KEGG   Ovis canadensis (bighorn sheep): 138440360
Entry
138440360         CDS       T11679                                 
Symbol
PIK3R3
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
ocan  Ovis canadensis (bighorn sheep)
Pathway
ocan01521  EGFR tyrosine kinase inhibitor resistance
ocan01522  Endocrine resistance
ocan01524  Platinum drug resistance
ocan04012  ErbB signaling pathway
ocan04014  Ras signaling pathway
ocan04015  Rap1 signaling pathway
ocan04024  cAMP signaling pathway
ocan04062  Chemokine signaling pathway
ocan04066  HIF-1 signaling pathway
ocan04068  FoxO signaling pathway
ocan04070  Phosphatidylinositol signaling system
ocan04071  Sphingolipid signaling pathway
ocan04072  Phospholipase D signaling pathway
ocan04081  Hormone signaling
ocan04140  Autophagy - animal
ocan04145  Phagocytosis
ocan04150  mTOR signaling pathway
ocan04151  PI3K-Akt signaling pathway
ocan04152  AMPK signaling pathway
ocan04210  Apoptosis
ocan04211  Longevity regulating pathway
ocan04213  Longevity regulating pathway - multiple species
ocan04218  Cellular senescence
ocan04360  Axon guidance
ocan04370  VEGF signaling pathway
ocan04380  Osteoclast differentiation
ocan04510  Focal adhesion
ocan04517  IgSF CAM signaling
ocan04518  Integrin signaling
ocan04550  Signaling pathways regulating pluripotency of stem cells
ocan04611  Platelet activation
ocan04613  Neutrophil extracellular trap formation
ocan04620  Toll-like receptor signaling pathway
ocan04625  C-type lectin receptor signaling pathway
ocan04630  JAK-STAT signaling pathway
ocan04650  Natural killer cell mediated cytotoxicity
ocan04660  T cell receptor signaling pathway
ocan04662  B cell receptor signaling pathway
ocan04664  Fc epsilon RI signaling pathway
ocan04666  Fc gamma R-mediated phagosome formation
ocan04668  TNF signaling pathway
ocan04670  Leukocyte transendothelial migration
ocan04722  Neurotrophin signaling pathway
ocan04725  Cholinergic synapse
ocan04750  Inflammatory mediator regulation of TRP channels
ocan04810  Regulation of actin cytoskeleton
ocan04910  Insulin signaling pathway
ocan04914  Progesterone-mediated oocyte maturation
ocan04915  Estrogen signaling pathway
ocan04917  Prolactin signaling pathway
ocan04919  Thyroid hormone signaling pathway
ocan04923  Regulation of lipolysis in adipocytes
ocan04926  Relaxin signaling pathway
ocan04929  GnRH secretion
ocan04930  Type II diabetes mellitus
ocan04931  Insulin resistance
ocan04932  Non-alcoholic fatty liver disease
ocan04933  AGE-RAGE signaling pathway in diabetic complications
ocan04935  Growth hormone synthesis, secretion and action
ocan04960  Aldosterone-regulated sodium reabsorption
ocan04973  Carbohydrate digestion and absorption
ocan05010  Alzheimer disease
ocan05017  Spinocerebellar ataxia
ocan05020  Prion disease
ocan05100  Bacterial invasion of epithelial cells
ocan05135  Yersinia infection
ocan05142  Chagas disease
ocan05146  Amoebiasis
ocan05160  Hepatitis C
ocan05161  Hepatitis B
ocan05162  Measles
ocan05163  Human cytomegalovirus infection
ocan05164  Influenza A
ocan05165  Human papillomavirus infection
ocan05166  Human T-cell leukemia virus 1 infection
ocan05167  Kaposi sarcoma-associated herpesvirus infection
ocan05168  Herpes simplex virus 1 infection
ocan05169  Epstein-Barr virus infection
ocan05170  Human immunodeficiency virus 1 infection
ocan05171  Coronavirus disease
ocan05200  Pathways in cancer
ocan05203  Viral carcinogenesis
ocan05205  Proteoglycans in cancer
ocan05206  MicroRNAs in cancer
ocan05207  Chemical carcinogenesis - receptor activation
ocan05208  Chemical carcinogenesis - reactive oxygen species
ocan05210  Colorectal cancer
ocan05211  Renal cell carcinoma
ocan05212  Pancreatic cancer
ocan05213  Endometrial cancer
ocan05214  Glioma
ocan05215  Prostate cancer
ocan05218  Melanoma
ocan05220  Chronic myeloid leukemia
ocan05221  Acute myeloid leukemia
ocan05222  Small cell lung cancer
ocan05223  Non-small cell lung cancer
ocan05224  Breast cancer
ocan05225  Hepatocellular carcinoma
ocan05226  Gastric cancer
ocan05230  Central carbon metabolism in cancer
ocan05231  Choline metabolism in cancer
ocan05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ocan05415  Diabetic cardiomyopathy
ocan05417  Lipid and atherosclerosis
ocan05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ocan00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    138440360 (PIK3R3)
   04014 Ras signaling pathway
    138440360 (PIK3R3)
   04015 Rap1 signaling pathway
