Oreochromis aureus (blue tilapia): 116336492 Help Entry 116336492         CDS       T07295                                  Symbol ryr1b Name (RefSeq) ryanodine receptor 1b   KO K04961   ryanodine receptor 1 Organism oau  Oreochromis aureus (blue tilapia) Pathway oau04020   Calcium signaling pathway oau04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:oau00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     116336492 (ryr1b)    04020 Calcium signaling pathway     116336492 (ryr1b)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:oau01009]     116336492 (ryr1b)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:oau04147]     116336492 (ryr1b)    04040 Ion channels [BR:oau04040]     116336492 (ryr1b) Protein phosphatases and associated proteins [BR:oau01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      116336492 (ryr1b) Exosome [BR:oau04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    116336492 (ryr1b) Ion channels [BR:oau04040]  Voltage-gated cation channels   Ryanodine receptor    116336492 (ryr1b) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec SPRY MIR RIH_assoc Ion_trans EF-hand_7 CDC45 Motif Other DBs NCBI-GeneID:  116336492 NCBI-ProteinID:  XP_039453884 Ensembl:  ENSOABG00000018690 LinkDB All DBs Position LG14:complement(6664506..6728686) Genome browser AA seq 5076 aa AA seqDB search MAEGGEGEEEIQFLRTDDQVVLQCTASVLKEQIKLCLSCEGFGNRLCFLETTSNAQNVPP DLAICTFILEQSLSVRALQEMLANTVEMTESSQGGGHRTLLYGHAILLRHHHSGMYLSCL TTSRSLTDKLAFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLH LSYASGDLMVDASFMQTLWNMNPISSGCELAEGYLTGGHVLRLFHGHMDECLAIATPEEG EEKRRMAHYEGGTVCSQARSLWRLEPLRISWSGSHMKWGQSFRIRHITTGRYLCLDEEKG LLVVDPEKANTKLSAFCFRASKEKVDVAQKRDVEGMGIPEIKYGESMCFVQHVSTGLWLT YAALDAKAARLGMMKRKVILHQEGHMDDALTVSRSQTEESQAARMIYSTTGLFRQFINGL DSLSGKNKSLGTGSLPLESVILSLQDLIFYFRPPEEELEHEEKQTKLRSLRNRQNLFQEE GMITIVLECIDRLNVYNTAAHFSEFAGEEAAESWKEIVNLLYELLASLIRGNRSNCALFC DNLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLD VLRSLCVCNGVAVRSNQNLITENLLPGRDLLLQTNIVNYVTSVRPNIFLGTCEGSTQYKK WYYEVMVDHVEAFVTAQASHLRVGWALTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHL WSGTVARQVASPSAHTLAADDVVSCCLDLSVPSISFRINGHPVQGMFENFNVDGLFFPVI SFSAGVKARFLLGGRHGDFKFMPPPGYAPCYEALLPRERMRIEHIKEYKHDFDGVRNLLG PTLSLTHTSFTPCPVDTIQIVLPPHLERIREKLAENIHELWAVTRIEQGWTYGIFRDDNK KLHPCLVDFQSLPEPEKNYNLQMSAETLKTLLALGCHVGMGDEKAEENLKKIKLPKTYVM SNGYKPAPLDLNHVKLTPNQNQLVEKLAENGHNVWARDRVRQGWTYSIVQDIVNKRNPRL VPYNLLDERTKKTNRDSVNNAVRTLIGYGYNIEPPDQESTGHGLENTRGDKVRIFRAEKS YAVTQGKWYFEFEAVTTGEMRVGWARPNVRSDTELGADELAYVFNGNKAQRWHIGNEPFG RQWQSGDVVGCMIDLTEMNIMFTLNGEMLISDSGSEMAFKDIEIGDGFIPVCTLGLSQVG RINLGQNVSSLRYFAICGLQEGFEPFAINMKRDITMWFSKSLPQFVPVPADHNHIEVSRV DGTVESAPCLKLTHKTFGSQNANTDMMFLRLSMPVQFHETFKIPAGTTPLTRALTIPEEE VAVVEPDSEFEVLKKSASRKEQEEDKKDPSVPKEISVENEKDTMSEKGKKKGFFSKAKKA