Oreochromis aureus (blue tilapia): 116336197 Help Entry 116336197         CDS       T07295                                  Name (RefSeq) ryanodine receptor 1-like   KO K04961   ryanodine receptor 1 Organism oau  Oreochromis aureus (blue tilapia) Pathway oau04020   Calcium signaling pathway oau04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:oau00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     116336197    04020 Calcium signaling pathway     116336197  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:oau01009]     116336197   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:oau04147]     116336197    04040 Ion channels [BR:oau04040]     116336197 Protein phosphatases and associated proteins [BR:oau01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      116336197 Exosome [BR:oau04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    116336197 Ion channels [BR:oau04040]  Voltage-gated cation channels   Ryanodine receptor    116336197 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec MIR SPRY RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  116336197 NCBI-ProteinID:  XP_039473924 LinkDB All DBs Position LG10:complement(14239371..14294894) Genome browser AA seq 5077 aa AA seqDB search MAEGADGEEEIQFLRTDDHVVLQCTASILKEQIKLCLSCEGFGNRLCFLETTSNAQNVPP DLAICCFILEQSLSVRALQEMLSNSSVDEAVDLDKWSSQGGGHRTLLYGHAILLKHTHSS MYLSCLTTSRSLTDKLAFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVS SERYLHLSYASGDLMVDASFMQTLWTMTPVMSGCELAEGFLTGGYVLRLFHGHMDECLAI PAADQGDDQRRVAHYEGGPVCSHARSLWRLEPLRIAWSGGHIKWGQSFRIRHITTGRYLC LDEEKGLLLVDPEKANSKMSAFCFRISKEKIEVTQKRDVEGMGIPEIKYGESMCFVQHVS SGLWLTYAAVDAKSARLGPLKRKAILHKEGHMDDALTVARSQTEESQAARMIYSTTGLFN QFIKGLDALSGKNKSANAPSLPMDAVVLSLQDLIFYFRPPEEELEHEDKQFKLRSLKNRQ NLFQEEGMITLVLDCVDRLNVYNTAAHFSEYAGEEAAESWKEIVNLLYELLASLIRGNRA NCALFCDNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGR NHKVLDVLCSLCVCNGVAVRSNQNLITENLLPGRDLLLQTNIINYVTSMRPNVFLGTCEG STQYKKWYFEVMVDHVEPFLTAQPYHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYG FDGLHLWSGRVPRHVATTNQHLLAAEDVISCCLDLSVPSISFRINGHPVQGMFENFNLDG LFFPVVSFSAGIRLRFLLGGRHGHFKFLPPPGYAPCYEAVLPRDRLRIEPIKEYKHDFDG VRNLLGPTQSLSHTAFTPCPVDTIQIVLPPHLERIREKLAENSHELWAVTRIEQGWTYGP FRDDNKKLHPCLVDFQSLPEPEKNYNLAMSGETLKTLLALGCHVGMGDEKAEENLKRTKL PKTYMQSNGYKPAPLDLNHVKLTPNQNTLVERLAENGHNVWARDRVRQGWTYSIVQDIMN KRNPRLVPYNLLDEKTKKTNRDTVCAAVRTLIGYGYNIEPPDQESSGHGPGSSRGDKIRV FRAEKSYAVTQGKWYFEFEAVTVGEMRVGWSRPNVRADTELGADELAYVFNGFKAQRWHI GNEPFGRQWQSGDVVGCMIDLTEMNIMFTLNGEMLISDSGSEMAFKDIEIGEGFIPVCSL GLSQVGRINLGQNVSSLRYFTICGLQEGFEPFAINMKRDITMWFSKSLPQFIPVPADHPH IEVSRVDGTVDTPPCIKATHKTFGSQNANTDLLFFRLSMPVEFHETFKIPAGTTLLTRNL TIPEDEVLEVDPGSDFEILKKSATRKEQEEEKKETSVPKETPAIKNGENEKDASTEKSKK KGFLFKAKKAALITPPPVVPTMPRLVEDVVPDDRDDMDIILNTTTYYYSVRVFAGQELSG