast differentiation
    101121455 (PIK3R1)
  09149 Aging
   04211 Longevity regulating pathway
    101121455 (PIK3R1)
   04213 Longevity regulating pathway - multiple species
    101121455 (PIK3R1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101121455 (PIK3R1)
   05206 MicroRNAs in cancer
    101121455 (PIK3R1)
   05205 Proteoglycans in cancer
    101121455 (PIK3R1)
   05207 Chemical carcinogenesis - receptor activation
    101121455 (PIK3R1)
   05208 Chemical carcinogenesis - reactive oxygen species
    101121455 (PIK3R1)
   05203 Viral carcinogenesis
    101121455 (PIK3R1)
   05230 Central carbon metabolism in cancer
    101121455 (PIK3R1)
   05231 Choline metabolism in cancer
    101121455 (PIK3R1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101121455 (PIK3R1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101121455 (PIK3R1)
   05212 Pancreatic cancer
    101121455 (PIK3R1)
   05225 Hepatocellular carcinoma
    101121455 (PIK3R1)
   05226 Gastric cancer
    101121455 (PIK3R1)
   05214 Glioma
    101121455 (PIK3R1)
   05221 Acute myeloid leukemia
    101121455 (PIK3R1)
   05220 Chronic myeloid leukemia
    101121455 (PIK3R1)
   05218 Melanoma
    101121455 (PIK3R1)
   05211 Renal cell carcinoma
    101121455 (PIK3R1)
   05215 Prostate cancer
    101121455 (PIK3R1)
   05213 Endometrial cancer
    101121455 (PIK3R1)
   05224 Breast cancer
    101121455 (PIK3R1)
   05222 Small cell lung cancer
    101121455 (PIK3R1)
   05223 Non-small cell lung cancer
    101121455 (PIK3R1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101121455 (PIK3R1)
   05170 Human immunodeficiency virus 1 infection
    101121455 (PIK3R1)
   05161 Hepatitis B
    101121455 (PIK3R1)
   05160 Hepatitis C
    101121455 (PIK3R1)
   05171 Coronavirus disease - COVID-19
    101121455 (PIK3R1)
   05164 Influenza A
    101121455 (PIK3R1)
   05162 Measles
    101121455 (PIK3R1)
   05168 Herpes simplex virus 1 infection
    101121455 (PIK3R1)
   05163 Human cytomegalovirus infection
    101121455 (PIK3R1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101121455 (PIK3R1)
   05169 Epstein-Barr virus infection
    101121455 (PIK3R1)
   05165 Human papillomavirus infection
    101121455 (PIK3R1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    101121455 (PIK3R1)
   05100 Bacterial invasion of epithelial cells
    101121455 (PIK3R1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101121455 (PIK3R1)
   05142 Chagas disease
    101121455 (PIK3R1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101121455 (PIK3R1)
   05017 Spinocerebellar ataxia
    101121455 (PIK3R1)
   05020 Prion disease
    101121455 (PIK3R1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101121455 (PIK3R1)
   05418 Fluid shear stress and atherosclerosis
    101121455 (PIK3R1)
   05415 Diabetic cardiomyopathy
    101121455 (PIK3R1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101121455 (PIK3R1)
   04932 Non-alcoholic fatty liver disease
    101121455 (PIK3R1)
   04931 Insulin resistance
    101121455 (PIK3R1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101121455 (PIK3R1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101121455 (PIK3R1)
   01524 Platinum drug resistance
    101121455 (PIK3R1)
   01522 Endocrine resistance
    101121455 (PIK3R1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:oas04131]
    101121455 (PIK3R1)
Membrane trafficking [BR:oas04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    101121455 (PIK3R1)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 SH2_1 AAA_13 CCDC113_CCDC96_CC Laminin_I Syntaxin
Other DBs
NCBI-GeneID: 101121455
NCBI-ProteinID: XP_004016968
LinkDB
Position
16:complement(11514385..11611717)
AA seq 454 aa
MYNTVWNMEDLDLEYAKTDINCGTDLMFYIEMDPPALPPKPPKPTTVANNGMNNNMSLQD
AEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKY
GFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLH
EYNTQFQEKSREYDRLYEDYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIE
KFKREGNETEIQRIMHNYEKLKSRISEIVDSRRRLEEDLKKQAAEYREIDKRMNSIKPDL
IQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSN
RNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSS
LKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR
NT seq 1365 nt   +upstreamnt  +downstreamnt
atgtacaacactgtttggaatatggaagacctggatttagaatatgctaagacagatata
aattgtggcacagacttgatgttttatatagaaatggatccaccagcactgcctcccaaa
ccaccaaaacccactactgtagccaacaacggtatgaataacaatatgtctttacaagat
gctgaatggtactggggagatatctcgagggaagaagtgaatgaaaaacttcgagataca
gctgacgggacctttttggtacgagacgcatctactaaaatgcatggggattacactctt
acactaaggaaaggaggaaataacaaattaatcaaaatatttcaccgagatgggaaatat
ggcttctctgacccattaaccttcaactctgtggttgaactaataaaccactaccggaat
gaatctctagctcagtataatcccaaactggatgtgaaattactttatccagtatccaaa
taccaacaggatcaagttgtcaaagaagataatattgaagctgtagggaaaaaattacat
gaatataacactcaatttcaagaaaaaagtcgggaatatgatagattatatgaagactat
acccgaacttcccaggaaatccaaatgaaaagaacagctattgaagcatttaatgaaacc
ataaaaatatttgaagaacagtgccaaacccaggagcggtacagcaaagaatacatagaa
aagttcaaacgtgaaggcaatgagacggaaatccaaaggattatgcataattacgaaaag
ttgaagtctcgaatcagtgaaattgtcgacagcagaaggagattggaagaggacttgaag
aagcaggcggctgagtatcgtgagattgacaaacgcatgaacagcatcaaaccagacctc
attcagctaagaaagacgagagaccaatacttgatgtggttgactcagaaaggtgtccgg
cagaagaaattgaatgagtggctgggcaatgaaaacactgaagaccaatattcactggta
gaagatgatgaggatttgccccaccatgacgagaagacttggaatgttggaagcagcaac
cgaaacaaagctgaaaacctgttgcgagggaagcgagacggcacttttcttgtccgggaa
agcagtaaacagggctgctacgcctgctctgtggtggtggacggtgaggtcaagcactgc
gtcatcaacaagacggccacgggctacggcttcgccgagccctacaacctgtacagctcc
ctcaaggagctcgtgctccactaccagcacacgtccctcgtgcagcacaacgactccctg
aacgtcacactagcctacccggtgtacgcgcagcagaggcgatga

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