AMTPLAPPPAPPTVPRLVEDVVPDDRDDPEIIQSTTTYYYSVRIFAGQEPSGVWVGWVTP DYHMYDQNFDLSKVRSVTVTVGDDKGNIHDSMKHSNCYMVWGGDLVSNQQTRFSQEDMVI GCLVDLATGLMTFTANGKEINTFYQVEPNTKLFPAVFVQPFSQNMVQLELGKLKNIMPIS AAMFRSERNNPVPQCPPRLDVQMLTPVIWSRMPNHFLKPEVGKVNERLGWMVECVEPLIM MALHIPEENRCIDILELSERQDLMKFHYHTLMLYCAVCALGNNRVAHALCSHVDESQLFY AIENTYLPGPLRSGYYDLLISIHLESAKRARLGTNREFIVPMTEETLSIKLYPDAIKAHS LPGVGLTTCLRPKLHFSSINFVGTDPDLYTISPVFPLQELKTKAISMLREAVLDGSQAMR DPVGGSVEFHFVPILKLISTLLIMGIFNDDDTKHILKMIDPNVFSGKEEEEAEEGGAAEG ENEEKKEEESEEAAEDELEDEGVGDEEEEELKELEKPEGEEEEAEPKEEGEEGEKDKEEA KRGKVDGEKAEEEKESEAVEAEAQEEEEGLEEGLLQMTLPESVKLQMCTLLQYFCDCELR HRVEAIVAFSDQFVHDIKSNQRVRYNQLMRAFTMSAAETARKTREFRSPPQDQVLMLTNF KHQEDEDSPVPEDVRETLAEFHKDLLLHCGIHIEEEPEEEEVDTSLRGRLLSLVDKVKSL RKKKEEEEKPEVEEEPKPSTLQELISHTMIHWAQESFVQNPELVRLMFSLLHRQYDGLGE LIRALPKAYAINAVSVQDTMELLECLGQIRSLLIVQMGPEEERLMIQSIGNIMNNKVFYQ HPNLMRALGMHETVMEVMVNVLGGGGDSKEIRFPQMVTSCCRFLCYFCRISRQNQRSMFD HLSYLLQNSGIGLGMRGSTPLDVAAASCIDNNELALALQEQDLEMVVTYLAGCGLQMCPM LLSKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENATVVVRLLIRRPECFGPALRGEG GNGLLAAMEEAIKISEDPARDGPTVKKDRRFMFGGEEQHEENRVHLGNAIMSFYSALIDL LGRCAPEMHLIQAGKGEALRIRAILRSLVPIEDLVGVISLPVQIPAYGKDGQIIEPKMSA SFVPDHKASMVLFLDRVYGIDNQDFLLHVLEVGFLPDMRAAASLDTVAFSTTEMALALNR YLCSAVLPLLTKCAPLFAGTDHRAIMIDSMLHTIYRLSRGRALTKAQRDVIEECLMSLCK YLRPSMLQHLLRRLVFDVPILNEYAKMPLKLLTNHYERCWKYYCLPNGWANFGVTSEEEL HLSRKLFWGIFESLAHKKFDAELFKIAMPCLCAIAGAIPPDYVDASYSSHTEKKASVDAE GNFDPKPVETTNTIIPERLDPFINKYAEHTHDKWAFEKIQNNWTYGEVLDENAKTHPMLR PYKTFSEKDKEIYRWPIKESIKAMLAWEWTIEKARDGEGEVEKKAAATTTTRKISQTAQA TYDPSHGYSPQPIDISGMALSRELQSMAEQLAENYHNTWGRKKKLELQSKGGGTHPLLVP YDTLTAKEKARDREKAQDLLKFLQLNGYAVTRGLKDMEQDISSIEKRFAYGFLQKLLKWM DIAQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLVNQYFKNHCLYFLSTPAKVLGS GGHSSNKEKEMIASIFCKLAALVRHRVSLFGTDAPAVVNCLHILSRSLDARTVMKSGPEI VKAGLRQFFESAADDIEKMVENLKLGKVSSRNQVKGVAQNINYTTTALLPVLTSLFDHIA QHQFGDDVMLDDLQISCYRLMCSIYSLGTVKTPHVEKQRPALGECLAHLAAAMPVAFLEP VLNEFNSFSVYTTKTPRERAILGLPNQVEELCPDIPELEILMKEIHDLAESGARYTEMPH VIEITLPMLCNYLPRWWERGPESFPEQDGQLCTAVTSEQLNQLLGSIMKIVVNNLGIDEA SWMKRLAVFAQPIVSRAKPEMLKSHFIPTMEKLKKRAAKVVAEEDHLRMEGKTEVDSENG TIRDEFAVLCRDLYALYPLLIRYVDNNRARWLTCPDPDAEELFRMVGEVFIFWSKSHNFK REEQNFVVMNEINNMSFLTADSKSKMSKAGDGESGGSEQERTKKKRRGDRYSVQTSLIVA ALKKMLPIGLNMCSPADQELINLAKIRYSLKDTDEEVREFLHNNLHLQGKVEDPAMRWQM SLYKEMSGKAEDADDPEKVVKRVQEVSAVLYHIEVTEHPFKSKKMVWHKLLSKQRRRAVV ACFRMTPLYNITTHRVTNMFLDAYKRNWLETEGYSFEDKMIDDLSKAMEEEEEEEEETET KPDPLHQLILHFSRTALTEKLKLDVDHLYMSYADIMAKSCHIGEEDEGGEQEGEEPSFEV RQTEMEKEMEKQRLLYQQSRLHNRGAAEMVLQMISACKGEPGAMVSSTLKLGISILNGGN SDVQQRMLDYLKDKKDVGFFLSVQSLMQTCSVLDLNAFERQNKAEGLGMVSEEGTNKKLE RDEKVMADDEFTCDLFRFLQLLCEGHNNDFQNYLRTQTGSTTTINVIICTVDYLLRLQES ISDFYWYYSGKDIIDEPGKRNFSKAMTVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAV VGFLHVFAHMMMKLAQDSSQIGLLKELLDLQKDMVVMLLSLLEGNVVNGTIARQMVDMLV ESSSNVEMILKFFDMFLKLKDIVASDAFRDYVTDPRGLISKKDFSKAMDSQKQYSPSEIQ FLLSCSEADENEMINFEEFADRFQEPAKDIGFNIAVLLTNLSEHVPHDTRLQNFLEQAES VLNYFRPFLGRIEIMGASRKIERIYFEISEENRNQWEMPQVRESKRQFIFDVVNEGGESE KMEMFVNFCEDTIFEMNIAASISEPEGDGAEEEDDEEEEEGGGDEGESGEGDEGNGEGEA PESASAFAEFLKSVVNFFNMFTFRNLRRRYRKLRKMTVKDMIIGLVTFVYTVLMGILMFV YSICKGFFTLIWKALFGGGLVEGAKKMTVTEILASMPDPTQDEVHGDLPPEPGAREVQDA DGVADLIDAVGGEEEEEDGEDREGGRLPGFNTPGGLGDIGETTPEEPPTPEGTPLLKRKL LAAAVGGQEEEEKGEHEEEAPQETEKADTENGEKTEKAEKAEPEPEVKEEEPEEQEEISV KTKVKKDKKSVKEGFKLWNELEVQRIKFMNYLSRNFYNLRFLALFIAFALNFILLFYKVS DTPPGEEEFEGSGLFEGSGIFEGSGAEEDGSGLDDGGDDDDEEGPLYYFLEESTGYMEPA MAFLGIVHTIISFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYVTEQPEDDDIKGQWD RLVLNTPTFPNNYWDKFVKRKVLDKYGDIYGRERIAELLGMDLASLDVSAMSHGKKPEPD TSMFSWITSIDIKYQIWKFGVVFTDNTFLYLVWYMLMSLLGHYNNFFFAAHLLDIAMGVK TLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMT CYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFG ELRDQQEQVREDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDET EHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 15231 nt NT seq  +upstreamnt  +downstreamnt atggcagaagggggagagggagaggaggagattcagttcctgcgaacggatgaccaggta gttctgcagtgcactgcctccgtcctgaaggaacagattaaactgtgtctctcctgcgag ggcttcgggaaccgtctctgcttcctagaaaccacatccaacgctcagaatgtgccccca gacctggccatatgcaccttcattctggagcagtctctctcagtccgtgctctgcaggag atgctggccaacaccgtggagatgaccgagtcgtcccagggtggaggtcatcgcacttta ctgtatggtcatgccatccttttgagacaccaccactcaggcatgtacttgagctgtttg actacatctcggtccctcacggacaagctggccttcgatgtaggcttacaagaggattcc accggtgaggcatgttggtggactattcatccagcctctaaacaaaggtcagaaggtgaa aaggtcagggtgggtgacgacctcatccttgtcagtgtgtcctctgagcgatacctgcat ctgtcctatgccagtggagatctcatggtggacgcttccttcatgcagactctttggaac atgaatccaattagttcaggctgtgaactagctgagggttatttaacaggaggtcatgtt ctcaggcttttccatggccacatggacgaatgtctggccatcgcaacaccagaggaagga gaagaaaagcgcaggatggctcattatgaaggcggtactgtgtgcagtcaggctcgatcc ctgtggaggctggaacccctcagaatcagttggagtggtagccacatgaagtggggacag tcttttcgtattcgccacatcacgacgggccggtacctgtgtcttgatgaggaaaagggc ctcttggtggtcgatccagagaaggcgaacaccaaactgtctgctttctgcttccgtgct tcaaaggagaaggtggacgtggctcagaagcgtgatgttgaggggatgggcattccagag attaagtatggagagtccatgtgctttgtccagcatgtgtctacaggcctgtggctcaca tacgctgccctggatgctaaagctgctcgtttgggaatgatgaagagaaaggttattctg caccaggagggccatatggacgatgccttgactgtgtcccgctctcagactgaagagtca caggctgctcgaatgatttacagcaccacaggcctcttcaggcagttcatcaatggattg gactctctcagtgggaagaacaagtcactagggacagggtcacttcctctggagtcggtc atcctctctcttcaggatctcatcttctactttcgcccgcctgaggaggaactggaacac gaagagaaacagaccaagcttcgctctctccgcaaccggcagaacctcttccaggaggag ggaatgataaccattgtgctggagtgcattgaccgcctgaacgtgtacaacactgctgcc cacttttctgaatttgcgggagaggaggctgcagagtcctggaaggagattgtcaacctc ctttatgagctgctggcttctctgatcaggggtaaccgatcaaattgtgcattgttctgt