VWVGWITPDYHQYDLHFDISKVRNVTVTVGDDKGNIHDSIKRSNCYIVWGGEFSSSQQTR VSQEDFVIGCLIDLDTGLMTFTGNGKEINTFYQVEPTTKLFPAVFVLPSSQNMVQFELGK LKNIMPISAAMFRSERKNPVPQCPPRLDVQMLTPVIWSRMPNNFLAPEMGRVSERLGWMV ECTEPLTMMALHIPEENRCIDILELSERMDLLKFHYHTLKLYSSVCALGNNRVAHALCSH VDESQLFYAIENTYLPGPMRSGFYDLLISMHLESAKRNRLGTNKEFIVPMTEETRSITLY SDKSHALPGVGLTTCLRPKLHFSSVGFVGTDQDIYTLSPVIPLQVLKTKALNMLTEAVQD GGQAMRDPVGGSVEFHFVPILKLISTLLIMGVFDDEDVTHILKMIEPTVFRGKQVEEPGE GDAKVQEEKDLPKVAAIKEGEQEALGEEEEEFEDDGLGYEEEEEELEEEEAIEEGESIVQ HEETVVETDPVNGEKGAEETEKEGKPLETGGEGKEEHLEQGLFQMKLPESVKLQMCTLLQ YFCDCELRHRVEAIIAFSDQFVSQIQSNQRQRYNELMQAFTMSAAETARKTREFRSPPQE QVNMLMNFKNSFEDEESPIPDEVRESLLAFHNTLLAHCGVHIEEEEQEEEVDNSVRGRLL RLLERVKKFREKKEEVESEPQEDKKPSTLQELISHTMIHWAQESFIQNPELVRMMFSLLH RQYDGLGELMRALPKAYTINAVSIQDTMDLLECLGQIRSLLIVQMGPEEERLIIQSIGNI MSNKVFYQHPNLMRALGMHETVMEVMVNVLGGGDSKEIRFPRVVTNCCRFLCYFCRISRQ NQRSMFDHLSYLLQNSGIGLGMRGSTPLDVAAASCIDNNELALALQEQDLEMVVKYLAGC GLQSCPMLLAKGYPDIGWNPCGGEKYLDFLRFAVFVNGESVEENANVVVRLLIRRPECFG PALRGEGGNGLLAAIEEAIKISEDPARDGPSVKKDRRFPMFGGEEQHEENRVHLGNAIMS FYSALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPIEDLVGVISLPLQIPAFGKDNS VIEPKMSASFVPDHKAPMVLFLDRVYGIDNQDFLLHVLEVGFLPDMRAAASLDTVAFSTT EMALALNRYLCSAVLPLITKCAPLFAGSDHRAIMIDSMLHTIYRLSRGRAFTKAQRDIIE ECLMALCKHLRPSMLQHLLRRLVFDVPILNEYAKMPLKLLTNHYERCWKYYCLPNGWANF GVASEEELHLTRKLFWGIFESLAHKKFDAEIFKISMPCICAIAGAIPPDYVDASYSSKTE KKASVDAEGNFDPKPVDTTNTIIPERLDPFINRYAEYTHDKWAFEKIQNNWSYGETLDEN AKTHPMLRPYKTFSEKDKEIYRWPIKESIKAMIAWEWNIEKAREEEESEKKKATSRKISQ TAQATYDPSHGYSPQPIDISHMALSRDLQSMAEQLAENYHNTWGRKKKLELQAKGGGTHP LLVPYDTLTAKEKARDREKAYELLKFLQLNGYAVTRGLKDMESDISSIEKRFAYGFLQKL LKWMEIAQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILMPLINQYFKNHCLYFLSTPAK VLGSGGHSSNKEKEMIASIFCKMSALVRHRVSLFGTDAPAIVNCLHILARSLDARTVMKS GPEIVKAGLRSFFESAADDIEKMVENLKLGKVSKGNQQVKGVSQNINYTTIALLPVLTSL FDHIAQHQFGDDVILDDLQMSCYRIMCSIYSLGTVKNLHVERQRPALGECLAHLAAAMPV AYLEPHLNEFNAFSVYTTKTPRERAILGLPNEVQELCPDIPELDTLLKEIGDLAESGARY TEMPHVIEITLPMLCNYLIRWWERGPENFPEMEGRLCTEVTSEHLNQLLGSIMKIVVNNL GIDEASWMKRLAVFSQPIVSRAKPEMLKSHFIPTMEKLKKRTSKVVAEEDHLRMEGKSEG DEEDGTIRDEFAVLCRDLYALYPLLIRYVDNNRARWLTCPDPDAEELFRMVGEVFIFWSK SHNFKREEQNFVVMNEINNMSFLTADSKSKMSKGGGSDTERTKKKKRGDRYSVQTSLIVA ALKKMLPIGLNMCSPADQELINLAKIRYSLRDTDEEVREFLQNNLHLQGKVDNPSMRWQM ALYKEMAGKAEDADAPPKVVKRVQEVSAVLYHLEVTEHPFKSKKMVWHKLLSKQRRRAVV ACFRMTPLYNIPRHRASNMFLEGYRRNWLHPEGFSFEDRMIDDLSKAMEQEEGDEEEEKE TKPDPLHQLILHFSRTALTEKSKLDTDHLYMAYADIMAKSCHIGEEEEGGEEMGENAEDE MSFEVRQSELEKEMEKQRLLYQQSRLHNRGAAEMVLQMISACKGETGPMVSTTLKLGISI LNGGNSEVQRKMLEYLKDKKDVGFFLSVQALMQTCCVLDLNAFERQNKAEGLGMVSEEGT NEKVMADDEFTCDLFRFLQLLCEGHNNDFQNYLRTQTGSTTTINVIICTVDYLLRLQESI SDFYWYYSGKDVIDEPGKKNFSKAMTVAKQIFNSLTEYIQGPCNGNQQSLAHSRLWDAIV GFLHVFAHMMMKLAQDSSQIGLLKELLDLQKDMVVMLLSLLEGNVVNGTIARQMVDMLVE SSSNVEMILKFFDMFLKLKDIVASDAFRDYVTDPRGLISKKDFQKAMDSQKQYSPSEIQF