    138440360 (PIK3R3)
   04370 VEGF signaling pathway
    138440360 (PIK3R3)
   04630 JAK-STAT signaling pathway
    138440360 (PIK3R3)
   04668 TNF signaling pathway
    138440360 (PIK3R3)
   04066 HIF-1 signaling pathway
    138440360 (PIK3R3)
   04068 FoxO signaling pathway
    138440360 (PIK3R3)
   04070 Phosphatidylinositol signaling system
    138440360 (PIK3R3)
   04072 Phospholipase D signaling pathway
    138440360 (PIK3R3)
   04071 Sphingolipid signaling pathway
    138440360 (PIK3R3)
   04024 cAMP signaling pathway
    138440360 (PIK3R3)
   04151 PI3K-Akt signaling pathway
    138440360 (PIK3R3)
   04152 AMPK signaling pathway
    138440360 (PIK3R3)
   04150 mTOR signaling pathway
    138440360 (PIK3R3)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    138440360 (PIK3R3)
   04517 IgSF CAM signaling
    138440360 (PIK3R3)
   04518 Integrin signaling
    138440360 (PIK3R3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagocytosis
    138440360 (PIK3R3)
   04140 Autophagy - animal
    138440360 (PIK3R3)
  09143 Cell growth and death
   04210 Apoptosis
    138440360 (PIK3R3)
   04218 Cellular senescence
    138440360 (PIK3R3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    138440360 (PIK3R3)
   04550 Signaling pathways regulating pluripotency of stem cells
    138440360 (PIK3R3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    138440360 (PIK3R3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    138440360 (PIK3R3)
   04613 Neutrophil extracellular trap formation
    138440360 (PIK3R3)
   04620 Toll-like receptor signaling pathway
    138440360 (PIK3R3)
   04625 C-type lectin receptor signaling pathway
    138440360 (PIK3R3)
   04650 Natural killer cell mediated cytotoxicity
    138440360 (PIK3R3)
   04660 T cell receptor signaling pathway
    138440360 (PIK3R3)
   04662 B cell receptor signaling pathway
    138440360 (PIK3R3)
   04664 Fc epsilon RI signaling pathway
    138440360 (PIK3R3)
   04666 Fc gamma R-mediated phagosome formation
    138440360 (PIK3R3)
   04670 Leukocyte transendothelial migration
    138440360 (PIK3R3)
   04062 Chemokine signaling pathway
    138440360 (PIK3R3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    138440360 (PIK3R3)
   04923 Regulation of lipolysis in adipocytes
    138440360 (PIK3R3)
   04929 GnRH secretion
    138440360 (PIK3R3)
   04915 Estrogen signaling pathway
    138440360 (PIK3R3)
   04914 Progesterone-mediated oocyte maturation
    138440360 (PIK3R3)
   04917 Prolactin signaling pathway
    138440360 (PIK3R3)
   04926 Relaxin signaling pathway
    138440360 (PIK3R3)
   04935 Growth hormone synthesis, secretion and action
    138440360 (PIK3R3)
   04919 Thyroid hormone signaling pathway
    138440360 (PIK3R3)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    138440360 (PIK3R3)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    138440360 (PIK3R3)
  09156 Nervous system
   04725 Cholinergic synapse
    138440360 (PIK3R3)
   04722 Neurotrophin signaling pathway
    138440360 (PIK3R3)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    138440360 (PIK3R3)
  09158 Development and regeneration
   04360 Axon guidance
    138440360 (PIK3R3)
   04380 Osteoclast differentiation
    138440360 (PIK3R3)
  09149 Aging
   04211 Longevity regulating pathway
    138440360 (PIK3R3)
   04213 Longevity regulating pathway - multiple species
    138440360 (PIK3R3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    138440360 (PIK3R3)
   05206 MicroRNAs in cancer
    138440360 (PIK3R3)
   05205 Proteoglycans in cancer
    138440360 (PIK3R3)
   05207 Chemical carcinogenesis - receptor activation
    138440360 (PIK3R3)
   05208 Chemical carcinogenesis - reactive oxygen species
    138440360 (PIK3R3)
   05203 Viral carcinogenesis
    138440360 (PIK3R3)
   05230 Central carbon metabolism in cancer
    138440360 (PIK3R3)
   05231 Choline metabolism in cancer
    138440360 (PIK3R3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    138440360 (PIK3R3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    138440360 (PIK3R3)
   05212 Pancreatic cancer
    138440360 (PIK3R3)
   05225 Hepatocellular carcinoma
    138440360 (PIK3R3)
   05226 Gastric cancer
    138440360 (PIK3R3)
   05214 Glioma
    138440360 (PIK3R3)
   05221 Acute myeloid leukemia
    138440360 (PIK3R3)
   05220 Chronic myeloid leukemia
    138440360 (PIK3R3)
   05218 Melanoma
    138440360 (PIK3R3)
   05211 Renal cell carcinoma