gacaatctcgactggttggtcagcaagctggaccgtctggaggcctcctcaggtattctt gaggtgctgtactgtgtcttaattgaaagccccgaggttctgaacatcatccaggagaac cacatcaaatccatcatctctctcttggacaaacatggaaggaaccataaggtgctggat gtcttgcgctctctttgtgtgtgtaatggtgtagctgtgaggtccaaccagaacctcatc actgaaaatctacttccaggtcgtgacctcttgctacagaccaacattgtaaactatgtc accagtgtaaggcccaacatctttttgggtacgtgtgaggggtcaacacagtataagaag tggtactacgaggtgatggtagaccatgtggaagcctttgtgacagcacaggcttctcac ctgcgggtaggctgggctttgactgaaggttatagcccctatcctggaggaggagaaggc tggggtggtaatggtgtgggagatgacctctactcatatggctttgatggactgcatctg tggtcaggtactgtggcccgccaggtggcttcgcccagtgcacatacactggctgccgat gatgttgtaagctgctgtctggatctcagtgtgcccagtatctccttccgtattaatggc cacccagttcagggaatgtttgaaaactttaatgttgatggcctcttctttcccgtcatt agcttttctgctggggtcaaggctcgattcctcctcggtggtcgccatggggactttaaa ttcatgcccccacctggttatgcgccatgctacgaggctttgttgcctagagagaggatg cgtattgaacatatcaaggagtacaagcatgactttgatggtgtgcgcaatcttctgggt cctactctgtccctcactcacacatctttcaccccctgccctgtggacacaattcagatt gtcttgccaccccacttggaacgtatccgagaaaaactggcagagaatattcacgaactc tgggctgtcactcgtattgagcagggctggacctatgggatttttagggatgacaacaag aaactccatccctgtctggtggacttccaaagtctgcctgaaccagaaaagaactacaat ctgcagatgtctgctgagactctcaagactctcctagcactgggttgccatgttggtatg ggtgatgagaaagcggaggagaatctaaagaaaatcaagcttcccaagacctatgtgatg agcaacggatacaagcctgccccgcttgatctcaaccatgtcaagctgacaccaaaccag aatcagcttgtagaaaaactggcagaaaatgggcataatgtttgggcaagggaccgagta cggcaaggatggacctacagcattgtccaggacatcgttaataagcgtaaccctcgtctg gtaccttacaacctgctggatgagagaactaagaaaaccaaccgagacagcgttaacaac gctgtccgtacactcattggctatggctacaacattgagcctccagatcaggagagcact ggccatggccttgagaacacccgtggggacaaagtacgaatcttcagggcagagaagtcg tatgctgtcacccaaggaaagtggtactttgagtttgaggcagtcacaacgggggagatg agagtgggctgggcacgtcctaatgtccgctctgacactgaactgggagcagatgagttg gcctacgtctttaatggcaataaggcccagcgatggcatattggcaatgaaccatttggc cgccagtggcagtctggtgatgtagttggctgtatgatagacctgactgagatgaacatc atgttcacgctcaatggagaaatgttgatcagtgactcaggctcagagatggctttcaaa gatattgaaattggggatggttttattccagtgtgtaccctgggtctatctcaggttgga aggattaatctgggtcaaaatgtcagcagcctgcgctattttgccatttgtggcctgcag gaaggatttgaaccttttgccatcaatatgaagcgagacatcaccatgtggttcagtaaa agtttgccccagtttgtgcctgtgcctgctgatcacaaccatattgaggtctcccgtgtt gatgggaccgtggaaagcgccccctgtctgaagttgacgcacaagacgtttgggtcgcag aacgccaacactgatatgatgttccttagactcagcatgcctgtgcagttccacgagacc tttaagatcccggcaggtaccacccctctcacccgtgccctcactatacctgaggaggaa gtcgcagtggtggaacctgactcagagtttgaagttttgaaaaagtctgccagtcgcaag gagcaggaggaagacaagaaggacccttctgtgcctaaggagatctctgtggaaaatgag aaggacacaatgtcagaaaagggaaagaaaaaaggatttttctccaaagccaagaaggca gccatgacacctcttgcccctcctcctgctcctccaacggtgccacgtttggtggaagac gtggtccctgatgacagagatgatcctgagatcatccaaagtaccaccacttattactac tctgtgaggatctttgctgggcaggagccgtctggtgtttgggttggctgggtcactcct gattaccacatgtatgatcaaaactttgacctctccaaggttcgcagtgtcactgtcaca