LLSCSEADENDMINYEEFASRFQEPAKDIGFNIAVLLTNLSEHVPHDTRLQNFLEQAESV LNYFRPFLGRIEIMGASRKIERIYFEISEVNRRQWEMPQVRESKRQFIFDVVNEGGESEK MEMFVNFCEDTIFEMNIASQISEQEEEEKGEEEDEGEEGGGEGGGGGEGNGGGDEDNNGR EGPHESTSAFADFINSMLSFLGIFTFRNLRRQYRRVRKMTFKEIVVALSTFFWTILMSIL HFIYNVCKGIFMIIWQTLFGGGLVEGAKNITVTEILASMPDPTQDDVHGDGPGEPRTGEE QDTGGVTDTGETGSGEEEEEDTQEKEGGRIPGMDAPGGLGDMGVEAPVEPPTPEGTPITK RKMAPEETDASQKPPEPPPVEEPPTEPEKADAETGEKTEKECESKEEVEPEKPKKSAAKK DKKLKKVGGFQIWTELETQRNKFMNYLSRNFYNLRFLALFLAFALNFILLFYKVSDSPPE GEEMEGSGLSEGSGLFEGSALFEGSGEELEGSGINGGGDEDEEDVPVYYYLEESTGYMQP TLSFLAMLHTVISFICIIGYNCLKIPLVIFKREKELARKLEFDGLYITEQPEDDDIKGQW DRLVLNTPSFPNNYWDKFVKRKVLDKYGDIYGRERIAELLGVDLASLDVSQQHEKKQEEP DNSVFAWATSIDIKYQIWKFGVVFTDGTFLYLCWYLVMSLLGHYNNFFFACHLLDIAMGV KTLRTILSSVTHNGKQLMMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMM TCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAF GELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTFDEHNLANYMFFLMYLINKDE TEHTGPESYVWKMYQERCWDFFPAGDCFRKQFEDQLS NT seq 15234 nt NT seq  +upstreamnt  +downstreamnt atggcagaaggtgcagatggagaggaagagattcaatttctgcgtacagatgaccatgta gtgctgcagtgcactgcatctattcttaaggaacagatcaagctgtgcctgtcatgtgaa ggttttggaaatcgtctgtgctttctcgagaccacgtcgaatgctcagaatgtccctcca gacctcgccatctgctgcttcattttggagcaatccctgtctgtgcgagcattacaggag atgttgtccaactcctctgtggatgaggcagtcgatttggacaaatggtcgtcacaaggt gggggtcatcgaaccctcctgtatggacatgccatcctcctgaaacacacccactccagc atgtacttgagctgtttgactacgtcgcgctcactgacagacaaactggcttttgatgtg ggcttgcaggaagactccacaggagaggcctgctggtggaccatccatccagcctctaag caaaggtctgaaggagagaaggtcagagtgggagatgacctcattcttgtcagtgtttct tcagagcgatacctgcacctgtcctatgccagtggtgatttaatggtagatgcttccttc atgcaaactctgtggaccatgacccctgtaatgtctggatgtgaactagctgaaggtttt ctgactggagggtatgtgctccggctgttccacggtcacatggacgagtgtttggcaatc ccagcagctgaccaaggggacgaccagcgcagagttgctcactatgaaggagggccagta tgcagtcatgctcgatccttatggagacttgagccactacgtattgcctggagtggaggc cacattaagtggggccagtctttccggatacgtcacataacaacaggccgatacctttgt ctggatgaggagaaaggacttctgttggtggacccagagaaggcaaattccaagatgtca gccttctgcttcaggatttcaaaggaaaaaattgaagtgacccagaaacgagatgtggag ggcatgggcatacctgagatcaagtatggagagtccatgtgctttgtacagcatgtttca tctggcctgtggcttacatatgctgctgttgatgccaaatctgcacgtctaggtcctctg aagagaaaggccatactccacaaagaaggtcacatggatgatgccctcacggttgctcga tctcagactgaagagtctcaagctgccaggatgatttacagcacaacaggcctcttcaac cagttcatcaaaggacttgatgctctaagtggaaaaaataagtctgccaatgccccgtct ctgcctatggacgcagtggtgctctcgttgcaggatctcattttctacttccgaccccct gaagaggaactggagcacgaggacaagcagttcaagctccgctccttaaaaaacagacag aacctttttcaggaagagggaatgattacgcttgttctggactgcgttgatcgcctcaat gtgtacaacacagcagcccatttctcagagtatgctggggaagaagctgctgagtcatgg aaagagattgtgaatttactgtatgaattgctagcttctttgatcagaggtaaccgtgcc aactgcgccctcttctgtgacaaccttgactggctggtcagtaaactggatcgtttggaa