KEGG   Oryctolagus cuniculus (rabbit): 100337757
Entry
100337757         CDS       T03373                                 
Name
(RefSeq) phosphoinositide 3-kinase regulatory subunit 5 isoform X1
  KO
K21290  phosphoinositide-3-kinase regulatory subunit 5/6
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu04022  cGMP-PKG signaling pathway
ocu04062  Chemokine signaling pathway
ocu04072  Phospholipase D signaling pathway
ocu04151  PI3K-Akt signaling pathway
ocu04261  Adrenergic signaling in cardiomyocytes
ocu04371  Apelin signaling pathway
ocu04611  Platelet activation
ocu04725  Cholinergic synapse
ocu04921  Oxytocin signaling pathway
ocu05145  Toxoplasmosis
ocu05167  Kaposi sarcoma-associated herpesvirus infection
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    100337757
   04022 cGMP-PKG signaling pathway
    100337757
   04151 PI3K-Akt signaling pathway
    100337757
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100337757
   04062 Chemokine signaling pathway
    100337757
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    100337757
  09156 Nervous system
   04725 Cholinergic synapse
    100337757
 09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    100337757
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100337757
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ocu04131]
    100337757
Membrane trafficking [BR:ocu04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100337757
SSDB
Motif
Pfam: PI3K_1B_p101 BUD22 ApoC-I Sporozoite_P67 DUF2284
Other DBs
NCBI-GeneID: 100337757
NCBI-ProteinID: XP_002719015
Ensembl: ENSOCUG00000022712
UniProt: G1TZJ0
LinkDB
Position
19:8037435..8109621
AA seq 880 aa
MQPGATTCTEDRIQHALDRCLHGLSLGRRSTSWSAGLCLNCWSLQELVSRDPGHFLILLE
QILQKTREVQEKGTYDLLAPLALLFYSTVLCTPHFPPDSDLLLKAARTYHRFLTWPIPYC
SICQELLTFIDAELKAPGISYQRLVRAEQGLPVRSRRSSTVTVLLLNPVEVQAEFLAVAN
KLSAPGHSPHSTYTTLLLHAFQATFGAHCDLPGLHCSLQSKTLAELEDIFTETAEAQELA
SGIGDAAEARQWLRTKLQAVGEKAGFPAVLDTPRAGKLHTIPLPVARCYTYSWNQDSFDI
LQEILLKEQELLQPGILGDDEEEEEEDEEEEEDEEDSDGHSAERDSLLSTGSLASRDSTL
SLASCQASGPALSQHLLTSFVAGLSDGMDSGYVEDSEESASEWPKRPGRQERRGHRRPGQ
KFNRIYKLFKSTSQLVLRKDSRGLEGSPDSALPLRRAGSLCSPLDSPASPPSRAQRSRSL
PQPRLGTQLPSWLLTPATRPQRRRPFLSGDEDPKASTLRVVVFGSDRISGKVARAYSNLR
TLESSRPLLTRFFKLQFFYVPVKRTGTGSSTCLAPRSQTPPLPTDSPRHPSPVELGSAPW
EESTNDISHYLGMLDPWYERNVLGLMHLPPEVLCQQSLKAETRPLEGSPAPLPILADMLL
YYCRFAARPVLLQVYQTELTFITGEKTTEIFIQSLELGHSAATRAIKASGPGSKRLGIDD
DREAIPLTLQIIYSKGAISGRSRWSNLEKVCTSVNLNKACRQQEELDSSMEALTLHLTEV
VKRQNPKSKKSFNQISTSQIKVDKVQIIGSSSCPFAVCLDQDERKILQSVVRCEVSPCYK
PEKSSLSPPAQTPPDLPARAAPDLCSLLCLPIMTFSGALP
NT seq 2643 nt   +upstreamnt  +downstreamnt
atgcagccgggggccacgacgtgcacggaggaccgtatccagcacgccctggaccgctgc
ttgcatggactcagcctcggccgccgctccacctcctggtcagctgggctgtgtctgaat
tgttggagcctccaggagctggtgagcagggaccccggccacttccttatcctgctggag
cagatcctgcaaaaaacccgagaggtccaagagaagggcacctatgacctcctggcacca
ctggccctgctgttctactccaccgtcctctgtacaccacacttcccaccagactcggac
ctcctcctgaaggcagccagaacctaccaccggttcctgacctggcccattccctactgc
agcatctgccaggagctgctcaccttcatcgacgctgaactcaaggccccaggaatctcc
taccagcgactggtgagagctgagcagggtctgcccgtcaggagccgccgcagttccacc
gttactgtgctgctgctgaaccccgtggaggtgcaggccgagttcctcgccgtagccaac
aagctaagtgcacctgggcactcgccccacagcacctacactaccctgctcctgcatgcc
ttccaggccaccttcggggcccactgcgacctcccgggcctgcactgcagcctgcagtcc
aagaccttagccgagcttgaagacatcttcacggagaccgcagaggcgcaggagctggca
tctggcatcggggacgcagctgaggcgcggcaatggctcaggaccaagctgcaggcggtg
ggagaaaaagccggcttccctgccgtcttggacactcccagagccggcaagctccacacc
atcccactccctgtcgccaggtgctacacctacagctggaaccaggacagctttgacatc
ctgcaggaaatcctgcttaaggagcaggagctgctccaaccagggatcctgggggacgat
gaagaggaagaagaggaagacgaggaggaggaggaagacgaggaggactcggacgggcat
tctgccgagagggactctctgctgtccactggctctttggcctcccgcgactccaccctg
tcccttgcctcctgccaggcctcagggccagccctctcccagcacctgctgacttccttc
gtggccggcctctcggacggcatggacagcggctacgtggaagacagtgaggagagcgcc
tctgagtggcccaagaggcccggccgccaggagcgccggggccaccgcaggcccgggcag
aagtttaacagaatctacaaactcttcaagagcactagccagctggtgttgcggaaggac
tcccggggcctggagggcagcccggattcggccctgcccctgcggcgggcagggagcctc
tgcagccccctggacagcccagcctcacccccgtcccgggcccagcgctcccgctccctg
ccccagcccaggctcggcacccagctccccagctggctgctcacccccgccacacgcccc
cagcgccgccgccccttcctgagtggggatgaggaccccaaagcttccacgctccgtgtc
gtggtcttcggctctgatcggatttcagggaaggtggctcgggcttacagcaacctccgg
acgctggagagcagccgcccactcctcacgcgcttcttcaagctccagttcttctacgtg
cctgtgaagcgaaccggaaccggctccagcacctgtctggcccctcgaagccagacgccc
ccactccccacagactccccgaggcaccccagccctgtagagctgggctcggccccgtgg
gaggagagcaccaatgacatctcccactacctcggcatgctcgacccctggtatgagcgc
aacgtgctaggcctcatgcacctgcccccggaagtcctatgccagcagtccctgaaggct
gaaacccggcccctggagggctccccagccccgctgcccatcctggctgatatgctgctc
tactactgccgctttgccgcccggccggtgctgctgcaggtctatcagacagagctgacc
ttcatcacgggggagaagaccacggagatctttatccagtccctggagctaggtcactct
gctgccacgcgggccatcaaggcttctggccccggaagcaagcggctgggcattgatgac
gaccgggaggccatccctctaacactacagattatttacagcaagggcgccatcagtggg
cgaagtcgctggagcaacctggagaaggtctgtacctctgtcaacctcaacaaggcttgc
cggcagcaggaggagctggactccagcatggaggccctgacgctacacctgacggaagtg
gtgaaaaggcagaaccccaaatccaagaagagctttaatcagattagcacatcccagatc
aaagtggacaaggtgcagatcatcggctccagcagctgccccttcgccgtgtgtctggac
caggacgagaggaagatcctgcagagcgtggtcaggtgtgaggtctctccctgctacaag
ccggagaagagcagcctcagcccaccggcccagacgccccccgacctgccagcccgggcg
gcccctgacctctgctccctcctctgcctgcccatcatgaccttcagcggggccctgccc
tag

KEGG   Oryctolagus cuniculus (rabbit): 100337822
Entry
100337822         CDS       T03373                                 
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu00562  Inositol phosphate metabolism
ocu01100  Metabolic pathways
ocu01521  EGFR tyrosine kinase inhibitor resistance
ocu01522  Endocrine resistance
ocu01524  Platinum drug resistance
ocu04012  ErbB signaling pathway
ocu04014  Ras signaling pathway
ocu04015  Rap1 signaling pathway
ocu04024  cAMP signaling pathway
ocu04062  Chemokine signaling pathway
ocu04066  HIF-1 signaling pathway
ocu04068  FoxO signaling pathway
ocu04070  Phosphatidylinositol signaling system
ocu04071  Sphingolipid signaling pathway
ocu04072  Phospholipase D signaling pathway
ocu04081  Hormone signaling
ocu04140  Autophagy - animal
ocu04150  mTOR signaling pathway
ocu04151  PI3K-Akt signaling pathway
ocu04152  AMPK signaling pathway
ocu04210  Apoptosis
ocu04211  Longevity regulating pathway
ocu04213  Longevity regulating pathway - multiple species
ocu04218  Cellular senescence
ocu04360  Axon guidance
ocu04370  VEGF signaling pathway
ocu04380  Osteoclast differentiation
ocu04510  Focal adhesion
ocu04550  Signaling pathways regulating pluripotency of stem cells
ocu04611  Platelet activation
ocu04613  Neutrophil extracellular trap formation
ocu04620  Toll-like receptor signaling pathway
ocu04625  C-type lectin receptor signaling pathway
ocu04630  JAK-STAT signaling pathway
ocu04650  Natural killer cell mediated cytotoxicity
ocu04660  T cell receptor signaling pathway
ocu04662  B cell receptor signaling pathway
ocu04664  Fc epsilon RI signaling pathway
ocu04666  Fc gamma R-mediated phagocytosis
ocu04668  TNF signaling pathway
ocu04670  Leukocyte transendothelial migration
ocu04722  Neurotrophin signaling pathway
ocu04725  Cholinergic synapse
ocu04750  Inflammatory mediator regulation of TRP channels
ocu04810  Regulation of actin cytoskeleton
ocu04910  Insulin signaling pathway
ocu04914  Progesterone-mediated oocyte maturation
ocu04915  Estrogen signaling pathway
ocu04917  Prolactin signaling pathway
ocu04919  Thyroid hormone signaling pathway
ocu04923  Regulation of lipolysis in adipocytes
ocu04926  Relaxin signaling pathway
ocu04929  GnRH secretion
ocu04930  Type II diabetes mellitus
ocu04931  Insulin resistance
ocu04932  Non-alcoholic fatty liver disease
ocu04933  AGE-RAGE signaling pathway in diabetic complications
ocu04935  Growth hormone synthesis, secretion and action
ocu04960  Aldosterone-regulated sodium reabsorption
ocu04973  Carbohydrate digestion and absorption
ocu05010  Alzheimer disease
ocu05017  Spinocerebellar ataxia
ocu05020  Prion disease
ocu05100  Bacterial invasion of epithelial cells
ocu05132  Salmonella infection
ocu05135  Yersinia infection
ocu05142  Chagas disease
ocu05146  Amoebiasis
ocu05160  Hepatitis C
ocu05161  Hepatitis B
ocu05162  Measles
ocu05163  Human cytomegalovirus infection
ocu05164  Influenza A
ocu05165  Human papillomavirus infection
ocu05166  Human T-cell leukemia virus 1 infection
ocu05167  Kaposi sarcoma-associated herpesvirus infection
ocu05168  Herpes simplex virus 1 infection
ocu05169  Epstein-Barr virus infection
ocu05170  Human immunodeficiency virus 1 infection
ocu05171  Coronavirus disease - COVID-19
ocu05200  Pathways in cancer
ocu05203  Viral carcinogenesis
ocu05205  Proteoglycans in cancer
ocu05206  MicroRNAs in cancer
ocu05207  Chemical carcinogenesis - receptor activation
ocu05208  Chemical carcinogenesis - reactive oxygen species
ocu05210  Colorectal cancer
ocu05211  Renal cell carcinoma
ocu05212  Pancreatic cancer
ocu05213  Endometrial cancer
ocu05214  Glioma
ocu05215  Prostate cancer
ocu05218  Melanoma
ocu05220  Chronic myeloid leukemia
ocu05221  Acute myeloid leukemia
ocu05222  Small cell lung cancer
ocu05223  Non-small cell lung cancer
ocu05224  Breast cancer
ocu05225  Hepatocellular carcinoma
ocu05226  Gastric cancer
ocu05230  Central carbon metabolism in cancer
ocu05231  Choline metabolism in cancer
ocu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ocu05415  Diabetic cardiomyopathy
ocu05417  Lipid and atherosclerosis
ocu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100337822
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    100337822
   04015 Rap1 signaling pathway
    100337822
   04630 JAK-STAT signaling pathway
    100337822
   04668 TNF signaling pathway
    100337822
   04066 HIF-1 signaling pathway
    100337822
   04068 FoxO signaling pathway
    100337822
   04070 Phosphatidylinositol signaling system
    100337822
   04072 Phospholipase D signaling pathway
    100337822
   04071 Sphingolipid signaling pathway
    100337822
   04024 cAMP signaling pathway
    100337822
   04151 PI3K-Akt signaling pathway
    100337822
   04152 AMPK signaling pathway
    100337822
   04150 mTOR signaling pathway
    100337822
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100337822