gtgggagatgacaaaggcaacatacatgacagcatgaagcacagtaattgttacatggtg tggggaggggatctggtcagcaatcagcaaacccgctttagccaggaggacatggtgatt ggctgccttgttgacctggcaacaggtctcatgacttttacggcaaatggaaaggagatt aatactttctaccaggtggagccgaacaccaaactcttccctgcagttttcgttcagccg ttcagtcagaacatggtgcagctagagttgggcaaactcaagaacatcatgcctatctca gctgcgatgttccgcagtgaacgtaacaatccagtccctcagtgccccccgaggctggat gtccagatgctgactccagttatctggagtcgtatgccaaatcacttcctcaaaccagag gtgggcaaagtaaatgagcggttaggctggatggtggagtgtgttgaacctctcatcatg atggcactgcacatcccagaggagaacaggtgtattgatatcctggagctgtcagagcgt caggatctgatgaagttccactatcatacactcatgctctactgtgctgtgtgtgcactt gggaacaaccgagtggctcatgctttatgcagtcatgtggatgaatcccagcttttctat gccattgagaacacctacctacctggacctctccgcagcggctactatgacctgcttatc agcattcatctggaatcagcaaaacgtgcacgcttgggcaccaacagggaattcatcgtt cccatgactgaagagaccctcagcatcaagctctatcctgatgcgataaaagcccactcc ttacctggtgttggtctcactacctgcttacggccaaagctgcatttctcatccatcaac tttgttggcacagaccctgatttgtacaccattagtcctgtctttcctctacaggagctg aaaacaaaggcgattagcatgttacgagaggccgtgctggatggtagccaggccatgcgg gatccagtaggaggcagtgtagagttccactttgtcccaatcttgaagctaatcagtaca ctgcttattatggggatcttcaatgatgatgacaccaagcacatcctcaagatgatcgac cccaatgttttcagtggaaaggaagaggaggaagctgaagagggtggagctgctgaagga gaaaatgaggaaaagaaggaggaggaatcagaagaagcagctgaggacgagcttgaggat gaaggggttggggatgaggaagaggaggagctaaaagagctggagaaaccagagggtgag gaggaagaggctgagcccaaggaagaaggagaagagggggaaaaggacaaagaagaggct aaaagaggaaaagtagatggagagaaagcagaggaagagaaggagtcagaggcagtggaa gcagaagcacaggaggaagaggagggtctggaggaaggactgctacagatgacgctgcca gagtctgtcaaactacagatgtgcacactcctgcagtacttctgcgattgcgagctgaga cacagagtggaagccattgttgcattctcagaccagtttgtccatgatattaagagcaat caacgtgtccgttacaaccagttaatgagagccttcaccatgtcagccgctgagactgca cgcaaaacccgggagttccgctcacctccacaggaccaggttcttatgctaacgaacttc aaacatcaagaggatgaagattctccagttcctgaggacgtgcgggaaacactggcagaa ttccacaaagacctcttgcttcactgtggcatacatattgaggaggaaccagaggaggag gaggtggacacttcactgaggggcagacttcttagtctggtagacaaggttaaaagcctc cgtaagaagaaggaggaggaggaaaagccagaggtggaggaagaaccaaaacccagcacc cttcaggagctgatctcccacaccatgatccactgggctcaggagtctttcgttcagaac cctgagctggtgcgcctgatgttcagccttctacaccgacagtacgacggtcttggcgag ctgatccgagcactgcccaaagcatatgccatcaatgccgtgtccgttcaggacaccatg gaactacttgagtgtttggggcagatccgatcactgctcatcgtccagatgggtcctgaa gaggagcggcttatgatccagagcattggaaatatcatgaataacaaggtgttctaccaa caccccaatctgatgagagctctgggtatgcatgagactgtgatggaagtgatggtcaac gtgttaggtggaggaggagattcgaaggagattcgattcccccaaatggtgaccagctgc tgtcgtttcctgtgttacttctgccgtatcagccgacagaaccagcgttctatgtttgac catctgagctacctgttacagaacagcggcatcggcttgggcatgcgtggatccacaccc ctggatgtggctgcagcctcctgtattgacaataacgagctggccttggctttacaagag caggacctggaaatggtggtgacttacttggcaggctgtggactgcagatgtgtccaatg ctcttgtctaagggctaccctgacattggctggaatccttgtggcggagagagatacctg