gcatcttcaggaatcctggaggtgttatattgcgtcctgattgagagtccagaggttttg aatattattcaagagaatcacatcaaatcaatcatctctctgctggataagcatggacgc aatcacaaggtcttggatgtgctttgttccctctgtgtgtgtaatggggtcgctgtaagg tcaaatcagaatctcatcacagagaatctgttaccaggacgtgaccttctacttcaaact aacatcatcaactatgtaaccagcatgagacccaatgttttccttggaacttgcgaagga tccactcagtataagaagtggtattttgaggtgatggtggaccacgtggagccgttcctt acggctcagccatatcatctccgtgtaggttgggctctgacagagggctacagtccttat cctggtggaggagaaggctgggggggtaacggggttggagatgatctctactcttatggt tttgacgggcttcacctctggtcaggacgtgttccacgtcatgtcgccacaacaaatcag cacctcctggcagcagaggatgtgatcagctgctgcttggatctgagcgtgcccagcatt tcctttcgtataaatggccatcctgttcagggaatgtttgagaacttcaacctagatgga ctgttctttccagttgtgagcttctctgcaggcatcagactgcgatttcttcttggaggt cgtcatgggcatttcaagtttctcccacctccaggctacgctccgtgctatgaagcagtg ctgcccagggaccgtttgcggatcgagcccatcaaagagtataagcatgattttgatggt gttcggaatctgctgggtccaactcagtccctttcacatacggccttcacaccttgccca gtcgacactatacagattgtgcttccacctcatttggagcgcattcgagagaagctcgca gaaaatagccacgagttatgggctgttacccgcattgaacaagggtggacgtatggacca tttcgcgatgataacaagaagctgcacccctgcctggtagatttccagagtctgcctgaa cctgagaagaactataatttagcaatgtctggagagacactgaagactctgttggcacta ggctgtcatgtaggaatgggagatgagaaagcagaagagaatctcaaaaggaccaaactc cctaaaacgtacatgcagagtaacggatacaagccagcccctttggaccttaaccatgtc aagctgactcctaatcaaaacactctagtggagagactggcagaaaatggacacaatgtt tgggcaagagaccgagtccgccagggatggacatacagtattgtccaggacattatgaac aagcgcaatcctcgtctggttccttataacctcctggatgaaaagacaaaaaagaccaac agagacacggtttgtgccgctgttcgcactctgattggttacggttacaacatagaacca cctgatcaggagagcagtggacatggaccaggcagctcccgtggagataaaatcagagtg ttcagagcagagaaatcttacgctgttacacaggggaagtggtactttgagtttgaagct gtgacagttggagagatgagagtgggctggtccaggcccaatgttcgtgcagacactgaa cttggtgcagatgagttggcgtatgtcttcaatggctttaaggcccaacgctggcacata ggaaatgagccatttggccgtcagtggcaatctggtgatgtggtgggttgtatgattgac ctcactgagatgaacatcatgttcacactcaatggagaaatgctgatcagtgattcgggc tcagagatggcctttaaggatatcgagataggagaaggcttcatacctgtgtgcagtctg ggcctgtctcaggtgggcaggatcaacctgggtcagaacgtcagcagtcttcgatacttt accatctgtggcctacaggaagggtttgaaccctttgctatcaacatgaaaagagacatt accatgtggttcagcaagagccttccccagtttattcctgtcccagctgatcatcctcac attgaggtgtcacgcgttgatgggacagttgatacccccccttgtattaaagcgacccac aagacatttggatctcagaatgccaacacagatctgctcttcttcagactcagcatgcca gttgagtttcatgagacctttaaaatcccagcagggaccactcttcttactcgcaatttg accatcccggaggatgaagtgttggaggtggacccaggctctgattttgaaatactcaaa aagtctgctactcgcaaggagcaggaggaagagaagaaggaaacctcagttcctaaagag acgcctgctatcaaaaatggagaaaacgagaaggatgcctccactgagaaaagcaaaaag aaaggtttccttttcaaggctaaaaaggcagcgttaataactccaccccctgttgtaccc accatgccccgcttagtggaagatgtagtaccagatgacagggatgacatggacatcatc ctcaataccactacatactattactcagtacgagtgtttgctggacaggagcttagtggc gtgtgggttggctggataacacctgactatcaccagtacgaccttcattttgatatcagc aaagtcagaaatgtaactgtcactgtaggtgatgataaaggcaacattcatgacagtatc