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100337822
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    100337822
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100337822
   04613 Neutrophil extracellular trap formation
    100337822
   04620 Toll-like receptor signaling pathway
    100337822
   04650 Natural killer cell mediated cytotoxicity
    100337822
   04660 T cell receptor signaling pathway
    100337822
   04662 B cell receptor signaling pathway
    100337822
   04664 Fc epsilon RI signaling pathway
    100337822
   04666 Fc gamma R-mediated phagocytosis
    100337822
   04670 Leukocyte transendothelial migration
    100337822
   04062 Chemokine signaling pathway
    100337822
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    100337822
   04929 GnRH secretion
    100337822
   04915 Estrogen signaling pathway
    100337822
   04917 Prolactin signaling pathway
    100337822
   04926 Relaxin signaling pathway
    100337822
   04935 Growth hormone synthesis, secretion and action
    100337822
   04919 Thyroid hormone signaling pathway
    100337822
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100337822
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100337822
  09156 Nervous system
   04725 Cholinergic synapse
    100337822
   04722 Neurotrophin signaling pathway
    100337822
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100337822
  09158 Development and regeneration
   04360 Axon guidance
    100337822
   04380 Osteoclast differentiation
    100337822
  09149 Aging
   04211 Longevity regulating pathway
    100337822
   04213 Longevity regulating pathway - multiple species
    100337822
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100337822
   05206 MicroRNAs in cancer
    100337822
   05205 Proteoglycans in cancer
    100337822
   05207 Chemical carcinogenesis - receptor activation
    100337822
   05208 Chemical carcinogenesis - reactive oxygen species
    100337822
   05203 Viral carcinogenesis
    100337822
   05230 Central carbon metabolism in cancer
    100337822
   05231 Choline metabolism in cancer
    100337822
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100337822
  09162 Cancer: specific types
   05210 Colorectal cancer
    100337822
   05212 Pancreatic cancer
    100337822
   05225 Hepatocellular carcinoma
    100337822
   05226 Gastric cancer
    100337822
   05214 Glioma
    100337822
   05221 Acute myeloid leukemia
    100337822
   05220 Chronic myeloid leukemia
    100337822
   05218 Melanoma
    100337822
   05211 Renal cell carcinoma
    100337822
   05215 Prostate cancer
    100337822
   05213 Endometrial cancer
    100337822
   05224 Breast cancer
    100337822
   05222 Small cell lung cancer
    100337822
   05223 Non-small cell lung cancer
    100337822
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100337822
   05170 Human immunodeficiency virus 1 infection
    100337822
   05161 Hepatitis B
    100337822
   05160 Hepatitis C
    100337822
   05171 Coronavirus disease - COVID-19
    100337822
   05164 Influenza A
    100337822
   05162 Measles
    100337822
   05163 Human cytomegalovirus infection
    100337822
   05167 Kaposi sarcoma-associated herpesvirus infection
    100337822
   05169 Epstein-Barr virus infection
    100337822
   05165 Human papillomavirus infection
    100337822
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100337822
   05100 Bacterial invasion of epithelial cells
    100337822
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100337822
   05142 Chagas disease
    100337822
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100337822
   05017 Spinocerebellar ataxia
    100337822
   05020 Prion disease
    100337822
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100337822
   05418 Fluid shear stress and atherosclerosis
    100337822
   05415 Diabetic cardiomyopathy
    100337822
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100337822
   04932 Non-alcoholic fatty liver disease
    100337822
   04931 Insulin resistance
    100337822
   04933 AGE-RAGE signaling pathway in diabetic complications
    100337822
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100337822
   01524 Platinum drug resistance
    100337822
   01522 Endocrine resistance
    100337822
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ocu04131]
    100337822
Enzymes [BR:ocu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100337822
Membrane trafficking [BR:ocu04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100337822
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1
Other DBs
NCBI-GeneID: 100337822
NCBI-ProteinID: XP_008264758
Ensembl: ENSOCUG00000010631
UniProt: U3KM40
LinkDB
Position
14:75694386..75792511
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFV
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRAFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccacgaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ttagtagaatgtttactgccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattaattactataaagcatgaactatttaaagaagcaagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaaggcgcctttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctgaatcgagaaattggttttgtt
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttagagatctgaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgataagcagaagtataccctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaagaaaacccggagcatgttgctatcctctgaacaactaaaa
ctatgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcttagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctttattctcaactgccaatggac
tgttttacaatgccatcttattccagacgcatctccactgctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gctacctatgtgaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc
taccatggaggagaacctttatgtgacaatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttctatatgctctgttaaaggccgaaagggtgctaaggaggaacactgt
ccactggcttggggaaatataaacttgtttgattacactgacactctggtatctggaaaa
atggctctgaatctttggccagtacctcatggattagaagatttactgaaccctattggt
gttactgggtcaaatccaaataaagaaactccatgcttagagttggagtttgactggttt
agcagtgtggtaaagtttccagatatgtcagtgattgaggaacatgccaattggtctgta
tccagagaagcaggatttagttattcccatgcaggactgagtaacagactagcaagagac
aatgaattaagagaaaatgataaagaacagctccgagcaatctgtacacgcgatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacattattgtgtaact
atcccagagattctacccaaattgcttctgtctgttaaatggaattctagagatgaagtt
gcccagatgtactgcttggtaaaagattggcctccaataaaacctgagcaggccatggag
ctcctggactgcaactacccagatccgatggttcgagcttttgctgttcgatgcttggaa
aaatatttaacagatgacaaactttctcagtatctgattcagctagtacaggtcctaaaa
tatgaacagtatttggataaccttctcgtgagatttttactcaagaaagcattgactaac
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctgcttttggagtcctactgccgggcatgtggaatgtatttgaag
cacctgaataggcaagttgaggctatggaaaagctcattaacttgactgacattctcaaa
caggagaagaaggatgaaacacaaaaggtacaaatgaagtttttagttgagcaaatgagg
caaccagatttcatggatgctctacagggctttctgtctcctttaaaccctgctcatcaa
ctgggaaatctcaggcttgaagagtgtcgaataatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactgtttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacacttcaaattattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
attggtgactgtgtgggacttattgaggtggtgagaaattctcacactatcatgcagatt
cagtgcaaaggtggcctgaaaggtgcactgcagttcaatagccatacactgcatcagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctgttcacccgttca
tgtgctggctattgcgttgcaactttcatcttgggaattggagatcggcacaacagtaac
atcatggtgaaagatgatggacaactgtttcatatagatttcggacactttttggaccac
aagaagaaaaaatttggttataagcgagaacgtgtaccatttgttctgacacaggatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaaaactagagaatttgagaggttt
caagagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactgcaatcttttgatgacattgca
tatattcgaaagaccctagccttagataaaactgagcaggaggctttggaatatttcatg
aaacaaatgaacgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgcattgaactga

KEGG   Oryctolagus cuniculus (rabbit): 100340526
Entry
100340526         CDS       T03373                                 
Name
(RefSeq) LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 6
  KO
K21290  phosphoinositide-3-kinase regulatory subunit 5/6
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu04022  cGMP-PKG signaling pathway
ocu04062  Chemokine signaling pathway
ocu04072  Phospholipase D signaling pathway
ocu04151  PI3K-Akt signaling pathway
ocu04261  Adrenergic signaling in cardiomyocytes
ocu04371  Apelin signaling pathway
ocu04611  Platelet activation
ocu04725  Cholinergic synapse
ocu04921  Oxytocin signaling pathway
ocu05145  Toxoplasmosis
ocu05167  Kaposi sarcoma-associated herpesvirus infection
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    100340526
   04022 cGMP-PKG signaling pathway
    100340526
   04151 PI3K-Akt signaling pathway
    100340526
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100340526
   04062 Chemokine signaling pathway
    100340526
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    100340526
  09156 Nervous system
   04725 Cholinergic synapse
    100340526
 09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    100340526
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100340526
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ocu04131]
    100340526
Membrane trafficking [BR:ocu04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100340526
SSDB
Motif
Pfam: PI3K_1B_p101
Other DBs
NCBI-GeneID: 100340526
NCBI-ProteinID: XP_051681149
Ensembl: ENSOCUG00000004052
LinkDB
Position
19:8126199..8174325
AA seq 761 aa
MESSDVELDLQRSVQAVLRELSAQVPALQSNQAGMWRWSLHKKLERDPARSPTLVRILLR
ELEKAESEDLRHVIIPLLHTLMYVLTKATGIPEELYRRTYAFCTRLLTLPAPYCTVALDC
AIRLKTEAAVPGTLYQRTVIAEQNLMSELYPYQERVFLFVDPELVSASVCTALLLEIQAA
QGQQTPEACMRHVVSHALQAALGEACHVGALHQKLQASPRRTLERYFHAVVAAVEQVASE
GSPSRAGHLERLEEIYCSLLGPAAAARGHRAGDPTQDRPPSTPLPSPYITFHLWTDEEQL
WKELLLFLRPQSQPRLSADLEALDLQGFRPDRDMARVSVLSTDSGIERDLPLGPEELPAP
GSPELERVGLQRKGGVKKRAWPPDLLMPAGWAGPSGLHRRTGRPGSDGELLPGVSRLHTA
RVLVLGDDRMLGRLAQAYHRLRKRETQKFCLTPRLSLQLYYIPVLGPQQSTTSGQLELGE
LAELAVFLGRADPWYESTVNTLCAAIHKLAEMPPSLDTSRAVDPFILDGITYYVRMGTHP
VYFQIYMVKIFFSDPSQDPVEDVFLTELKAKIQDSKSPKDGFSPRRRGVAESLGAELSMC
YQKALLSHRPREVTVSLRSTGLVLKTIPTGDTEVAGTPLCPAAAAPVTDHTCLHVSVTEV
IKSSNLAGRSFSTVTNTFRTANIQIQSQDQRPLTLTLDKDSRRTFKDVIRFQVAPCPEPS