gatttcctccgctttgctgtcttcgttaatggagagagcgtggaagagaatgccaccgtt gtggtgcgtctgctcatccgtcgccctgaatgctttggcccagccctgagaggagagggt ggtaatggcctcctggctgcaatggaggaggccatcaagatatcagaggatccggcaaga gatgggcccactgttaagaaagacaggcgcttcatgtttggtggtgaggaacagcacgag gagaaccgtgtgcatctgggaaatgccatcatgtccttttactcggctctcattgatctg ctgggtcgctgtgccccagagatgcatctgatccaagcgggtaaaggcgaagctctaaga atcagggccatcctgaggtctctggtgcctatagaggacctggtgggggtaatcagctta cctgtgcagattccagcatatggcaaagatggccagattattgagcccaagatgtctgcc agttttgtgccagaccacaaggcctccatggtgctcttcctcgacagagtgtacggtatt gataaccaggacttcctgcttcatgtgcttgaggttggcttcttgcctgacatgagagct gcagcttctctggatacggtggcattcagcacaactgaaatggccttggctctgaaccgc tacctctgttcggctgttctccctcttcttacaaagtgtgctccattgtttgctggaaca gaccaccgagccatcatgatcgactccatgctccacacaatttatcgcctgtctcgtggc cgagcccttaccaaggctcagagggatgttatagaggagtgtctcatgtccctctgcaaa taccttcgaccctctatgctgcagcatttgcttagacggctggtgtttgatgtacccatc ctcaatgaatatgcaaagatgcctctcaagctgctgaccaatcactatgagcgctgttgg aagtactactgcttgccaaatggatgggcgaactttggggtgacttctgaggaggagctg catctttctcgaaaactcttttggggaatcttcgaatcgttggcacataagaaatttgat gcagagctcttcaagattgccatgccctgcctctgtgctatagctggagccatcccccct gactatgtggatgccagctactcctctcacactgagaaaaaggcctctgtggatgctgaa ggcaactttgatccaaaaccagtagagaccaccaacactatcatcccagagagactggat cctttcatcaacaagtatgcagaacacactcatgataaatgggcgtttgaaaagattcag aacaactggacgtatggagaggtgctagatgagaatgctaagactcacccgatgctccgg ccatacaaaacattctctgaaaaggacaaggagatttatcgttggcccattaaagaatcc atcaaagctatgctggcatgggagtggaccatagagaaagcaagggatggagaaggagaa gtcgagaaaaaggccgccgccaccaccaccacgcgcaaaatctctcaaactgctcaggcc acttatgatccgagtcacggatacagccctcagccaatagacatctcaggaatggccctc tccagagagctgcaatctatggctgaacagctagcagaaaactatcacaacacctggggc aggaagaagaagttggagctacagtccaaaggtggtggtactcatcctttgctcgtgcct tatgacacattgacggctaaggagaaggccagagacagggagaaagcccaggacctgctc aagttcctccagcttaatggatacgctgtgacgaggggtctaaaggatatggaacaggac atttcctccattgagaagcgttttgcctatgggttccttcagaagcttcttaaatggatg gacattgcccaggaattcatcgctcatcttgaggctgtagttagcagcggtagagtggaa aagtcaccacacgaacaagaaatcaaattctttgccaagatcctcttgccgctggtaaat cagtactttaagaaccactgcctgtactttctctccactcctgccaaagtattgggcagt ggaggacattcctcgaataaagagaaggagatgattgcaagtatcttctgtaagttggct gctttggtgaggcacagagtatctctttttggaacggatgcacctgcagtggtaaactgc ctgcacattctctcacgatcactggatgccaggactgttatgaaatcaggccctgagatt gttaaagccggcctgcgtcagttctttgagagtgctgcggatgacattgagaagatggtt gagaatctgaaactgggcaaggtgtccagtcgaaaccaggttaagggtgtcgcacagaat atcaactacaccaccactgccctgctgccagtcctcacttcactgtttgaccacattgcc caacaccagtttggtgatgatgtcatgttggacgacttgcagatatcctgctatcgtcta atgtgcagtatctactctttgggcactgtgaagactccacatgtggagaaacagcgacca gctcttggcgagtgtttggcccacttagcagctgctatgccggtagcctttcttgaacca gtgctaaatgaattcaactcattttctgtttacacaaccaagactcctagagagagagcg attcttggtcttcccaatcaagtagaagagctgtgtcctgacatcccagaactggagatt