aaacgcagcaattgctatattgtatggggaggggagttcagtagctcccagcagacccga gtcagtcaggaggattttgtgattggctgtctcattgatttggacactggactaatgact ttcactggaaatggaaaagagatcaatacattttatcaggtagagccaaccacaaaattg tttccggctgtctttgttctgccttccagtcagaatatggttcagtttgaattaggcaag ctcaagaacatcatgccgatctcagccgcgatgtttcgaagtgaacgcaaaaatccagtc ccccagtgtcctcctagactggatgtccagatgttaactccagttatctggagccgaatg cctaacaacttcctagctccagagatgggacgtgttagtgagagactaggctggatggtg gagtgtacggagccactcactatgatggcccttcacatccccgaggaaaacaggtgtatt gacatcttggagctgtctgaacggatggatttgctgaagttccactaccatactctaaag ctatacagctcagtttgtgcactgggaaacaaccgtgtggcacatgctttgtgcagccac gtggatgaatcgcagctcttttacgccatagagaacacctacctacctggaccaatgagg agcggcttttatgacctgctcatcagcatgcacctggagtcagctaaaaggaatcggctg gggaccaacaaggaattcatagttccaatgacagaagaaacacgtagtatcactctgtac tccgacaaatctcacgctttacctggcgtcggcctaactacatgtctgcgtccaaaactt catttctcttctgttgggtttgtgggaacagatcaagatatttacactcttagtccagtc attcccctacaggtgctaaagaccaaagctctgaacatgctgactgaggcagtgcaggat ggaggtcaagccatgagagatcctgtgggaggcagtgttgagtttcatttcgttccaatc ctaaagctcatcagtacccttctcataatgggtgtgtttgatgatgaagatgtcacacac atcctgaagatgattgagcccacagtctttagaggcaagcaagtggaggagcctggtgag ggggatgccaaggtgcaagaagagaaggatcttcctaaagtagcagcgattaaagaaggg gagcaggaagccctgggggaagaagaagaggaatttgaggatgatgggttgggttatgaa gaagaggaggaagaactggaggaagaagaagcaatagaggagggtgaatctatcgtgcaa catgaggaaacagtggttgagacagacccggtaaatggtgagaaaggagctgaggaaaca gagaaagaggggaaacctttagagacgggcggggagggaaaagaagaacatctagagcaa ggacttttccagatgaagctaccagagtctgtgaaactgcagatgtgcactctgctgcag tatttctgtgactgtgagctacgtcatagagtggaggccatcattgcattttctgaccag tttgtcagccagatacagtccaaccagaggcagcgctacaatgaactcatgcaggccttc accatgagtgctgccgagactgctcgcaagacccgtgaatttcgctccccaccacaggag caagtcaacatgctcatgaacttcaagaactcttttgaggatgaagagtccccaattcct gatgaagtccgcgaatctctgctcgcctttcacaacactttgctggcacactgtggtgtt cacattgaagaggaggaacaagaggaagaagtggataattctgtccgtggacggctcctt cgattgctggaaagggtgaaaaagtttcgtgagaagaaggaggaggtggagtctgagcca caagaagacaaaaaaccaagcacattgcaggagttgatttcacatactatgatccactgg gcgcaggagtcatttatccagaaccctgagctcgtgcgtatgatgttcagcctccttcac aggcagtatgatggactcggtgagctcatgcgtgcccttccgaaggcctacaccatcaat gcagtttccattcaggacaccatggacctcttggagtgcttgggccagatccgctcactg cttattgtccagatgggtccagaagaggagagacttataattcaaagcattgggaacatc atgagtaacaaagttttctatcagcaccccaacttgatgcgagctctgggcatgcatgaa actgtcatggaggtcatggtcaatgtacttggcggtggggactcaaaagagatcagattt cctcgggtggtgacaaactgctgccgtttcctctgctacttctgtcgcatcagtcgtcaa aatcagcgttcaatgtttgaccatctcagctaccttctccagaacagtggcattggcctt ggaatgcgtggctccacccccttggatgtggctgcagcatcttgtattgacaataacgag ctggcattggctcttcaagagcaggatcttgaaatggtagtgaagtatttagccggatgt ggacttcagagctgtccaatgctactggctaaaggataccctgacatcgggtggaatcct tgtggtggagagaaatatcttgattttcttcgttttgctgtttttgtcaatggagaaagc