Oryctolagus cuniculus (rabbit): 100009315 Help Entry 100009315         CDS       T03373                                  Symbol ADCY5 Name (RefSeq) adenylate cyclase type 5   KO K08045   adenylate cyclase 5 [EC:4.6.1.1] Organism ocu  Oryctolagus cuniculus (rabbit) Pathway ocu00230   Purine metabolism ocu01100   Metabolic pathways ocu01522   Endocrine resistance ocu04015   Rap1 signaling pathway ocu04022   cGMP-PKG signaling pathway ocu04024   cAMP signaling pathway ocu04062   Chemokine signaling pathway ocu04072   Phospholipase D signaling pathway ocu04081   Hormone signaling ocu04082   Neuroactive ligand signaling ocu04114   Oocyte meiosis ocu04211   Longevity regulating pathway ocu04213   Longevity regulating pathway - multiple species ocu04261   Adrenergic signaling in cardiomyocytes ocu04270   Vascular smooth muscle contraction ocu04371   Apelin signaling pathway ocu04540   Gap junction ocu04611   Platelet activation ocu04713   Circadian entrainment ocu04714   Thermogenesis ocu04723   Retrograde endocannabinoid signaling ocu04724   Glutamatergic synapse ocu04725   Cholinergic synapse ocu04726   Serotonergic synapse ocu04727   GABAergic synapse ocu04728   Dopaminergic synapse ocu04750   Inflammatory mediator regulation of TRP channels ocu04911   Insulin secretion ocu04912   GnRH signaling pathway ocu04913   Ovarian steroidogenesis ocu04914   Progesterone-mediated oocyte maturation ocu04915   Estrogen signaling pathway ocu04916   Melanogenesis ocu04918   Thyroid hormone synthesis ocu04921   Oxytocin signaling pathway ocu04923   Regulation of lipolysis in adipocytes ocu04924   Renin secretion ocu04925   Aldosterone synthesis and secretion ocu04926   Relaxin signaling pathway ocu04927   Cortisol synthesis and secretion ocu04928   Parathyroid hormone synthesis, secretion and action ocu04934   Cushing syndrome ocu04935   Growth hormone synthesis, secretion and action ocu04970   Salivary secretion ocu04971   Gastric acid secretion ocu04972   Pancreatic secretion ocu04976   Bile secretion ocu05012   Parkinson disease ocu05030   Cocaine addiction ocu05031   Amphetamine addiction ocu05032   Morphine addiction ocu05034   Alcoholism ocu05163   Human cytomegalovirus infection ocu05166   Human T-cell leukemia virus 1 infection ocu05200   Pathways in cancer ocu05207   Chemical carcinogenesis - receptor activation ocu05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:ocu00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     100009315 (ADCY5)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     100009315 (ADCY5)    04371 Apelin signaling pathway     100009315 (ADCY5)    04072 Phospholipase D signaling pathway     100009315 (ADCY5)    04024 cAMP signaling pathway     100009315 (ADCY5)    04022 cGMP-PKG signaling pathway     100009315 (ADCY5)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     100009315 (ADCY5)    04081 Hormone signaling     100009315 (ADCY5)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     100009315 (ADCY5)   09144 Cellular community - eukaryotes    04540 Gap junction     100009315 (ADCY5)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     100009315 (ADCY5)    04062 Chemokine signaling pathway     100009315 (ADCY5)   09152 Endocrine system    04911 Insulin secretion     100009315 (ADCY5)    04923 Regulation of lipolysis in adipocytes     100009315 (ADCY5)    04912 GnRH signaling pathway     100009315 (ADCY5)    04913 Ovarian steroidogenesis     100009315 (ADCY5)    04915 Estrogen signaling pathway     100009315 (ADCY5)    04914 Progesterone-mediated oocyte maturation     100009315 (ADCY5)    04921 Oxytocin signaling pathway     100009315 (ADCY5)    04926 Relaxin signaling pathway     100009315 (ADCY5)    04935 Growth hormone synthesis, secretion and action     100009315 (ADCY5)    04918 Thyroid hormone synthesis     100009315 (ADCY5)    04928 Parathyroid hormone synthesis, secretion and action     100009315 (ADCY5)    04916 