ttgatgaaagagatccatgacctggctgagtctggagctcgctacacagaaatgccccat gtgattgagatcaccttgcccatgctgtgtaactatctcccccgctggtgggagagaggc ccagagagcttccccgagcaggatggccaactctgcaccgccgtcacctccgagcaactc aaccagctgctgggtagcatcatgaagattgtggttaacaacctgggtatagatgaagcc tcttggatgaaaagattagcagtgtttgctcagcccattgtcagcagggctaaaccagag atgcttaaatcccactttatcccaaccatggaaaagctgaagaagcgtgcagcaaaggtg gtggcagaggaggatcatctgcgcatggagggcaaaacagaggtggacagtgaaaacggg accattcgagatgagtttgctgtactctgtcgggacttgtatgctctctaccctttgctc attcgctatgtggacaacaacagggcaaggtggctgacttgtccagacccagatgcagag gagcttttcaggatggtgggcgaggtcttcattttctggtccaaatcccacaactttaag agggaggagcagaacttcgtggtgatgaatgagatcaacaacatgtccttcctgactgct gacagtaagagcaagatgagcaaggccggagatggagagtccggcggctcagagcaggag cgtaccaagaagaagcgacggggggaccgctactccgtgcagacctcccttattgtagca gcgctaaagaagatgcttcccatcggcctcaatatgtgctctcctgcagaccaggaactc atcaaccttgccaagatcagatactcgctgaaagacacagatgaagaggtgagggaattc ttgcacaacaacctgcatctgcaaggcaaggtggaggacccagcaatgcgctggcagatg tctctttataaagagatgtctggaaaagcagaagatgccgatgatccggagaaggtggtg aaaagagtacaagaggtgtctgctgtcctttaccacattgaagtgactgaacatcccttc aagtcaaagaaaatggtttggcacaagctgctgtctaaacaacgtcgcagagctgtggtg gcctgtttcaggatgacgcctctgtacaacatcaccacgcacagggtaaccaacatgttc ttggatgcatacaaacgcaactggttagaaaccgagggttactcatttgaagacaagatg attgatgacttatcaaaagccatggaggaggaggaggaagaggaagaggagactgagacg aagcctgacccccttcatcagctgattcttcatttcagccgcacagctcttacagaaaag cttaaacttgatgttgaccatctctatatgtcatatgctgatattatggcaaagagctgc cacattggtgaggaggacgaagggggagaacaggagggggaggagccatcctttgaggtg cgacagacagagatggaaaaggagatggagaaacagaggctcttgtaccagcagtcccgt ctgcacaaccgtggtgctgcagagatggtgctgcagatgatcagcgcctgtaaaggtgaa cctggagccatggtttcttctacactcaaactgggaatctccatcctcaatggaggcaac agtgatgtacagcagaggatgctggactatctgaaggataaaaaggatgtggggttcttc cttagcgttcagtctctgatgcagacctgcagtgttttggacttgaacgcttttgagaga cagaacaaggctgagggacttgggatggtttcagaagaaggcaccaataagaagctagaa cgtgatgagaaagtgatggcagacgatgaatttacatgtgacctcttccgcttccttcaa cttctttgtgagggccacaataacgattttcagaactacttaagaactcagacaggcagc acaactactataaatgtcatcatctgcactgtggactaccttcttcgactccaggagtcg attagtgacttttactggtactactcaggaaaagacataattgatgagcctggtaagagg aatttctccaaagcaatgactgtggccaagcaggtcttcaacagcctgactgagtacatc cagggtccctgtactgggaaccaacaatctctggcccacagcagattgtgggacgctgtt gtgggctttctacatgtctttgctcacatgatgatgaaacttgctcaggactccagtcaa atcggtctcttgaaggagcttttagatctgcagaaggacatggtagtgatgcttctgtca ctgcttgaaggcaatgtggtgaatggcaccattgccaggcaaatggttgacatgttggtg gagtcctccagcaatgtggagatgatccttaagttcttcgacatgttcctcaagctcaag gatatagtggcgtctgatgccttccgtgattatgtgactgatccacgtggtcttatttca aagaaggacttctccaaggccatggacagtcagaagcaatactctccttctgaaatccag ttcctcctctcatgctcagaggctgatgagaatgaaatgatcaactttgaggagtttgct gatcgtttccaggagccagcaaaagatatcggtttcaatattgctgttctgctcacaaac