gtagaggagaatgcaaatgtggtggtgcgtctcctcatccgtaggcctgagtgctttggt ccagccttgagaggggagggtggtaatggactcctggctgcaattgaggaggcaatcaaa atatcagaggaccctgcaagggatggccctagtgttaagaaagatagacgctttcccatg tttggaggagaggaacagcatgaggagaacagggttcacctgggaaatgccattatgtct ttttactctgctcttattgacctgctgggaagatgtgctccagagatgcatttgatccag gctggtaaaggtgaggctctcaggatcagggccattctgaggtctctggtccctatagaa gatctggtgggagtcatcagtcttcctcttcagattccagcttttggaaaagacaacagc gttattgaaccaaagatgtctgctagctttgtgccagatcacaaggctcccatggtgctg ttcttggacagagtttatggtattgacaaccaagatttccttctccatgtgctggaggtg ggctttttgcctgacatgagagctgctgcctccctggatacggttgcttttagcaccact gagatggctctggctttgaaccgctacctctgctctgctgtgttgccactcatcaccaag tgtgccccgctctttgctggcagtgaccatcgagccataatgattgactccatgttgcac acaatctacaggctgtctcgtggacgagccttcacaaaagcccaaagagacattattgaa gagtgcctcatggctctgtgcaagcatctacgtccgtctatgcttcagcatctgctaagg cggctggtatttgatgtgcccattctcaatgagtatgccaaaatgcctctaaagctttta accaatcactatgagcgttgttggaaatattattgcctccctaatggttgggctaatttt ggagttgcatcagaagaggagctgcatcttacacgcaaactgttttgggggatctttgaa tcactagctcacaagaaatttgatgctgaaattttcaaaatttcaatgccatgcatctgc gccattgctggagccattcctcctgactatgtagatgccagctactcctccaagacagag aaaaaggcatcagtagatgcagagggaaactttgatcctaaacctgtggatacaacaaac actatcatccctgagagattggatccctttatcaacagatatgccgaatacactcatgac aaatgggcctttgaaaagattcagaataactggtcatacggtgagacactggatgaaaat gcaaaaacccaccccatgcttagaccgtacaagacattctcagagaaggacaaagagatc taccgatggccaattaaagagtcaatcaaagccatgattgcatgggaatggaacattgag aaagctagagaggaggaagagtcagagaagaagaaggcaacatcacgaaaaatctcacag actgcacaggcaacttatgatccaagccatggctatagtccacagcccattgatatctcc catatggctctttcaagagatctgcagtcaatggcagaacaactggcagaaaattaccat aacacctggggaagaaagaaaaaattggagctgcaagcaaaaggaggtggaacgcatcct ctgctcgtgccctacgataccctgacagctaaagaaaaggcacgagacagagagaaggct tatgagctgctgaagttcttgcagcttaatggatatgctgtcacaagaggccttaaagac atggagtcggacatatcatccattgaaaagaggtttgcgtatggtttccttcagaaactg ctgaaatggatggaaatcgcacaggagttcatcgcacatcttgaggctgtggttagcagc ggacgagtggaaaagtctccccatgagcaggaaatcaaattctttgccaagatcttgatg cctctaataaatcagtatttcaaaaatcactgcctctactttttgtctacacctgcaaaa gtcctgggtagtggcgggcattcttccaataaggagaaggagatgattgcaagtatcttc tgtaaaatgtctgctttggtgaggcacagagtttctctctttggaacggatgccccagca attgttaactgtcttcacattctggctcgatcactggatgcaaggacggtaatgaagtca ggacctgagattgttaaagcagggctacgatcgttctttgagagtgctgctgatgatatt gagaagatggttgaaaatctcaaactgggcaaagtatcgaaaggcaatcagcaagtgaaa ggcgtctctcagaacatcaactacaccaccattgcactgctcccagtacttacttccctg tttgatcacattgctcagcatcaatttggagatgatgtcatcttggatgatctgcagatg tcatgctatcggatcatgtgcagcatctactccctggggactgtgaagaatctacatgtt gagaggcagaggccagctcttggagagtgtttggcacaccttgcagcagctatgccggtg gcctacttagaaccccatctaaatgaatttaatgctttctctgtatacaccacaaagact cccagagagagagccatcttgggccttcccaatgaggtccaggaattatgtccagacatc