SETQKSKPSWLSSHGQQPMETTKAQPRPLRMPINTFSGIIQ
NT seq 2286 nt   +upstreamnt  +downstreamnt
atggagagctcagatgtggagctggatctgcagaggagcgtacaagctgtgctccgggag
ctcagcgcccaggtccccgccctgcagagcaaccaagcaggcatgtggaggtggtccctg
cacaagaagctcgagcgagatcctgctaggagtcccacgctggttcgcattctgctcagg
gaactggaaaaggcagagagcgaggacctgcggcacgtcatcattcccttgctgcacacc
ctcatgtacgtgctcacgaaggccacgggcatccccgaggagctgtaccgcaggacctac
gccttctgcaccaggctcctgaccctgcccgcgccctactgcacagttgccttggactgc
gccatcaggctcaagaccgaggcggccgtgcccgggacgctataccagaggactgtcatc
gctgaacagaacctgatgagcgagctgtatccctaccaagagagagtgttcctcttcgtg
gatccggagctggtgtctgcatctgtgtgcacggctctgctgctggagatccaggcggcc
caggggcagcagacgcccgaggcctgcatgcgccacgtggtctcccacgccctgcaggcg
gctctgggggaggcctgccacgtgggcgcactgcaccagaagctgcaggccagcccccgc
cgcaccctggagcgctatttccacgccgtggtggcagccgtggagcaggtggcaagcgag
ggcagcccgagccgcgccggacacctggagcggctggaggagatttactgctcgctgctg
ggcccggcagccgccgccagggggcatcgcgcaggtgaccccacccaggaccggccacca
agcacccccctgcccagcccctacatcactttccacctgtggacggacgaggagcagctc
tggaaggagctgctgctcttcctccgcccacagtcccagccacgcctcagcgctgacctg
gaggccttggatctgcagggcttccggccagaccgggacatggcccgagtgtccgtgctg
tccacggacagcggcatcgagcgtgaccttcctctggggcccgaggagctgccggcgccc
ggcagcccagagctggagcgtgtggggctgcagcgcaaagggggcgtcaagaagcgggcg
tggcctccggacctcctgatgcctgctggctgggccgggccctcagggctgcaccgcagg
acgggcaggcccggcagtgatggggagctactgcccggtgtctcccggctgcacacggcc
cgcgtgctggtgctgggtgatgacaggatgctgggacgcctggcccaggcctaccacaga
ctcaggaaacgggagacccagaagttctgcctcacccccaggctcagcctgcagctctac
tacatccccgtgctggggccacagcagtccactacgtccgggcagctggagctgggggag
ctggcggagctggccgtgttcctgggccgcgcagacccctggtacgagagcacggtgaac
accctgtgtgccgccatccacaagctggctgagatgcctccctccctggacacttcccgg
gccgtggaccccttcatcctggatggtatcacctactacgtccgcatgggcacccacccc
gtctacttccagatctacatggtcaagatcttcttcagtgaccccagccaagaccccgtg
gaggatgtttttctcaccgagctgaaggccaagatccaagactccaagtcccccaaagat
gggttttcccctaggaggcgaggtgtggccgagagcctgggggctgagctgtccatgtgc
taccagaaggccttgctcagccacagaccccgggaggtcactgtctccctgcggagcact
gggctggtcctgaagaccatcccgactggtgacactgaagtcgcagggaccccgctctgc
cccgctgctgctgctccggtgacagaccacacgtgtctgcatgtcagtgtgacggaggtc
atcaagtcctccaacctggcaggaagatccttctccacagttaccaacaccttccggaca
gccaacatccagatccagagccaggaccagaggccgctgaccctgaccctggacaaagac
agtcggcgcacattcaaggacgtaatcaggttccaggtcgctccctgcccagagccgtct
tccgagacccagaagtccaagccatcgtggctcagttcccacgggcagcagccgatggag
accaccaaagcccagcccagaccccttcgcatgcccatcaacacattctccggcatcatc
cagtga

KEGG   Oryctolagus cuniculus (rabbit): 100344144
Entry
100344144         CDS       T03373                                 
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
  KO
K21289  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [EC:2.7.1.153]
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu00562  Inositol phosphate metabolism
ocu01100  Metabolic pathways
ocu04022  cGMP-PKG signaling pathway
ocu04062  Chemokine signaling pathway
ocu04072  Phospholipase D signaling pathway
ocu04151  PI3K-Akt signaling pathway
ocu04261  Adrenergic signaling in cardiomyocytes
ocu04371  Apelin signaling pathway
ocu04611  Platelet activation
ocu04725  Cholinergic synapse
ocu04921  Oxytocin signaling pathway
ocu05132  Salmonella infection
ocu05145  Toxoplasmosis
ocu05167  Kaposi sarcoma-associated herpesvirus infection
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100344144
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    100344144
   04022 cGMP-PKG signaling pathway
    100344144
   04151 PI3K-Akt signaling pathway
    100344144
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100344144
   04062 Chemokine signaling pathway
    100344144
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    100344144
  09156 Nervous system
   04725 Cholinergic synapse
    100344144
 09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    100344144
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100344144
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ocu04131]
    100344144
Enzymes [BR:ocu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100344144
Membrane trafficking [BR:ocu04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100344144
SSDB
Motif
Pfam: PIK3CG_ABD PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_C2 DUF4135
Other DBs
NCBI-GeneID: 100344144
NCBI-ProteinID: XP_002712080
Ensembl: ENSOCUG00000012739
UniProt: G1T3Z0
LinkDB
Position
7:complement(130069993..130105392)
AA seq 1102 aa
MELESSEQPVVLREDHGRRRRRMKPRSPAASLSSMELIPIEFVLPTSQRDSKTPETALLH
VAGHGNVEQMKGQVWLRALETSVAADFYHRLGPDHFLLLYQKKGQWYEIYDKYQVVQTLD
CLRYWKLLHRSPGQIHVVQRHAPSEETLAFQRQLTALIGYDVTDVSNVHDDELEFTRRRL
LTPRMAEVASRDPRLYAMHPWVTSKPLPEYLARKITNNCIFIVIHRSTTSQTIKVSADDT
PGNILHSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIRNFQWVRQCLKNG
EEIHLVLDAPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRK
FRVKVRGIDIPVLPRNADLTVFVEANIQHGQQVLCQRRTSAKPFTEEVLWNVWLEFSIKI
KDLPKGALLNLQIYCGKAPALSGKASADTPGAESRGKAQLLYYVNLLLIDHRFLLRHGEY
VLHMWQISGKGEDQGSFNADKLTSATNPDKENAMSISILLDNYCHPIALPKHRPTPDPEG
DRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYETLKHPKAYPKLFSSVKWGQ
QETVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYL
LQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAY
LRGCGTAMLHDLTQQVLVIEMLQKVTIDIKSLSAEKYDVSSQVILQLKQKLENLQNSNLP
TSFRVPYDPGLKAGTLVIEKCKVMASKKKPLWLEFKCADPTALSKETIGIIFKHGDDLRQ
DMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTG
AFKDEVLNHWLKEKCPIEDKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMISETGNL
FHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDVCVKAYLAL
RHHTNLLIVLFSMMLMTGMPQLTSKEDIEYIRDALTVGKSEEDAKKYFLDQIEVCRDKGW
TVQFNWFLHLVLGIKQGEKHSA
NT seq 3309 nt   +upstreamnt  +downstreamnt
atggagctggagagctctgaacagcccgtggttctgagagaggaccacgggcgccggcgc
cggaggatgaagccgcgcagccccgcggccagcctgtcctccatggagctcatccccatc
gagttcgtgctgcccaccagccagcgcgacagcaagacgccggagacggcgctgctgcac
gtggcgggccacggcaacgtggagcagatgaagggccaggtgtggctgcgcgcgctggag
acgagcgtggccgcagacttctaccaccggctgggcccggaccacttcctcctgctctac
cagaaaaaggggcagtggtacgagatctacgacaagtaccaggtggtgcagacgctggac
tgcctgcgctactggaagctgctgcacaggagcccgggccagatccacgtagtccagcgg
cacgcgccctctgaggagacgctggcctttcagcggcagctcaccgccctgattggctat
gatgtgactgacgtcagcaacgtgcacgacgacgagctggagttcacgcgccggcgcctg
ctgactccacgcatggcggaagtggccagccgcgacccccggctgtacgccatgcacccc
tgggtgacgtccaagcccctgccggagtacctagcgaggaagattaccaacaactgcatc
ttcatcgtcatccaccgcagcaccaccagccagaccatcaaggtctcggccgacgacacg
cctggcaacatcctccatagcttcttcaccaagatggccaagaagaagtccctgatggac
atcccggagagccaaagcgaacaggattttgtgctgcgcgtctgcggccgggatgagtac
ctggtgggtgaaacgcccatcagaaatttccagtgggtgaggcagtgcctgaaaaatgga
gaggagattcacctagtgctcgacgcgcccccggacccagccctggacgaggtgaggaag
gaagagtggcccctggtggatgactgcacgggagtcaccggctaccacgagcagctgacc
atccacggcaaggaccatgagagcgtgttcactgtgtcgctgtgggactgtgaccggaag
ttcagggtcaaggtcagagggatcgatatcccggtcctgccgcggaacgccgacctcacg
gttttcgtggaggcaaacatccagcacgggcagcaagtgctttgccaaaggagaaccagc
gccaagcccttcacggaggaggtgctctggaatgtgtggctggagttcagtatcaaaatc
aaggacttgcccaagggcgcgcttctgaacctgcagatctactgcggcaaggcgcccgcg
ctgtcgggcaaggcctctgccgacactcccggtgcagagtccaggggcaaggctcagctg
ctctattacgtgaacctgctgctgatagatcatcgcttcctcctgcgccacggcgagtac
gtgctccacatgtggcagatatcgggcaagggagaagaccaggggagcttcaatgctgac
aagctcacgtctgcaaccaaccccgacaaggagaacgccatgtccatctccattcttctg
gacaattactgccacccaatagctttgcctaagcatcgacccacccctgaccctgaaggg
gaccgggtacgagccgaaatgcccaaccagcttcgcaagcagctggaagcaatcatagcc
acggatccacttaacccgctcacagcagaagacaaagagctgctgtggcattttagatac
gagacccttaagcatccgaaagcgtatcctaagctgtttagctcggtgaaatggggacag
caagaaactgtggccaaaacataccagttgttagcccgacgggaggtctgggatcaaagt
gctttggatgtggggttaacaatgcaactcctggactgcaacttttcggatgagaatgta
agagccattgcagttcagaaactggagagcttagaagatgatgatgtcttgcattacctt
ctgcagctggtccaggccgtgaaatttgaaccataccatgacagtgccctggccagattt
ctgctgaagcgtggtttaaggaacaaaagaattggtcacttcttgttttggttcttgaga
agtgagatagcccagtccagacactatcagcagaggttcgccgtgatcctggaagcctat
ctgaggggctgtggcacagccatgctgcacgacttgacccaacaagtccttgtaatcgag
atgttacaaaaagtcaccattgacattaaatcactctctgctgaaaagtatgacgtcagt
tcccaagttattctacagcttaagcaaaaacttgaaaatctacaaaattctaacctcccg
acgagttttagagttccatacgaccctggattgaaagcaggaacactggtgattgagaaa
tgtaaagtgatggcctccaagaaaaagcccctgtggctcgagtttaaatgtgccgatcct
acagccctttcaaaggagaccattggaattatctttaaacatggtgacgatctacgccaa
gacatgcttattttacagattctacgaatcatggagtccatctgggaaacagaatctttg
gatctgtgcctcttgccatatggttgcatttcaactggtgacaaaataggaatgatcgag
atcgtgaaagacgccacgaccattgccaaaattcagcaaagcaccgtgggcaacacgggc
gcctttaaggatgaagtcttgaaccactggctcaaggaaaaatgcccgattgaggacaag
tttcaggcagcagtggagagatttgtttattcctgtgcaggctactgtgtggcaaccttt
gttcttggaataggtgacagacacaacgacaatattatgatctccgagacaggaaaccta
ttccatatcgacttcgggcacattcttgggaactacaaaagtttcctgggcattaataaa
gagagagtgccatttgtgctaaccccagacttcctgtttgtgatggggacttctgggaag
aagacaagtccacacttccagaaatttcaggacgtctgtgtcaaggcctacctcgccctt
cgccatcacacaaacctgctgatcgtcctcttctccatgatgctgatgacagggatgccc
cagctaacaagcaaagaagacatcgagtacatccgggacgccttaacggtgggcaagagt
gaggaggacgccaagaagtattttcttgatcagattgaagtttgcagagacaaagggtgg
accgtgcagtttaactggttcctgcatcttgttttgggcatcaaacaaggagagaagcat
tcagcctga

KEGG   Oryctolagus cuniculus (rabbit): 100345181
Entry
100345181         CDS       T03373                                 
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu00562  Inositol phosphate metabolism
ocu01100  Metabolic pathways
ocu01521  EGFR tyrosine kinase inhibitor resistance
ocu01522  Endocrine resistance
ocu01524  Platinum drug resistance
ocu04012  ErbB signaling pathway
ocu04014  Ras signaling pathway
ocu04015  Rap1 signaling pathway
ocu04024  cAMP signaling pathway
ocu04062  Chemokine signaling pathway
ocu04066  HIF-1 signaling pathway
ocu04068  FoxO signaling pathway
ocu04070  Phosphatidylinositol signaling system
ocu04071  Sphingolipid signaling pathway
ocu04072  Phospholipase D signaling pathway
ocu04081  Hormone signaling
ocu04140  Autophagy - animal
ocu04150  mTOR signaling pathway
ocu04151  PI3K-Akt signaling pathway
ocu04152  AMPK signaling pathway
ocu04210  Apoptosis
ocu04211  Longevity regulating pathway
ocu04213  Longevity regulating pathway - multiple species
ocu04218  Cellular senescence
ocu04360  Axon guidance
ocu04370  VEGF signaling pathway
ocu04380  Osteoclast differentiation
ocu04510  Focal adhesion
ocu04550  Signaling pathways regulating pluripotency of stem cells