    138440360 (PIK3R3)
   05215 Prostate cancer
    138440360 (PIK3R3)
   05213 Endometrial cancer
    138440360 (PIK3R3)
   05224 Breast cancer
    138440360 (PIK3R3)
   05222 Small cell lung cancer
    138440360 (PIK3R3)
   05223 Non-small cell lung cancer
    138440360 (PIK3R3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    138440360 (PIK3R3)
   05170 Human immunodeficiency virus 1 infection
    138440360 (PIK3R3)
   05161 Hepatitis B
    138440360 (PIK3R3)
   05160 Hepatitis C
    138440360 (PIK3R3)
   05171 Coronavirus disease
    138440360 (PIK3R3)
   05164 Influenza A
    138440360 (PIK3R3)
   05162 Measles
    138440360 (PIK3R3)
   05168 Herpes simplex virus 1 infection
    138440360 (PIK3R3)
   05163 Human cytomegalovirus infection
    138440360 (PIK3R3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    138440360 (PIK3R3)
   05169 Epstein-Barr virus infection
    138440360 (PIK3R3)
   05165 Human papillomavirus infection
    138440360 (PIK3R3)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    138440360 (PIK3R3)
   05100 Bacterial invasion of epithelial cells
    138440360 (PIK3R3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    138440360 (PIK3R3)
   05142 Chagas disease
    138440360 (PIK3R3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    138440360 (PIK3R3)
   05017 Spinocerebellar ataxia
    138440360 (PIK3R3)
   05020 Prion disease
    138440360 (PIK3R3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    138440360 (PIK3R3)
   05418 Fluid shear stress and atherosclerosis
    138440360 (PIK3R3)
   05415 Diabetic cardiomyopathy
    138440360 (PIK3R3)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    138440360 (PIK3R3)
   04932 Non-alcoholic fatty liver disease
    138440360 (PIK3R3)
   04931 Insulin resistance
    138440360 (PIK3R3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    138440360 (PIK3R3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    138440360 (PIK3R3)
   01524 Platinum drug resistance
    138440360 (PIK3R3)
   01522 Endocrine resistance
    138440360 (PIK3R3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ocan04131]
    138440360 (PIK3R3)
Membrane trafficking [BR:ocan04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    138440360 (PIK3R3)
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 SH2_1 DicA_C ODF2_C Exonuc_VII_L
Other DBs
NCBI-GeneID: 138440360
NCBI-ProteinID: XP_069445862
LinkDB
Position
1:complement(21306752..21413514)
AA seq 461 aa
MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAITNGIKDSSVSL
QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG
KYGFSDPLTFNSVVELISHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK
LQEYHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKEY
IERFRKEGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMNSIKP
DLIQLRKIRDQHLVWLNHKGVRQKRLNAWLGIKNEDADETYFINEEDENLPHYDEKTWFV
EDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFAEPYN
LYSSLKELVLHYQQTSLVQHNDSLNVRLAYPVHAQMPSLCR
NT seq 1386 nt   +upstreamnt  +downstreamnt
atgtacaatacggtgtggagtatggaccgcgatgacgcagactggagggaggtgatgatg
ccctattcgacagaactgatattttatattgaaatggatcctccagctcttccaccaaag
ccacctaagccaatgacttcagccattacaaatggaataaaggacagttctgtttctctt
caggatgcagaatggtactggggggatatttcaagggaggaggtaaatgacaaattacgg
gacatgccagatggtaccttcttggtcagagatgcctcaaccaaaatgcagggagattac
actttgaccttgcggaagggaggcaataataagctaataaagatttatcatcgagatggt
aaatatggcttttctgatcctctgacatttaattctgtggtggagctcattagccactat
catcatgaatctcttgcccagtacaatcccaaacttgatgtgaaactgatgtacccagtg
tccagataccaacaggatcagttggtaaaagaagataatattgatgccgtcggtaaaaaa
ctgcaggagtatcactctcagtatcaggaaaagagtaaagaatatgacagactatatgaa
gaatataccagaacatcccaggaaatacagatgaagaggactgcaattgaagcttttaat
gaaacaattaaaatatttgaagagcagtgtcatacacaagaacaacatagcaaagaatat
attgagcgatttcgaaaagaagggaatgaaaaggaaattgaacgaattatgatgaattat
gacaagttgaaatcacgtctgggtgagattcatgatagcaaaatgcgtctcgaacaggat
ttgaagaaacaagctttggataaccgagaaatagacaaaaagatgaatagtatcaaacct
gacctgatccagctgcgcaagatcagagatcagcaccttgtgtggctcaatcacaaagga
gtgagacagaagcgcctaaatgcctggctgggaatcaagaatgaggatgctgatgagacc
tattttatcaatgaggaagatgaaaacctgccccattatgatgagaaaacctggtttgtt
gaggatatcaaccgagtacaagcagaggacttgctttatgggaaacctgacggtgcattc
ttaatccgtgagagtagcaagaaaggatgttatgcttgctctgtggtcgccgacggagag
gtgaagcactgcgtcatctacagcactgctcggggctacggcttcgcagagccctacaac
ctgtacagctccctgaaggagctggtgctccactaccagcagacgtccctcgtgcagcac
aacgactctctcaacgtcaggctcgcctaccctgtccacgcacagatgccctcgctctgc
agataa

DBGET integrated database retrieval system