Ovis aries (sheep): 106991367 Help Entry 106991367         CDS       T03117                                  Symbol IRS2 Name (RefSeq) insulin receptor substrate 2   KO K07187   insulin receptor substrate 2 Organism oas  Ovis aries (sheep) Pathway oas04022   cGMP-PKG signaling pathway oas04068   FoxO signaling pathway oas04081   Hormone signaling oas04140   Autophagy - animal oas04152   AMPK signaling pathway oas04211   Longevity regulating pathway oas04213   Longevity regulating pathway - multiple species oas04910   Insulin signaling pathway oas04920   Adipocytokine signaling pathway oas04923   Regulation of lipolysis in adipocytes oas04930   Type II diabetes mellitus oas04931   Insulin resistance oas04932   Non-alcoholic fatty liver disease oas04935   Growth hormone synthesis, secretion and action oas05010   Alzheimer disease oas05206   MicroRNAs in cancer Brite KEGG Orthology (KO) [BR:oas00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     106991367 (IRS2)    04022 cGMP-PKG signaling pathway     106991367 (IRS2)    04152 AMPK signaling pathway     106991367 (IRS2)   09133 Signaling molecules and interaction    04081 Hormone signaling     106991367 (IRS2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     106991367 (IRS2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     106991367 (IRS2)    04923 Regulation of lipolysis in adipocytes     106991367 (IRS2)    04920 Adipocytokine signaling pathway     106991367 (IRS2)    04935 Growth hormone synthesis, secretion and action     106991367 (IRS2)   09149 Aging    04211 Longevity regulating pathway     106991367 (IRS2)    04213 Longevity regulating pathway - multiple species     106991367 (IRS2)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     106991367 (IRS2)   09164 Neurodegenerative disease    05010 Alzheimer disease     106991367 (IRS2)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     106991367 (IRS2)    04932 Non-alcoholic fatty liver disease     106991367 (IRS2)    04931 Insulin resistance     106991367 (IRS2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 MEKK4_N Motif Other DBs NCBI-GeneID:  106991367 NCBI-ProteinID:  XP_027829586 LinkDB All DBs Position 10:complement(84003686..84034222) Genome browser AA seq 1322 aa AA seqDB search MASPPEHGPPGPAGGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEA GGGPAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDEYF AVAAENEQEQEGWYRALTDLVSEGRAGAGDAPPAAAATSGSCSASLPGALGGSAGAAAAD DSYGLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQ LMSIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFR PRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSACRV RTASEGDGGAAAGAAAGAGAAAGSPLSPGPVRAPLSRSHTLSGGRAGKAALAPAGGGLQH SRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPPPPGPHPHLQHPLHPQRPSSGSASASG SPSDPGFMSLDEYGSSPGDLRVYCGHRSNTPESIAETPPARDGSAGELYGYMTMERPLSH CGGRAYRRVSGDGAPDLDRGLRKRTYSLTTPARQRPAPQPSSASLDEYTLMRATFSGSSG RLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGTDDGYVPMTPGVAPLRTGGGSC RGDDYMPMSPTSVSAPKQILQPRPAPAALPPAGAAGPTPASAAGRAFPGTAGGYKTGSPA ESSPEDSGYMRMWCGSKLSMESADGKLLPNGDYLNMSPSDAGTTGTPPDFFSAAGETLRG MPGYCYSSLPRSYKAPHACHGDSDQYVLMSSPVGRVLEEEQLEPAPGPAQPASAFPAAAA GSGHPQPPHPAVPSPGRLGGGGGSRPDGFLAQRCRAVRPTRLSLEGLPALPRMHEYPLPP EPRSPGEYINIDFGEAGARLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSGDSRQ RSPLSDYMNLDFSSPKSPQPGAQGRDPVGSLDALLSPEASVYPPLPPRPAAPSSALQPPP PPPPPGELYRLPAAPASKGPGAASSSSDTGDNGDYTEMAFGVAATPPQPIVAPPKPDGAR VSSPVSGLKRLSLMDQVSGVEAFLQAGQPPDPHRGAKVIRADPQGGRRRHSSETFSSTTT VTPVSPSFAHTPKRHNSASVENVSLRKGSEGGGGGGSSGILGGCDEPPSSPRQLPPPTPQ QARAWTPAQPGGGLVGCPGGTSSPMRRETSTGFQNGLNYIAIDVRDEPGLSPPLQQHPHA QTGDRSAWGRTRSLGGLISAVGAGSPAAVCGGPGPGALPAANAYASIDFLTHHLKEATVV KE NT seq 3969 nt NT seq  +upstreamnt  +downstreamnt atggcgagcccgccggagcacgggccccccgggccggcgggcggggacggccccaacctc aacaacaacaacaacaacaacaaccacagcgtgcgcaagtgcggctacctgcgcaagcag aagcacggccacaagcgcttcttcgtgctgcgcgggcccggcgcgggcggcgacgaggcg