ocu04611  Platelet activation
ocu04613  Neutrophil extracellular trap formation
ocu04620  Toll-like receptor signaling pathway
ocu04625  C-type lectin receptor signaling pathway
ocu04630  JAK-STAT signaling pathway
ocu04650  Natural killer cell mediated cytotoxicity
ocu04660  T cell receptor signaling pathway
ocu04662  B cell receptor signaling pathway
ocu04664  Fc epsilon RI signaling pathway
ocu04666  Fc gamma R-mediated phagocytosis
ocu04668  TNF signaling pathway
ocu04670  Leukocyte transendothelial migration
ocu04722  Neurotrophin signaling pathway
ocu04725  Cholinergic synapse
ocu04750  Inflammatory mediator regulation of TRP channels
ocu04810  Regulation of actin cytoskeleton
ocu04910  Insulin signaling pathway
ocu04914  Progesterone-mediated oocyte maturation
ocu04915  Estrogen signaling pathway
ocu04917  Prolactin signaling pathway
ocu04919  Thyroid hormone signaling pathway
ocu04923  Regulation of lipolysis in adipocytes
ocu04926  Relaxin signaling pathway
ocu04929  GnRH secretion
ocu04930  Type II diabetes mellitus
ocu04931  Insulin resistance
ocu04932  Non-alcoholic fatty liver disease
ocu04933  AGE-RAGE signaling pathway in diabetic complications
ocu04935  Growth hormone synthesis, secretion and action
ocu04960  Aldosterone-regulated sodium reabsorption
ocu04973  Carbohydrate digestion and absorption
ocu05010  Alzheimer disease
ocu05017  Spinocerebellar ataxia
ocu05020  Prion disease
ocu05100  Bacterial invasion of epithelial cells
ocu05132  Salmonella infection
ocu05135  Yersinia infection
ocu05142  Chagas disease
ocu05146  Amoebiasis
ocu05160  Hepatitis C
ocu05161  Hepatitis B
ocu05162  Measles
ocu05163  Human cytomegalovirus infection
ocu05164  Influenza A
ocu05165  Human papillomavirus infection
ocu05166  Human T-cell leukemia virus 1 infection
ocu05167  Kaposi sarcoma-associated herpesvirus infection
ocu05168  Herpes simplex virus 1 infection
ocu05169  Epstein-Barr virus infection
ocu05170  Human immunodeficiency virus 1 infection
ocu05171  Coronavirus disease - COVID-19
ocu05200  Pathways in cancer
ocu05203  Viral carcinogenesis
ocu05205  Proteoglycans in cancer
ocu05206  MicroRNAs in cancer
ocu05207  Chemical carcinogenesis - receptor activation
ocu05208  Chemical carcinogenesis - reactive oxygen species
ocu05210  Colorectal cancer
ocu05211  Renal cell carcinoma
ocu05212  Pancreatic cancer
ocu05213  Endometrial cancer
ocu05214  Glioma
ocu05215  Prostate cancer
ocu05218  Melanoma
ocu05220  Chronic myeloid leukemia
ocu05221  Acute myeloid leukemia
ocu05222  Small cell lung cancer
ocu05223  Non-small cell lung cancer
ocu05224  Breast cancer
ocu05225  Hepatocellular carcinoma
ocu05226  Gastric cancer
ocu05230  Central carbon metabolism in cancer
ocu05231  Choline metabolism in cancer
ocu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ocu05415  Diabetic cardiomyopathy
ocu05417  Lipid and atherosclerosis
ocu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100345181
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    100345181
   04015 Rap1 signaling pathway
    100345181
   04630 JAK-STAT signaling pathway
    100345181
   04668 TNF signaling pathway
    100345181
   04066 HIF-1 signaling pathway
    100345181
   04068 FoxO signaling pathway
    100345181
   04070 Phosphatidylinositol signaling system
    100345181
   04072 Phospholipase D signaling pathway
    100345181
   04071 Sphingolipid signaling pathway
    100345181
   04024 cAMP signaling pathway
    100345181
   04151 PI3K-Akt signaling pathway
    100345181
   04152 AMPK signaling pathway
    100345181
   04150 mTOR signaling pathway
    100345181
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100345181
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100345181
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    100345181
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100345181
   04613 Neutrophil extracellular trap formation
    100345181
   04620 Toll-like receptor signaling pathway
    100345181
   04650 Natural killer cell mediated cytotoxicity
    100345181
   04660 T cell receptor signaling pathway
    100345181
   04662 B cell receptor signaling pathway
    100345181
   04664 Fc epsilon RI signaling pathway
    100345181
   04666 Fc gamma R-mediated phagocytosis
    100345181
   04670 Leukocyte transendothelial migration
    100345181
   04062 Chemokine signaling pathway
    100345181
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    100345181
   04929 GnRH secretion
    100345181
   04915 Estrogen signaling pathway
    100345181
   04917 Prolactin signaling pathway
    100345181
   04926 Relaxin signaling pathway
    100345181
   04935 Growth hormone synthesis, secretion and action
    100345181
   04919 Thyroid hormone signaling pathway
    100345181
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100345181
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100345181
  09156 Nervous system
   04725 Cholinergic synapse
    100345181
   04722 Neurotrophin signaling pathway
    100345181
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100345181
  09158 Development and regeneration
   04360 Axon guidance
    100345181
   04380 Osteoclast differentiation
    100345181
  09149 Aging
   04211 Longevity regulating pathway
    100345181
   04213 Longevity regulating pathway - multiple species
    100345181
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100345181
   05206 MicroRNAs in cancer
    100345181
   05205 Proteoglycans in cancer
    100345181
   05207 Chemical carcinogenesis - receptor activation
    100345181
   05208 Chemical carcinogenesis - reactive oxygen species
    100345181
   05203 Viral carcinogenesis
    100345181
   05230 Central carbon metabolism in cancer
    100345181
   05231 Choline metabolism in cancer
    100345181
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100345181
  09162 Cancer: specific types
   05210 Colorectal cancer
    100345181
   05212 Pancreatic cancer
    100345181
   05225 Hepatocellular carcinoma
    100345181
   05226 Gastric cancer
    100345181
   05214 Glioma
    100345181
   05221 Acute myeloid leukemia
    100345181
   05220 Chronic myeloid leukemia
    100345181
   05218 Melanoma
    100345181
   05211 Renal cell carcinoma
    100345181
   05215 Prostate cancer
    100345181
   05213 Endometrial cancer
    100345181
   05224 Breast cancer
    100345181
   05222 Small cell lung cancer
    100345181
   05223 Non-small cell lung cancer
    100345181
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100345181
   05170 Human immunodeficiency virus 1 infection
    100345181
   05161 Hepatitis B
    100345181
   05160 Hepatitis C
    100345181
   05171 Coronavirus disease - COVID-19
    100345181
   05164 Influenza A
    100345181
   05162 Measles
    100345181
   05163 Human cytomegalovirus infection
    100345181
   05167 Kaposi sarcoma-associated herpesvirus infection
    100345181
   05169 Epstein-Barr virus infection
    100345181
   05165 Human papillomavirus infection
    100345181
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100345181
   05100 Bacterial invasion of epithelial cells
    100345181
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100345181
   05142 Chagas disease
    100345181
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100345181
   05017 Spinocerebellar ataxia
    100345181
   05020 Prion disease
    100345181
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100345181
   05418 Fluid shear stress and atherosclerosis
    100345181
   05415 Diabetic cardiomyopathy
    100345181
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100345181
   04932 Non-alcoholic fatty liver disease
    100345181
   04931 Insulin resistance
    100345181
   04933 AGE-RAGE signaling pathway in diabetic complications
    100345181
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100345181
   01524 Platinum drug resistance
    100345181
   01522 Endocrine resistance
    100345181
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ocu04131]
    100345181
Enzymes [BR:ocu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100345181
Membrane trafficking [BR:ocu04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100345181
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 DUF4381 Tom37_C
Other DBs
NCBI-GeneID: 100345181
NCBI-ProteinID: XP_051674606
Ensembl: ENSOCUG00000004899
LinkDB
Position
14:complement(33423689..33593442)
AA seq 1070 aa
MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQLLW
KQVHNYPMFNLLMEIDAYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDALKDPEVNEFRRKMRKFSEEKIQSLVGLSWIDWLKQTYPPEH
DPSSLENLEDKLYGGKLIVAVHFENSQDVFSFQVSPNMNPIKINELAIQKRLTIHGKEDE
ASPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKTRITSHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTIVSSEISGKNDHIWNEPLEFDINTCDLPRMARLCFAVYAVLDKVKTKKSTKTI
NPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRSGDVILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASNDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALANRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNRAKGKEAMHTCLKQNAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcttcagtttcataatgcctcctgctatggcagacatccttgacatctgggcagtg
gattcacagatagcatctgatggctccatacctgtggatttccttttgcccactgggatt
tatatccagttggaggtacctcgggaagccaccatttcttatattaagcagttgttatgg
aagcaagttcacaattacccaatgtttaaccttctgatggaaattgacgcctatatgttt
gcatgtgtgaatcaaactgctgtatatgaagaactcgaagatgaaacacgaagactttgt
gatgttagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattagactcaaaaatcggagtccttataggaaaaggtttgcatgaatttgatgccttg
aaggatcctgaagtcaatgaatttcgaagaaaaatgcgcaaattcagtgaggaaaagatt
cagtcacttgtgggattgtcttggatagactggctaaagcagacatacccaccggagcat
gacccatccagccttgaaaacttagaagataaactctatggaggaaagctcattgtggct
gttcattttgaaaactctcaggatgtgtttagttttcaagtgtctcctaatatgaatcct
atcaaaataaatgagttggcaatccaaaaacgtttgactattcatgggaaggaagatgag
gctagcccctatgactacgtgttgcaagtcagtggacgagtggagtatgtatttggtgat
cacccactaattcagttccagtatatccggaattgtgtaatgaacagaactttgccccat
tttatacttgtggaatgctgcaagatcaagaaaatgtatgaacaggagatgattgccata
gaagctgccataaatcgaaattcatctaatcttcctcttcctttaccaccaaagaaaaca
cgaattacttctcatgtttgggagaataataatccattccaaattgtcttagttaaagga