ctgtcagagcatgtaccccatgacactcgccttcagaacttcctggaacaggcagagagc gtgctcaactatttccgccctttccttggccgtatcgagatcatgggagccagcaggaag atcgaacgcatttactttgaaatcagtgaggagaaccgcaatcagtgggagatgcctcaa gtcagagagtccaagcgccagttcatctttgatgtggtcaacgagggtggcgagagtgag aaaatggagatgtttgtgaacttctgtgaggacaccatttttgagatgaacattgctgca tctatctctgagccagagggagatggtgcagaagaagaagatgatgaagaagaagaggaa ggtggaggagatgaaggagagtctggagaaggagatgaaggaaatggtgagggtgaagct ccggagtcagcttctgcctttgcagagtttctgaagagcgtggttaacttctttaacatg ttcaccttccgtaacctccggcgtcgataccgcaaacttagaaaaatgacggtaaaggac atgattatcggcctggttacattcgtctacactgttttgatgggcatcctgatgtttgtc tatagcatatgcaagggtttcttcacactaatatggaaggcactgtttggtggcggctta gtagagggtgccaagaagatgacagtcacagagatcctggccagtatgcccgatcccacc caagatgaagttcatggggacctaccgcctgaaccgggtgctagggaagtccaagatgca gatggagtggcagacctcatagatgctgtgggtggagaggaggaagaagaggatggtgag gacagagaaggtggacggttgcctggctttaatactcctggaggacttggagacattgga gagacaacaccagaagaacctccgactccagagggcactcctctgttgaagaggaaactg ctggctgctgcagtaggaggacaagaagaggaagaaaaaggtgaacacgaagaagaggct cctcaggagacagagaaagcagacaccgagaatggtgagaaaacagagaaagcagagaag gcagagcctgaacccgaggtaaaggaggaagagcctgaggaacaagaagagataagtgtg aagaccaaagtgaagaaggacaagaaatctgttaaggagggctttaaactgtggaatgag ctggaggttcagaggattaaattcatgaactacctttctcgtaacttctacaatttacgt ttcttggccctgttcattgccttcgctctcaatttcatcctgctcttctacaaggtgtct gacactcctccaggtgaggaagagtttgaaggttctggtctctttgagggttctggtatt tttgaaggctccggtgctgaggaagacggatcaggattagatgacggaggagatgatgat gatgaagaaggccctttgtactactttttggaagagagcactgggtacatggagccagca atggctttccttggtattgttcacaccatcatctccttcctctgtatcatcggttacaac tgcctgaaggtccctctggttatcttcaaaagagagaaagaactggccagaaagctggaa ttcgatggcctctatgtcactgagcagcctgaggacgatgacatcaagggccagtgggac agactggtgctcaacactccaaccttccccaacaattactgggacaagtttgtgaaaaga aaggttctggataaatatggggacatttatggcagagagagaattgcggagctgcttggt atggacttggcttctcttgatgtcagcgccatgagccatggaaaaaagcctgaacctgac acctcaatgttcagctggataacatctattgacatcaaataccagatctggaagtttggt gtggtcttcactgacaatactttcctctacctggtttggtacatgttgatgtctctgctt gggcactacaacaacttcttctttgctgctcatcttcttgacattgcaatgggcgtcaaa accttgcgcacaattttgtcctctgtcacccacaacggcaaacagctggtgatgacagtg ggtttgctggccgtggtggtgtacctgtacactgtggtggcctttaacttcttccgcaag ttctacaacaagagtgaagacgaggatgagccggacatgaagtgtgatgacatgatgact tgttacctgttccacatgtacgttggtgtgcgagctggcggtggtataggagatgaaatt gaggacccagccggtgatgaatacgagctttaccgcgttgtctttgacattacattcttc ttcttcgttattgtcatcctgctggctatcatccagggtttgatcattgatgcatttgga gagctgagagaccagcaggagcaagtcagagaggacatggagacaaagtgtttcatctgt ggaatagggagcgactactttgatacgacgccgcatggctttgagacacacactttagaa gagcataacttagccaattacatgttcttcttgatgtatttaatcaataaagatgaaaca gaacacacaggacaggagtcatatgtgtggaagatgtaccaggagcgatgctgggacttc ttccctgctggagactgcttcaggaagcagtatgaggaccagcttggataa

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