ggcgggggcccggcgccgcagccgccgcggctcgagtactacgagagcgagaagaagtgg cggagcaaggcgggcgccccgaagcgggtcatcgcgctcgactgctgcctgaacatcaac aagcgcgccgacgccaagcacaagtacctgatcgccctctacaccaaggacgagtacttc gccgtggcagccgagaacgagcaggagcaggagggctggtaccgcgcgctcaccgacctg gtcagcgagggccgcgcgggcgccggcgacgcgccccccgccgccgccgccacctccggg tcctgcagcgcctccctgcccggcgccctgggcggctcggcgggcgccgccgcggccgat gacagctacgggctggtggcgcccgccacggccgcctaccgcgaggtgtggcaggtaaac ctgaagcccaagggcctgggccagagcaagaacctgacgggcgtgtaccgcctgtgcctg tcggcgcgcaccatcggcttcgtgaagctgaactgcgagcagccgtcggtgacgctgcag ctcatgagcatccgccgctgcggccactcggacagcttcttcttcatcgaggtgggccgc tcggccgtgacgggccccggcgagctgtggatgcaggcggacgactcggtggtggcgcag aacatccacgagaccatcctggaggccatgaaggcgctcaaggagctcttcgagttccgg ccgcgcagcaagagccagtcgtccggctcgtcggccacgcaccccatcagcgtgcccggt gcgcgccgccaccaccacttggtcaacctgcccccgagccagacggggctggtgcgccgc tcgcgcaccgacagcctggccgccaccccgcccgccgccaagtgcagcgcgtgccgggtg cgcacagccagcgagggcgacggcggcgccgcggcgggggcggcggcgggggccggggcg gcggcgggcagccccctgagcccgggcccggtgcgcgcgcccctgagccgctcgcacacg ctgagcggcggccgcgcgggcaaggcggcgctggcgccggcagggggcggcctgcagcac agccgctccatgtccatgcccgtggcgcactcgcccccggcggctaccagccccggcagc ctgtcgtccagcagcgggcacggctcgggctcctacccgccgccccccggcccgcacccg cacctgcagcaccccctgcacccccagcgcccctccagcggcagcgcctcggcctcgggc tcccccagcgaccccggcttcatgtccttggacgagtatggctccagccccggggacctg agggtctactgcggccaccggagcaacacgcccgagtccatcgctgagacgcccccggcg cgggacggcagcgcgggcgagctgtacggctacatgaccatggagcggccgctgagccac tgcggcggccgcgcctaccgcagggtctccggggacggcgccccagacttggaccgaggg ctgagaaagcggacttactcgctgaccacgcctgcccggcagcggcccgcgccccagccg tcctccgcgtccctggatgagtacaccttgatgcgggccaccttctcgggcagttccggc cgcctgtgcccatcctgccccgcgtcttctcccaaagtggcctaccacccgtaccctgag gactacggcgacatcgagatcggctcgcaccgcagctccagcagcaacctgggcacggac gacggctacgtgcccatgacccccggcgtggcccccctgcggacgggcggcgggagctgc aggggcgacgactacatgcccatgagccccaccagcgtgtcggccccgaagcagatcttg cagccgcggcccgcacccgccgccttgccccctgcgggggccgcggggcccacgcccgcg tcggcggccggcagagctttcccgggcactgcgggcggctacaagaccggctccccggcc gagagctcccccgaggacagcgggtacatgcgcatgtggtgtggttccaagctgtccatg gagagcgccgacggcaagctgctgcccaacggggactacctcaacatgtcccccagcgac gcgggcaccacgggcaccccgcccgacttcttctcggccgcgggggagacgctgcggggc atgcccggctactgctacagctctctgccccgctcctacaaggccccccacgcctgccac ggcgacagcgaccagtacgtgctcatgagctcgcctgtgggccgggtcctggaggaggag cagctggagccggcccccggccccgcgcagccggccagtgccttcccggccgcggcggct ggcagcggccacccccagccacctcatcccgccgtgccttctcccgggaggctcggcggt ggcggaggcagccgccccgacggcttcctggcccagcgctgccgggcagtgaggcccacg cgcctgtccctggaggggctgccggccctgccccgcatgcacgagtacccgctgcccccc gagcccaggagtccaggcgagtacattaacatcgacttcggggaggccggcgcgcgcctg tcgccgcccgcgcccccactcctggcctcggccgcctcgtcgtcctcgctgttgtccgcc agcagcccggcctcgtccctgggctccggcaccccgggcacgagcggggacagccggcag cgctccccgctctccgactacatgaacctcgacttcagctcgcctaagtcgccgcagccg ggcgcccagggccgcgaccccgtaggctccttggacgccctgttgtcccccgaggcctcc gtgtacccgccactgcccccgcgcccggccgccccctcctcggccctgcagccgccgccg ccgccgcccccgccaggcgagctgtaccgcctgcctgcggcacccgcctccaagggcccg ggcgcggcctcctcgtcctcggacacgggggacaatggtgactacaccgagatggccttt ggcgtggccgccaccccgccacaaccaattgtggcgcccccaaagcccgacggtgcccgc gtgagcagcccggtgtcaggcctcaagaggctgagcctcatggatcaggtgtcgggagtc gaggccttcctgcaggctggccagcccccagatccgcaccggggggccaaggtcatccgc gcggacccgcaggggggccgccgccgccacagctccgagaccttctcctcgaccaccact gtgacccccgtgtccccgtccttcgctcacacccccaagcgtcacaactcggcctcggtg gagaacgtctctctcaggaaaggcagcgaaggaggcggcggcgggggcagcagcggcatc ctgggtgggtgcgatgagcccccctcgtcgccccgccagttgcccccgccgacacctcag caggcgcgggcctggacgccggctcagcccggcggcggcctggtcggctgtcccgggggc accagctcgccgatgcgccgggagacctccaccggcttccagaacggcctcaactacatc gccatcgacgtgagggacgagccggggctgtcgccgcccctgcagcagcacccgcacgcg cagacgggcgacaggagcgcctggggccgcacccggagcctcgggggtctcatcagcgcc gtgggcgccggcagccctgccgcggtgtgcggagggccgggccctggcgccctgcccgcg gccaacgcctacgccagcatcgacttcttgacgcatcacctgaaggaggccacggtggtg aaagagtga

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