aataagcttaacacagaagaaactgtaaaagttcatgtcagagctggtctttttcacggt
accgagctcctgtgtaaaaccatcgtaagctcagagatatcggggaaaaatgatcacatt
tggaatgaaccattggaatttgatattaatacttgtgacttgccaagaatggctcgattg
tgttttgctgtttatgcagttttagataaagtgaaaacaaagaagtcaactaaaactatt
aatccctctaaatatcagaccatcaggaaagctggaaaagtgcattatcctgtagcctgg
gtaaatacgatggtttttgactttaaaggacagttgagatctggagacgtaatattgcac
agctggtcttcatttcctgatgaactagaagaaatgttgaatccaatgggaaccgttcag
acaaatccatacactgaaaatgcaacagctttgcatattaaatttccagaaaataagaaa
caaccttattattaccctccctttgataagattattgaaaaggcagctgagattgcaagc
aacgatagtgctaatgtatcaagtcgaggtgggaaaaagtttcttgcagtactgaaagaa
atcttggacagagatccattgtcccaactgtgtgagaatgaaatggatcttatttggact
ttgcgacaagactgcagagagaacttcccacagtcactgccaaaattactcctatcaata
aagtggaataaacttgaggatgttgctcagcttcaagcactgcttcagatttggcctaaa
ttgcctcctcgggaggctttggagcttctggatttcaactacccagaccagtatgtgcgg
gaatatgctgtgggctgccttcggcagatgagtgatgaagaactctcgcagtacctttta
caactggtgcaagttttgaaatatgagccatttcttgattgtgccctgtctagattccta
ttagaaagagcgcttgctaatcggcggatagggcagtttctattttggcatcttaggtca
gaagtgcacattcctgctgtctcagtacagtttggcgtcatccttgaagcatactgcagg
ggaagtgtagggcacatgaaagtgctttccaaacaggttgaagcactcaataagttaaaa
accttaaatagtttaataaaactgaatgcagtgaagctaaacagagccaaagggaaggag
gccatgcacacctgtttaaaacagaatgcttaccgagaagccctctctgacctgcagtca
cccctgaacccatgtgtcatcctctcagaactctatgttgaaaagtgcaaatacatggat
tctaaaatgaaacctttgtggctggtatacaacaacaaggtatttggtgaggattcggtt
ggagtgatttttaaaaacggtgatgatttacgacaggatatgttgacacttcagatgctg
cgcttgatggatttactctggaaagaagctggtctggatcttcggatgctgccttatggc
tgtttagcaacaggagatcgctctggcctcattgaagttgtgagcacctctgaaacaatc
gctgacattcagctgaacagtagcaatgtggctgctgcagcagccttcaacaaagacgcc
cttctgaactggcttaaagagtacaattctggggatgacctggaccgagccattgaggag
tttaccctgtcctgtgctggctactgtgtagcctcttacgtcctcgggattggtgacaga
cacagtgacaacatcatggtcaaaaaaactggccagctcttccacattgactttggacat
attcttggaaatttcaaatctaagtttggcattaaaagggagcgagtgccttttatactt
acttatgattttattcatgttattcaacaaggaaaaacaggaaacacagaaaagtttggc
cggttccgccagtgctgtgaggacgcatatctcatcttacgacggcatgggaatctcttc
atcacgctctttgcactgatgttgacagcagggcttcctgagctcacctcagtcaaggat
atacagtatctgaaggactctcttgccttaggaaagagtgaagaagaagcactcaaacaa
tttaagcagaaatttgatgaggcgctcagggaaagctggactactaaagtgaactggatg
gcccacacagttcgcaaagactaccgatcttaa

KEGG   Oryctolagus cuniculus (rabbit): 100345250
Entry
100345250         CDS       T03373                                 
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu01521  EGFR tyrosine kinase inhibitor resistance
ocu01522  Endocrine resistance
ocu01524  Platinum drug resistance
ocu04012  ErbB signaling pathway
ocu04014  Ras signaling pathway
ocu04015  Rap1 signaling pathway
ocu04024  cAMP signaling pathway
ocu04062  Chemokine signaling pathway
ocu04066  HIF-1 signaling pathway
ocu04068  FoxO signaling pathway
ocu04070  Phosphatidylinositol signaling system
ocu04071  Sphingolipid signaling pathway
ocu04072  Phospholipase D signaling pathway
ocu04081  Hormone signaling
ocu04140  Autophagy - animal
ocu04150  mTOR signaling pathway
ocu04151  PI3K-Akt signaling pathway
ocu04152  AMPK signaling pathway
ocu04210  Apoptosis
ocu04211  Longevity regulating pathway
ocu04213  Longevity regulating pathway - multiple species
ocu04218  Cellular senescence
ocu04360  Axon guidance
ocu04370  VEGF signaling pathway
ocu04380  Osteoclast differentiation
ocu04510  Focal adhesion
ocu04550  Signaling pathways regulating pluripotency of stem cells
ocu04611  Platelet activation
ocu04613  Neutrophil extracellular trap formation
ocu04620  Toll-like receptor signaling pathway
ocu04625  C-type lectin receptor signaling pathway
ocu04630  JAK-STAT signaling pathway
ocu04650  Natural killer cell mediated cytotoxicity
ocu04660  T cell receptor signaling pathway
ocu04662  B cell receptor signaling pathway
ocu04664  Fc epsilon RI signaling pathway
ocu04666  Fc gamma R-mediated phagocytosis
ocu04668  TNF signaling pathway
ocu04670  Leukocyte transendothelial migration
ocu04722  Neurotrophin signaling pathway
ocu04725  Cholinergic synapse
ocu04750  Inflammatory mediator regulation of TRP channels
ocu04810  Regulation of actin cytoskeleton
ocu04910  Insulin signaling pathway
ocu04914  Progesterone-mediated oocyte maturation
ocu04915  Estrogen signaling pathway
ocu04917  Prolactin signaling pathway
ocu04919  Thyroid hormone signaling pathway
ocu04923  Regulation of lipolysis in adipocytes
ocu04926  Relaxin signaling pathway
ocu04929  GnRH secretion
ocu04930  Type II diabetes mellitus
ocu04931  Insulin resistance
ocu04932  Non-alcoholic fatty liver disease
ocu04933  AGE-RAGE signaling pathway in diabetic complications
ocu04935  Growth hormone synthesis, secretion and action
ocu04960  Aldosterone-regulated sodium reabsorption
ocu04973  Carbohydrate digestion and absorption
ocu05010  Alzheimer disease
ocu05017  Spinocerebellar ataxia
ocu05020  Prion disease
ocu05100  Bacterial invasion of epithelial cells
ocu05135  Yersinia infection
ocu05142  Chagas disease
ocu05146  Amoebiasis
ocu05160  Hepatitis C
ocu05161  Hepatitis B
ocu05162  Measles
ocu05163  Human cytomegalovirus infection
ocu05164  Influenza A
ocu05165  Human papillomavirus infection
ocu05166  Human T-cell leukemia virus 1 infection
ocu05167  Kaposi sarcoma-associated herpesvirus infection
ocu05168  Herpes simplex virus 1 infection
ocu05169  Epstein-Barr virus infection
ocu05170  Human immunodeficiency virus 1 infection
ocu05171  Coronavirus disease - COVID-19
ocu05200  Pathways in cancer
ocu05203  Viral carcinogenesis
ocu05205  Proteoglycans in cancer
ocu05206  MicroRNAs in cancer
ocu05207  Chemical carcinogenesis - receptor activation
ocu05208  Chemical carcinogenesis - reactive oxygen species
ocu05210  Colorectal cancer
ocu05211  Renal cell carcinoma
ocu05212  Pancreatic cancer
ocu05213  Endometrial cancer
ocu05214  Glioma
ocu05215  Prostate cancer
ocu05218  Melanoma
ocu05220  Chronic myeloid leukemia
ocu05221  Acute myeloid leukemia
ocu05222  Small cell lung cancer
ocu05223  Non-small cell lung cancer
ocu05224  Breast cancer
ocu05225  Hepatocellular carcinoma
ocu05226  Gastric cancer
ocu05230  Central carbon metabolism in cancer
ocu05231  Choline metabolism in cancer
ocu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ocu05415  Diabetic cardiomyopathy
ocu05417  Lipid and atherosclerosis
ocu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    100345250
   04015 Rap1 signaling pathway
    100345250
   04630 JAK-STAT signaling pathway
    100345250
   04668 TNF signaling pathway
    100345250
   04066 HIF-1 signaling pathway
    100345250
   04068 FoxO signaling pathway
    100345250
   04070 Phosphatidylinositol signaling system
    100345250
   04072 Phospholipase D signaling pathway
    100345250
   04071 Sphingolipid signaling pathway
    100345250
   04024 cAMP signaling pathway
    100345250
   04151 PI3K-Akt signaling pathway
    100345250
   04152 AMPK signaling pathway
    100345250
   04150 mTOR signaling pathway
    100345250
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100345250
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100345250
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    100345250
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100345250
   04613 Neutrophil extracellular trap formation
    100345250
   04620 Toll-like receptor signaling pathway
    100345250
   04650 Natural killer cell mediated cytotoxicity
    100345250
   04660 T cell receptor signaling pathway
    100345250
   04662 B cell receptor signaling pathway
    100345250
   04664 Fc epsilon RI signaling pathway
    100345250
   04666 Fc gamma R-mediated phagocytosis
    100345250
   04670 Leukocyte transendothelial migration
    100345250
   04062 Chemokine signaling pathway
    100345250
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    100345250
   04929 GnRH secretion
    100345250
   04915 Estrogen signaling pathway
    100345250
   04917 Prolactin signaling pathway
    100345250
   04926 Relaxin signaling pathway
    100345250
   04935 Growth hormone synthesis, secretion and action
    100345250
   04919 Thyroid hormone signaling pathway
    100345250
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100345250
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100345250
  09156 Nervous system
   04725 Cholinergic synapse
    100345250
   04722 Neurotrophin signaling pathway
    100345250
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100345250
  09158 Development and regeneration
   04360 Axon guidance
    100345250
   04380 Osteoclast differentiation
    100345250
  09149 Aging
   04211 Longevity regulating pathway
    100345250
   04213 Longevity regulating pathway - multiple species
    100345250
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100345250
   05206 MicroRNAs in cancer
    100345250
   05205 Proteoglycans in cancer
    100345250
   05207 Chemical carcinogenesis - receptor activation
    100345250
   05208 Chemical carcinogenesis - reactive oxygen species
    100345250
   05203 Viral carcinogenesis
    100345250
   05230 Central carbon metabolism in cancer
    100345250
   05231 Choline metabolism in cancer
    100345250
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100345250
  09162 Cancer: specific types
   05210 Colorectal cancer
    100345250
   05212 Pancreatic cancer
    100345250
   05225 Hepatocellular carcinoma
    100345250
   05226 Gastric cancer
    100345250
   05214 Glioma
    100345250
   05221 Acute myeloid leukemia
    100345250
   05220 Chronic myeloid leukemia
    100345250
   05218 Melanoma
    100345250
   05211 Renal cell carcinoma
    100345250
   05215 Prostate cancer
    100345250
   05213 Endometrial cancer
    100345250
   05224 Breast cancer
    100345250
   05222 Small cell lung cancer
    100345250
   05223 Non-small cell lung cancer
    100345250
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100345250
   05170 Human immunodeficiency virus 1 infection
    100345250
   05161 Hepatitis B
    100345250
   05160 Hepatitis C
    100345250
   05171 Coronavirus disease - COVID-19
    100345250
   05164 Influenza A
    100345250
   05162 Measles
    100345250
   05163 Human cytomegalovirus infection
    100345250