ccagagctggatactctgctgaaggagatcggggacttggcagagtcgggggctcgttac actgagatgcctcatgtgattgaaattactttacccatgctttgtaactacctcattcgc tggtgggagagaggacctgaaaattttcctgagatggagggccgactgtgcactgaggtc acgtcagaacaccttaatcagctgctaggaagcatcatgaaaattgtagtgaacaacctg ggaatagatgaagcctcctggatgaagagattggctgtgttttcacagcccattgttagc agagcaaagccagaaatgctcaagtctcactttatcccaacaatggagaaactaaagaaa cgcacatcaaaggtggtggctgaggaggaccacttaaggatggagggaaaatcagaggga gatgaggaagatggtactatacgtgatgagtttgctgtcctctgtagagacttgtatgcc ctttaccctctacttattcgttatgtggacaataacagagcgaggtggctgacatgtcct gacccagatgcagaagagctcttccgaatggttggagaagtctttattttctggtccaaa tctcataacttcaagcgagaggaacaaaactttgtggtgatgaatgagatcaataacatg tcattcctcaccgctgacagcaagagtaaaatgagcaagggtggaggctcagatactgag cgtaccaagaagaagaaacggggagatcgttactcagtccagacctcacttattgtggct gccttgaaaaagatgctccccataggcctaaacatgtgctctcctgctgatcaggagctt atcaacttggccaagatccgatactctttgagagacacagatgaagaagtaagagagttc ctgcagaataacctgcatctacagggcaaggtggacaacccatccatgcgctggcagatg gcgctgtacaaggagatggcagggaaggctgaagatgcagatgccccaccgaaagttgtt aagagagtgcaggaggtttctgcggtcctctaccaccttgaagtgacggagcatccgttt aaatccaagaagatggtgtggcacaaactgttgtccaagcaacgacgcagagctgtggtc gcatgctttaggatgacaccactatataacattccaaggcacagagcttcaaacatgttc cttgagggatacaggcgcaactggcttcatcctgaaggcttctcatttgaagacagaatg atagacgacttatctaaagcaatggagcaagaggagggagatgaggaagaggagaaggaa acaaagccagatccccttcatcagctaattctccattttagtcgtactgctcttacagag aagagtaaactggatactgatcatctttatatggcatatgcggatattatggcaaagagt tgtcatattggtgaggaagaagaaggtggagaggaaatgggggaaaatgctgaggatgag atgtcctttgaggtgcgacagtcagaactggaaaaagaaatggagaaacaaagactcttg taccagcagtctagactgcataatcgtggcgctgcagaaatggtcctgcaaatgatcagt gcctgcaaaggtgaaacgggcccaatggtgtctacaaccctcaagctgggtatttctatc cttaacggtgggaacagtgaggttcagcggaaaatgctggagtacttaaaggacaagaag gatgtgggcttctttttgagtgtccaggcattgatgcagacttgctgtgtcctggatcta aatgcctttgagaggcagaacaaggcagaggggctgggcatggtttcagaggaaggcacc aatgagaaagtgatggcagatgatgagttcacctgtgacctcttccgtttcttgcagttg ctttgtgaaggtcacaataatgattttcagaactacttgcggactcaaacaggcagcaca accaccatcaatgtcatcatctgtacagtggactaccttctccgtctccaggagtctata agtgacttctactggtattactctgggaaggatgtcatcgatgaaccaggcaaaaaaaat ttctccaaagctatgacagtggcaaaacagattttcaacagtctaactgaatatatccag ggtccatgcaatggcaaccaacagtccctggcccacagcaggctgtgggatgctattgtt ggctttcttcatgtctttgcccacatgatgatgaagctggcacaggactccagccagatt ggtcttctgaaggagcttcttgacctacagaaagatatggttgttatgttgctgtcttta ttggagggaaatgtggtaaatggtacaatcgctcgccagatggtagacatgttggtagag tcctccagcaatgtggagatgatactcaagttctttgacatgttcctcaaactgaaagat atcgtggcctcagatgctttccgtgattatgtgacagaccctcgagggcttatctcaaag aaggacttccagaaggcgatggacagtcaaaagcagtactccccctctgagattcagttt cttttgtcctgctcagaagcagatgaaaatgacatgatcaattatgaagagtttgccagt cgcttccaggaacccgccaaagacattggcttcaacattgctgtgctgctcaccaatctg