Melanogenesis     100009315 (ADCY5)    04924 Renin secretion     100009315 (ADCY5)    04925 Aldosterone synthesis and secretion     100009315 (ADCY5)    04927 Cortisol synthesis and secretion     100009315 (ADCY5)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     100009315 (ADCY5)    04270 Vascular smooth muscle contraction     100009315 (ADCY5)   09154 Digestive system    04970 Salivary secretion     100009315 (ADCY5)    04971 Gastric acid secretion     100009315 (ADCY5)    04972 Pancreatic secretion     100009315 (ADCY5)    04976 Bile secretion     100009315 (ADCY5)   09156 Nervous system    04724 Glutamatergic synapse     100009315 (ADCY5)    04727 GABAergic synapse     100009315 (ADCY5)    04725 Cholinergic synapse     100009315 (ADCY5)    04728 Dopaminergic synapse     100009315 (ADCY5)    04726 Serotonergic synapse     100009315 (ADCY5)    04723 Retrograde endocannabinoid signaling     100009315 (ADCY5)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     100009315 (ADCY5)   09149 Aging    04211 Longevity regulating pathway     100009315 (ADCY5)    04213 Longevity regulating pathway - multiple species     100009315 (ADCY5)   09159 Environmental adaptation    04713 Circadian entrainment     100009315 (ADCY5)    04714 Thermogenesis     100009315 (ADCY5)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100009315 (ADCY5)    05207 Chemical carcinogenesis - receptor activation     100009315 (ADCY5)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     100009315 (ADCY5)    05163 Human cytomegalovirus infection     100009315 (ADCY5)   09164 Neurodegenerative disease    05012 Parkinson disease     100009315 (ADCY5)   09165 Substance dependence    05030 Cocaine addiction     100009315 (ADCY5)    05031 Amphetamine addiction     100009315 (ADCY5)    05032 Morphine addiction     100009315 (ADCY5)    05034 Alcoholism     100009315 (ADCY5)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     100009315 (ADCY5)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     100009315 (ADCY5)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     100009315 (ADCY5) Enzymes [BR:ocu01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      100009315 (ADCY5) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  AC_N Guanylate_cyc Adcy_cons_dom TBK1_ULD GBR2_CC Motif Other DBs NCBI-GeneID:  100009315 NCBI-ProteinID:  NP_001076097 Ensembl:  ENSOCUG00000015141 UniProt:  P40144 LinkDB All DBs Position 14:96751653..96914736 Genome browser AA seq 1264 aa AA seqDB search MSGSKGVSPPGYAAQTAAAPASRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGA VTPQQQQQQQRLASRWRGDDDDEPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRR QRRGAAGGGSTRAPPAGGGCGGGSAAAAAAAGGTEVRPRSVELGLEERRGKGRAVDELEA GAVEGGEGAEDGGSSADSSNGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRL NQSSLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILVMAVLCNRAAFHQDH MGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLL STLHLAIALRTNAQDRFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQA RLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEG FTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCC VEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEA GGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIA KMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESTNPEDEVD EFLGRAIDARSIDRLRSEHVRRFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICC VQITIVPHSMFMLSFYLACFLLLTLVVFVSMIYSCVKLFPRPLQSLSRKIVRSKMNSTLV GVFTITLVFLSAFVNMFMCNSKDLLDCLAAEHNISVIHVNACHVVESAFNYSLGNEQGFC GNSRPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELTYVLIVEVPRVTLFDN ADLLVTANAIDISSNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFL WKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASI ANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLND STYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYD IWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGG PPLS NT seq 3795 nt NT seq  +upstreamnt  +downstreamnt atgtccggctccaaaggcgtgagccctccgggctacgcggcgcagacagcggcggcgccg gcgtcccggggaggccccgaacatcgctcagcttggggggaggccgactctcgtgccaat ggctacccccacgcccccgggggttctgctcgcggctccaccaagaaaccagggggggcg gtgaccccacagcagcagcaacagcagcagcgcctggccagccgctggcgcggcgacgac gacgacgagccgccgttgagcggcgacgatcccttggccgggggcttcggctttagcttc cgctccaagtccgcctggcaggagcgcggcggcgacgactgcggtcgcggcagccggcgg cagcggcggggcgcggccggcgggggcagcactcgggcgccccctgcgggcggcggctgc ggcggcggctcggcggcagcggccgctgcggcgggcgggacggaggtgcgcccccgttcg gtggagctgggcctggaggagcggcgaggcaagggccgcgcggtggacgagctggaggcc ggtgccgtcgagggcggtgaaggggcagaggatggcggcagctccgcggactccagcaac gggcccggcgcggtgctgtcgctgggcgcctgctgcctggcgttgctgcagattttccgc tccaagaagttcccgtccgacaagctggagcggctgtaccagcgctacttcttccgcctg aaccagagcagcctcaccatgctcatggccgtgctggtgctcgtgtgcctcgtcatgctg gccttccacgcggcgcgccccccactccagctgccctacctggcggtgctggcggccgcc gtgggcgtgatcctcgtcatggccgtgctgtgcaaccgcgcagccttccaccaggaccac atgggcctggcctgctatgcgctcatcgccgtggtgctggctgtccaggtggtgggcctg ctgctgccccagccgcgcagtgcctccgagggcatctggtggaccgtgttcttcatctac accatctacacgctgctgcctgtgcgcatgcgggctgcggtcctcagcggggtgctcctg tccaccctgcacctggccatcgccctgcgcaccaacgcccaggaccggttcctgctcaag cagctggtctccaacgtcctcatcttctcctgcaccaacattgtgggcgtctgcacccac tatccggccgaggtctcccagaggcaggccttccaggagacccgcgagtgcatccaggca cggctccactcgcagcgggagaaccagcaacaggagcggctcctgctgtccgtccttccc cgccacgttgccatggagatgaaagcagacatcaatgccaagcaggaggatatgatgttc cataagatctacatccagaaacatgacaacgtgagcatcctgttcgctgacattgagggc ttcaccagcctggcgtcccagtgcaccgcccaggagctggtcatgaccctcaacgagctc ttcgcccgcttcgacaagctggctgcggagaatcactgtttacgcattaagatcctgggg gattgctactactgcgtgtcggggctgcccgaagccagggccgaccacgcccactgctgc gtggagatgggcatggacatgatcgaggccatctcgttggtccgggaggtgacgggcgtg aacgtgaacatgcgcgtgggaattcacagcggccgagtgcactgcggtgtccttggcctg aggaagtggcagttcgacgtatggtctaatgacgtcacgctggccaaccacatggaggcc ggcggcaaggcaggacgcatccacatcaccaaggccaccctcaactacctgaacggcgac tacgaggtggagccaggctgcgggggcgagcgcaacgcctacctcaaggagcacagcatc gagaccttcctcatcctgcgctgcacccagaagcggaaagaagagaaggccatgatcgcc aagatgaaccgccagcgaaccaactccatcgggcacaacccgccacactggggggccgag cgccccttctacaaccacctgggtggcaaccaggtctccaaggagatgaagcggatgggc tttgaagaccccaaggacaagaacgcccaggagagtacgaaccccgaggatgaagtggat gagtttctgggccgggcaatcgacgccaggagcatcgacaggctgcggtccgagcacgtc cgcaggttcctcttgaccttcagggagcctgacttagagaagaagtactccaagcaggtg gacgaccgctttggtgcctacgtggcgtgtgcctcgctcgtcttcctcttcatctgctgt gtccagatcaccatcgtgccccactccatgttcatgctgagtttctacctggcctgcttc ctgctgctgaccttggtggtgtttgtgtccatgatctactcctgcgtgaagctcttcccg cgcccgctgcagagcctgtccaggaagatcgtgcgctccaagatgaacagcaccctggtc ggagtgttcaccatcaccctggtgttcctgtcggctttcgtcaacatgttcatgtgcaac tccaaggatctgctggactgcctggcggcggagcacaacatcagcgtgatccatgtcaac gcgtgccacgtggtggagtcggccttcaactacagcctgggcaacgagcagggcttctgt ggcaactccaggcccaactgcaacttccccgagtacttcacctacagcgtgctgctcagc ctgctggcctgctccgtgttcctgcagatcagctgcatcgggaagctggtgctcatgctg gccatcgagctcacctacgtgctcatcgtcgaggtgccccgggtcacgctctttgacaat gccgacctgctggtcaccgccaacgccatagacatcagcagcaacgggacctcccagtgc ccggagcacgcgaccaaggtggcgctgaaggtggtgacgcccatcataatctccgtcttt gtgctggccctgtacctgcacgcccagcaggtggagtccaccgcccgcctggacttcctc tggaaactgcaggccacggaggagaaggaggagatggaggagctgcaggcctacaaccgg cggctgctgcacaacatcctgcccaaggacgtggccgcccacttcctggcccgcgagcgg cgcaatgacgagctgtactaccagtcctgcgagtgcgtggccgtcatgttcgcctccatc gccaacttctccgagttctacgtggagctagaggccaacaacgagggcgtcgagtgcctg cggctgctgaacgagatcatcgccgactttgacgagatcatcagtgaggatcggttcagg cagctggagaagattaagaccatcggcagcacctacatggccgcctcgggcctcaacgac tccacctacgacaaggtgggcaagacacacatcaaagcgctggccgacttcgccatgaag ctgatggaccaaatgaaatacatcaacgagcactccttcaacaacttccagatgaagatc ggactcaacattggccccgtggtggctggggtgatcggggcacgtaagccccagtacgac atctggggcaacacagtgaacgtggccagccgtatggacagcaccggcgtgcccgaccgc atccaggtcaccacggacatgtaccaggtgctggccgccaacacataccagctggagtgc cggggtgtggtcaaggtcaagggcaaaggcgagatgatgacgtacttcctcaacggcggg cccccgctcagttag

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