   05167 Kaposi sarcoma-associated herpesvirus infection
    100345250
   05169 Epstein-Barr virus infection
    100345250
   05165 Human papillomavirus infection
    100345250
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100345250
   05100 Bacterial invasion of epithelial cells
    100345250
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100345250
   05142 Chagas disease
    100345250
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100345250
   05017 Spinocerebellar ataxia
    100345250
   05020 Prion disease
    100345250
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100345250
   05418 Fluid shear stress and atherosclerosis
    100345250
   05415 Diabetic cardiomyopathy
    100345250
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100345250
   04932 Non-alcoholic fatty liver disease
    100345250
   04931 Insulin resistance
    100345250
   04933 AGE-RAGE signaling pathway in diabetic complications
    100345250
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100345250
   01524 Platinum drug resistance
    100345250
   01522 Endocrine resistance
    100345250
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ocu04131]
    100345250
Membrane trafficking [BR:ocu04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100345250
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 SH2_1 AAA_13 Transcrip_act
Other DBs
NCBI-GeneID: 100345250
NCBI-ProteinID: XP_051713797
Ensembl: ENSOCUG00000014319
LinkDB
Position
13:120488828..120643323
AA seq 525 aa
MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPMTSAVTNGMKDSSVSL
QDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDG
KYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKK
LQEYHSQYQEKSKEYDRLYEEYTRTSQLSAMAWESSRRWPLHPHGRPGRSSWLLASDRRS
SGHCGHLGSEPSDGRPFSLSLPLTVCNSTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQH
SKEYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKMRLEQDLKKQALDNREIDKKMN
SIKPDLIQLRKIRDQHLVWLNHKGVRQKRLNAWLGIKNEDADETYFINEEDENLPHYDEK
TWFVEDINRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKHCVIYSTARGYGFA
EPYNLYSSLKELVLHYQHTSLVQHNDSLNVRLAYPVHAQMPSLCR
NT seq 1578 nt   +upstreamnt  +downstreamnt
atgtacaatacggtgtggagtatggaccgcgatgacgcagactggagggaggtgatgatg
ccctattcgacagaactgatattttatattgaaatggatcctccagctcttccaccaaag
ccacctaagccaatgacttcagcagttacaaatggaatgaaagacagttctgtttctctc
caggatgcagaatggtactggggggatatttcaagagaggaggtaaatgacaaattacgg
gacatgccagatggtaccttcttggtccgagatgcctcaacaaagatgcagggggattat
actttgacattgcggaagggaggcaataataagttaataaagatctatcatcgggatggt
aaatatggcttttctgatcctctgacatttaattctgttgtggagctcattaaccactat
catcatgaatctcttgctcagtacaatcccaaacttgacgtgaagctaatgtacccagta
tccagataccaacaggatcagttggtaaaagaagacaacattgatgcagtaggtaaaaaa
ctacaagagtaccactctcagtatcaggaaaagagtaaggaatatgatagattatatgaa
gaatataccagaacatcccagctctctgctatggcctgggaaagcagtagaagatggccc
ctgcacccacatgggagacccggaagaagctcctggctcctggcttcggatcggcgcagc
tctggccattgcggccacttggggagtgagccatcggatggaagacctttctctctgtct
ctccctctcactgtctgtaactctacctctcaagaaatacagatgaagaggactgcaatt
gaagcttttaatgaaacaattaaaatatttgaggagcagtgtcacacacaagaacaacat
agcaaagaatatattgagcgatttcgtagggaggggaatgaaaaggagattgaacgaatt
atgatgaattatgacaagttgaaatcacgtctgggtgagattcacgatagcaaaatgcgt
cttgagcaggatttgaagaaacaagctttggacaaccgagaaatagataaaaaaatgaat
agtatcaaacctgacctgattcagctgcgcaagatccgagatcagcaccttgtgtggctc
aatcacaaaggagtgaggcagaagcgcctgaatgcctggctgggaatcaagaatgaggat
gccgatgaaacctattttatcaatgaggaagatgaaaacctgccacattatgatgagaaa
acctggttcgttgaggatatcaatcgagtacaagcagaggacttgctttatgggaaaccc
gatggtgcattcttaattcgtgagagtagcaagaaaggatgctatgcttgctctgtggtc
gctgacggggaggtgaagcactgtgtgatctacagcaccgcgcggggctacggctttgca
gagccctacaacctgtacagctcgctgaaggagctggtgctccattaccagcacacgtcc
ctggttcagcacaacgactccctcaacgtcaggctcgcctaccccgtccacgcacagatg
ccctcgctctgcagataa

KEGG   Oryctolagus cuniculus (rabbit): 100348663
Entry
100348663         CDS       T03373                                 
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu00562  Inositol phosphate metabolism
ocu01100  Metabolic pathways
ocu01521  EGFR tyrosine kinase inhibitor resistance
ocu01522  Endocrine resistance
ocu01524  Platinum drug resistance
ocu04012  ErbB signaling pathway
ocu04014  Ras signaling pathway
ocu04015  Rap1 signaling pathway
ocu04024  cAMP signaling pathway
ocu04062  Chemokine signaling pathway
ocu04066  HIF-1 signaling pathway
ocu04068  FoxO signaling pathway
ocu04070  Phosphatidylinositol signaling system
ocu04071  Sphingolipid signaling pathway
ocu04072  Phospholipase D signaling pathway
ocu04081  Hormone signaling
ocu04140  Autophagy - animal
ocu04150  mTOR signaling pathway
ocu04151  PI3K-Akt signaling pathway
ocu04152  AMPK signaling pathway
ocu04210  Apoptosis
ocu04211  Longevity regulating pathway
ocu04213  Longevity regulating pathway - multiple species
ocu04218  Cellular senescence
ocu04360  Axon guidance
ocu04370  VEGF signaling pathway
ocu04380  Osteoclast differentiation
ocu04510  Focal adhesion
ocu04550  Signaling pathways regulating pluripotency of stem cells
ocu04611  Platelet activation
ocu04613  Neutrophil extracellular trap formation
ocu04620  Toll-like receptor signaling pathway
ocu04625  C-type lectin receptor signaling pathway
ocu04630  JAK-STAT signaling pathway
ocu04650  Natural killer cell mediated cytotoxicity
ocu04660  T cell receptor signaling pathway
ocu04662  B cell receptor signaling pathway
ocu04664  Fc epsilon RI signaling pathway
ocu04666  Fc gamma R-mediated phagocytosis
ocu04668  TNF signaling pathway
ocu04670  Leukocyte transendothelial migration
ocu04722  Neurotrophin signaling pathway
ocu04725  Cholinergic synapse
ocu04750  Inflammatory mediator regulation of TRP channels
ocu04810  Regulation of actin cytoskeleton
ocu04910  Insulin signaling pathway
ocu04914  Progesterone-mediated oocyte maturation
ocu04915  Estrogen signaling pathway
ocu04917  Prolactin signaling pathway
ocu04919  Thyroid hormone signaling pathway
ocu04923  Regulation of lipolysis in adipocytes
ocu04926  Relaxin signaling pathway
ocu04929  GnRH secretion
ocu04930  Type II diabetes mellitus
ocu04931  Insulin resistance
ocu04932  Non-alcoholic fatty liver disease
ocu04933  AGE-RAGE signaling pathway in diabetic complications
ocu04935  Growth hormone synthesis, secretion and action
ocu04960  Aldosterone-regulated sodium reabsorption
ocu04973  Carbohydrate digestion and absorption
ocu05010  Alzheimer disease
ocu05017  Spinocerebellar ataxia
ocu05020  Prion disease
ocu05100  Bacterial invasion of epithelial cells
ocu05132  Salmonella infection
ocu05135  Yersinia infection
ocu05142  Chagas disease
ocu05146  Amoebiasis
ocu05160  Hepatitis C
ocu05161  Hepatitis B
ocu05162  Measles
ocu05163  Human cytomegalovirus infection
ocu05164  Influenza A
ocu05165  Human papillomavirus infection
ocu05166  Human T-cell leukemia virus 1 infection
ocu05167  Kaposi sarcoma-associated herpesvirus infection
ocu05168  Herpes simplex virus 1 infection
ocu05169  Epstein-Barr virus infection
ocu05170  Human immunodeficiency virus 1 infection
ocu05171  Coronavirus disease - COVID-19
ocu05200  Pathways in cancer
ocu05203  Viral carcinogenesis
ocu05205  Proteoglycans in cancer
ocu05206  MicroRNAs in cancer
ocu05207  Chemical carcinogenesis - receptor activation
ocu05208  Chemical carcinogenesis - reactive oxygen species
ocu05210  Colorectal cancer
ocu05211  Renal cell carcinoma
ocu05212  Pancreatic cancer
ocu05213  Endometrial cancer
ocu05214  Glioma
ocu05215  Prostate cancer
ocu05218  Melanoma
ocu05220  Chronic myeloid leukemia
ocu05221  Acute myeloid leukemia
ocu05222  Small cell lung cancer
ocu05223  Non-small cell lung cancer
ocu05224  Breast cancer
ocu05225  Hepatocellular carcinoma
ocu05226  Gastric cancer
ocu05230  Central carbon metabolism in cancer
ocu05231  Choline metabolism in cancer
ocu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ocu05415  Diabetic cardiomyopathy
ocu05417  Lipid and atherosclerosis
ocu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    100348663
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    100348663
   04015 Rap1 signaling pathway
    100348663
   04630 JAK-STAT signaling pathway
    100348663
   04668 TNF signaling pathway
    100348663
   04066 HIF-1 signaling pathway
    100348663
   04068 FoxO signaling pathway
    100348663
   04070 Phosphatidylinositol signaling system
    100348663
   04072 Phospholipase D signaling pathway
    100348663
   04071 Sphingolipid signaling pathway
    100348663
   04024 cAMP signaling pathway
    100348663
   04151 PI3K-Akt signaling pathway
    100348663
   04152 AMPK signaling pathway
    100348663
   04150 mTOR signaling pathway
    100348663
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100348663
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100348663
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    100348663
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100348663
   04613 Neutrophil extracellular trap formation
    100348663
   04620 Toll-like receptor signaling pathway
    100348663
   04650 Natural killer cell mediated cytotoxicity
    100348663
   04660 T cell receptor signaling pathway
    100348663
   04662 B cell receptor signaling pathway
    100348663
   04664 Fc epsilon RI signaling pathway
    100348663
   04666 Fc gamma R-mediated phagocytosis
    100348663
   04670 Leukocyte transendothelial migration
    100348663
   04062 Chemokine signaling pathway
    100348663
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    100348663
   04929 GnRH secretion
    100348663
   04915 Estrogen signaling pathway
    100348663
   04917 Prolactin signaling pathway
    100348663
   04926 Relaxin signaling pathway
    100348663
   04935 Growth hormone synthesis, secretion and action
    100348663
   04919 Thyroid hormone signaling pathway
    100348663
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100348663
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100348663
  09156 Nervous system
   04725 Cholinergic synapse
    100348663
   04722 Neurotrophin signaling pathway
    100348663
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100348663
  09158 Development and regeneration
   04360 Axon guidance
    100348663