tctgagcatgtccctcatgacaccaggctacagaacttcctggaacaagcagagagtgtg ctgaactacttccgtccgttcttggggcgtattgaaataatgggagccagcagaaaaatt gaacgcatctactttgaaatcagtgaggttaaccgcagacagtgggagatgcctcaagta agagagtccaaacggcagttcatctttgatgtcgtcaatgagggtggcgaatcagagaag atggagatgtttgtcaacttctgtgaagacaccatctttgagatgaatatagcctcacaa atttcagagcaggaggaagaggaaaagggggaagaagaagatgaaggggaagaaggggga ggtgagggtggaggaggtggggaaggaaatggaggaggagatgaggataataatggaagg gaagggccacatgaatcaacctctgcctttgcagattttataaacagcatgttaagcttc ctcggcattttcaccttccgtaaccttcgcagacagtatcgtagagtgagaaagatgacc ttcaaggagattgtagtggccttgtccacttttttctggaccatactgatgagtatacta cacttcatttacaatgtatgcaaaggtatctttatgatcatctggcaaacactgtttgga ggtggcttggtagagggagccaaaaatatcacagtcactgagattttagccagcatgcca gatcccacccaggacgatgtgcatggcgatggaccaggggagccaaggacaggggaggaa caggacactggaggtgtaacagatactggtgagactgggagtggagaggaagaagaggag gatacccaagaaaaagagggtgggaggataccaggaatggatgctccaggtggacttgga gatatgggcgtggaggcaccagttgaacctccaactcctgaaggaactcccataacaaag agaaaaatggcaccagaagagactgatgctagtcagaaaccaccagaacctcctcctgta gaagaacctcctacggagcctgaaaaggctgatgctgaaactggagagaaaacagagaaa gaatgtgagagcaaagaagaagtagaaccagaaaaaccaaagaaatcagcagccaaaaaa gacaagaagctgaaaaaggttggaggttttcaaatctggactgagctggaaacccaaagg aataaatttatgaactatctttccagaaacttctacaacctgcgttttttggctctgttc cttgcatttgcactgaacttcattcttcttttctataaggtgtcggacagcccgcctgag ggtgaagagatggaaggctctggactatctgagggaagcgggctgttcgaagggtctgcg ttgtttgaaggttcaggcgaagagcttgaaggatccggaattaatggtggaggagatgaa gatgaggaagatgttccagtttattactatttagaggagagcactggatacatgcagcct actttgtcctttcttgcgatgcttcacacagtcatttcattcatctgtatcattggctac aactgcctgaagattcctctggtcatttttaaaagagagaaagaacttgcgagaaagctg gaatttgatggcctctacatcactgagcaaccggaggatgatgacatcaaggggcagtgg gacagattagtcctgaatacaccctctttcccaaacaactactgggataaatttgtcaag cgaaaggttcttgataaatacggagacatttatggaagagaaagaattgctgagctcctg ggggttgatttagcttccctggatgtgagtcaacaacatgagaagaaacaggaagaacca gataactctgtgtttgcatgggcgacttctattgacatcaagtaccagatctggaaattt ggtgtggtgttcacagatggtacttttctttacctctgttggtacttggtgatgtctttg cttgggcattacaacaacttcttcttcgcctgtcatttgctggatattgcgatgggtgtc aagactcttcgcactatcctgtcctcagtcacacacaatggcaaacagctcatgatgaca gtgggcttgctggccgtggttgtgtatctttacaccgtagttgccttcaatttcttccgc aagttttacaacaagagtgaagatgaagacgaaccagatatgaaatgtgacgatatgatg acttgttatctgttccacatgtatgtgggtgtccgagcaggcggaggcattggagatgag attgaagacccagctggagatgaatacgagctttatcgagtggtctttgatattactttc tttttcttcgtcattgttatcctgctggccatcattcagggtctgatcattgacgccttt ggagaactcagagaccaacaagagcaagtcaaggaagacatggagacgaaatgcttcata tgtggcattggaagtgactactttgatacaacgccgcatggctttgagactcacactttt gatgaacacaacctggccaattacatgttctttttaatgtaccttatcaacaaagatgag accgagcacactgggccggagtcatatgtgtggaagatgtaccaggagcgctgttgggac ttcttcccagctggagactgtttcagaaaacagtttgaggatcagctctcttaa

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