   04380 Osteoclast differentiation
    100348663
  09149 Aging
   04211 Longevity regulating pathway
    100348663
   04213 Longevity regulating pathway - multiple species
    100348663
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100348663
   05206 MicroRNAs in cancer
    100348663
   05205 Proteoglycans in cancer
    100348663
   05207 Chemical carcinogenesis - receptor activation
    100348663
   05208 Chemical carcinogenesis - reactive oxygen species
    100348663
   05203 Viral carcinogenesis
    100348663
   05230 Central carbon metabolism in cancer
    100348663
   05231 Choline metabolism in cancer
    100348663
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100348663
  09162 Cancer: specific types
   05210 Colorectal cancer
    100348663
   05212 Pancreatic cancer
    100348663
   05225 Hepatocellular carcinoma
    100348663
   05226 Gastric cancer
    100348663
   05214 Glioma
    100348663
   05221 Acute myeloid leukemia
    100348663
   05220 Chronic myeloid leukemia
    100348663
   05218 Melanoma
    100348663
   05211 Renal cell carcinoma
    100348663
   05215 Prostate cancer
    100348663
   05213 Endometrial cancer
    100348663
   05224 Breast cancer
    100348663
   05222 Small cell lung cancer
    100348663
   05223 Non-small cell lung cancer
    100348663
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100348663
   05170 Human immunodeficiency virus 1 infection
    100348663
   05161 Hepatitis B
    100348663
   05160 Hepatitis C
    100348663
   05171 Coronavirus disease - COVID-19
    100348663
   05164 Influenza A
    100348663
   05162 Measles
    100348663
   05163 Human cytomegalovirus infection
    100348663
   05167 Kaposi sarcoma-associated herpesvirus infection
    100348663
   05169 Epstein-Barr virus infection
    100348663
   05165 Human papillomavirus infection
    100348663
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100348663
   05100 Bacterial invasion of epithelial cells
    100348663
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100348663
   05142 Chagas disease
    100348663
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100348663
   05017 Spinocerebellar ataxia
    100348663
   05020 Prion disease
    100348663
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100348663
   05418 Fluid shear stress and atherosclerosis
    100348663
   05415 Diabetic cardiomyopathy
    100348663
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100348663
   04932 Non-alcoholic fatty liver disease
    100348663
   04931 Insulin resistance
    100348663
   04933 AGE-RAGE signaling pathway in diabetic complications
    100348663
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100348663
   01524 Platinum drug resistance
    100348663
   01522 Endocrine resistance
    100348663
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ocu04131]
    100348663
Enzymes [BR:ocu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     100348663
Membrane trafficking [BR:ocu04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100348663
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_p85B PI3K_rbd PI3K_C2 DOCK-C2
Other DBs
NCBI-GeneID: 100348663
NCBI-ProteinID: XP_051714052
Ensembl: ENSOCUG00000011054
LinkDB
Position
13:complement(140564979..140604326)
AA seq 1044 aa
MPPGVDCPMEFWTKEENQNVAVDFLLPTGIYLNFPVSRNANLSTIKQVLWHRAQYEPLFH
MLSDPEAYVFTCVSQTAEPQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLL
IGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAVRRQQLGWEAWLQYSFPLQLEPSARSWGA
GALHAPNRALLVNVKFEGSEESFTFQVSTKDMPLALMACALRKKATVFRQPLAEQPEDYT
LQVNGRHEYLYGSYALCQFQYIRSCLHSGLTPHLTMVHSSSILAMRDEQSSPAPQVQKPR
TKPPPVPMKKPSSVSLWSLEQPFCIELVQGSRVNADERMKLVVQAGLFHGNETLCKTVSS
AEVSVSSEPVWKQRLEFDISICDLPRMARLCFALYAVVEKAKKARSTKKKSKKADCPIAW
ANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRGNPNTESAAALVICLPEVAP
HPVYYPPLEKILELGRHGERAPTSEEEQLQLREILERRGSGELYEHEKDLVWKMRHEVQE
RFPEALARLLLVTKWNKHEDVAQMLHLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSL
RKLTDEELFQYLLQLVQVLKYESYLDCELTKFLLGRALANRKIGHFLFWHLRSEMHVPSV
ALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQKTTKPQTKELMHLCMR
QEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIVYSNEEAGSEGSVGIIFKN
GDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLN
KSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIM
IRESGQLFHVDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYC
ERAYTILRRHGLLFLHLFALMRAAGLPELSCPKDIQYLKDSLALGKTEEEALKHFRVKFN
EALRESWKTKVNWLAHNVSKDNRQ
NT seq 3135 nt   +upstreamnt  +downstreamnt
atgccccctggggttgactgccccatggaattctggaccaaggaagagaatcagaatgtg
gcggtggacttcctgctgcccacgggcatctacctcaacttccctgtgtcccgcaatgcc
aacctcagcaccatcaagcaggtactgtggcaccgcgcgcagtacgagccactgttccac
atgctcagtgaccccgaggcctacgtgttcacgtgcgtcagccagacggcagagccgcag
gagctggaggacgagcagcggcggctgtgcgacgtgcagcccttcctgcccgtgctgcgc
ctggtggcccgcgagggcgaccgcgtgaagaagctcatcaactcgcagatcagcctgctc
atcggcaaaggcctccatgagttcgactccctgcgcgacccagaggtcaacgacttccgc
accaagatgcgccagttctgcgaggaggcggccgtgcgcaggcagcagctgggctgggag
gcctggctgcagtacagcttccccctgcagctggagccctcggcacgcagctggggggcc
ggcgccctgcacgcccccaaccgggccctgctggtcaatgtcaagttcgagggcagtgag
gagagcttcactttccaggtgtccaccaaggacatgcccctggcactgatggcctgtgcc
ctccggaagaaggccacggtgttccggcagcccctggccgaacagccagaggactacacg
ctgcaggtgaacgggcggcacgagtacctgtacggcagctacgccctctgccagttccag
tacatccgcagctgcctgcacagcgggctcaccccgcacctgaccatggtgcactcctcc
tctatcctggccatgcgggacgagcagagcagccccgcccctcaggtccagaaacctcgc
accaagccgccccccgttcccatgaagaagccctcctctgtgtcgctgtggtcgctggag
cagcccttctgcatcgagctggtccagggcagcagggtgaatgccgatgagcggatgaag
ctggtggtgcaggccgggctcttccacggcaacgagacgctgtgcaagacggtgtccagc
gcggaggtgagcgtgagctccgagcccgtgtggaagcagcggctggagtttgacatcagc
atctgcgacctgccgcgcatggcccggctctgcttcgcgctctacgccgtggtcgagaag
gccaagaaggcgcgctccaccaagaagaagtccaagaaggcggactgccccatcgcctgg
gccaacctcatgctcttcgactacaaggaccagctcaagaccggggagcgctgcctctac
atgtggccctctgtcccagacgagaaaggggagctgctgaaccccacggggaccgtgcgt
ggtaaccccaacactgagagcgccgccgccctggtcatctgcctgcccgaggtggccccc
caccctgtgtactacccgcccctggagaagatcctggagctggggcgacacggggagcga
gcgcccacctcggaggaggagcagctgcagctgcgggagatcctggagcgacgggggtcc
ggggagctgtacgagcacgagaaggacctggtgtggaagatgcggcacgaagtccaggag
cgcttcccggaggcgctggcccggctgctgctggtcaccaagtggaacaaacatgaggat
gtggcccagatgctgcacctgctgtgctcctggcccgagctgcccgtgctgagtgccctg
gagctgctggacttcagcttccccgactgccacgtgggctcctttgccatcaagtccctg
cggaagctgacggatgaggagcttttccagtacctgctgcagctggtacaggtgctcaag
tacgagtcctacctggactgcgagctgaccaagttcttgctgggccgggccctggccaac
cgcaagatcggccacttcctcttctggcacctccgctccgagatgcacgtgccctccgtg
gctttgcgcttcggcctcatcatggaggcctactgcaggggcagcacccatcacatgaag
gtgctgatgaagcagggggaagcactgagcaagctgaaggccctgaatgacttcgtcaag
gtgagctctcagaagaccaccaagccgcagaccaaggagctgatgcacctgtgcatgcgc
caggaggcctacctggaggccctctcgcacctgcagtccccgctcgaccccagcaccctg
ctggccgaagtctgcgtggagcagtgcaccttcatggactccaagatgaagcccctgtgg
atcgtgtacagcaacgaggaggcgggcagcgagggcagcgtgggcatcatcttcaagaac
ggggacgacctccgccaggacatgctgacgctgcagatgatccagctcatggacgtcctg
tggaagcaggagggcctggacttgaggatgaccccctatggctgcctccccacgggggac
cgcacaggcctgatcgaggtagttctccactcggacaccattgccaacatccagctgaac
aagagcaacatggcggccacggctgccttcaacaaggacgctctgctcaactggctcaag
tccaagaaccctggggaggccctggaccgtgccattgaggagttcaccctctcctgtgcc
ggctactgtgtggccacatacgtgctgggcatcggcgaccggcacagtgacaacatcatg
atccgtgagagtggacagctgttccatgttgacttcggtcacttcctggggaatttcaag
accaagttcggaatcaaccgtgagcgagtccccttcatcctcacctacgactttgtccac
gtgattcagcaggggaagaccaacaacagtgagaagtttgaaaggttccggggctactgt
gagagagcgtacaccatcctgcggcgccacgggctcctcttcctccacctctttgccctg
atgcgggcagcgggcctccccgagctcagctgccccaaagacatccagtatctcaaggac
tccctggccctggggaagacagaggaggaggcactgaagcacttccgggtgaagtttaac
gaagccctgcgggagagctggaagaccaaagtgaactggctggcccacaacgtgtccaaa
gacaatcggcagtag

KEGG   Oryctolagus cuniculus (rabbit): 100357841
Entry
100357841         CDS       T03373                                 
Name
(RefSeq) phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1
  KO
K02649  phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu01521  EGFR tyrosine kinase inhibitor resistance
ocu01522  Endocrine resistance
ocu01524  Platinum drug resistance
ocu04012  ErbB signaling pathway
ocu04014  Ras signaling pathway
ocu04015  Rap1 signaling pathway
ocu04024  cAMP signaling pathway
ocu04062  Chemokine signaling pathway
ocu04066  HIF-1 signaling pathway
ocu04068  FoxO signaling pathway
ocu04070  Phosphatidylinositol signaling system
ocu04071  Sphingolipid signaling pathway
ocu04072  Phospholipase D signaling pathway
ocu04081  Hormone signaling
ocu04140  Autophagy - animal
ocu04150  mTOR signaling pathway
ocu04151  PI3K-Akt signaling pathway
ocu04152  AMPK signaling pathway
ocu04210  Apoptosis
ocu04211  Longevity regulating pathway
ocu04213  Longevity regulating pathway - multiple species
ocu04218  Cellular senescence
ocu04360  Axon guidance
ocu04370  VEGF signaling pathway
ocu04380  Osteoclast differentiation
ocu04510  Focal adhesion
ocu04550  Signaling pathways regulating pluripotency of stem cells
ocu04611  Platelet activation
ocu04613  Neutrophil extracellular trap formation
ocu04620  Toll-like receptor signaling pathway
ocu04625  C-type lectin receptor signaling pathway
ocu04630  JAK-STAT signaling pathway
ocu04650  Natural killer cell mediated cytotoxicity
ocu04660  T cell receptor signaling pathway
ocu04662  B cell receptor signaling pathway
ocu04664  Fc epsilon RI signaling pathway
ocu04666  Fc gamma R-mediated phagocytosis
ocu04668  TNF signaling pathway
ocu04670  Leukocyte transendothelial migration
ocu04722  Neurotrophin signaling pathway
ocu04725  Cholinergic synapse
ocu04750  Inflammatory mediator regulation of TRP channels
ocu04810  Regulation of actin cytoskeleton
ocu04910  Insulin signaling pathway
ocu04914  Progesterone-mediated oocyte maturation
ocu04915  Estrogen signaling pathway
ocu04917  Prolactin signaling pathway
ocu04919  Thyroid hormone signaling pathway
ocu04923  Regulation of lipolysis in adipocytes
ocu04926  Relaxin signaling pathway
ocu04929  GnRH secretion
ocu04930  Type II diabetes mellitus
ocu04931  Insulin resistance
ocu04932  Non-alcoholic fatty liver disease
ocu04933  AGE-RAGE signaling pathway in diabetic complications
ocu04935  Growth hormone synthesis, secretion and action
ocu04960  Aldosterone-regulated sodium reabsorption
ocu04973  Carbohydrate digestion and absorption
ocu05010  Alzheimer disease
ocu05017  Spinocerebellar ataxia
ocu05020  Prion disease
ocu05100  Bacterial invasion of epithelial cells
ocu05135  Yersinia infection
ocu05142  Chagas disease
ocu05146  Amoebiasis
ocu05160  Hepatitis C
ocu05161  Hepatitis B
ocu05162  Measles
ocu05163  Human cytomegalovirus infection
ocu05164  Influenza A
ocu05165  Human papillomavirus infection
ocu05166  Human T-cell leukemia virus 1 infection
ocu05167  Kaposi sarcoma-associated herpesvirus infection
ocu05168  Herpes simplex virus 1 infection
ocu05169  Epstein-Barr virus infection
ocu05170  Human immunodeficiency virus 1 infection
ocu05171  Coronavirus disease - COVID-19
ocu05200  Pathways in cancer
ocu05203  Viral carcinogenesis
ocu05205  Proteoglycans in cancer
ocu05206  MicroRNAs in cancer
ocu05207  Chemical carcinogenesis - receptor activation
ocu05208  Chemical carcinogenesis - reactive oxygen species
ocu05210  Colorectal cancer
ocu05211  Renal cell carcinoma
ocu05212  Pancreatic cancer
ocu05213  Endometrial cancer
ocu05214  Glioma
ocu05215  Prostate cancer
ocu05218  Melanoma
ocu05220  Chronic myeloid leukemia
ocu05221  Acute myeloid leukemia
ocu05222  Small cell lung cancer
ocu05223  Non-small cell lung cancer
ocu05224  Breast cancer
ocu05225  Hepatocellular carcinoma
ocu05226  Gastric cancer
ocu05230  Central carbon metabolism in cancer
ocu05231  Choline metabolism in cancer
ocu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ocu05415  Diabetic cardiomyopathy
ocu05417  Lipid and atherosclerosis
ocu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    100357841
   04015 Rap1 signaling pathway
    100357841
   04630 JAK-STAT signaling pathway
    100357841
   04668 TNF signaling pathway
    100357841
   04066 HIF-1 signaling pathway
    100357841
   04068 FoxO signaling pathway
    100357841
   04070 Phosphatidylinositol signaling system
    100357841
   04072 Phospholipase D signaling pathway
    100357841
   04071 Sphingolipid signaling pathway
    100357841
   04024 cAMP signaling pathway
    100357841
   04151 PI3K-Akt signaling pathway
    100357841
   04152 AMPK signaling pathway
    100357841
   04150 mTOR signaling pathway
    100357841
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    100357841
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100357841
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    100357841
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100357841
   04613 Neutrophil extracellular trap formation
    100357841
   04620 Toll-like receptor signaling pathway
    100357841
   04650 Natural killer cell mediated cytotoxicity
    100357841
   04660 T cell receptor signaling pathway
    100357841
   04662 B cell receptor signaling pathway
    100357841
   04664 Fc epsilon RI signaling pathway
    100357841
   04666 Fc gamma R-mediated phagocytosis
    100357841
   04670 Leukocyte transendothelial migration
    100357841
   04062 Chemokine signaling pathway
    100357841
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    100357841
   04929 GnRH secretion
    100357841
   04915 Estrogen signaling pathway
    100357841
   04917 Prolactin signaling pathway
    100357841
   04926 Relaxin signaling pathway
    100357841
   04935 Growth hormone synthesis, secretion and action
    100357841
   04919 Thyroid hormone signaling pathway
    100357841
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    100357841
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100357841
  09156 Nervous system
   04725 Cholinergic synapse
    100357841
   04722 Neurotrophin signaling pathway
    100357841
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100357841
  09158 Development and regeneration
   04360 Axon guidance
    100357841
   04380 Osteoclast differentiation
    100357841
  09149 Aging
   04211 Longevity regulating pathway
    100357841
   04213 Longevity regulating pathway - multiple species
    100357841
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100357841
   05206 MicroRNAs in cancer
    100357841
   05205 Proteoglycans in cancer
    100357841
   05207 Chemical carcinogenesis - receptor activation
    100357841
   05208 Chemical carcinogenesis - reactive oxygen species
    100357841
   05203 Viral carcinogenesis
    100357841
   05230 Central carbon metabolism in cancer
    100357841
   05231 Choline metabolism in cancer
    100357841
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100357841
  09162 Cancer: specific types
   05210 Colorectal cancer
    100357841
   05212 Pancreatic cancer
    100357841
   05225 Hepatocellular carcinoma
    100357841
   05226 Gastric cancer
    100357841
   05214 Glioma
    100357841
   05221 Acute myeloid leukemia
    100357841
   05220 Chronic myeloid leukemia
    100357841
   05218 Melanoma
    100357841
   05211 Renal cell carcinoma
    100357841
   05215 Prostate cancer
    100357841
   05213 Endometrial cancer
    100357841
   05224 Breast cancer
    100357841
   05222 Small cell lung cancer
    100357841
   05223 Non-small cell lung cancer
    100357841
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100357841
   05170 Human immunodeficiency virus 1 infection
    100357841
   05161 Hepatitis B
    100357841
   05160 Hepatitis C
    100357841
   05171 Coronavirus disease - COVID-19
    100357841
   05164 Influenza A
    100357841
   05162 Measles
    100357841
   05163 Human cytomegalovirus infection
    100357841
   05167 Kaposi sarcoma-associated herpesvirus infection
    100357841
   05169 Epstein-Barr virus infection
    100357841
   05165 Human papillomavirus infection
    100357841
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    100357841
   05100 Bacterial invasion of epithelial cells
    100357841
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100357841
   05142 Chagas disease
    100357841
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100357841
   05017 Spinocerebellar ataxia
    100357841
   05020 Prion disease
    100357841
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100357841
   05418 Fluid shear stress and atherosclerosis
    100357841
   05415 Diabetic cardiomyopathy
    100357841
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100357841
   04932 Non-alcoholic fatty liver disease
    100357841
   04931 Insulin resistance
    100357841
   04933 AGE-RAGE signaling pathway in diabetic complications
    100357841
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100357841
   01524 Platinum drug resistance
    100357841
   01522 Endocrine resistance
    100357841
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ocu04131]
    100357841
Membrane trafficking [BR:ocu04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    100357841
SSDB
Motif
Pfam: PI3K_P85_iSH2 SH2 RhoGAP SH2_1 SH3_1 AAA_13 SH3_2 SH3_9 Laminin_I Exonuc_VII_L
Other DBs
NCBI-GeneID: 100357841
NCBI-ProteinID: XP_002714116
Ensembl: ENSOCUG00000005116
UniProt: G1SN87
LinkDB
Position
11:complement(5158515..5246120)
AA seq 724 aa
MSAEGYQYRALYDYKKERDEDIDLHLGDILTVNKGSLVALGFSEGQEARPEDIGWLNGYN
ETTGERGDFPGTYVEYIGRKRISPPTPKPRPPRPLPVAPGSAKSEADSEPPASTLPDLAE
QFAPPDVAPPLLIKLLEAIEKKGLECSTLYRTPSSSNPAELRQLLDCDAASVDLEAMDVQ
VLADAFKRYLLDLPNPVIPVAVYSEMLSLAQEIQSAEEYTQVLKKLIRSPNIPHQYWLTL
QYLLKHFFRLSQASSKSLLTARALAEIFSPMLFRFPAASPDNTEHLVKVIEILICNEWSD
RQPAPALPPKPPKPTTVANNGTNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDA
STKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKL
DVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMK
RTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNYDKLKSRISEIID
SRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGN
ENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAETLLRGKRDGTFLVRESSKQGCYACS
VVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYA
QQRR
NT seq 2175 nt   +upstreamnt  +downstreamnt
atgagtgccgagggctaccagtaccgggcgctgtacgactacaagaaggagagggacgag
gacatcgacttgcacttgggggacatactgactgtgaacaaagggtccttggtggcgctg
ggcttcagcgaggggcaggaagcccggcccgaagacatcggctggctaaacggctataat
gagaccacgggggagaggggcgacttcccggggacctacgtggaatacatcggaaggaag
agaatctcgcctcctactccgaagccccggccgcctcgaccccttcctgttgcgccaggt
tctgccaaatccgaggcggacagtgagccaccagcttccacgcttccggatcttgcagag
cagttcgcccctcccgacgttgccccgcctcttcttatcaagctcttggaagccattgag
aagaaaggtctggaatgttcaaccctctacaggacgccgagctccagcaaccctgcagaa
ctacgacagcttcttgattgtgacgcagcctccgtggacctggaagcgatggatgtgcaa
gtgttagccgatgctttcaaacgctatctcctggacttacccaatcccgtcatccccgta
gccgtgtacagcgagatgctttccttagcccaagaaatacagagcgccgaagaatatacc
caggtgttgaagaagctcatccggtcgcccaacatacctcatcagtattggctcacgctt
cagtatttgctaaaacacttcttcaggctctcgcaggcctccagcaagagtctcttaact
gcaagagcgctcgcagaaattttcagccctatgcttttcagattccctgcggccagccct
gataatactgagcacctcgttaaagttatagaaattttaatctgcaacgaatggagtgat
cgacaacctgcaccagcactgccccccaaaccaccaaaacccactactgtcgccaacaac
gggacgaacaacaacatgtccctgcaggacgcagaatggtactggggggacatctcaagg
gaagaggtgaacgagaaacttcgagatacggcagatgggaccttcttggtacgagacgca
tctactaagatgcatggtgattatactctcacactaaggaaaggaggaaataacaaatta
atcaaaatatttcaccgagatgggaaatatggcttctctgacccattaaccttcaactct
gtggttgaactaataaaccactaccggaatgaatccctagcgcagtataatcccaaactg
gatgtgaagttgctttatccagtgtccaaataccaacaggatcaggttgttaaagaagat
aatattgaagctgtagggaaaaagttacatgaatataacactcaatttcaagagaaaagc
cgggaatatgatagattatatgaagagtatacccgtacttcccaggaaatccaaatgaaa
agaacagctattgaagcatttaatgaaaccataaaaatatttgaagaacagtgccaaacc
caagagcggtacagcaaagaatacatagaaaagttcaaacgcgaaggcaatgagaaggaa
atacaaaggattatgcacaattatgataagttaaagtctcgaatcagcgagattatcgac
agcaggagacgcctggaggaggacttgaagaagcaggcggccgagtaccgggagatcgac
aaacgcatgaacagcatcaaaccagacctcatccagctgagaaagacgagagaccaatac
ttgatgtggctgacgcagaaaggtgtccggcagaagaagctgaacgagtggcttggcaac
gagaacacggaagaccaatactcgctggtggaggacgacgaggacctgccccaccacgac
gagaagacgtggaacgtcggcagcagcaaccgcaacaaagccgaaaccctgctgcgcggg
aagcgggacggcacctttctggtccgggagagcagcaaacagggctgctacgcctgctcc
gtggtggtggacggcgaggtcaagcactgtgtcatcaacaagacggccaccggctatggc
ttcgccgagccctataacctgtacagctccctgaaagaactggtgctacattaccaacac
acctcgctcgtgcagcacaacgactctctcaacgtcacactagcctacccggtctatgca
cagcagaggcgatga

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